• 495 Citations
  • 13 Scopus h-Index
20022019
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Research Output 2002 2019

2019

A Systematic Review and Network Meta-Analysis of Regorafenib and TAS-102 in Refractory Metastatic Colorectal Cancer

Sonbol, M. B., Benkhadra, R., Wang, Z., Firwana, B., Walden, D. J., Mody, K., Hubbard, J. M., Murad, M. H., Ahn, D. & Bekaii-Saab, T., Jan 1 2019, In : Oncologist.

Research output: Contribution to journalReview article

Colorectal Neoplasms
Disease-Free Survival
Survival
irinotecan
oxaliplatin
1 Citation (Scopus)

CanStem111P trial: A Phase III study of napabucasin plus nab-paclitaxel with gemcitabine

Sonbol, M. B., Ahn, D., Goldstein, D., Okusaka, T., Tabernero, J., Macarulla, T., Reni, M., Li, C. P., O'Neil, B., Van Cutsem, E. & Bekaii-Saab, T., Apr 1 2019, In : Future Oncology. 15, 12, p. 1295-1302 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Adenocarcinoma
Clinical Trials
Safety
7 Citations (Scopus)

Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers: A Phase 2 Clinical Trial

Shroff, R. T., Javle, M. M., Xiao, L., Kaseb, A. O., Varadhachary, G. R., Wolff, R. A., Raghav, K. P. S., Iwasaki, M., Masci, P., Ramanathan, R. K., Ahn, D., Bekaii-Saab, T. & Borad, M. J., Jan 1 2019, In : JAMA Oncology.

Research output: Contribution to journalArticle

gemcitabine
Biliary Tract Neoplasms
Nanoparticles
Cisplatin
Clinical Trials

Phase i immunotherapy trial with two chimeric HER-2 B-Cell peptide vaccines emulsified in montanide ISA 720VG and Nor-MDP adjuvant in patients with advanced solid tumors

Bekaii-Saab, T., Wesolowski, R., Ahn, D., Wu, C., Mortazavi, A., Lustberg, M., Ramaswamy, B., Fowler, J., Wei, L., Overholser, J. & Kaumaya, P. T. P., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3495-3507 13 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Immunotherapy
B-Lymphocytes
Vaccines
Neoplasms
2 Citations (Scopus)

Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study

Bekaii-Saab, T., Ou, F-S., Ahn, D., Boland, P. M., Ciombor, K. K., Heying, E. N., Dockter, T. J., Jacobs, N. L., Pasche, B. C., Cleary, J. M., Meyers, J. P., Desnoyers, R. J., McCune, J. S., Pedersen, K., Barzi, A., Chiorean, E. G., Sloan, J. A., Lacouture, M. E., Lenz, H. J. & Grothey, A., Aug 1 2019, In : The Lancet Oncology. 20, 8, p. 1070-1082 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Clobetasol
regorafenib
Appointments and Schedules
Therapeutics
1 Citation (Scopus)

Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies

Sonbol, M. B., Ahn, D. & Bekaii-Saab, T., Mar 1 2019, In : Biomedicines. 7, 1, 17.

Research output: Contribution to journalReview article

Open Access
Neoplastic Stem Cells
Stem cells
Neoplasms
Tumors
Therapeutics

Watch and Wait in Rectal Cancer: Who's In and Who's Out?

Ahn, D. & Bekaii-Saab, T., Mar 1 2019, In : Journal of oncology practice. 15, 3, p. 133-134 2 p.

Research output: Contribution to journalArticle

Rectal Neoplasms
2018
3 Citations (Scopus)

Biweekly cisplatin and gemcitabine in patients with advanced biliary tract cancer

Ahn, D., Reardon, J., Ahn, C. W., Bupathi, M., Mikhail, S., Wu, C. S. Y. & Bekaii-Saab, T., Apr 15 2018, In : International Journal of Cancer. 142, 8, p. 1671-1675 5 p.

Research output: Contribution to journalArticle

gemcitabine
Biliary Tract Neoplasms
Cisplatin
Survival
Disease-Free Survival

Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer

Ramsey, M. L., Talbert, E., Ahn, D., Bekaii-Saab, T., Badi, N., Bloomston, P. M., Conwell, D. L., Cruz-Monserrate, Z., Dillhoff, M., Farren, M. R., Hinton, A., Krishna, S. G., Lesinski, G. B., Mace, T., Manilchuk, A., Noonan, A., Pawlik, T. M., Rajasekera, P. V., Schmidt, C., Guttridge, D. & 1 others, Hart, P. A., Jan 1 2018, (Accepted/In press) In : Pancreatology.

