• 1105 Citations
  • 15 Scopus h-Index
20022019
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Research Output 2002 2019

A Systematic Review and Network Meta-Analysis of Regorafenib and TAS-102 in Refractory Metastatic Colorectal Cancer

Sonbol, M. B., Benkhadra, R., Wang, Z., Firwana, B., Walden, D. J., Mody, K., Hubbard, J. M., Murad, M. H., Ahn, D. & Bekaii-Saab, T., Jan 1 2019, In : Oncologist.

Research output: Contribution to journalReview article

Colorectal Neoplasms
Disease-Free Survival
Survival
irinotecan
oxaliplatin
2 Citations (Scopus)

CanStem111P trial: A Phase III study of napabucasin plus nab-paclitaxel with gemcitabine

Sonbol, M. B., Ahn, D., Goldstein, D., Okusaka, T., Tabernero, J., Macarulla, T., Reni, M., Li, C. P., O'Neil, B., Van Cutsem, E. & Bekaii-Saab, T., Apr 1 2019, In : Future Oncology. 15, 12, p. 1295-1302 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Adenocarcinoma
Clinical Trials
Safety
5 Citations (Scopus)

Circulating tumor DNA profiling of advanced biliary tract cancers

Mody, K., Kasi, P. M., Yang, J. D., Surapaneni, P. K., Bekaii-Saab, T., Ahn, D. H., Mahipal, A., Sonbol, M. B., Starr, J. S., Roberts, A., Nagy, R., Lanman, R. & Borad, M. J., Jan 1 2019, In : JCO Precision Oncology. 3

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
DNA Fingerprinting
Neoplasms
DNA
Mutation
11 Citations (Scopus)

Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers: A Phase 2 Clinical Trial

Shroff, R. T., Javle, M. M., Xiao, L., Kaseb, A. O., Varadhachary, G. R., Wolff, R. A., Raghav, K. P. S., Iwasaki, M., Masci, P., Ramanathan, R. K., Ahn, D., Bekaii-Saab, T. & Borad, M. J., Jan 1 2019, In : JAMA Oncology.

Research output: Contribution to journalArticle

gemcitabine
Biliary Tract Neoplasms
Nanoparticles
Cisplatin
Clinical Trials

Metastatic neuroendocrine tumor with cardiac involvement utilizing multi-modality imaging

Arsanjani, R., Agasthi, P., Ahn, D. H., Mookadam, F. & Yang, M., Jan 1 2019, In : Korean Circulation Journal. 49, 6, p. 557-558 2 p.

Research output: Contribution to journalComment/debate

Neuroendocrine Tumors
2 Citations (Scopus)

Phase i immunotherapy trial with two chimeric HER-2 B-Cell peptide vaccines emulsified in montanide ISA 720VG and Nor-MDP adjuvant in patients with advanced solid tumors

Bekaii-Saab, T., Wesolowski, R., Ahn, D., Wu, C., Mortazavi, A., Lustberg, M., Ramaswamy, B., Fowler, J., Wei, L., Overholser, J. & Kaumaya, P. T. P., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3495-3507 13 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Immunotherapy
B-Lymphocytes
Vaccines
Neoplasms

Phase II Trial of Trifluridine/Tipiracil in Patients with Advanced, Refractory Biliary Tract Carcinoma

Chakrabarti, S., Zemla, T. J., Ahn, D. H., Ou, F. S., Fruth, B., Borad, M. J., Hartgers, M. L., Wessling, J., Walkes, R. L., Alberts, S. R., McWilliams, R. R., Liu, M. C., Durgin, L. M., Bekaii-Saab, T. S. & Mahipal, A., Jan 1 2019, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
Trifluridine
Biliary Tract
Carcinoma
Confidence Intervals
Safety
8 Citations (Scopus)

Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study

Bekaii-Saab, T., Ou, F-S., Ahn, D., Boland, P. M., Ciombor, K. K., Heying, E. N., Dockter, T. J., Jacobs, N. L., Pasche, B. C., Cleary, J. M., Meyers, J. P., Desnoyers, R. J., McCune, J. S., Pedersen, K., Barzi, A., Chiorean, E. G., Sloan, J. A., Lacouture, M. E., Lenz, H. J. & Grothey, A., Aug 1 2019, In : The Lancet Oncology. 20, 8, p. 1070-1082 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Clobetasol
regorafenib
Appointments and Schedules
Therapeutics
2 Citations (Scopus)

Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies

Sonbol, M. B., Ahn, D. & Bekaii-Saab, T., Mar 1 2019, In : Biomedicines. 7, 1, 17.

