Claudia F Lucchinetti, MD

  • 35035 Citations
  • 84 Scopus h-Index
1988 …2020

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5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus

Lucchinetti, C. F., Kimmel, D. W., Pavelko, K. & Rodriguez, M., Sep 1997, In : Experimental Neurology. 147, 1, p. 123-129 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Absence of cortical demyelination in neuromyelitis optica

Popescu, B. F. G., Parisi, J. E., Cabrera-Gómez, J. A., Newell, K., Mandler, R. N., Pittock, S. J., Lennon, V. A., Weinshenker, B. G. & Lucchinetti, C. F., Dec 7 2010, In : Neurology. 75, 23, p. 2103-2109 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

A case of multiple sclerosis presenting with inflammatory cortical demyelination

Popescu, B. F. G., Bunyan, R. F., Parisi, J. E., Ransohoff, R. M. & Lucchinetti, C. F., May 17 2011, In : Neurology. 76, 20, p. 1705-1710 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

A comparison of cryoprobe and crush lesions in the rat sciatic nerve

Kerns, J. M., Braverman, B., Mathew, A., Lucchinetti, C. & Ivankovich, A. D., Oct 1991, In : Pain. 47, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Activity of a newly identified serine protease in CNS demyelination

Scarisbrick, I. A., Blaber, S. I., Lucchinetti, C. F., Genain, C. P., Blaber, M. & Rodriguez, M., Jan 1 2002, In : Brain. 125, 6, p. 1283-1296 14 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations

Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome

Pohl, D., Alper, G., Van Haren, K., Kornberg, A. J., Lucchinetti, C. F., Tenembaum, S. & Belman, A. L., Aug 30 2016, In : Neurology. 87, 9, p. S38-S45

Research output: Contribution to journalArticle

113 Scopus citations

A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions

Bitsch, A., Kuhlmann, T., Stadelmann, C., Lassmann, H., Lucchinetti, C. & Brück, W., Jun 23 2001, In : Annals of neurology. 49, 6, p. 793-796 4 p.

Research output: Contribution to journalArticle

159 Scopus citations

Amphiphysin autoimmunity: Paraneoplastic accompaniments

Pittock, S. J., Lucchinetti, C. F., Parisi, J. E., Benarroch, E. E., Mokri, B., Stephan, C. L., Kim, K. K., Kilimann, M. W. & Lennon, V. A., Jul 1 2005, In : Annals of neurology. 58, 1, p. 96-107 12 p.

Research output: Contribution to journalArticle

222 Scopus citations

Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis

Quintana, F. J., Farez, M. F., Viglietta, V., Iglesias, A. H., Merbl, Y., Izquierdo, G., Lucas, M., Basso, A. S., Khoury, S. J., Lucchinetti, C. F., Cohen, I. R. & Weiner, H. L., Dec 2 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 48, p. 18889-18894 6 p.

Research output: Contribution to journalArticle

189 Scopus citations

Anti-neuronal nuclear autoantibody type 2: Paraneoplastic accompaniments

Pittock, S. J., Lucchinetti, C. F. & Lennon, V. A., May 1 2003, In : Annals of neurology. 53, 5, p. 580-587 8 p.

Research output: Contribution to journalArticle

190 Scopus citations

AQP4 autoantibody assay performance in clinical laboratory service

Fryer, J. P., Lennon, V. A., Pittock, S. J., Jenkins, S. M., Fallier-Becker, P., Clardy, S. L., Horta, E., Jedynak, E. A., Lucchinetti, C. F., Shuster, E. A., Weinshenker, B. G., Wingerchuk, D. M. & McKeon, A., Apr 24 2014, In : Neurology: Neuroimmunology and NeuroInflammation. 1, 1, 11.

Research output: Contribution to journalArticle

50 Scopus citations

A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases

Lucchinetti, C., Brück, W., Parisi, J., Scheithauer, B., Rodriguez, M. & Lassmann, H., Dec 1 1999, In : Brain. 122, 12, p. 2279-2295 17 p.

Research output: Contribution to journalArticle

363 Scopus citations

Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Autoantibody Status Predict Outcome of Recurrent Optic Neuritis

Jitprapaikulsan, J., Chen, J., Flanagan, E., Tobin, W. O., Fryer, J. P., Weinshenker, B. G., McKeon, A., Lennon, V. A., Leavitt, J. A., Tillema, J-M., Lucchinetti, C. F., Keegan, B. M., Kantarci, O. H., Khanna, C., Jenkins, S. M., Spears, G. M., Sagan, J. & Pittock, S. J., Jan 1 2018, (Accepted/In press) In : Ophthalmology.