Research output: Contribution to journalArticle

Cachexia
Pancreatic Neoplasms
Disease Progression
Interleukin-6
Weight Loss
2 Citations (Scopus)
Immune System
Adenocarcinoma
Neoplasms
Therapeutics
Aptitude
Stomach Neoplasms

Novel immunotherapy strategies for hepatobiliary cancers

Deleon, T. T., Zhou, Y., Nagalo, B., Yokoda, R. T., Ahn, D., Ramanathan, R. K., Salomao, M. A., Aqel, B. A., Mahipal, A., Bekaii-Saab, T. & Borad, M. J., Sep 1 2018, In : Immunotherapy. 10, 12, p. 1077-1091 15 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
Oncolytic Virotherapy
Therapeutics
T-Cell Antigen Receptor
8 Citations (Scopus)

Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma

Deleon, T. T., Ahn, D., Bogenberger, J. M., Anastasiadis, P. Z., Arora, M., Ramanathan, R. K., Aqel, B. A., Vasmatzis, G., Truty, M., Oklu, R., Bekaii-Saab, T. & Borad, M. J., Mar 1 2018, In : Future Oncology. 14, 6, p. 553-566 14 p.

Research output: Contribution to journalReview article

Biliary Tract Neoplasms
Hepatocellular Carcinoma
Neoplasms
Biomarkers
Therapeutics
3 Citations (Scopus)

Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer

Finn, R. S., Ahn, D., Javle, M. M., Tan, B. R., Weekes, C. D., Bendell, J. C., Patnaik, A., Khan, G. N., Laheru, D., Chavira, R., Christy-Bittel, J., Barrett, E., Sawyer, M. B. & Bekaii-Saab, T., May 22 2018, (Accepted/In press) In : Investigational New Drugs. p. 1-7 7 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Mitogen-Activated Protein Kinase Kinases
Mutation
MEK162
Pharmacokinetics

Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis—Case Report and SEER Analysis

Weidner, T. K., Kidwell, J. T., Glasgow, A. E., Menias, C. O., Ahn, D., Pai, R., Heigh, R. I. & Mishra, N., Jan 1 2018, (Accepted/In press) In : Clinical Colorectal Cancer.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Small Intestine
2017
20 Citations (Scopus)

A modified regimen of biweekly gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer is both tolerable and effective: A retrospective analysis

Ahn, D., Krishna, K., Blazer, M., Reardon, J., Wei, L., Wu, C., Ciombor, K. K., Noonan, A. M., Mikhail, S. & Bekaii-Saab, T., Feb 1 2017, In : Therapeutic Advances in Medical Oncology. 9, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Disease-Free Survival
Survival
Adenocarcinoma
10 Citations (Scopus)
Biliary Tract Neoplasms
Gallbladder Neoplasms
Cholangiocarcinoma
Neoplasm Genes
Therapeutics

Continued disappointments with targeted agents in first-line therapy of advanced gastric cancers

Ahn, D. & Grothey, A. F., 2017, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Overall survival and clinical characteristics of BRCA-associated cholangiocarcinoma: Amulticenter retrospective study

Golan, T., Raitses-Gurevich, M., Kelley, R. K., Bocobo, A. G., Borgida, A., Shroff, R. T., Holter, S., Gallinger, S., Ahn, D., Aderka, D., Apurva, J., Bekaii-Saab, T., Friedman, E. & Javle, M., Jul 1 2017, In : Oncologist. 22, 7, p. 804-810 7 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Retrospective Studies
Survival
Germ-Line Mutation
Confidence Intervals

Response to Drs von Hoff and Renschler

Ahn, D. & Bekaii-Saab, T., Jun 1 2017, In : Therapeutic Advances in Medical Oncology. 9, 6, p. 445-446 2 p.

Research output: Contribution to journalLetter

9 Citations (Scopus)

Second-line treatment in patients with pancreatic ductal adenocarcinoma: A meta-analysis

Sonbol, M. B., Firwana, B., Wang, Z., Almader-Douglas, D., Borad, M. J., Makhoul, I., Ramanathan, R. K., Ahn, D. & Bekaii-Saab, T., Dec 1 2017, In : Cancer. 123, 23, p. 4680-4686 7 p.