Research output: Contribution to journalReview article

Open Access
Neoplastic Stem Cells
Stem cells
Neoplasms
Tumors
Therapeutics

The Role of Maintenance Strategies in Metastatic Colorectal Cancer: A Systematic Review and Network Meta-analysis of Randomized Clinical Trials

Sonbol, M. B., Mountjoy, L. J., Firwana, B., Liu, A. J., Almader-Douglas, D., Mody, K., Hubbard, J., Borad, M., Ahn, D. H., Murad, M. H. & Bekaii-Saab, T., Jan 1 2019, (Accepted/In press) In : JAMA Oncology.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Randomized Controlled Trials
Maintenance
Observation
Disease-Free Survival

Watch and Wait in Rectal Cancer: Who's In and Who's Out?

Ahn, D. & Bekaii-Saab, T., Mar 1 2019, In : Journal of oncology practice. 15, 3, p. 133-134 2 p.

Research output: Contribution to journalArticle

Rectal Neoplasms
2018
3 Citations (Scopus)

Biweekly cisplatin and gemcitabine in patients with advanced biliary tract cancer

Ahn, D., Reardon, J., Ahn, C. W., Bupathi, M., Mikhail, S., Wu, C. S. Y. & Bekaii-Saab, T., Apr 15 2018, In : International Journal of Cancer. 142, 8, p. 1671-1675 5 p.

Research output: Contribution to journalArticle

gemcitabine
Biliary Tract Neoplasms
Cisplatin
Survival
Disease-Free Survival
8 Citations (Scopus)

Cholangiocarcinoma with FGFR genetic aberrations: A unique clinical phenotype

Jain, A., Borad, M. J., Kelley, R. K., Wang, Y., Abdel-Wahab, R., Meric-Bernstam, F., Baggerly, K. A., Kaseb, A. O., Al-shamsi, H. O., Ahn, D. H., DeLeon, T., Bocobo, A. G., Bekaii-Saab, T., Shroff, R. T. & Javle, M., Jan 1 2018, In : JCO Precision Oncology. 2

Research output: Contribution to journalArticle

Cholangiocarcinoma
Phenotype
Survival
Mutation
Kaplan-Meier Estimate
1 Citation (Scopus)

Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer

Ramsey, M. L., Talbert, E., Ahn, D., Bekaii-Saab, T., Badi, N., Bloomston, P. M., Conwell, D. L., Cruz-Monserrate, Z., Dillhoff, M., Farren, M. R., Hinton, A., Krishna, S. G., Lesinski, G. B., Mace, T., Manilchuk, A., Noonan, A., Pawlik, T. M., Rajasekera, P. V., Schmidt, C., Guttridge, D. & 1 others, Hart, P. A., Jan 1 2018, (Accepted/In press) In : Pancreatology.

Research output: Contribution to journalArticle

Cachexia
Pancreatic Neoplasms
Disease Progression
Interleukin-6
Weight Loss
3 Citations (Scopus)
Immune System
Adenocarcinoma
Neoplasms
Therapeutics
Aptitude
Stomach Neoplasms

Novel immunotherapy strategies for hepatobiliary cancers

Deleon, T. T., Zhou, Y., Nagalo, B., Yokoda, R. T., Ahn, D., Ramanathan, R. K., Salomao, M. A., Aqel, B. A., Mahipal, A., Bekaii-Saab, T. & Borad, M. J., Sep 1 2018, In : Immunotherapy. 10, 12, p. 1077-1091 15 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
Oncolytic Virotherapy
Therapeutics
T-Cell Antigen Receptor
10 Citations (Scopus)

Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma

Deleon, T. T., Ahn, D., Bogenberger, J. M., Anastasiadis, P. Z., Arora, M., Ramanathan, R. K., Aqel, B. A., Vasmatzis, G., Truty, M., Oklu, R., Bekaii-Saab, T. & Borad, M. J., Mar 1 2018, In : Future Oncology. 14, 6, p. 553-566 14 p.

