• 2926 Citations
  • 23 Scopus h-Index
20032018
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Research Output 2003 2018

  • 2926 Citations
  • 23 Scopus h-Index
  • 29 Article
  • 5 Review article
2018
23 Citations (Scopus)

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

Wang, F., Zhang, S., Vuckovic, I., Jeon, R., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Sep 4 2018, In : Cell Metabolism. 28, 3, p. 463-475.e4

Research output: Contribution to journalArticle

Glycolysis
Oxidative Phosphorylation
Macrophages
Glucose
Adenosine Triphosphate
20 Citations (Scopus)

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

Wang, F., Zhang, S., Jeon, R., Vuckovic, I., Jiang, X., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Macrophages
Glycolysis
Interferon-gamma
Cell Survival
Interferons
2016
51 Citations (Scopus)

1α,25-dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Folmes, C., Wang, X., Lanza, I. R., Schaible, N. S., Salisbury, J. L., Nair, K. S., Terzic, A., Sieck, G. C. & Kumar, R., Jan 15 2016, In : Journal of Biological Chemistry. 291, 3, p. 1514-1528 15 p., 15.

Research output: Contribution to journalArticle

Calcitriol
Oxygen Consumption
Muscle Cells
Muscle
Skeletal Muscle
35 Citations (Scopus)

Energy metabolism in the acquisition and maintenance of stemness

Folmes, C. & Terzic, A., Apr 1 2016, In : Seminars in Cell and Developmental Biology. 52, p. 68-75 8 p.

Research output: Contribution to journalReview article

Energy Metabolism
Maintenance
Stem Cells
Stem Cell Niche
Developmental Biology
19 Citations (Scopus)

Mitochondria in pluripotent stem cells: Stemness regulators and disease targets

Folmes, C., Ma, H., Mitalipov, S. & Terzic, A., Jun 1 2016, In : Current Opinion in Genetics and Development. 38, p. 1-7 7 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Mitochondria
Eukaryotic Cells
Mitochondrial DNA
Epigenomics
2 Citations (Scopus)

Noninvasive Monitoring of the Mitochondrial Function in Mesenchymal Stromal Cells

Franchi, F., Peterson, K. M., Paulmurugan, R., Folmes, C., Lanza, I. R., Lerman, A. & Rodriguez-Porcel, M. G., Feb 10 2016, (Accepted/In press) In : Molecular Imaging and Biology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Reporter Genes
Firefly Luciferases
Stem Cells
Myocardial Reperfusion
2015
92 Citations (Scopus)

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs

Kang, E., Wang, X., Tippner-Hedges, R., Ma, H., Folmes, C., Gutierrez, N. M., Lee, Y., Van Dyken, C., Ahmed, R., Li, Y., Koski, A., Hayama, T., Luo, S., Harding, C. O., Amato, P., Jensen, J., Battaglia, D., Lee, D., Wu, D., Terzic, A. & 3 others, Wolf, D. P., Huang, T. & Mitalipov, S., Sep 1 2015, (Accepted/In press) In : Cell Stem Cell.

Research output: Contribution to journalArticle

Mitochondrial DNA
Mutation
Fibroblasts
Induced Pluripotent Stem Cells
Skin
27 Citations (Scopus)

Metabolic determinants of embryonic development and stem cell fate

Folmes, C. & Terzic, A., 2015, In : Reproduction, Fertility and Development. 27, 1, p. 82-88 7 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Embryonic Development
stem cells
Stem Cells
embryogenesis
85 Citations (Scopus)

Metabolic rescue in pluripotent cells from patients with mtDNA disease

Ma, H., Folmes, C., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N. M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P. & 6 others, Wolf, D. P., Huang, T., Terzic, A., Laurent, L. C., Belmonte, J. C. I. & Mitalipov, S., Aug 13 2015, In : Nature. 524, 7564, p. 234-238 5 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Pluripotent Stem Cells
Leigh Disease
Induced Pluripotent Stem Cells
Mitochondrial Encephalomyopathies
2014
29 Citations (Scopus)

Metabolic regulation of redox status in stem cells

Perales-Clemente, E., Folmes, C. & Terzic, A., Oct 10 2014, In : Antioxidants and Redox Signaling. 21, 11, p. 1648-1659 12 p.

Research output: Contribution to journalArticle

Stem cells
Oxidation-Reduction
Reactive Oxygen Species
Stem Cells
Energy Metabolism
3 Citations (Scopus)

Stem cell lineage specification: You become what you eat

Folmes, C. & Terzic, A., Sep 2 2014, In : Cell Metabolism. 20, 3, p. 389-391 3 p.

