• 1275 Citations
  • 18 Scopus h-Index
20022020

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2020

Acute Toxicities and Short-Term Patient Outcomes After Intensity-Modulated Proton Beam Radiation Therapy or Intensity-Modulated Photon Radiation Therapy for Esophageal Carcinoma: A Mayo Clinic Experience

Bhangoo, R. S., DeWees, T. A., Yu, N. Y., Ding, J. X., Liu, C., Golafshar, M. A., Rule, W. G., Vora, S. A., Ross, H. J., Ahn, D. H., Beamer, S. E., Jaroszewski, D. E., Hallemeier, C. L., Liu, W., Ashman, J. B. & Sio, T. T., 2020, (Accepted/In press) In : Advances in Radiation Oncology.

Research output: Contribution to journalArticle

Open Access

Homologous Recombination Repair Defect May Predict Treatment Response to Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors

Zhu, M., Bassam Sonbol, M., Halfdanarson, T. R., Hobday, T. J., Ahn, D., Ma, W. W. & Bekaii-Saab, T., 2020, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access

Phase II Trial of Trifluridine/Tipiracil in Patients with Advanced, Refractory Biliary Tract Carcinoma

Chakrabarti, S., Zemla, T. J., Ahn, D. H., Ou, F. S., Fruth, B., Borad, M. J., Hartgers, M. L., Wessling, J., Walkes, R. L., Alberts, S. R., McWilliams, R. R., Liu, M. C., Durgin, L. M., Bekaii-Saab, T. S. & Mahipal, A., May 1 2020, In : Oncologist. 25, 5, p. 380-e763

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Real-World Dosing Patterns and Outcomes of Patients with Metastatic Pancreatic Cancer Treated with a Liposomal Irinotecan Regimen in the United States

Barzi, A., Miksad, R., Surinach, A., Corvino, F. A., Wang, S., Torres, A. Z., Mamlouk, K., Pulgar, S., Valderrama, A., Bekaii-Saab, T. & Ahn, D., Feb 1 2020, In : Pancreas. 49, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Role of Maintenance Strategies in Metastatic Colorectal Cancer: A Systematic Review and Network Meta-analysis of Randomized Clinical Trials

Sonbol, M. B., Mountjoy, L. J., Firwana, B., Liu, A. J., Almader-Douglas, D., Mody, K., Hubbard, J., Borad, M., Ahn, D. H., Murad, M. H. & Bekaii-Saab, T., Mar 2020, In : JAMA Oncology. 6, 3

Research output: Contribution to journalArticle

5 Scopus citations

A Systematic Review and Network Meta-Analysis of Regorafenib and TAS-102 in Refractory Metastatic Colorectal Cancer

Sonbol, M. B., Benkhadra, R., Wang, Z., Firwana, B., Walden, D. J., Mody, K., Hubbard, J. M., Murad, M. H., Ahn, D. H. & Bekaii-Saab, T., Sep 1 2019, In : Oncologist. 24, 9, p. 1174-1179 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

CanStem111P trial: A Phase III study of napabucasin plus nab-paclitaxel with gemcitabine

Sonbol, M. B., Ahn, D. H., Goldstein, D., Okusaka, T., Tabernero, J., Macarulla, T., Reni, M., Li, C. P., O'Neil, B., Van Cutsem, E. & Bekaii-Saab, T., Apr 2019, In : Future Oncology. 15, 12, p. 1295-1302 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Circulating tumor DNA profiling of advanced biliary tract cancers

Mody, K., Kasi, P. M., Yang, J. D., Surapaneni, P. K., Bekaii-Saab, T., Ahn, D. H., Mahipal, A., Sonbol, M. B., Starr, J. S., Roberts, A., Nagy, R., Lanman, R. & Borad, M. J., Jan 1 2019, In : JCO Precision Oncology. 3

Research output: Contribution to journalArticle

8 Scopus citations

Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers: A Phase 2 Clinical Trial

Shroff, R. T., Javle, M. M., Xiao, L., Kaseb, A. O., Varadhachary, G. R., Wolff, R. A., Raghav, K. P. S., Iwasaki, M., Masci, P., Ramanathan, R. K., Ahn, D. H., Bekaii-Saab, T. S. & Borad, M. J., Jun 2019, In : JAMA Oncology. 5, 6, p. 824-830 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Phase i immunotherapy trial with two chimeric HER-2 B-Cell peptide vaccines emulsified in montanide ISA 720VG and Nor-MDP adjuvant in patients with advanced solid tumors

Bekaii-Saab, T., Wesolowski, R., Ahn, D. H., Wu, C., Mortazavi, A., Lustberg, M., Ramaswamy, B., Fowler, J., Wei, L., Overholser, J. & Kaumaya, P. T. P., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3495-3507 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study

Bekaii-Saab, T. S., Ou, F. S., Ahn, D. H., Boland, P. M., Ciombor, K. K., Heying, E. N., Dockter, T. J., Jacobs, N. L., Pasche, B. C., Cleary, J. M., Meyers, J. P., Desnoyers, R. J., McCune, J. S., Pedersen, K., Barzi, A., Chiorean, E. G., Sloan, J., Lacouture, M. E., Lenz, H. J. & Grothey, A. F., Aug 1 2019, In : The Lancet Oncology. 20, 8, p. 1070-1082 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Watch and Wait in Rectal Cancer: Who's In and Who's Out?