Research output: Contribution to journalArticle

30 Scopus citations

Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down- Regulating EAAT2

Hinson, S. R., Roemer, S. F., Lucchinetti, C. F., Fryer, J. P., Kryzer, T. J., Chamberlain, J. L., Howe, C. L., Pittock, S. J. & Lennon, V. A., Oct 27 2008, In : Journal of Experimental Medicine. 205, 11, p. 2473-2481 9 p.

Research output: Contribution to journalArticle

226 Scopus citations

Aquaporin 4 IgG serostatus and outcome in recurrent longitudinally extensive transverse myelitis

Jiao, Y., Fryer, J. P., Lennon, V. A., McKeon, A., Jenkins, S. M., Smith, C. Y., Quek, A. M. L., Weinshenker, B. G., Wingerchuk, D. M., Shuster, E. A., Lucchinetti, C. F. & Pittock, S. J., Jan 2014, In : JAMA neurology. 71, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

A randomized controlled crossover trial of aspirin for fatigue in multiple sclerosis

Wingerchuk, D. M., Benarroch, E. E., O'Brien, P. C., Keegan, B. M., Lucchinetti, C. F., Noseworthy, J. H., Weinshenker, B. G. & Rodriguez, M., Apr 12 2005, In : Neurology. 64, 7, p. 1267-1269 3 p.

Research output: Contribution to journalArticle

85 Scopus citations

A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease

Weinshenker, B. G., O'Brien, P. C., Petterson, T. M., Noseworthy, J. H., Lucchinetti, C. F., Dodick, D. W., Pineda, A. A., Stevens, L. N. & Rodriguez, M., 1999, In : Annals of neurology. 46, 6, p. 878-886 9 p.

Research output: Contribution to journalArticle

632 Scopus citations

A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica

Lucchinetti, C. F., Mandler, R. N., McGavern, D., Bruck, W., Gleich, G., Ransohoff, R. M., Trebst, C., Weinshenker, B., Wingerchuk, D., Parisi, J. E. & Lassmann, H., 2002, In : Brain. 125, 7, p. 1450-1461 12 p.

Research output: Contribution to journalArticle

Open Access
885 Scopus citations
200 Scopus citations

A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis

Lennon, P. V. A., Wingerchuk, D. M., Kryzer, T. J., Pittock, S. J., Lucchinetti, C. F., Fujihara, K., Nakashima, I. & Weinshenker, B. G., Dec 11 2004, In : Lancet. 364, 9451, p. 2106-2112 7 p.

Research output: Contribution to journalArticle

2160 Scopus citations

Association of MOG-IgG Serostatus with Relapse after Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders

López-Chiriboga, A. S., Majed, M., Fryer, J., Dubey, D., McKeon, A., Flanagan, E. P., Jitprapaikulsan, J., Kothapalli, N., Tillema, J. M., Chen, J., Weinshenker, B., Wingerchuk, D., Sagen, J., Gadoth, A., Lennon, V. A., Keegan, B. M., Lucchinetti, C. & Pittock, S. J., Nov 2018, In : JAMA neurology. 75, 11, p. 1355-1363 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Autoimmune aquaporin-4 myopathy in neuromyelitis optica spectrum

Guo, Y., Lennon, V. A., Bogdan, B. F., Grouse, C. K., Topel, J., Milone, M., Lassmann, H., Parisi, J. E., Pittock, S. J., Stefoski, D., Balabanov, R. & Lucchinetti, C. F., Aug 2014, In : JAMA neurology. 71, 8, p. 1025-1029 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis

Metz, I., Lucchinetti, C. F., Openshaw, H., Garcia-Merino, A., Lassmann, H., Freedman, M. S., Atkins, H. L., Azzarelli, B., Kolar, O. J. & Brück, W., May 1 2007, In : Brain. 130, 5, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

Azathioprine: Tolerability, efficacy, and predictors of benefit in neuromyelitis optica

Costanzi, C., Matiello, M., Lucchinetti, C. F., Weinshenker, B. G., Pittock, S. J., Mandrekar, J., Thapa, P. & McKeon, A., Aug 16 2011, In : Neurology. 77, 7, p. 659-666 8 p.

