• 32579 Citations
  • 85 Scopus h-Index
1982 …2019
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Research Output 1982 2019

  • 32579 Citations
  • 85 Scopus h-Index
  • 403 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Letter
2019

An expanded variant list and assembly annotation identifies multiple novel coding and noncoding genes for prostate cancer risk using a normal prostate tissue eQTL data set

DeRycke, M. S., Larson, M. C., Nair, A. A., McDonnell, S. K., French, A. J., Tillmans, L. S., Riska, S. M., Baheti, S., Fogarty, Z. C., Larson, N., O'Brien, D. R., Cheville, J., Wang, L., Schaid, D. J. & Thibodeau, S. N., Apr 1 2019, In : PloS one. 14, 4, e0214588.

Research output: Contribution to journalArticle

Open Access
Quantitative Trait Loci
prostatic neoplasms
Prostate
quantitative trait loci
Prostatic Neoplasms
1 Citation (Scopus)

A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR

Safarova, M. S., Satterfield, B. A., Fan, X., Austin, E. E., Ye, Z., Bastarache, L., Zheng, N., Ritchie, M. D., Borthwick, K. M., Williams, M. S., Larson, E. B., Scrol, A., Jarvik, G. P., Crosslin, D. R., Leppig, K., Rasmussen-Torvik, L. J., Pendergrass, S. A., Sturm, A. C., Namjou, B., Shah, A. S. & 12 others, Carroll, R. J., Chung, W. K., Wei, W. Q., Feng, Q. P., Stein, C. M., Roden, D. M., Manolio, T. A., Schaid, D. J., Denny, J. C., Hebbring, S. J., De Andrade, M. & Kullo, I. J., Dec 1 2019, In : npj Genomic Medicine. 4, 1, 3.

Research output: Contribution to journalArticle

Open Access
Electronic Health Records
Precision Medicine
Genetic Models
Myopia
Linkage Disequilibrium

A review of kernel methods for genetic association studies

Larson, N. B., Chen, J. & Schaid, D. J., Jan 1 2019, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

Genetic Association Studies
Pedigree
1 Citation (Scopus)

Atlas-CNV: a validated approach to call single-exon CNVs in the eMERGESeq gene panel

Chiang, T., Liu, X., Wu, T. J., Hu, J., Sedlazeck, F. J., White, S., Schaid, D., Andrade, M. D., Jarvik, G. P., Crosslin, D., Stanaway, I., Carrell, D. S., Connolly, J. J., Hakonarson, H., Groopman, E. E., Gharavi, A. G., Fedotov, A., Bi, W., Leduc, M. S., Murdock, D. R. & 10 others, Jiang, Y., Meng, L., Eng, C. M., Wen, S., Yang, Y., Muzny, D. M., Boerwinkle, E., Salerno, W., Venner, E. & Gibbs, R. A., Jan 1 2019, In : Genetics in Medicine.

Research output: Contribution to journalArticle

Open Access
Atlases
Exons
Genes
Ligation
Software
4 Citations (Scopus)

Current perspectives in assessing humoral immunity after measles vaccination

Haralambieva, I. H., Kennedy, R. B., Ovsyannikova, I. G., Schaid, D. J. & Poland, G. A., Jan 2 2019, In : Expert Review of Vaccines. 18, 1, p. 75-87 13 p.

Research output: Contribution to journalReview article

Measles
Humoral Immunity
Vaccination
Measles Vaccine
Vaccines

Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network

Zhang, X., Veturi, Y., Verma, S., Bone, W., Verma, A., Lucas, A., Hebbring, S., Denny, J. C., Stanaway, I. B., Jarvik, G. P., Crosslin, D., Larson, E. B., Rasmussen-Torvik, L., Pendergrass, S. A., Smoller, J. W., Hakonarson, H., Sleiman, P., Weng, C., Fasel, D., Wei, W. Q. & 4 others, Kullo, I. J., Schaid, D. J., Chung, W. K. & Ritchie, M. D., Jan 1 2019, In : Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 24, p. 272-283 12 p.

Research output: Contribution to journalArticle

Electronic Health Records
Genomics
Cardiovascular Diseases
Phenotype
Nervous System Diseases
1 Citation (Scopus)
document markup languages
HTML
Prostatic Neoplasms
cancer
communication
1 Citation (Scopus)

Familial recurrence risk with varying amount of family history

Schaid, D. J., McDonnell, S. K. & Thibodeau, S. N., Jan 1 2019, In : Genetic epidemiology.

Research output: Contribution to journalArticle

Recurrence
Prostatic Neoplasms
Binomial Distribution
Registries
Genes

Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer

Ruddy, K. J., Schaid, D. J., Partridge, A. H., Larson, N. B., Batzler, A., Häberle, L., Dittrich, R., Widschwendter, P., Fink, V., Bauer, E., Schwitulla, J., Rübner, M., Ekici, A. B., Aivazova-Fuchs, V., Stewart, E. A., Beckmann, M. W., Ginsburg, E., Wang, L., Weinshilboum, R. M., Couch, F. J. & 4 others, Janni, W., Rack, B., Vachon, C. & Fasching, P. A., Jan 1 2019, (Accepted/In press) In : Fertility and Sterility.

Research output: Contribution to journalArticle

Amenorrhea
Breast Neoplasms
Drug Therapy
Menstruation
Phosphopantothenoyl-cysteine decarboxylase

Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics

Yazdani, A., Yazdani, A., Elsea, S. H., Schaid, D. J., Kosorok, M. R., Dangol, G. & Samiei, A., May 21 2019, In : BMC genomics. 20, 1, 395.