Research output: Contribution to journalReview article

Biliary Tract Neoplasms
Hepatocellular Carcinoma
Neoplasms
Biomarkers
Therapeutics
3 Citations (Scopus)

Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer

Finn, R. S., Ahn, D., Javle, M. M., Tan, B. R., Weekes, C. D., Bendell, J. C., Patnaik, A., Khan, G. N., Laheru, D., Chavira, R., Christy-Bittel, J., Barrett, E., Sawyer, M. B. & Bekaii-Saab, T., May 22 2018, (Accepted/In press) In : Investigational New Drugs. p. 1-7 7 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Mitogen-Activated Protein Kinase Kinases
Mutation
MEK162
Pharmacokinetics

Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis—Case Report and SEER Analysis

Weidner, T. K., Kidwell, J. T., Glasgow, A. E., Menias, C. O., Ahn, D., Pai, R., Heigh, R. I. & Mishra, N., Jan 1 2018, (Accepted/In press) In : Clinical Colorectal Cancer.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Small Intestine
2017
21 Citations (Scopus)

A modified regimen of biweekly gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer is both tolerable and effective: A retrospective analysis

Ahn, D., Krishna, K., Blazer, M., Reardon, J., Wei, L., Wu, C., Ciombor, K. K., Noonan, A. M., Mikhail, S. & Bekaii-Saab, T., Feb 1 2017, In : Therapeutic Advances in Medical Oncology. 9, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Disease-Free Survival
Survival
Adenocarcinoma
13 Citations (Scopus)
Biliary Tract Neoplasms
Gallbladder Neoplasms
Cholangiocarcinoma
Neoplasm Genes
Therapeutics
1 Citation (Scopus)

Continued disappointments with targeted agents in first-line therapy of advanced gastric cancers

Ahn, D. & Grothey, A. F., 2017, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Overall survival and clinical characteristics of BRCA-associated cholangiocarcinoma: Amulticenter retrospective study

Golan, T., Raitses-Gurevich, M., Kelley, R. K., Bocobo, A. G., Borgida, A., Shroff, R. T., Holter, S., Gallinger, S., Ahn, D., Aderka, D., Apurva, J., Bekaii-Saab, T., Friedman, E. & Javle, M., Jul 1 2017, In : Oncologist. 22, 7, p. 804-810 7 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Retrospective Studies
Survival
Germ-Line Mutation
Confidence Intervals

Response to Drs von Hoff and Renschler

Ahn, D. & Bekaii-Saab, T., Jun 1 2017, In : Therapeutic Advances in Medical Oncology. 9, 6, p. 445-446 2 p.

Research output: Contribution to journalLetter

10 Citations (Scopus)

Second-line treatment in patients with pancreatic ductal adenocarcinoma: A meta-analysis

Sonbol, M. B., Firwana, B., Wang, Z., Almader-Douglas, D., Borad, M. J., Makhoul, I., Ramanathan, R. K., Ahn, D. & Bekaii-Saab, T., Dec 1 2017, In : Cancer. 123, 23, p. 4680-4686 7 p.

Research output: Contribution to journalArticle

oxaliplatin
irinotecan
Meta-Analysis
Adenocarcinoma
Disease-Free Survival
1 Citation (Scopus)

Signaling pathways as therapeutic targets in biliary tract cancer

Yang, J., Farren, M. R., Ahn, D., Bekaii-Saab, T. & Lesinski, G. B., May 4 2017, In : Expert Opinion on Therapeutic Targets. 21, 5, p. 485-498 14 p.

Research output: Contribution to journalReview article

Biliary Tract Neoplasms
Mitogen-Activated Protein Kinase Kinases
Phosphatidylinositol 3-Kinase
STAT3 Transcription Factor
Signal transduction
1 Citation (Scopus)

Targeting the stroma in pancreatic cancer

Ahn, D. & Ramanathan, R. K., Dec 1 2017, In : Chinese Clinical Oncology. 6, 6, 65.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Tumor Microenvironment
Therapeutic Uses
Immunosuppression
Neoplasms
3 Citations (Scopus)
Oncolytic Virotherapy
Viruses
Tumors
Neoplasms
Oncolytic Viruses
4 Citations (Scopus)

The Efficacy of Adjuvant Chemotherapy in Patients with Stage II/III Resected Rectal Cancer Treated with Neoadjuvant Chemoradiation Therapy