Research output: Contribution to journalArticle

oxaliplatin
irinotecan
Meta-Analysis
Adenocarcinoma
Disease-Free Survival
1 Citation (Scopus)

Signaling pathways as therapeutic targets in biliary tract cancer

Yang, J., Farren, M. R., Ahn, D., Bekaii-Saab, T. & Lesinski, G. B., May 4 2017, In : Expert Opinion on Therapeutic Targets. 21, 5, p. 485-498 14 p.

Research output: Contribution to journalReview article

Biliary Tract Neoplasms
Mitogen-Activated Protein Kinase Kinases
Phosphatidylinositol 3-Kinase
STAT3 Transcription Factor
Signal transduction
1 Citation (Scopus)

Targeting the stroma in pancreatic cancer

Ahn, D. & Ramanathan, R. K., Dec 1 2017, In : Chinese Clinical Oncology. 6, 6, 65.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Tumor Microenvironment
Therapeutic Uses
Immunosuppression
Neoplasms
3 Citations (Scopus)
Oncolytic Virotherapy
Viruses
Tumors
Neoplasms
Oncolytic Viruses
3 Citations (Scopus)

The Efficacy of Adjuvant Chemotherapy in Patients with Stage II/III Resected Rectal Cancer Treated with Neoadjuvant Chemoradiation Therapy

Ahn, D., Wu, C., Wei, L., Williams, T. M., Wuthrick, E., Abdel-Misih, S., Harzman, A., Husain, S., Schmidt, C., Goldberg, R. M. & Bekaii-Saab, T., Jan 1 2017, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 40, 6, p. 531-534 4 p.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Adjuvant Chemotherapy
Rectal Neoplasms
Survival
Recurrence

Virotherapies in pancreatic cancer

Ahn, D. & Ramanathan, R. K., Sep 27 2017, Current and Emerging Therapies in Pancreatic Cancer. Springer International Publishing, p. 309-322 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic Neoplasms
2016

Adjuvant Chemotherapy for Rectal Cancer After Neoadjuvant Treatment: FOLFOX, 5-FU, or Observation

Ahn, D. & Bekaii-Saab, T., Oct 1 2016, In : Current Colorectal Cancer Reports. 12, 5, p. 260-265 6 p.

Research output: Contribution to journalReview article

Neoadjuvant Therapy
Adjuvant Chemotherapy
Rectal Neoplasms
Fluorouracil
Observation
10 Citations (Scopus)

Adjuvant therapy for pancreas cancer in an era of value based cancer care

Ahn, D., Williams, T. M., Goldstein, D. A., El-Rayes, B. & Bekaii-Saab, T., Jan 1 2016, In : Cancer Treatment Reviews. 42, p. 10-17 8 p.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Drug Therapy
Neoplasms
Therapeutics
Insurance Benefits
51 Citations (Scopus)

Biliary cancer: Utility of next-generation sequencing for clinical management

Javle, M., Bekaii-Saab, T., Jain, A., Wang, Y., Kelley, R. K., Wang, K., Kang, H. C., Catenacci, D., Ali, S., Krishnan, S., Ahn, D., Bocobo, A. G., Zuo, M., Kaseb, A., Miller, V., Stephens, P. J., Meric-Bernstam, F., Shroff, R. & Ross, J., Dec 15 2016, In : Cancer. 122, 24, p. 3838-3847 10 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Cholangiocarcinoma
Mutation
Survival
Gallbladder
1 Citation (Scopus)

Colorectal clinical trials: What is on the horizon?

Ahn, D. & Goldberg, R. M., Feb 1 2016, In : Future Oncology. 12, 4, p. 525-531 7 p.

Research output: Contribution to journalReview article

Clinical Trials
Colorectal Neoplasms
Therapeutics
Immunotherapy
Survival Rate
6 Citations (Scopus)

Genomic diversity of colorectal cancer: Changing landscape and emerging targets

Ahn, D., Ciombor, K. K., Mikhail, S. & Bekaii-Saab, T., Jul 7 2016, In : World Journal of Gastroenterology. 22, 25, p. 5668-5677 10 p.