Research output: Contribution to journalArticle

Open Access
Metabolomics
Genome
Mutation
Triglycerides
Genes
2 Citations (Scopus)

Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network

the eMERGE Consortium, Sep 5 2019, In : American journal of human genetics. 105, 3, p. 588-605 18 p.

Research output: Contribution to journalArticle

Genetic Testing
Clinical Decision Support Systems
Precision Medicine
Gene Targeting
Information Dissemination
1 Citation (Scopus)

Multivariate generalized linear model for genetic pleiotropy

Schaid, D. J., Tong, X., Batzler, A., Sinnwell, J. P., Qing, J. & Biernacka, J. M., Jan 1 2019, In : Biostatistics (Oxford, England). 20, 1, p. 111-128 18 p.

Research output: Contribution to journalArticle

Generalized Linear Model
Null hypothesis
Null
Gene
Testing
6 Citations (Scopus)

Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination

Voigt, E. A., Ovsyannikova, I. G., Kennedy, R. B., Grill, D. E., Goergen, K. M., Schaid, D. J. & Poland, G. A., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Enzyme-Linked Immunospot Assay
Sex Characteristics
Human Influenza
Vaccination
Influenza Vaccines

Targeted Sequencing Study to Uncover Shared Genetic Susceptibility Between Peripheral Artery Disease and Coronary Heart Disease-Brief Report

Safarova, M. S., Fan, X., Austin, E. E., van Zuydam, N., Hopewell, J., Schaid, D. J. & Kullo, I. J., Jun 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 6, p. 1227-1233 7 p.

Research output: Contribution to journalArticle

Open Access
Peripheral Arterial Disease
Genetic Predisposition to Disease
Coronary Disease
Gene Frequency
Genes
2018
6 Citations (Scopus)

A small-sample kernel association test for correlated data with application to microbiome association studies

Zhan, X., Xue, L., Zheng, H., Plantinga, A., Wu, M. C., Schaid, D. J., Zhao, N. & Chen, J., Jan 1 2018, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

Microbiota
Twin Studies
Pedigree
Sample Size
Longitudinal Studies
78 Citations (Scopus)

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Schumacher, F. R., Al Olama, A. A., Berndt, S. I., Benlloch, S., Ahmed, M., Saunders, E. J., Dadaev, T., Leongamornlert, D., Anokian, E., Cieza-Borrella, C., Goh, C., Brook, M. N., Sheng, X., Fachal, L., Dennis, J., Tyrer, J., Muir, K., Lophatananon, A., Stevens, V. L., Gapstur, S. M. & 167 others, Carter, B. D., Tangen, C. M., Goodman, P. J., Thompson, I. M., Batra, J., Chambers, S., Moya, L., Clements, J., Horvath, L., Tilley, W., Risbridger, G. P., Gronberg, H., Aly, M., Nordström, T., Pharoah, P., Pashayan, N., Schleutker, J., Tammela, T. L. J., Sipeky, C., Auvinen, A., Albanes, D., Weinstein, S., Wolk, A., Håkansson, N., West, C. M. L., Dunning, A. M., Burnet, N., Mucci, L. A., Giovannucci, E., Andriole, G. L., Cussenot, O., Cancel-Tassin, G., Koutros, S., Beane Freeman, L. E., Sorensen, K. D., Orntoft, T. F., Borre, M., Maehle, L., Grindedal, E. M., Neal, D. E., Donovan, J. L., Hamdy, F. C., Martin, R. M., Travis, R. C., Key, T. J., Hamilton, R. J., Fleshner, N. E., Finelli, A., Ingles, S. A., Stern, M. C., Rosenstein, B. S., Kerns, S. L., Ostrer, H., Lu, Y. J., Zhang, H. W., Feng, N., Mao, X., Guo, X., Wang, G., Sun, Z., Giles, G. G., Southey, M. C., MacInnis, R. J., Fitzgerald, L. M., Kibel, A. S., Drake, B. F., Vega, A., Gómez-Caamaño, A., Szulkin, R., Eklund, M., Kogevinas, M., Llorca, J., Castaño-Vinyals, G., Penney, K. L., Stampfer, M., Park, J. Y., Sellers, T. A., Lin, H. Y., Stanford, J. L., Cybulski, C., Wokolorczyk, D., Lubinski, J., Ostrander, E. A., Geybels, M. S., Nordestgaard, B. G., Nielsen, S. F., Weischer, M., Bisbjerg, R., Røder, M. A., Iversen, P., Brenner, H., Cuk, K., Holleczek, B., Maier, C., Luedeke, M., Schnoeller, T., Kim, J., Logothetis, C. J., John, E. M., Teixeira, M. R., Paulo, P., Cardoso, M., Neuhausen, S. L., Steele, L., Ding, Y. C., De Ruyck, K., De Meerleer, G., Ost, P., Razack, A., Lim, J., Teo, S. H., Lin, D. W., Newcomb, L. F., Lessel, D., Gamulin, M., Kulis, T., Kaneva, R., Usmani, N., Singhal, S., Slavov, C., Mitev, V., Parliament, M., Claessens, F., Joniau, S., Van Den Broeck, T., Larkin, S., Townsend, P. A., Aukim-Hastie, C., Dominguez, M. G., Castelao, J. E., Martinez, M. E., Roobol, M. J., Jenster, G., Van Schaik, R. H. N., Menegaux, F., Truong, T., Koudou, Y. A., Xu, J., Khaw, K. T., Cannon-Albright, L., Pandha, H., Michael, A., Thibodeau, S. N., McDonnell, S. K., Schaid, D. J., Lindstrom, S., Turman, C., Ma, J., Hunter, D. J., Riboli, E., Siddiq, A., Canzian, F., Kolonel, L. N., Le Marchand, L., Hoover, R. N., Machiela, M. J., Cui, Z., Kraft, P., Amos, C. I., Conti, D. V., Easton, D. F., Wiklund, F., Chanock, S. J., Henderson, B. E., Kote-Jarai, Z., Haiman, C. A. & Eeles, R. A., Jul 1 2018, In : Nature Genetics. 50, 7, p. 928-936 9 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Confidence Intervals
Genome-Wide Association Study
Genotype
Population