Ahn, D. & Bekaii-Saab, T., Mar 1 2019, In : Journal of oncology practice. 15, 3, p. 133-134 2 p.

Research output: Contribution to journalArticle

2018

Biweekly cisplatin and gemcitabine in patients with advanced biliary tract cancer

Ahn, D., Reardon, J., Ahn, C. W., Bupathi, M., Mikhail, S., Wu, C. S. Y. & Bekaii-Saab, T., Apr 15 2018, In : International Journal of Cancer. 142, 8, p. 1671-1675 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cholangiocarcinoma with FGFR genetic aberrations: A unique clinical phenotype

Jain, A., Borad, M. J., Kelley, R. K., Wang, Y., Abdel-Wahab, R., Meric-Bernstam, F., Baggerly, K. A., Kaseb, A. O., Al-shamsi, H. O., Ahn, D. H., DeLeon, T., Bocobo, A. G., Bekaii-Saab, T., Shroff, R. T. & Javle, M., Jan 1 2018, In : JCO Precision Oncology. 2

Research output: Contribution to journalArticle

18 Scopus citations

Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer

Ramsey, M. L., Talbert, E., Ahn, D., Bekaii-Saab, T., Badi, N., Bloomston, P. M., Conwell, D. L., Cruz-Monserrate, Z., Dillhoff, M., Farren, M. R., Hinton, A., Krishna, S. G., Lesinski, G. B., Mace, T., Manilchuk, A., Noonan, A., Pawlik, T. M., Rajasekera, P. V., Schmidt, C., Guttridge, D. & 1 others, Hart, P. A., Jan 1 2018, (Accepted/In press) In : Pancreatology.

Research output: Contribution to journalArticle

2 Scopus citations

Efficacy of TAS-120, an irreversible fibroblast growth factor receptor (FGFR) inhibitor, in cholangiocarcinoma patients with FGFR pathway alterations who were previously treated with chemotherapy and other FGFR inhibitors

Meric-Bernstam, F., Arkenau, H., Tran, B., Bahleda, R., Kelley, R., Hierro, C., Ahn, D., Zhu, A., Javle, M., Winkler, R., He, H., Huang, J. & Goyal, L., Jun 1 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, p. v100

Research output: Contribution to journalArticle

Open Access

Efficacy of TAS-120, an irreversible fibroblast growth factor receptor inhibitor (FGFRi), in patients with cholangiocarcinoma and FGFR pathway alterations previously treated with chemotherapy and other FGFRi's

Tran, B., Meric-Bernstam, F., Arkenau, H. T., Bahleda, R., Kelley, R. K., Hierro, C., Ahn, D., Zhu, A., Javle, M., Winkler, R., He, H., Huang, J. & Goyal, L., Nov 1 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, p. ix49-ix50

Research output: Contribution to journalArticle

Open Access

Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer

Finn, R. S., Ahn, D., Javle, M. M., Tan, B. R., Weekes, C. D., Bendell, J. C., Patnaik, A., Khan, G. N., Laheru, D., Chavira, R., Christy-Bittel, J., Barrett, E., Sawyer, M. B. & Bekaii-Saab, T., May 22 2018, (Accepted/In press) In : Investigational New Drugs. p. 1-7 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Real-world dosing patterns of patients (pts) with metastatic pancreatic cancer (mPC) treated with liposomal irinotecan (nal-IRI) in US oncology clinics

Ahn, D., Barzi, A., Miksad, R. A., Surinach, A., Corvino, F. A., Valderrama, A., Mamlouk, K., Pulgar, S. & Bekaii-Saab, T., Oct 1 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, p. viii251

Research output: Contribution to journalArticle

Open Access

Regorafenib Dose Optimization Study (ReDOS): Randomized phase II trial to evaluate escalating dosing strategy and pre-emptive topical steroids for regorafenib in refractory metastatic colorectal cancer (mCRC) - An ACCRU Network study

Bekaii-Saab, T., Ou, F., Anderson, D., Ahn, D., Boland, P., Ciombor, K., Jacobs, N., Desnoyers, R., Cleary, J., Meyers, J., Chiorean, E., Pedersen, K., Barzi, A., Sloan, J., McCune, J., Lacouture, M., Lenz, H. & Grothey, A., Jun 1 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, p. v105

Research output: Contribution to journalArticle

Open Access

Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis—Case Report and SEER Analysis

Weidner, T. K., Kidwell, J. T., Glasgow, A. E., Menias, C. O., Ahn, D., Pai, R., Heigh, R. I. & Mishra, N., Jan 1 2018, (Accepted/In press) In : Clinical Colorectal Cancer.