Research output: Contribution to journalArticle

Cell Lineage
Stem Cells
Hematopoietic Stem Cells
Glutamine
Nucleotides
2013
74 Citations (Scopus)

Disease-causing mitochondrial Heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS

Folmes, C., Martinez-Fernandez, A., Perales-Clemente, E., Li, X., McDonald, A., Oglesbee, D., Hrstka, S. C., Terzic, C. M., Terzic, A. & Nelson, T. J., Jul 2013, In : Stem Cells. 31, 7, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

MELAS Syndrome
Induced Pluripotent Stem Cells
Mitochondrial Diseases
Mitochondrial DNA
Clone Cells
23 Citations (Scopus)

Lipid metabolism greases the stem cell engine

Folmes, C., Park, S. & Terzic, A., Feb 5 2013, In : Cell Metabolism. 17, 2, p. 153-155 3 p.

Research output: Contribution to journalArticle

Malonyl Coenzyme A
Fatty Acid Synthases
Lipogenesis
Neural Stem Cells
Neurogenesis
19 Citations (Scopus)

Metabolome and metaboproteome remodeling in nuclear reprogramming

Folmes, C., Kent Arrell, D., Zlatkovic-Lindor, J., Martinez-Fernandez, A., Terzic, C. M., Nelson, T. J. & Terzic, A., Aug 1 2013, In : Cell Cycle. 12, 15, p. 2355-2365 11 p.

Research output: Contribution to journalArticle

Metabolome
Induced Pluripotent Stem Cells
Glycolysis
Energy Metabolism
Down-Regulation
35 Citations (Scopus)
Induced Pluripotent Stem Cells
Metabolomics
Cellular Reprogramming
Energy Metabolism
Mitochondria
1 Citation (Scopus)

Stem cell systems informatics for advanced clinical biodiagnostics: Tracing molecular signatures from bench to bedside

Faustino, A. S., Arrell, D. K., Folmes, C., Terzic, A. & Terzic, C. M., 2013, In : Croatian Medical Journal. 54, 4, p. 319-329 11 p.

Research output: Contribution to journalArticle

Molecular Diagnostic Techniques
Point-of-Care Systems
Medical Informatics
Stem Cell Transplantation
Gene Expression Profiling
2012
30 Citations (Scopus)

Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk

Smith, A. J., Nelson, N. G., Oommen, S., Hartjes, K. A., Folmes, C., Terzic, A. & Nelson, T. J., 2012, In : Stem cells translational medicine. 1, 10, p. 709-718 10 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Teratoma
DNA Damage
Induced Pluripotent Stem Cells
Hypersensitivity
63 Citations (Scopus)

Energy metabolism plasticity enables stemness programs

Folmes, C., Nelson, T. J., Dzeja, P. P. & Terzic, A., Apr 2012, In : Annals of the New York Academy of Sciences. 1254, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Energy Metabolism
Plasticity
Tissue
Organelle Biogenesis
Glycolysis
31 Citations (Scopus)

Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance

Ussher, J. R., Folmes, C., Keung, W., Fillmore, N., Jaswal, J. S., Cadete, V. J., Beker, D. L., Lam, V. H., Zhang, L. & Lopaschuk, G. D., May 22 2012, In : PLoS One. 7, 5, e37703.

Research output: Contribution to journalArticle

serine C-palmitoyltransferase
ceramides
Ceramides
glycolysis
Glycolysis
313 Citations (Scopus)

Metabolic plasticity in stem cell homeostasis and differentiation

Folmes, C., Dzeja, P. P., Nelson, T. J. & Terzic, A., Nov 2 2012, In : Cell Stem Cell. 11, 5, p. 596-606 11 p.

Research output: Contribution to journalArticle

Cell Differentiation
Homeostasis
Stem Cells
Epigenomics
Energy Metabolism
48 Citations (Scopus)

Mitochondria in control of cell fate

Folmes, C., Dzeja, P. P., Nelson, T. J. & Terzic, A., Feb 17 2012, In : Circulation Research. 110, 4, p. 526-529 4 p.

Research output: Contribution to journalArticle

Cell Lineage
Cardiac Myocytes
Mitochondria
Stem Cells
Embryonic Structures
2011
42 Citations (Scopus)

Energy metabolism in nuclear reprogramming

Folmes, C., Nelson, T. J. & Terzic, A., Dec 2011, In : Biomarkers in Medicine. 5, 6, p. 715-729 15 p.