Correction to: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci (Nature Genetics, (2018), 50, 7, (928-936), 10.1038/s41588-018-0142-8)

Breast and Prostate Cancer Cohort Consortium (BPC3), The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Cancer of the Prostate in Sweden (CAPS), Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, The Profile Study, Australian Prostate Cancer BioResource (APCB), The IMPACT Study & Canary PASS Investigators, Jul 1 2018, In : Nature Genetics. 51, 2, 1 p.

Research output: Contribution to journalComment/debate

Genetic Loci
Names
Prostatic Neoplasms
17 Citations (Scopus)

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Dadaev, T., Saunders, E. J., Newcombe, P. J., Anokian, E., Leongamornlert, D. A., Brook, M. N., Cieza-Borrella, C., Mijuskovic, M., Wakerell, S., Olama, A. A. A., Schumacher, F. R., Berndt, S. I., Benlloch, S., Ahmed, M., Goh, C., Sheng, X., Zhang, Z., Muir, K., Govindasami, K., Lophatananon, A. & 290 others, Stevens, V. L., Gapstur, S. M., Carter, B. D., Tangen, C. M., Goodman, P., Thompson, I. M., Batra, J., Chambers, S., Moya, L., Clements, J., Horvath, L., Tilley, W., Risbridger, G., Gronberg, H., Aly, M., Nordström, T., Pharoah, P., Pashayan, N., Schleutker, J., Tammela, T. L. J., Sipeky, C., Auvinen, A., Albanes, D., Weinstein, S., Wolk, A., Hakansson, N., West, C., Dunning, A. M., Burnet, N., Mucci, L., Giovannucci, E., Andriole, G., Cussenot, O., Cancel-Tassin, G., Koutros, S., Freeman, L. E. B., Sorensen, K. D., Orntoft, T. F., Borre, M., Maehle, L., Grindedal, E. M., Neal, D. E., Donovan, J. L., Hamdy, F. C., Martin, R. M., Travis, R. C., Key, T. J., Hamilton, R. J., Fleshner, N. E., Finelli, A., Ingles, S. A., Stern, M. C., Rosenstein, B., Kerns, S., Ostrer, H., Lu, Y. J., Zhang, H. W., Feng, N., Mao, X., Guo, X., Wang, G., Sun, Z., Giles, G. G., Southey, M. C., MacInnis, R. J., Fitzgerald, L. M., Kibel, A. S., Drake, B. F., Vega, A., Gómez-Caamaño, A., Fachal, L., Szulkin, R., Eklund, M., Kogevinas, M., Llorca, J., Castaño-Vinyals, G., Penney, K. L., Stampfer, M., Park, J. Y., Sellers, T. A., Lin, H. Y., Stanford, J. L., Cybulski, C., Wokolorczyk, D., Lubinski, J., Ostrander, E. A., Geybels, M. S., Nordestgaard, B. G., Nielsen, S. F., Weisher, M., Bisbjerg, R., Røder, M. A., Iversen, P., Brenner, H., Cuk, K., Holleczek, B., Maier, C., Luedeke, M., Schnoeller, T., Kim, J., Logothetis, C. J., John, E. M., Teixeira, M. R., Paulo, P., Cardoso, M., Neuhausen, S. L., Steele, L., Ding, Y. C., De Ruyck, K., De Meerleer, G., Ost, P., Razack, A., Lim, J., Teo, S. H., Lin, D. W., Newcomb, L. F., Lessel, D., Gamulin, M., Kulis, T., Kaneva, R., Usmani, N., Slavov, C., Mitev, V., Parliament, M., Singhal, S., Claessens, F., Joniau, S., Van Den Broeck, T., Larkin, S., Townsend, P. A., Aukim-Hastie, C., Gago-Dominguez, M., Castelao, J. E., Martinez, M. E., Roobol, M. J., Jenster, G., Van Schaik, R. H. N., Menegaux, F., Truong, T., Koudou, Y. A., Xu, J., Khaw, K. T., Cannon-Albright, L., Pandha, H., Michael, A., Kierzek, A., Thibodeau, S. N., McDonnell, S. K., Schaid, D. J., Lindstrom, S., Turman, C., Ma, J., Hunter, D. J., Riboli, E., Siddiq, A., Canzian, F., Kolonel, L. N., Le Marchand, L., Hoover, R. N., Machiela, M. J., Kraft, P., Cook, M., Thwaites, A., Guy, M., Whitmore, I., Morgan, A., Fisher, C., Hazel, S., Livni, N., Spurdle, A., Srinivasan, S., Kedda, M. A., Aitken, J., Gardiner, R., Hayes, V., Butler, L., Taylor, R., Yeadon, T., Eckert, A., Saunders, P., Haynes, A. M., Papargiris, M., Kujala, P., Talala, K., Murtola, T., Taari, K., Dearnaley, D., Barnett, G., Bentzen, S., Elliott, R., Ranu, H., Hicks, B., Vogt, A., Hutchinson, A., Cox, A., Davis, M., Brown, P., George, A., Marsden, G., Lane, A., Lewis, S. J., Berry, C., Kulkarni, G. S., Toi, A., Evans, A., Zlotta, A. R., Van Der Kwast, T. H., Imai, T., Saito, S., Marzec, J., Cao, G., Lin, J., Ling, J., Li, M., Zhao, S. C., Ren, G., Yu, Y., Wu, Y., Wu, J., Zhou, B., Zhang, Y., Li, J., He, W., Guo, J., Pedersen, J., Hopper, J. L., Milne, R., Klim, A., Carballo, A., Lobato-Busto, R., Peleteiro, P., Calvo, P., Aguado, M., Ruiz-Dominguez, J. M., Cecchini, L., Mengual, L., Alcaraz, A., Bustamante, M., Gracia-Lavedan, E., Dierssen-Sotos, T., Gomez-Acebo, I., Pow-Sang, J., Park, H., Zachariah, B., Kluzniak, W., Kolb, S., Klarskov, P., Stegmaier, C., Vogel, W., Herkommer, K., Bohnert, P., Maia, S., Silva, M. P., De Langhe, S., Thierens, H., Tan, M. H., Ong, A. T., Kastelan, Z., Popov, E., Kachakova, D., Mitkova, A., Vlahova, A., Dikov, T., Christova, S., Carracedo, A., Bangma, C., Schroder, F. H., Cenee, S., Tretarre, B., Rebillard, X., Mulot, C., Sanchez, M., Adolfsson, J., Stattin, P., Johansson, J. E., Cavalli-Bjoerkman, C., Karlsson, A., Broms, M., Wu, H., Tillmans, L., Riska, S., Freedman, M., Wiklund, F., Chanock, S., Henderson, B. E., Easton, D. F., Haiman, C. A., Eeles, R. A., Conti, D. V. & Kote-Jarai, Z., Dec 1 2018, In : Nature Communications. 9, 1, 2256.