Research output: Contribution to journalReview article

Colorectal Neoplasms
Neoplasms
Therapeutics
Immunotherapy
Genome
1 Citation (Scopus)

Modified irinotecan and infusional 5-fluorouracil (mFOLFIRI) in patients with refractory advanced pancreas cancer (APC): a single-institution experience

Bupathi, M., Ahn, D., Wu, C., Ciombor, K. K., Stephens, J. A., Reardon, J., Goldstein, D. A. & Bekaii-Saab, T., Apr 1 2016, In : Medical Oncology. 33, 4, 37.

Research output: Contribution to journalArticle

irinotecan
Pancreatic Neoplasms
Fluorouracil
gemcitabine
Disease-Free Survival
13 Citations (Scopus)

Next-generation sequencing survey of biliary tract cancer reveals the association between tumor somatic variants and chemotherapy resistance

Ahn, D., Javle, M., Ahn, C. W., Jain, A., Mikhail, S., Noonan, A. M., Wu, C., Shroff, R. T., Chen, J. L. & Bekaii-Saab, T., Dec 1 2016, In : Cancer. 122, 23, p. 3657-3666 10 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Drug Therapy
Mutation
Cyclin-Dependent Kinase Inhibitor p16
gemcitabine
37 Citations (Scopus)

Randomized Phase 2 Trial of the Oncolytic Virus Pelareorep (Reolysin) in Upfront Treatment of Metastatic Pancreatic Adenocarcinoma

Noonan, A. M., Farren, M. R., Geyer, S. M., Huang, Y., Tahiri, S., Ahn, D., Mikhail, S., Ciombor, K. K., Pant, S., Aparo, S., Sexton, J., Marshall, J. L., Mace, T. A., Wu, C. S., El-Rayes, B., Timmers, C. D., Zwiebel, J., Lesinski, G. B., Villalona-Calero, M. A. & Bekaii-Saab, T., Jun 1 2016, In : Molecular Therapy. 24, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Disease-Free Survival
Carboplatin
Paclitaxel
Adenocarcinoma
24 Citations (Scopus)

Systemic immune activity predicts overall survival in treatment-Naïve patients with metastatic pancreatic cancer

Farren, M. R., Mace, T. A., Geyer, S., Mikhail, S., Wu, C., Ciombor, K., Tahiri, S., Ahn, D., Noonan, A. M., Villalona-Calero, M., Bekaii-Saab, T. & Lesinski, G. B., May 15 2016, In : Clinical Cancer Research. 22, 10, p. 2565-2574 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Survival
Adenocarcinoma
T-Lymphocytes
Therapeutics
5 Citations (Scopus)

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors

Ahn, D., Ozer, H. G., Hancioglu, B., Lesinski, G. B., Timmers, C. & Bekaii-Saab, T., Jan 1 2016, In : Oncotarget. 7, 5, p. 5306-5312 7 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Exome
Mitogen-Activated Protein Kinase Kinases
Neoplasms
Genes
2015
Pancreatic Neoplasms
Standard of Care
Combination Drug Therapy
Cause of Death
Therapeutics
20 Citations (Scopus)

Results of an abbreviated phase-II study with the Akt Inhibitor MK-2206 in Patients with Advanced Biliary Cancer

Ahn, D., Li, J., Wei, L., Doyle, A., Marshall, J. L., Schaaf, L. J., Phelps, M. A., Villalona-Calero, M. A. & Bekaii-Saab, T., Jul 10 2015, In : Scientific Reports. 5, 12122.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Pharmacokinetics
Cytotoxins
MK 2206
Patient Selection
2014
19 Citations (Scopus)
Neoplasms
Pancreatic Neoplasms
Ampulla of Vater
Carcinoma
Gastrointestinal Neoplasms
2013
13 Citations (Scopus)

Baseline tumour measurements predict survival in advanced non-small cell lung cancer

Gerber, D. E., Dahlberg, S. E., Sandler, A. B., Ahn, D., Schiller, J. H., Brahmer, J. R. & Johnson, D. H., Sep 17 2013, In : British Journal of Cancer. 109, 6, p. 1476-1481 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Survival
Neoplasms
Disease-Free Survival
Paclitaxel
19 Citations (Scopus)

Influence of medical comorbidities on the presentation and outcomes of stage I-III non-small-cell lung cancer

