• 20671 Citations
  • 82 Scopus h-Index
1976 …2019

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1997

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse

Balk, M. L., Bray, J., Day, C., Epperly, M., Greenberger, J., Evans, C. H. & Niyibizi, C., Jul 1 1997, In : Bone. 21, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: A feasibility study

Kang, R., Marui, T., Ghivizzani, S. C., Nita, I. M., Georgescu, H. I., Suh, J. K., Robbins, P. D. & Evans, C. H., Jan 1 1997, In : Osteoarthritis and Cartilage. 5, 2, p. 139-143 5 p.

Research output: Contribution to journalArticle

118 Scopus citations

Gene therapy for arthritis: Principles and clinical practice

Kang, R., Ghivizzani, S. C., Herndon, J. H., Robbinst, P. D. & Evans, C. H., Jan 1 1997, In : Biochemical Society Transactions. 25, 2, p. 533-537 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Gene transfer to the patellar tendon

Gerich, T. G., Kang, R., Fu, F. H., Robbins, P. D. & Evans, C. H., Jan 1 1997, In : Knee Surgery, Sports Traumatology, Arthroscopy. 5, 2, p. 118-123 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Gentransfer in die Patellarsehne von Kaninchen: Eine vorbereitende Studie zur lokoregionaren Expression von Wachstumsfaktoren

Translated title of the contribution: Gene transfer to the patellar tendon - An experimental study in rabbitsGerich, T. G., Ghivizani, S., Fu, F. H., Robbins, P. D. & Evans, C. H., Jul 16 1997, In : Wiener Klinische Wochenschrift. 109, 11, p. 384-389 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human IL-1Ra Gene Transfer into Human Synovial Fibroblasts Is Chondroprotective

Müller-Ladner, U., Roberts, C. R., Franklin, B. N., Gay, R. E., Robbins, P. D., Evans, C. H. & Gay, S., Apr 1 1997, In : Journal of Immunology. 158, 7, p. 3492-3498 7 p.

Research output: Contribution to journalArticle

141 Scopus citations

Identification of inducible nitric oxide synthase in human macrophages surrounding loosened hip prostheses

Watkins, S. C., Macaulay, W., Turner, D., Kang, R., Rubash, H. E. & Evans, C. H., Apr 19 1997, In : American Journal of Pathology. 150, 4, p. 1199-1206 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Interleukin-1α as an autocrine regulator in rabbit synovial fibroblasts

Engle, J. M., Georgescu, H. I. & Evans, C. H., Oct 2 1997, In : Inflammation Research. 46, SUPPL. 2, p. S175-S176

Research output: Contribution to journalArticle

3 Scopus citations

In vitro transfer von genen in spinale gewebe

Translated title of the contribution: In vitro transfer of genes into spinal tissuesReinecke, J. A., Wehling, P., Robbins, P., Evans, C. H., Sager, M., Schulze-Allen, G. & Koch, H., Dec 1 1997, In : Zeitschrift fur Orthopadie und Ihre Grenzgebiete. 135, 5, p. 412-416 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vivo suppression of early experimental osteoarthritis by interleukin- 1 receptor antagonist using gene therapy

Pelletier, J. P., Caron, J. P., Evans, C., Robbins, P. D., Georgescu, H. I., Jovanovic, D., Fernandes, J. C. & Martel-Pelletier, J., Jun 20 1997, In : Arthritis and rheumatism. 40, 6, p. 1012-1019 8 p.

Research output: Contribution to journalArticle

304 Scopus citations

Nitric oxide and proteoglycan turnover in rabbit articular cartilage

Stefanovic-Racic, M., Mollers, M. O., Miller, L. A. & Evans, C. H., May 1 1997, In : Journal of Orthopaedic Research. 15, 3, p. 442-449 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: Prolyl hydroxylase as a possible target

Cao, M., Westerhausen-Larson, A., Niyibizi, C., Kavalkovich, K., Georgescu, H. I., Rizzo, C. F., Hebda, P. A., Stefanovic-Racic, M. & Evans, C. H., May 15 1997, In : Biochemical Journal. 324, 1, p. 305-310 6 p.

Research output: Contribution to journalArticle

148 Scopus citations

The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations

Cameron, M., Buchgraber, A., Passler, H., Vogt, M., Thonar, E., Fu, F. & Evans, C. H., Jan 1 1997, In : American Journal of Sports Medicine. 25, 6, p. 751-754 4 p.

Research output: Contribution to journalArticle

165 Scopus citations

Toward a biochemical understanding of human intervertebral disc degeneration and herniation: Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases

Kang, J. D., Stefanovic-Racic, M., McIntyre, L. A., Georgescu, H. I. & Evans, C. H., May 15 1997, In : Spine. 22, 10, p. 1065-1073 9 p.