Research output: Contribution to journalArticle

loci
Meta-Analysis
Prostatic Neoplasms
cancer
magnetic permeability
60 Citations (Scopus)

From genome-wide associations to candidate causal variants by statistical fine-mapping

Schaid, D. J., Chen, W. & Larson, N., Aug 1 2018, In : Nature Reviews Genetics. 19, 8, p. 491-504 14 p.

Research output: Contribution to journalReview article

Genome-Wide Association Study
Linkage Disequilibrium
Genetic Markers
Genome
Data Curation
4 Citations (Scopus)

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Nov 5 2018, In : Nature Communications. 9, 1, 1 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
cancer
magnetic permeability
chromosomes
loci
4 Citations (Scopus)

Polymorphisms in the wilms tumor gene are associated with interindividual variations in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination

Voigt, E. A., Haralambieva, I. H., Larrabee, B. L., Kennedy, R. B., Ovsyannikova, I. G., Schaid, D. J. & Poland, G. A., Feb 15 2018, In : Journal of Infectious Diseases. 217, 4, p. 560-566 7 p.

Research output: Contribution to journalArticle

Wilms' Tumor Genes
Rubella virus
Mumps
Rubella
Measles
2017
3 Citations (Scopus)

A DAB2IP genotype: Sex interaction is associated with abdominal aortic aneurysm expansion

Ye, Z., Austin, E., Schaid, D. J., Bailey, K. R., Pellikka, P. & Kullo, I. J., Oct 1 2017, In : Journal of Investigative Medicine. 65, 7, p. 1077-1082 6 p.

Research output: Contribution to journalArticle

Abdominal Aortic Aneurysm
Genotype
Blood Pressure
Aneurysm
Arterial Pressure
7 Citations (Scopus)

A large population-based association study between HLA and KIR genotypes and measles vaccine antibody responses

Ovsyannikova, I. G., Schaid, D. J., Larrabee, B. R., Haralambieva, I. H., Kennedy, R. B. & Poland, G. A., Feb 1 2017, In : PLoS One. 12, 2, e0171261.

Research output: Contribution to journalArticle

KIR Receptors
Measles Vaccine
immunoglobulins
Antibody Formation
Genotype
4 Citations (Scopus)

Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA

Chen, J., Behnam, E., Huang, J., Moffatt, M. F., Schaid, D. J., Liang, L. & Lin, X., May 26 2017, In : BMC Genomics. 18, 1, 413.

Research output: Contribution to journalArticle

Plague
Protect-It
Datasets
9 Citations (Scopus)

Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine

Haralambieva, I. H., Ovsyannikova, I. G., Kennedy, R. B., Larrabee, B. R., Zimmermann, M. T., Grill, D. E., Schaid, D. J. & Poland, G. A., Apr 1 2017, In : Human Genetics. 136, 4, p. 421-435 15 p.

Research output: Contribution to journalArticle

Measles Vaccine
Neutralizing Antibodies
Antibody Formation
Single Nucleotide Polymorphism
Genome
2 Citations (Scopus)

gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels

Larson, N., Mcdonnell, S., Cannon Albright, L., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J. E., Cussenot, O., Cancel-Tassin, G., Giles, G. G., Macinnis, R. J., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., 2017, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

Genes
Gene Components
Case-Control Studies
Schizophrenia
Technology
4 Citations (Scopus)

Heritability of vaccine-induced measles neutralizing antibody titers

Schaid, D. J., Haralambieva, I. H., Larrabee, B. R., Ovsyannikova, I. G., Kennedy, R. B. & Poland, G. A., Mar 7 2017, In : Vaccine. 35, 10, p. 1390-1394 5 p.