Ahn, D., Mehta, N., Yorio, J. T., Xie, Y., Yan, J. & Gerber, D. E., Nov 1 2013, In : Clinical Lung Cancer. 14, 6, p. 644-650 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Comorbidity
Survival
Logistic Models
Survival Analysis
27 Citations (Scopus)

Upper extremity venous thrombosis in patients with cancer with peripherally inserted central venous catheters: A retrospective analysis of risk factors

Ahn, D., Illum, H. B., Wang, D. H., Sharma, A. & Dowell, J. E., Jan 1 2013, In : Journal of Oncology Practice. 9, 1

Research output: Contribution to journalArticle

Central Venous Catheters
Upper Extremity
Venous Thrombosis
Catheters
Platelet Aggregation Inhibitors
2012
6 Citations (Scopus)

Embolic stroke secondary to an indwelling catheter in a patient with a patent foramen ovale: A case report and review of the literature

Ahn, D., Elizabeth Brickner, M. & Dowell, J., May 1 2012, In : Clinical Advances in Hematology and Oncology. 10, 5, p. 335-337 3 p.

Research output: Contribution to journalReview article

Antineoplastic Combined Chemotherapy Protocols
Central Venous Catheterization
Patent Foramen Ovale
Indwelling Catheters
Non-Small Cell Lung Carcinoma
2011
22 Citations (Scopus)

Capsule endoscopy with PILLCAM ESO for detecting esophageal varices: A meta-analysis

Guturu, P., Sagi, S. V., Ahn, D., Jaganmohan, S., Kuo, Y. F. & Sood, G. K., Mar 1 2011, In : Minerva Gastroenterologica e Dietologica. 57, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Duodenoscopy
Capsule Endoscopy
Esophageal and Gastric Varices
Meta-Analysis
Odds Ratio
2010
7 Citations (Scopus)

Meta-analysis of capsule endoscopy in patients diagnosed or suspected with esophageal varices

Ahn, D. & Guturu, P., Feb 14 2010, In : World Journal of Gastroenterology. 16, 6, p. 785-786 2 p.

Research output: Contribution to journalArticle

Capsule Endoscopy
Esophageal and Gastric Varices
Meta-Analysis
Duodenoscopy
Publication Bias
8 Citations (Scopus)

Randomized clinical trials in stroke research

Ahn, C. & Ahn, D., Jan 1 2010, In : Journal of Investigative Medicine. 58, 2, p. 277-281 5 p.

Research output: Contribution to journalShort survey

Randomized Controlled Trials
Stroke
Research
Causality
Research Personnel
2009
4 Citations (Scopus)
Random Allocation
Sample Size
Cluster Analysis
Costs and Cost Analysis
Health
2005
17 Citations (Scopus)

Inhibition of ras oncogenic activity by ras protooncogenes

Diaz, R., Lue, J., Mathews, J., Yoon, A., Ahn, D., Garcia-España, A., Leonardi, P., Vargas, M. P. & Pellicer, A., Jan 10 2005, In : International Journal of Cancer. 113, 2, p. 241-248 8 p.

Research output: Contribution to journalArticle

ras Genes
Alleles
Cyclin A
NIH 3T3 Cells
Guanosine Triphosphate
2004
18 Citations (Scopus)

Complex effects of Ras proto-oncogenes in tumorigenesis

Diaz, R., Lopez-Barcons, L., Ahn, D., Garcia-Espana, A., Yoon, A., Matthews, J., Mangues, R., Perez-Soler, R. & Pellicer, A., Apr 1 2004, In : Carcinogenesis. 25, 4, p. 535-539 5 p.

Research output: Contribution to journalArticle

ras Genes
Proto-Oncogenes
Carcinogenesis
Methylcholanthrene
Knockout Mice
2003
34 Citations (Scopus)

Mice deficient for N-ras: Impaired antiviral immune response and T-cell function

Pérez de Castro, I., Diaz, R., Malumbres, M., Hernández, M. I., Jagirdar, J., Jiménez, M., Ahn, D. & Pellicer, A., Apr 1 2003, In : Cancer Research. 63, 7, p. 1615-1622 8 p.

Research output: Contribution to journalArticle

Thymocytes
Antiviral Agents
T-Lymphocytes
ras Proteins
T-Cell Antigen Receptor