Research output: Contribution to journalArticle

177 Scopus citations

Bcl-2-expressing oligodendrocytes in multiple sclerosis lesions

Kuhlmann, T., Lucchinetti, C., Zettl, U. K., Bitsch, A., Lassmann, H. & Brück, W., Jan 1 1999, In : Glia. 28, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Beneficial plasma exchange response in central nervous system inflammatory demyelination

Magaña, S. M., Keegan, B. M., Weinshenker, B. G., Erickson, B. J., Pittock, S. J., Lennon, V. A., Rodriguez, M., Thomsen, K., Weigand, S., Mandrekar, J., Linbo, L. & Lucchinetti, C. F., Jul 2011, In : Archives of neurology. 68, 7, p. 870-878 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Brain abnormalities in neuromyelitis optica

Pittock, S. J., Lennon, V. A., Krecke, K., Wingerchuk, D. M., Lucchinetti, C. F. & Weinshenker, B. G., Mar 1 2006, In : Archives of neurology. 63, 3, p. 390-396 7 p.

Research output: Contribution to journalArticle

552 Scopus citations

Bright red nuclei

Pittock, S. J., Weinshenker, B. G. & Lucchinetti, C. F., Feb 24 2004, In : Neurology. 62, 4, 1 p.

Research output: Contribution to journalArticle

Open Access

CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages

Trebst, C., Staugaitis, S. M., Kivisäkk, P., Mahad, D., Cathcart, M. K., Tucky, B., Wei, T., Rani, M. R. S., Horuk, R., Aldape, K. D., Pardo, C. A., Lucchinetti, C. F., Lassmann, H. & Ransohoff, R. M., Feb 1 2003, In : American Journal of Pathology. 162, 2, p. 427-438 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

CCR5Δ32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis

Kantarci, O. H., Morales, Y., Ziemer, P. A., Hebrink, D. D., Mahad, D. J., Atkinson, E. J., Achenbach, S. J., De Andrade, M., Mack, M., Ransohoff, R. M., Lassmann, H., Bruck, W., Weinshenker, B. G. & Lucchinetti, C. F., Dec 1 2005, In : Journal of neuroimmunology. 169, 1-2, p. 137-143 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Chapter 7 Pathology and Pathogenesis of Multiple Sclerosis

Lucchinetti, C. F., Brück, W. & Lassmann, H., Dec 1 2003, In : Blue Books of Practical Neurology. 27, C, p. 93-113 21 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chemokine receptors as biomarkers in multiple sclerosis

Fox, R. J., Kivisäkk, P., Lee, J. C., Tucky, B., Lucchinetti, C., Rudick, R. A. & Ransohoff, R. M., 2006, In : Disease Markers. 22, 4, p. 227-233 7 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Childhood-onset multiple sclerosis with progressive dementia and pathological cortical demyelination

Bunyan, R. F., Popescu, B. F. G., Carter, J. L., Caselli, R. J., Parisi, J. E. & Lucchinetti, C. F., Apr 2011, In : Archives of neurology. 68, 4, p. 525-528 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Clinical, Radiologic, and Prognostic Features of Myelitis Associated with Myelin Oligodendrocyte Glycoprotein Autoantibody

Dubey, D., Pittock, S. J., Krecke, K. N., Morris, P. P., Sechi, E., Zalewski, N. L., Weinshenker, B. G., Shosha, E., Lucchinetti, C. F., Fryer, J. P., Lopez-Chiriboga, A. S., Chen, J. C., Jitprapaikulsan, J., McKeon, A., Gadoth, A., Keegan, B. M., Tillema, J. M., Naddaf, E., Patterson, M. C., Messacar, K. & 2 others, Tyler, K. L. & Flanagan, E. P., Mar 2019, In : JAMA neurology. 76, 3, p. 301-309 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Clinical/scientific notes

Iorio, R., Lucchinetti, C. F., Lennon, V. A., Costanzi, C., Hinson, S., Weinshenker, B. G. & Pittock, S. J., Oct 25 2011, In : Neurology. 77, 17, p. 1644-1646 3 p.

Research output: Contribution to journalArticle

34 Scopus citations

Clinical/scientific notes

Clardy, S. L., Lucchinetti, C. F., Krecke, K. N., Lennon, V. A., O'Toole, O., Weinshenker, B. G., Boyd, C. D., Krieger, S., McGraw, C., Guo, Y. & Pittock, S. J., May 20 2014, In : Neurology. 82, 20, p. 1841-1843 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

Frischer, J. M., Weigand, S. D., Guo, Y., Kale, N., Parisi, J. E., Pirko, I., Mandrekar, J., Bramow, S., Metz, I., Brück, W., Lassmann, H. & Lucchinetti, C. F., Nov 2015, In : Annals of neurology. 78, 5, p. 710-721 12 p.

Research output: Contribution to journalArticle

172 Scopus citations

Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis

Lucchinetti, C. F., Gavrilova, R. H., Metz, I., Parisi, J. E., Scheithauer, B. W., Weigand, S., Thomsen, K., Mandrekar, J., Altintas, A., Erickson, B. J., König, F., Giannini, C., Lassmann, H., Linbo, L., Pittock, S. J. & Brück, W., Jul 2008, In : Brain. 131, 7, p. 1759-1775 17 p.