Research output: Contribution to journalArticle

Measles Vaccine
Neutralizing Antibodies
neutralizing antibodies
heritability
vaccines
1 Citation (Scopus)

Immunoglobulin GM and KM genes and measles vaccine-induced humoral immunity

Ovsyannikova, I. G., Larrabee, B. R., Schaid, D. J. & Poland, G. A., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Measles Vaccine
Humoral Immunity
Neutralizing Antibodies
neutralizing antibodies
humoral immunity
17 Citations (Scopus)

Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer

Winter, J. M., Gildea, D. E., Andreas, J. P., Gatti, D. M., Williams, K. A., Lee, M., Hu, Y., Zhang, S., Mullikin, J. C., Wolfsberg, T. G., McDonnell, S. K., Fogarty, Z. C., Larson, M. C., French, A. J., Schaid, D. J., Thibodeau, S. N., Churchill, G. A. & Crawford, N. P. S., Jan 25 2017, In : Cell Systems. 4, 1, p. 31-45.e6

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasm Metastasis
Population
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 8

Network-directed cis-mediator analysis of normal prostate tissue expression profiles reveals downstream regulatory associations of prostate cancer susceptibility loci

Larson, N., McDonnell, S. K., Fogarty, Z., Larson, M. C., Cheville, J., Riska, S., Baheti, S., Weber, A. M., Nair, A. A., Wang, L., O'Brien, D., Davila, J., Schaid, D. J. & Thibodeau, S. N., Oct 17 2017, In : Oncotarget. 8, 49, p. 85896-85908 13 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Prostate
Prostatic Neoplasms
Transcription Factors
Gene Expression
12 Citations (Scopus)

Polygenic risk scores in familial Alzheimer disease

Tosto, G., Bird, T. D., Tsuang, D., Bennett, D. A., Boeve, B. F., Cruchaga, C., Faber, K., Foroud, T. M., Farlow, M., Goate, A. M., Bertlesen, S., Graff Radford, N. R., Medrano, M., Lantigua, R., Manly, J., Ottman, R., Rosenberg, R., Schaid, D. J., Schupf, N., Stern, Y. & 2 others, Sweet, R. A. & Mayeux, R., Mar 21 2017, In : Neurology. 88, 12, p. 1180-1186 7 p.

Research output: Contribution to journalArticle

Alzheimer Disease
National Institute on Aging (U.S.)
Age of Onset
Hispanic Americans
Single Nucleotide Polymorphism
6 Citations (Scopus)

Whole exome sequencing in 75 high-risk families with validation and replication in independent case-control studies identifies TANGO2, OR5H14, and CHAD as new prostate cancer susceptibility genes

Karyadi, D. M., Geybels, M. S., Karlins, E., Decker, B., McIntosh, L., Hutchinson, A., Kolb, S., McDonnell, S. K., Hicks, B., Middha, S., FitzGerald, L. M., DeRycke, M. S., Yeager, M., Schaid, D. J., Chanock, S. J., Thibodeau, S. N., Berndt, S. I., Stanford, J. L. & Ostrander, E. A., 2017, In : Oncotarget. 8, 1, p. 1495-1507 13 p.

Research output: Contribution to journalArticle

Exome
Neoplasm Genes
Case-Control Studies
Prostatic Neoplasms
Alleles
2016
5 Citations (Scopus)

A multi-locus genetic risk score for abdominal aortic aneurysm

Ye, Z., Austin, E., Schaid, D. J. & Kullo, I. J., Mar 1 2016, In : Atherosclerosis. 246, p. 274-279 6 p.

Research output: Contribution to journalArticle

Genetic Loci
Abdominal Aortic Aneurysm
Aortic Aneurysm
Abdominal Aorta
Vascular Diseases
20 Citations (Scopus)

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Gusev, A., Shi, H., Kichaev, G., Pomerantz, M., Li, F., Long, H. W., Ingles, S. A., Kittles, R. A., Strom, S. S., Rybicki, B. A., Nemesure, B., Isaacs, W. B., Zheng, W., Pettaway, C. A., Yeboah, E. D., Tettey, Y., Biritwum, R. B., Adjei, A. A., Tay, E., Truelove, A. & 108 others, Niwa, S., Chokkalingam, A. P., John, E. M., Murphy, A. B., Signorello, L. B., Carpten, J., Leske, M. C., Wu, S. Y., Hennis, A. J. M., Neslund-Dudas, C., Hsing, A. W., Chu, L., Goodman, P. J., Klein, E. A., Witte, J. S., Casey, G., Kaggwa, S., Cook, M. B., Stram, D. O., Blot, W. J., Eeles, R. A., Easton, D., Kote-Jarai, Z., Al Olama, A. A., Benlloch, S., Muir, K., Giles, G. G., Southey, M. C., Fitzgerald, L. M., Gronberg, H., Wiklund, F., Aly, M., Henderson, B. E., Schleutker, J., Wahlfors, T., Tammela, T. L. J., Nordestgaard, B. G., Key, T. J., Travis, R. C., Neal, D. E., Donovan, J. L., Hamdy, F. C., Pharoah, P., Pashayan, N., Khaw, K. T., Stanford, J. L., Thibodeau, S. N., McDonnell, S. K., Schaid, D. J., Maier, C., Vogel, W., Luedeke, M., Herkommer, K., Kibel, A. S., Cybulski, C., Wokolorczyk, D., Kluzniak, W., Cannon-Albright, L., Teerlink, C., Brenner, H., Dieffenbach, A. K., Arndt, V., Park, J. Y., Sellers, T. A., Lin, H. Y., Slavov, C., Kaneva, R., Mitev, V., Batra, J., Spurdle, A., Clements, J. A., Teixeira, M. R., Pandha, H., Michael, A., Paulo, P., Maia, S., Kierzek, A., Conti, D. V., Albanes, D., Berg, C., Berndt, S. I., Campa, D., Crawford, E. D., Diver, W. R., Gapstur, S. M., Gaziano, J. M., Giovannucci, E., Hoover, R., Hunter, D. J., Johansson, M., Kraft, P., Le Marchand, L., Lindström, S., Navarro, C., Overvad, K., Riboli, E., Siddiq, A., Stevens, V. L., Trichopoulos, D., Vineis, P., Yeager, M., Trynka, G., Raychaudhuri, S., Schumacher, F. R., Price, A. L., Freedman, M. L., Haiman, C. A. & Pasaniuc, B., Apr 7 2016, In : Nature Communications. 7, 10979.