Research output: Contribution to journalArticle

Energy Metabolism
Induced Pluripotent Stem Cells
Metabolomics
Biomarkers
Organelle Biogenesis
12 Citations (Scopus)

Regenerative medicine: On the vanguard of health care

Terzic, A., Folmes, C., Martinez-Fernandez, A. & Behfar, A., 2011, In : Mayo Clinic Proceedings. 86, 7, p. 600-602 3 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Delivery of Health Care
503 Citations (Scopus)

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming

Folmes, C., Nelson, T. J., Martinez-Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y. H., Terzic, C. M. & Terzic, A., Aug 3 2011, In : Cell Metabolism. 14, 2, p. 264-271 8 p.

Research output: Contribution to journalArticle

Glycolysis
Energy Metabolism
Electron Transport Complex I
Induced Pluripotent Stem Cells
Metabolomics
2010
34 Citations (Scopus)

Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function

Jessen, N., Koh, H. J., Folmes, C., Wagg, C., Fujii, N., Løfgren, B., Wolf, C. M., Berul, C. I., Hirshman, M. F., Lopaschuk, G. D. & Goodyear, L. J., Jul 1 2010, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1802, 7-8, p. 593-600 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Ischemia
Adenosine Triphosphate
Recovery of Function
Sirolimus
931 Citations (Scopus)

Myocardial fatty acid metabolism in health and disease

Lopaschuk, G. D., Ussher, J. R., Folmes, C., Jaswal, J. S. & Stanley, W. C., Jan 29 2010, In : Physiological Reviews. 90, 1, p. 207-258 52 p.

Research output: Contribution to journalReview article

Fatty Acids
Health
Heart Diseases
Pathology
Ketones
5 Citations (Scopus)

Novel O-palmitolylated beta-E1 subunit of pyruvate dehydrogenase is phosphorylated during ischemia/reperfusion injury

Folmes, C., Sawicki, G., Cadete, V. J. J., Masson, G., Barr, A. J. & Lopaschuk, G. D., Jul 9 2010, In : Proteome Science. 8, 38.

Research output: Contribution to journalArticle

Reperfusion Injury
Reperfusion
Oxidation
Glucose
Pyruvic Acid
2009
30 Citations (Scopus)

High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency

Folmes, C., Sowah, D., Clanachan, A. S. & Lopaschuk, G. D., Jul 1 2009, In : Journal of Molecular and Cellular Cardiology. 47, 1, p. 142-148 7 p.

Research output: Contribution to journalArticle

Fatty Acids
Ischemia
Fats
Palmitates
Glycolysis
27 Citations (Scopus)

Suppression of 5′-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts

Folmes, C., Wagg, C. S., Shen, M., Clanachan, A. S., Tian, R. & Lopaschuk, G. D., Jul 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 1

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Recovery of Function
Reperfusion
Fatty Acids
Ischemia
2007
164 Citations (Scopus)

Cardiac energy metabolism in obesity

Lopaschuk, G. D., Folmes, C. & Stanley, W. C., Aug 1 2007, In : Circulation Research. 101, 4, p. 335-347 13 p.

Research output: Contribution to journalReview article

Energy Metabolism
Obesity
Adipokines
Adiponectin
Leptin
61 Citations (Scopus)

Role of malonyl-CoA in heart disease and the hypothalamic control of obesity

Folmes, C. & Lopaschuk, G. D., Jan 15 2007, In : Cardiovascular Research. 73, 2, p. 278-287 10 p.

Research output: Contribution to journalReview article

Malonyl Coenzyme A
Heart Diseases
Obesity
Fatty Acids
Acetyl-CoA Carboxylase
2006
54 Citations (Scopus)

Fatty acids attenuate insulin regulation of 5′-AMP-activated protein kinase and insulin cardioprotection after ischemia

Folmes, C., Clanachan, A. S. & Lopaschuk, G. D., Jul 1 2006, In : Circulation Research. 99, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Fatty Acids
Ischemia
Insulin
Palmitates
2005
30 Citations (Scopus)

Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis

Folmes, C., Clanachan, A. S. & Lopaschuk, G. D., Jan 1 2005, In : Current Atherosclerosis Reports. 7, 1, p. 63-70 8 p.

Research output: Contribution to journalReview article

Atherosclerosis
Fatty Acids
Glucose
Trimetazidine
Niacin
2003
10 Citations (Scopus)

Sarcolemmal and mitochondrial effects of a KATP opener, P-1075, in "polarized" and "depolarized" Langendorff-perfused rat hearts

Jilkina, O., Kuzio, B., Grover, G. J., Folmes, C., Kong, H. J. & Kupriyanov, V. V., Dec 3 2003, In : Biochimica et Biophysica Acta - Biomembranes. 1618, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Rats
Heart Arrest
Rubidium
Phosphocreatine
Glyburide