Research output: Contribution to journalArticle

2017

A modified regimen of biweekly gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer is both tolerable and effective: A retrospective analysis

Ahn, D., Krishna, K., Blazer, M., Reardon, J., Wei, L., Wu, C., Ciombor, K. K., Noonan, A. M., Mikhail, S. & Bekaii-Saab, T., Feb 1 2017, In : Therapeutic Advances in Medical Oncology. 9, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Continued disappointments with targeted agents in first-line therapy of advanced gastric cancers

Ahn, D. & Grothey, A. F., 2017, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

2 Scopus citations

Overall survival and clinical characteristics of BRCA-associated cholangiocarcinoma: Amulticenter retrospective study

Golan, T., Raitses-Gurevich, M., Kelley, R. K., Bocobo, A. G., Borgida, A., Shroff, R. T., Holter, S., Gallinger, S., Ahn, D., Aderka, D., Apurva, J., Bekaii-Saab, T., Friedman, E. & Javle, M., Jul 1 2017, In : Oncologist. 22, 7, p. 804-810 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Second-line treatment in patients with pancreatic ductal adenocarcinoma: A meta-analysis

Sonbol, M. B., Firwana, B., Wang, Z., Almader-Douglas, D., Borad, M. J., Makhoul, I., Ramanathan, R. K., Ahn, D. & Bekaii-Saab, T., Dec 1 2017, In : Cancer. 123, 23, p. 4680-4686 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

The Efficacy of Adjuvant Chemotherapy in Patients with Stage II/III Resected Rectal Cancer Treated with Neoadjuvant Chemoradiation Therapy

Ahn, D., Wu, C., Wei, L., Williams, T. M., Wuthrick, E., Abdel-Misih, S., Harzman, A., Husain, S., Schmidt, C., Goldberg, R. M. & Bekaii-Saab, T., Jan 1 2017, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 40, 6, p. 531-534 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Biliary cancer: Utility of next-generation sequencing for clinical management

Javle, M., Bekaii-Saab, T., Jain, A., Wang, Y., Kelley, R. K., Wang, K., Kang, H. C., Catenacci, D., Ali, S., Krishnan, S., Ahn, D., Bocobo, A. G., Zuo, M., Kaseb, A., Miller, V., Stephens, P. J., Meric-Bernstam, F., Shroff, R. & Ross, J., Dec 15 2016, In : Cancer. 122, 24, p. 3838-3847 10 p.

Research output: Contribution to journalArticle

80 Scopus citations

Modified irinotecan and infusional 5-fluorouracil (mFOLFIRI) in patients with refractory advanced pancreas cancer (APC): a single-institution experience

Bupathi, M., Ahn, D. H., Wu, C., Ciombor, K. K., Stephens, J. A., Reardon, J., Goldstein, D. A. & Bekaii-Saab, T., Apr 1 2016, In : Medical Oncology. 33, 4, 37.

Research output: Contribution to journalArticle

1 Scopus citations

Next-generation sequencing survey of biliary tract cancer reveals the association between tumor somatic variants and chemotherapy resistance

Ahn, D., Javle, M., Ahn, C. W., Jain, A., Mikhail, S., Noonan, A. M., Wu, C., Shroff, R. T., Chen, J. L. & Bekaii-Saab, T., Dec 1 2016, In : Cancer. 122, 23, p. 3657-3666 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Randomized Phase 2 Trial of the Oncolytic Virus Pelareorep (Reolysin) in Upfront Treatment of Metastatic Pancreatic Adenocarcinoma

Noonan, A. M., Farren, M. R., Geyer, S. M., Huang, Y., Tahiri, S., Ahn, D., Mikhail, S., Ciombor, K. K., Pant, S., Aparo, S., Sexton, J., Marshall, J. L., Mace, T. A., Wu, C. S., El-Rayes, B., Timmers, C. D., Zwiebel, J., Lesinski, G. B., Villalona-Calero, M. A. & Bekaii-Saab, T., Jun 1 2016, In : Molecular Therapy. 24, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Systemic immune activity predicts overall survival in treatment-Naïve patients with metastatic pancreatic cancer