Research output: Contribution to journalArticle

Atlases
African Americans
Prostatic Neoplasms
cancer
Tissue
11 Citations (Scopus)

Genetically defined race, but not sex, is associated with higher humoral and cellular immune responses to measles vaccination

Voigt, E. A., Ovsyannikova, I. G., Haralambieva, I. H., Kennedy, R. B., Larrabee, B. R., Schaid, D. J. & Poland, G. A., Sep 22 2016, In : Vaccine. 34, 41, p. 4913-4919 7 p.

Research output: Contribution to journalArticle

Measles Vaccine
Measles
Humoral Immunity
humoral immunity
Cellular Immunity
13 Citations (Scopus)

Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

The PRACTICAL Consortium & International Consortium for Prostate Cancer Genetics, Aug 1 2016, In : Human Genetics. 135, 8, p. 923-938 16 p.

Research output: Contribution to journalArticle

Haplotypes
Single Nucleotide Polymorphism
Genome
Genome-Wide Association Study
Prostatic Neoplasms
62 Citations (Scopus)

Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types

Kar, S. P., Beesley, J., Al Olama, A. A., Michailidou, K., Tyrer, J., Kote-Jarai, Z. A., Lawrenson, K., Lindstrom, S., Ramus, S. J., Thompson, D. J., Kibel, A. S., Dansonka-Mieszkowska, A., Michael, A., Dieffenbach, A. K., Gentry-Maharaj, A., Whittemore, A. S., Wolk, A., Monteiro, A., Peixoto, A., Kierzek, A. & 260 others, Cox, A., Rudolph, A., Gonzalez-Neira, A., Wu, A. H., Lindblom, A., Swerdlow, A., Ziogas, A., Ekici, A. B., Burwinkel, B., Karlan, B. Y., Nordestgaard, B. G., Blomqvist, C., Phelan, C., McLean, C., Pearce, C. L., Vachon, C. M., Cybulski, C., Slavov, C., Stegmaier, C., Maier, C., Ambrosone, C. B., Hogdall, C. K., Teerlink, C. C., Kang, D., Tessier, D. C., Schaid, D. J., Stram, D. O., Cramer, D. W., Neal, D. E., Eccles, D., Flesch-Janys, D., Velez Edwards, D. R., Wokozorczyk, D., Levine, D. A., Yannoukakos, D., Sawyer, E. J., Bandera, E. V., Poole, E. M., Goode, E. L., Khusnutdinova, E., Hogdall, E., Song, F., Bruinsma, F., Heitz, F., Modugno, F., Hamdy, F. C., Wiklund, F., Giles, G. G., Olsson, H., Wildiers, H., Ulmer, H. U., Pandha, H., Risch, H. A., Darabi, H., Salvesen, H. B., Nevanlinna, H., Gronberg, H., Brenner, H., Brauch, H., Anton-Culver, H., Song, H., Lim, H. Y., McNeish, I., Campbell, I., Vergote, I., Gronwald, J., Lubiński, J., Stanford, J. L., Benitez, J., Doherty, J. A., Permuth, J. B., Chang-Claude, J., Donovan, J. L., Dennis, J., Schildkraut, J. M., Schleutker, J., Hopper, J. L., Kupryjanczyk, J., Park, J. Y., Figueroa, J., Clements, J. A., Knight, J. A., Peto, J., Cunningham, J. M., Pow-Sang, J., Batra, J., Czene, K., Lu, K. H., Herkommer, K., Khaw, K. T., Matsuo, K., Muir, K., Offitt, K., Chen, K., Moysich, K. B., Aittomaki, K., Odunsi, K., Kiemeney, L. A., Massuger, L. F. A. G., Fitzgerald, L. M., Cook, L. S., Cannon-Albright, L., Hooning, M. J., Pike, M. C., Bolla, M. K., Luedeke, M., Teixeira, M. R., Goodman, M. T., Schmidt, M. K., Riggan, M., Aly, M., Rossing, M. A., Beckmann, M. W., Moisse, M., Sanderson, M., Southey, M. C., Jones, M., Lush, M., Hildebrandt, M. A. T., Hou, M. F., Schoemaker, M. J., Garcia-Closas, M., Bogdanova, N., Rahman, N., Le, N. D., Orr, N., Wentzensen, N., Pashayan, N., Peterlongo, P., Guenel, P., Brennan, P., Paulo, P., Webb, P. M., Broberg, P., Fasching, P. A., Devilee, P., Wang, Q., Cai, Q., Li, Q., Kaneva, R., Butzow, R., Kopperud, R. K., Schmutzler, R. K., Stephenson, R. A., Macinnis, R. J., Hoover, R. N., Winqvist, R., Ness, R., Milne, R. L., Travis, R. C., Benlloch, S., Olson, S. H., McDonnell, S. K., Tworoger, S. S., Maia, S., Berndt, S., Lee, S. C., Teo, S. H., Thibodeau, S. N., Bojesen, S. E., Gapstur, S. M., Kjar, S. K., Pejovic, T., Tammela, T. L. J., Eeles, A., Easton, D., Kote-Jarai, Z. S., Al Olama, A. A., Benlloch, S., Muir, K., Giles, G. G., Southey, M. C., Fitzgerald, L. M., Gronberg, H., Wiklund, F., Aly, M., Henderson, B. E., Schumacher, F., Haiman, C. A., Schleutker, J., Wahlfors, T., Tammela, T. L. J., Nordestgaard, B. G., Key, T. J., Travis, R. C., Neal, D. E., Donovan, J. L., Hamdy, F. C., Pharoah, P., Pashayan, N., Khaw, K. T., Stanford, J. L., Thibodeau, S. N., McDonnell, S. K., Schaid, D. J., Couch, F. J., Vogel, W., Luedeke, M., Herkommer, K., Kibel, A. S., Cybulski, C., Wokozorczyk, D., Kluzniak, W., Cannon-Albright, L., Brenner, H., Dieffenbach, A. K., Arndt, V., Park, J. Y., Sellers, T., Lim, H. Y., Slavov, C., Kaneva, R., Mitev, V., Batra, J., Spurdle, A., Teixeira, M. R., Paulo, P., Maia, S., Pandha, H., Michael, A., Kierzek, A., Dork, T., Bruning, T., Wahlfors, T., Key, T. J., Edwards, T. L., Menon, U., Hamann, U., Mitev, V., Kosma, V. M., Setiawan, V. W., Kristensen, V., Arndt, V., Vogel, W., Zheng, W., Sieh, W., Blot, W. J., Kluzniak, W., Shu, X. O., Gao, Y. T., Schumacher, F., Freedman, M. L., Berchuck, A., Dunning, A. M., Simard, J., Haiman, C. A., Spurdle, A., Sellers, T. A., Hunter, D. J., Henderson, B. E., Kraft, P., Chanock, S. J., Couch, F. J., Hall, P., Gayther, S. A., Easton, D. F., Chenevix-Trench, G., Eeles, R., Pharoah, P. D. P. & Lambrechts, D., Sep 1 2016, In : Cancer Discovery. 6, 9, p. 1052-1067 16 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Meta-Analysis
Prostatic Neoplasms
Genome
Breast Neoplasms
67 Citations (Scopus)