Research output: Contribution to journalArticle

333 Scopus citations

Transfer of genes to chondrocytic cells of the lumbar spine: Proposal for a treatment strategy of spinal disorders by local gene therapy

Wehling, P., Schulitz, K. P., Robbins, P. D., Evans, C. H. & Reinecke, J. A., May 15 1997, In : Spine. 22, 10, p. 1092-1097 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Virusvermittelter Gentransfer in die Patellarsehne. Eine experimentelle Studie am Kaninchen

Translated title of the contribution: Virally mediated gene transfer to the patellar tendon. An experimental study on rabbitsGerich, T. G., Lobenhoffer, H. P., Fu, F. H., Robbins, P. D. & Evans, C. H., May 1 1997, In : Unfallchirurg. 100, 5, p. 354-362 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
1996

Direct gene delivery to synovium: An evaluation of potential vectors in vitro and in vivo

Nita, I., Ghivizzani, S. C., Galea-Lauri, J., Bandara, G., Georgescu, H. I., Robbins, P. D. & Evans, C. H., May 1 1996, In : Arthritis and rheumatism. 39, 5, p. 820-828 9 p.

Research output: Contribution to journalArticle

162 Scopus citations

Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts

Lin, C. W., Robbins, P. D., Georgescu, H. I. & Evans, C. H., Feb 25 1996, In : Experimental Cell Research. 223, 1, p. 117-126 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Gene transfer to the rabbit patellar tendon: Potential for genetic enhancement of tendon and ligament healing

Gerich, T. G., Kang, R., Fu, F. H., Robbins, P. D. & Evans, C. H., Dec 1 1996, In : Gene Therapy. 3, 12, p. 1089-1093 5 p.

Research output: Contribution to journalArticle

88 Scopus citations

Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2

Kang, J. D., Georgescu, H. I., McIntyre-Larkin, L., Stefanovic-Racic, M., Donaldson, W. F. & Evans, C. H., Feb 1 1996, In : Spine. 21, 3, p. 271-277 7 p.

Research output: Contribution to journalArticle

516 Scopus citations

Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain

Dekosky, S. T., Styren, S. D., O'Malley, M. E., Goss, J. R., Kochanek, P., Marion, D., Evans, C. H. & Robbins, P. D., Feb 14 1996, In : Annals of neurology. 39, 1, p. 123-127 5 p.

Research output: Contribution to journalArticle

90 Scopus citations

Neurophysiologic Changes in Lumbar Nerve Root Inflammation in the Rat after Treatment with Cytokine Inhibitors: Evidence for a Role of Interleukin-1

Wehling, P., Cleveland, S. J., Heininger, K., Schulitz, K. P., Reinecke, J. & Evans, C. H., Apr 15 1996, In : Spine. 21, 8, p. 931-935 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Nitric oxide and cartilage metabolism

Evans, C. H., Watkins, S. C. & Stefanović-Račić, M., Sep 18 1996, In : Methods in enzymology. 269, p. 75-88 14 p.

Research output: Contribution to journalArticle

60 Scopus citations

Nitric oxide in arthritis

Evans, C. H. & Stefanovic-Racic, M., Aug 1996, In : Methods: A Companion to Methods in Enzymology. 10, 1, p. 38-42 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Prospects for gene therapy in sports medicine

Gerich, T. G., Fu, F. H., Robbins, P. D. & Evans, C. H., Jan 1 1996, In : Knee Surgery, Sports Traumatology, Arthroscopy. 4, 3, p. 180-187 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy

Otani, K., Nita, I., Macaulay, W., Georgescu, H. I., Robbins, P. D. & Evans, C. H., May 1 1996, In : Journal of Immunology. 156, 9, p. 3558-3562 5 p.

Research output: Contribution to journalArticle

176 Scopus citations

The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures

Stefanovic-Racic, M., Morales, T. I., Taskiran, D., McIntyre, L. A. & Evans, C. H., Feb 1 1996, In : Journal of Immunology. 156, 3, p. 1213-1220 8 p.

Research output: Contribution to journalArticle

99 Scopus citations
1995

Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis

Stefanovic-Racic, M., Meyers, K., Meschter, C., Coffey, J. W., Hoffman, R. A. & Evans, C. H., Jan 1 1995, In : Journal of Rheumatology. 22, 10, p. 1922-1928 7 p.

Research output: Contribution to journalArticle

105 Scopus citations

Effect of growth factors on the proliferation of fibroblasts from the medial collateral and anterior cruciate ligaments

Schmidt, C. C., Georgescu, H. I., Kwoh, C. K., Blomstrom, G. L., Engle, C. P., Larkin, L. A., Evans, C. H. & Woo, S. LY., Mar 1995, In : Journal of Orthopaedic Research. 13, 2, p. 184-190 7 p.

Research output: Contribution to journalArticle

147 Scopus citations

Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin e2

Kang, J. D., Georgescu, H. I., Mc Lntyre-Larkin, L., Stefanovic-Racic, M. & Evans, C. H., Nov 1995, In : Spine. 20, 22, p. 2373-2378 6 p.