Farren, M. R., Mace, T. A., Geyer, S., Mikhail, S., Wu, C., Ciombor, K., Tahiri, S., Ahn, D., Noonan, A. M., Villalona-Calero, M., Bekaii-Saab, T. & Lesinski, G. B., May 15 2016, In : Clinical Cancer Research. 22, 10, p. 2565-2574 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors

Ahn, D. H., Ozer, H. G., Hancioglu, B., Lesinski, G. B., Timmers, C. & Bekaii-Saab, T., 2016, In : Oncotarget. 7, 5, p. 5306-5312 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Results of an abbreviated phase-II study with the Akt Inhibitor MK-2206 in Patients with Advanced Biliary Cancer

Ahn, D., Li, J., Wei, L., Doyle, A., Marshall, J. L., Schaaf, L. J., Phelps, M. A., Villalona-Calero, M. A. & Bekaii-Saab, T., Jul 10 2015, In : Scientific Reports. 5, 12122.

Research output: Contribution to journalArticle

30 Scopus citations
2013

Baseline tumour measurements predict survival in advanced non-small cell lung cancer

Gerber, D. E., Dahlberg, S. E., Sandler, A. B., Ahn, D. H., Schiller, J. H., Brahmer, J. R. & Johnson, D. H., Sep 17 2013, In : British journal of cancer. 109, 6, p. 1476-1481 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Influence of medical comorbidities on the presentation and outcomes of stage I-III non-small-cell lung cancer

Ahn, D. H., Mehta, N., Yorio, J. T., Xie, Y., Yan, J. & Gerber, D. E., Nov 1 2013, In : Clinical Lung Cancer. 14, 6, p. 644-650 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Upper extremity venous thrombosis in patients with cancer with peripherally inserted central venous catheters: A retrospective analysis of risk factors

Ahn, D. H., Illum, H. B., Wang, D. H., Sharma, A. & Dowell, J. E., Jan 1 2013, In : Journal of oncology practice. 9, 1, p. e8-e12

Research output: Contribution to journalArticle

29 Scopus citations
2011

Capsule endoscopy with PILLCAM ESO for detecting esophageal varices: A meta-analysis

Guturu, P., Sagi, S. V., Ahn, D., Jaganmohan, S., Kuo, Y. F. & Sood, G. K., Mar 1 2011, In : Minerva Gastroenterologica e Dietologica. 57, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010

Meta-analysis of capsule endoscopy in patients diagnosed or suspected with esophageal varices

Ahn, D. & Guturu, P., Feb 14 2010, In : World journal of gastroenterology. 16, 6, p. 785-786 2 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009
4 Scopus citations
2005

Inhibition of ras oncogenic activity by ras protooncogenes

Diaz, R., Lue, J., Mathews, J., Yoon, A., Ahn, D., Garcia-España, A., Leonardi, P., Vargas, M. P. & Pellicer, A., Jan 10 2005, In : International Journal of Cancer. 113, 2, p. 241-248 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2004

Complex effects of Ras proto-oncogenes in tumorigenesis

Diaz, R., Lopez-Barcons, L., Ahn, D., Garcia-Espana, A., Yoon, A., Matthews, J., Mangues, R., Perez-Soler, R. & Pellicer, A., Apr 1 2004, In : Carcinogenesis. 25, 4, p. 535-539 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: Introduction of the tumor infiltration index

Lu, S., Ahn, D., Johnson, G., Law, M., Zagzag, D. & Grossman, R. I., Jul 1 2004, In : Radiology. 232, 1, p. 221-228 8 p.

Research output: Contribution to journalArticle

251 Scopus citations
2003

Mice deficient for N-ras: Impaired antiviral immune response and T-cell function

Pérez de Castro, I., Diaz, R., Malumbres, M., Hernández, M. I., Jagirdar, J., Jiménez, M., Ahn, D. & Pellicer, A., Apr 1 2003, In : Cancer research. 63, 7, p. 1615-1622 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Peritumoral diffusion tensor imaging of high-grade gliomas and metastatic brain tumors

Lu, S., Ahn, D., Johnson, G. & Cha, S., May 1 2003, In : American Journal of Neuroradiology. 24, 5, p. 937-941 5 p.

Research output: Contribution to journalArticle

310 Scopus citations
2002

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

Diaz, R., Ahn, D., Lopez-Barcons, L., Malumbres, M., De Castro, I. P., Lue, J., Ferrer-Miralles, N., Mangues, R., Tsong, J., Garcia, R., Perez-Soler, R. & Pellicer, A., Aug 1 2002, In : Cancer research. 62, 15, p. 4514-4518 5 p.

Research output: Contribution to journalArticle

47 Scopus citations