Ahn, D., Wu, C., Wei, L., Williams, T. M., Wuthrick, E., Abdel-Misih, S., Harzman, A., Husain, S., Schmidt, C., Goldberg, R. M. & Bekaii-Saab, T., Jan 1 2017, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 40, 6, p. 531-534 4 p.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Adjuvant Chemotherapy
Rectal Neoplasms
Survival
Recurrence

Virotherapies in pancreatic cancer

Ahn, D. & Ramanathan, R. K., Sep 27 2017, Current and Emerging Therapies in Pancreatic Cancer. Springer International Publishing, p. 309-322 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic Neoplasms
2016

Adjuvant Chemotherapy for Rectal Cancer After Neoadjuvant Treatment: FOLFOX, 5-FU, or Observation

Ahn, D. & Bekaii-Saab, T., Oct 1 2016, In : Current Colorectal Cancer Reports. 12, 5, p. 260-265 6 p.

Research output: Contribution to journalReview article

Neoadjuvant Therapy
Adjuvant Chemotherapy
Rectal Neoplasms
Fluorouracil
Observation
10 Citations (Scopus)

Adjuvant therapy for pancreas cancer in an era of value based cancer care

Ahn, D., Williams, T. M., Goldstein, D. A., El-Rayes, B. & Bekaii-Saab, T., Jan 1 2016, In : Cancer Treatment Reviews. 42, p. 10-17 8 p.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Drug Therapy
Neoplasms
Therapeutics
Insurance Benefits
57 Citations (Scopus)

Biliary cancer: Utility of next-generation sequencing for clinical management

Javle, M., Bekaii-Saab, T., Jain, A., Wang, Y., Kelley, R. K., Wang, K., Kang, H. C., Catenacci, D., Ali, S., Krishnan, S., Ahn, D., Bocobo, A. G., Zuo, M., Kaseb, A., Miller, V., Stephens, P. J., Meric-Bernstam, F., Shroff, R. & Ross, J., Dec 15 2016, In : Cancer. 122, 24, p. 3838-3847 10 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Cholangiocarcinoma
Mutation
Survival
Gallbladder
1 Citation (Scopus)

Colorectal clinical trials: What is on the horizon?

Ahn, D. & Goldberg, R. M., Feb 1 2016, In : Future Oncology. 12, 4, p. 525-531 7 p.

Research output: Contribution to journalReview article

Clinical Trials
Colorectal Neoplasms
Therapeutics
Immunotherapy
Survival Rate
7 Citations (Scopus)

Genomic diversity of colorectal cancer: Changing landscape and emerging targets

Ahn, D., Ciombor, K. K., Mikhail, S. & Bekaii-Saab, T., Jul 7 2016, In : World Journal of Gastroenterology. 22, 25, p. 5668-5677 10 p.

Research output: Contribution to journalReview article

Colorectal Neoplasms
Neoplasms
Therapeutics
Immunotherapy
Genome
1 Citation (Scopus)

Modified irinotecan and infusional 5-fluorouracil (mFOLFIRI) in patients with refractory advanced pancreas cancer (APC): a single-institution experience

Bupathi, M., Ahn, D., Wu, C., Ciombor, K. K., Stephens, J. A., Reardon, J., Goldstein, D. A. & Bekaii-Saab, T., Apr 1 2016, In : Medical Oncology. 33, 4, 37.

Research output: Contribution to journalArticle

irinotecan
Pancreatic Neoplasms
Fluorouracil
gemcitabine
Disease-Free Survival
14 Citations (Scopus)

Next-generation sequencing survey of biliary tract cancer reveals the association between tumor somatic variants and chemotherapy resistance

Ahn, D., Javle, M., Ahn, C. W., Jain, A., Mikhail, S., Noonan, A. M., Wu, C., Shroff, R. T., Chen, J. L. & Bekaii-Saab, T., Dec 1 2016, In : Cancer. 122, 23, p. 3657-3666 10 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Drug Therapy
Mutation
Cyclin-Dependent Kinase Inhibitor p16
gemcitabine
39 Citations (Scopus)

Randomized Phase 2 Trial of the Oncolytic Virus Pelareorep (Reolysin) in Upfront Treatment of Metastatic Pancreatic Adenocarcinoma