Research output: Contribution to journalArticle

268 Scopus citations

Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease

Pittock, S. J., McClelland, R. L., Achenbach, S. J., Konig, F., Bitsch, A., Brück, W., Lassmann, H., Parisi, J. E., Scheithauer, B. W., Rodriguez, M., Weinshenker, B. G. & Lucchinetti, C. F., Dec 2005, In : Journal of Neurology, Neurosurgery and Psychiatry. 76, 12, p. 1693-1697 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Clinical–radiological–pathological spectrum of central nervous system–idiopathic inflammatory demyelinating disease in the elderly

Tobin, W., Costanzi, C., Guo, Y., Parisi, J. E., Weigand, S. D. & Lucchinetti, C. F., Jan 1 2017, In : Multiple Sclerosis Journal. 23, 9, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

CNS aquaporin-4 autoimmunity in children

McKeon, A., Lennon, V. A., Lotze, T., Tenenbaum, S., Ness, J. M., Rensel, M., Kuntz, N. L., Fryer, J. P., Homburger, H., Hunter, J., Weinshenker, B. G., Krecke, K., Lucchinetti, C. F. & Pittock, S. J., Jul 8 2008, In : Neurology. 71, 2, p. 93-100 8 p.

Research output: Contribution to journalArticle

227 Scopus citations

Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica

Mckeon, A., Lennon, V. A., Jacob, A., Matiello, M., Lucchinetti, C. F., Kale, N., Chan, K. H., Weinshenker, B. G., Apiwattinakul, M., Wingerchuk, D. M. & Pittock, S. J., Jan 1 2009, In : Muscle and Nerve. 39, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

100 Scopus citations

Corrigendum: Multiple sclerosis - A quiet revolution

Ransohoff, R. M., Hafler, D. A. & Lucchinetti, C. F., May 11 2015, In : Nature Reviews Neurology. 11, 5, p. 246 1 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cortical demyelination and diffuse white matter injury in multiple sclerosis

Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E. & Lassmann, H., Nov 2005, In : Brain. 128, 11, p. 2705-2712 8 p.

Research output: Contribution to journalArticle

1138 Scopus citations

Crystal-storing histiocytosis: An unusual relapsing inflammatory CNS disorder

Costanzi, C., Bourdette, D., Parisi, J. E., Woltjer, R., Rodriguez, F., Steensma, D. & Lucchinetti, C. F., Apr 2012, In : Multiple Sclerosis and Related Disorders. 1, 2, p. 95-99 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Dark rims: Novel sequence enhances diagnostic specificity in multiple sclerosis

Tillema, J. M., Weigand, S. D., Dayan, M., Shu, Y., Kantarci, O. H., Lucchinetti, C. F. & Port, J. D., Jun 1 2018, In : American Journal of Neuroradiology. 39, 6, p. 1052-1058 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Default mode network disruption secondary to a lesion in the anterior thalamus

Jones, D. T., Mateen, F. J., Lucchinetti, C. F., Jack, C. R. & Welker, K. M., Feb 1 2011, In : Archives of neurology. 68, 2, p. 242-247 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Demyelination versus remyelination in progressive multiple sclerosis

Bramow, S., Frischer, J. M., Lassmann, H., Koch-Henriksen, N., Lucchinetti, C. F., Sørensen, P. S. & Laursen, H., Oct 2010, In : Brain. 133, 10, p. 2983-2998 16 p.

Research output: Contribution to journalArticle

148 Scopus citations

Diagnosis of neuromyelitis spectrum disorders: Comparative sensitivities and specificities of immunohistochemical and immunoprecipitation assays

McKeon, A., Fryer, J. P., Apiwattanakul, M., Lennon, V. A., Hinson, S. R., Kryzer, T. J., Lucchinetti, C. F., Weinshenker, B. G., Wingerchuk, D. M., Shuster, E. A. & Pittock, S. J., Sep 1 2009, In : Archives of neurology. 66, 9, p. 1134-1138 5 p.

Research output: Contribution to journalArticle

88 Scopus citations

Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)

Tobin, W. O., Guo, Y., Krecke, K. N., Parisi, J. E., Lucchinetti, C. F., Pittock, S. J., Mandrekar, J., Dubey, D., Debruyne, J. & Keegan, B. M., Sep 1 2017, In : Brain. 140, 9, p. 2415-2425 11 p.

Research output: Contribution to journalArticle

51 Scopus citations