Incorporating a Genetic Risk Score into Coronary Heart Disease Risk Estimates: Effect on LDL Cholesterol Levels (the MIGENES Clinical Trial)

Kullo, I. J., Jouni, H., Austin, E. E., Brown, S. A., Kruisselbrink, T. M., Isseh, I. N., Haddad, R. A., Marroush, T. S., Shameer, K., Olson, J. E., Broeckel, U., Green, R. C., Schaid, D. J., Montori, V. M. & Bailey, K. R., Feb 26 2016, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

LDL Cholesterol
Coronary Disease
Clinical Trials
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Dietary Fats
15 Citations (Scopus)

Incorporating functional annotations for fine-mapping causal variants in a bayesian framework using summary statistics

Chen, W., McDonnell, S. K., Thibodeau, S. N., Tillmans, L. S. & Schaid, D. J., Nov 1 2016, In : Genetics. 204, 3, p. 933-958 26 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Genome-Wide Association Study
Meta-Analysis
Prostate
Lipids
66 Citations (Scopus)

PALB2, CHEK2 and ATM rare variants and cancer risk: Data from COGS

KConFab investigators & Australian Ovarian Cancer Study Group, Sep 2 2016, (Accepted/In press) In : Journal of Medical Genetics.

Research output: Contribution to journalArticle

Neoplasms
Breast Neoplasms
Mutation
Ovarian Neoplasms
Case-Control Studies
3 Citations (Scopus)

Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies

Larson, N., McDonnell, S., Albright, L. C., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J., Cussenot, O., Cancel-Tassin, G., Giles, G., MacInnis, R., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., Sep 1 2016, In : Genetic Epidemiology. 40, 6, p. 461-469 9 p.

Research output: Contribution to journalArticle

Case-Control Studies
Gene Frequency
Sample Size
Prostatic Neoplasms
Genome
14 Citations (Scopus)

Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort

The PRACTICAL Consortium, 2016, In : BMC Medicine. 14, 1, 66.