Noonan, A. M., Farren, M. R., Geyer, S. M., Huang, Y., Tahiri, S., Ahn, D., Mikhail, S., Ciombor, K. K., Pant, S., Aparo, S., Sexton, J., Marshall, J. L., Mace, T. A., Wu, C. S., El-Rayes, B., Timmers, C. D., Zwiebel, J., Lesinski, G. B., Villalona-Calero, M. A. & Bekaii-Saab, T., Jun 1 2016, In : Molecular Therapy. 24, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Disease-Free Survival
Carboplatin
Paclitaxel
Adenocarcinoma
25 Citations (Scopus)

Systemic immune activity predicts overall survival in treatment-Naïve patients with metastatic pancreatic cancer

Farren, M. R., Mace, T. A., Geyer, S., Mikhail, S., Wu, C., Ciombor, K., Tahiri, S., Ahn, D., Noonan, A. M., Villalona-Calero, M., Bekaii-Saab, T. & Lesinski, G. B., May 15 2016, In : Clinical Cancer Research. 22, 10, p. 2565-2574 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Survival
Adenocarcinoma
T-Lymphocytes
Therapeutics
5 Citations (Scopus)

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors

Ahn, D., Ozer, H. G., Hancioglu, B., Lesinski, G. B., Timmers, C. & Bekaii-Saab, T., Jan 1 2016, In : Oncotarget. 7, 5, p. 5306-5312 7 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Exome
Mitogen-Activated Protein Kinase Kinases
Neoplasms
Genes
2015
Pancreatic Neoplasms
Standard of Care
Combination Drug Therapy
Cause of Death
Therapeutics
24 Citations (Scopus)

Results of an abbreviated phase-II study with the Akt Inhibitor MK-2206 in Patients with Advanced Biliary Cancer

Ahn, D., Li, J., Wei, L., Doyle, A., Marshall, J. L., Schaaf, L. J., Phelps, M. A., Villalona-Calero, M. A. & Bekaii-Saab, T., Jul 10 2015, In : Scientific Reports. 5, 12122.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Pharmacokinetics
Cytotoxins
MK 2206
Patient Selection
2014
21 Citations (Scopus)
Neoplasms
Pancreatic Neoplasms
Ampulla of Vater
Carcinoma
Gastrointestinal Neoplasms
2013
15 Citations (Scopus)

Baseline tumour measurements predict survival in advanced non-small cell lung cancer

Gerber, D. E., Dahlberg, S. E., Sandler, A. B., Ahn, D., Schiller, J. H., Brahmer, J. R. & Johnson, D. H., Sep 17 2013, In : British Journal of Cancer. 109, 6, p. 1476-1481 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Survival
Neoplasms
Disease-Free Survival
Paclitaxel
22 Citations (Scopus)

Influence of medical comorbidities on the presentation and outcomes of stage I-III non-small-cell lung cancer

Ahn, D., Mehta, N., Yorio, J. T., Xie, Y., Yan, J. & Gerber, D. E., Nov 1 2013, In : Clinical Lung Cancer. 14, 6, p. 644-650 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Comorbidity
Survival
Logistic Models
Survival Analysis
28 Citations (Scopus)

Upper extremity venous thrombosis in patients with cancer with peripherally inserted central venous catheters: A retrospective analysis of risk factors

Ahn, D., Illum, H. B., Wang, D. H., Sharma, A. & Dowell, J. E., Jan 1 2013, In : Journal of Oncology Practice. 9, 1

Research output: Contribution to journalArticle

Central Venous Catheters
Upper Extremity
Venous Thrombosis
Catheters
Platelet Aggregation Inhibitors
2012
6 Citations (Scopus)

Embolic stroke secondary to an indwelling catheter in a patient with a patent foramen ovale: A case report and review of the literature

Ahn, D., Elizabeth Brickner, M. & Dowell, J., May 1 2012, In : Clinical Advances in Hematology and Oncology. 10, 5, p. 335-337 3 p.

Research output: Contribution to journalReview article

Antineoplastic Combined Chemotherapy Protocols
Central Venous Catheterization
Patent Foramen Ovale
Indwelling Catheters
Non-Small Cell Lung Carcinoma
2011
22 Citations (Scopus)

Capsule endoscopy with PILLCAM ESO for detecting esophageal varices: A meta-analysis

Guturu, P., Sagi, S. V., Ahn, D., Jaganmohan, S., Kuo, Y. F. & Sood, G. K., Mar 1 2011, In : Minerva Gastroenterologica e Dietologica. 57, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Duodenoscopy
Capsule Endoscopy
Esophageal and Gastric Varices
Meta-Analysis
Odds Ratio