Research output: Contribution to journalArticle

Random Allocation
Prostatic Neoplasms
Population
Puberty
Sexual Maturation
204 Citations (Scopus)

REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants

Ioannidis, N. M., Rothstein, J. H., Pejaver, V., Middha, S., McDonnell, S. K., Baheti, S., Musolf, A., Li, Q., Holzinger, E., Karyadi, D., Cannon-Albright, L. A., Teerlink, C. C., Stanford, J. L., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E. M., Schleutker, J., Carpten, J. D., Powell, I. J. & 21 others, Cussenot, O., Cancel-Tassin, G., Giles, G. G., MacInnis, R. J., Maier, C., Hsieh, C. L., Wiklund, F., Catalona, W. J., Foulkes, W. D., Mandal, D., Eeles, R. A., Kote-Jarai, Z., Bustamante, C. D., Schaid, D. J., Hastie, T., Ostrander, E. A., Bailey-Wilson, J. E., Radivojac, P., Thibodeau, S. N., Whittemore, A. S. & Sieh, W., Oct 6 2016, In : American Journal of Human Genetics. 99, 4, p. 877-885 9 p.

Research output: Contribution to journalArticle

Exome
Virulence
Area Under Curve
Gene Frequency
ROC Curve
19 Citations (Scopus)

Small Sample Kernel Association Tests for Human Genetic and Microbiome Association Studies

Chen, J., Chen, W., Zhao, N., Wu, M. C. & Schaid, D. J., Jan 1 2016, In : Genetic Epidemiology. 40, 1, p. 5-19 15 p.

Research output: Contribution to journalArticle

Microbiota
Medical Genetics
Genetic Association Studies
Economic Inflation
Politics
16 Citations (Scopus)

Statistical methods for testing genetic pleiotropy

Schaid, D. J., Tong, X., Larrabee, B., Kennedy, R. B., Poland, G. A. & Sinnwell, J. P., Oct 1 2016, In : Genetics. 204, 2, p. 483-497 15 p.

Research output: Contribution to journalArticle

Genetic Pleiotropy
Smallpox
Sample Size
Genes
Vaccination
21 Citations (Scopus)

The role of cardiovascular risk factors and stroke in familial Alzheimer disease

Tosto, G., Bird, T. D., Bennett, D. A., Boeve, B. F., Brickman, A. M., Cruchaga, C., Faber, K., Foroud, T. M., Farlow, M., Goate, A. M., Graff Radford, N. R., Lantigua, R., Manly, J., Ottman, R., Rosenberg, R., Schaid, D. J., Schupf, N., Stern, Y., Sweet, R. A. & Mayeux, R., Oct 1 2016, In : JAMA Neurology. 73, 10, p. 1231-1237 7 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Stroke
Odds Ratio
Apolipoprotein E4
Cardiovascular Diseases
2015
55 Citations (Scopus)

A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences

Hoffmann, T. J., Van Den Eeden, S. K., Sakoda, L. C., Jorgenson, E., Habel, L. A., Graff, R. E., Passarelli, M. N., Cario, C. L., Emami, N. C., Chao, C. R., Ghai, N. R., Shan, J., Ranatunga, D. K., Quesenberry, C. P., Aaronson, D., Presti, J., Wang, Z., Berndt, S. I., Chanock, S. J., McDonnell, S. K. & 15 others, French, A. J., Schaid, D. J., Thibodeau, S. N., Li, Q., Freedman, M. L., Penney, K. L., Mucci, L. A., Haiman, C. A., Henderson, B. E., Seminara, D., Kvale, M. N., Kwok, P. Y., Schaefer, C., Risch, N. & Witte, J. S., Aug 1 2015, In : Cancer Discovery. 5, 8, p. 878-891 14 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Prostatic Neoplasms
Single Nucleotide Polymorphism
Hispanic Americans
African Americans
15 Citations (Scopus)

A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2

Vachon, C. M., Schaid, D. J., Ingle, J. N., Wickerham, D. L., Kubo, M., Mushiroda, T., Goetz, M. P., Carlson, E. E., Paik, S., Wolmark, N., Nakamura, Y., Wang, L. M., Weinshilboum, R. M. & Couch, F. J., 2015, In : Breast Cancer Research and Treatment. 149, 2, p. 517-523 7 p.

Research output: Contribution to journalArticle

Tamoxifen
Breast Neoplasms
Selective Estrogen Receptor Modulators
Raloxifene Hydrochloride
Single Nucleotide Polymorphism
2 Citations (Scopus)

A powerful nonparametric statistical framework for family-based association analyses

Li, M., He, Z., Schaid, D. J., Cleves, M. A., Nick, T. G. & Lu, Q., Jan 1 2015, In : Genetics. 200, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

Pedigree
Phenotype
Population
Tobacco Use Disorder
Genetic Research
21 Citations (Scopus)

Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases

Helfand, B. T., Roehl, K. A., Cooper, P. R., McGuire, B. B., Fitzgerald, L. M., Cancel-Tassin, G., Cornu, J. N., Bauer, S., Van Blarigan, E. L., Chen, X., Duggan, D., Ostrander, E. A., Gwo-Shu, M., Zhang, Z. F., Chang, S. C., Jeong, S., Fontham, E. T. H., Smith, G., Mohler, J. L., Berndt, S. I. & 25 others, McDonnell, S. K., Kittles, R., Rybicki, B. A., Freedman, M., Kantoff, P. W., Pomerantz, M., Breyer, J. P., Smith, J. R., Rebbeck, T. R., Mercola, D., Isaacs, W. B., Wiklund, F., Cussenot, O., Thibodeau, S. N., Schaid, D. J., Cannon-Albright, L., Cooney, K. A., Chanock, S. J., Stanford, J. L., Chan, J. M., Witte, J., Xu, J., Bensen, J. T., Taylor, J. A. & Catalona, W. J., 2015, In : Human Genetics. 134, 4, p. 439-450 12 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Prostatic Neoplasms
African Americans
Neoplasm Grading
Genome-Wide Association Study