Research output: Contribution to journalArticle

162 Scopus citations

Modulation of chondrocyte proteoglycan synthesis by endogeneously produced nitric oxide

Stefanovic-Racic, M., Taskiran, D., Georgescu, H. I. & Evans, C. H., Aug 1 1995, In : Inflammation Research. 44, 2 Supplement, p. S216-S217

Research output: Contribution to journalArticle

17 Scopus citations

Nitric oxide and its role in orthopaedic disease

Evans, C. H., Stefanovic-Racic, M. & Lancaster, J., Jan 1 1995, In : Clinical orthopaedics and related research. 312, p. 275-294 20 p.

Research output: Contribution to journalArticle

137 Scopus citations

Progress toward the treatment of arthritis by gene therapy

Evans, C. H. & Robbins, P. D., Jan 1 1995, In : Annals of Medicine. 27, 5, p. 543-546 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carry/no the hIL-1ra cDNA

Boggs, S. S., Patrene, K. D., Mueller, G. M., Evans, C. H., Doughty, L. A. & Robbins, P. D., Dec 1 1995, In : Gene Therapy. 2, 9, p. 632-638 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Section review: Biologicals & immunologicals: Gene therapy as a treatment for rheumatoid arthritis

Evans, C. & Robbins, P., Sep 1 1995, In : Expert Opinion on Investigational Drugs. 4, 9, p. 843-852 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
1994

Nitric oxide and energy production in articular chondrocytes

Stefanovic‐Racic, M., Stadler, J., Georgescu, H. I. & Evans, C. H., May 1994, In : Journal of Cellular Physiology. 159, 2, p. 274-280 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture

Häuselmann, H. J., Oppliger, L., Michel, B. A., Stefanovic-Racic, M. & Evans, C. H., Oct 3 1994, In : FEBS Letters. 352, 3, p. 361-364 4 p.

Research output: Contribution to journalArticle

122 Scopus citations

Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1

Taskiran, D., Stefanovicracic, M., Georgescu, H. & Evans, C., Apr 15 1994, In : Biochemical and Biophysical Research Communications. 200, 1, p. 142-148 7 p.

Research output: Contribution to journalArticle

336 Scopus citations

Nitric oxide synthesis and its regulation by rabbit synoviocytes

Stefanovic-Racic, M., Stadler, J., Georgescu, H. I. & Evans, C. H., Jan 1 1994, In : Journal of Rheumatology. 21, 10, p. 1892-1898 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

N‐Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats

Stefanovic‐Racic, M., Meyers, K., Meschter, C., Coffey, J. W., Hoffman, R. A. & Evans, C. H., Jul 1994, In : Arthritis & Rheumatism. 37, 7, p. 1062-1069 8 p.

Research output: Contribution to journalArticle

202 Scopus citations

Particle‐induced synthesis of collagenase by synovial fibroblasts: An immunocytochemical study

Greis, P. E., Georgescu, H. I., Fu, F. H. & Evans, C. H., Mar 1994, In : Journal of Orthopaedic Research. 12, 2, p. 286-293 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

PERSPEKTIVEN DER GENTHERAPIE BEI RHEUMATISCHEN UND DEGENERATIVEN ERKRANKUNGEN DER WIRBELSAULE UND DER GELENKE

Translated title of the contribution: Prospectives of gentherapy in orthopaedic diseases of the spine and the jointsEvans, C. H., Wehling, P. & Reinecke, J., Dec 1 1994, In : Zeitschrift fur Orthopadie und Ihre Grenzgebiete. 132, 6, p. 449-452 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Retroviral Vectors for Use in Human Gene Therapy for Cancer, Gaucher Disease, and Arthritis

ROBBINS, PAUL. D., TAHARA, HIDEAKI., MUELLER, GUNHILD., HUNG, GREG., BAHNSON, ALFRED., ZITVOGEL, LAURENCE., GALEA‐LAURI, JOANNA., OHASHI, TOYA., PATRENE, KEN., BOGGS, SALLIE. S., EVANS, CHRISTOPHER. H., BARRANGER, JOHN. A. & LOTZE, MICHAEL. T., May 1994, In : Annals of the New York Academy of Sciences. 716, 1, p. 72-89 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium

Hung, G. L., Galea-Lauri, J., Mueller, G. M., Georgescu, H. I., Larkin, L. A., Suchanek, M. K., Tindal, M. H., Robbins, P. D. & Evans, C. H., Dec 1 1994, In : Gene Therapy. 1, 1, p. 64-69 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee

Cameron, M. L., Fu, F. H., Paessler, H. H., Schneider, M. & Evans, C. H., Mar 1 1994, In : Knee Surgery, Sports Traumatology, Arthroscopy. 2, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

116 Scopus citations
1993

Characterization of monoclonal antibodies against rabbit CD44: Evidence of a role for CD44 in modulating synoviocyte metabolism

Galea-Lauri, J., Wilkinson, J. M. & Evans, C. H., Oct 1993, In : Molecular Immunology. 30, 15, p. 1383-1392 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

DIE WIRKUNG VON ZYTOKINEN AUF DAS REGENERATIONSERGEBNIS KOMPRIMIERTER NERVENWURZELN UND DURCHTRENNTER PERIPHERER NERVEN

Translated title of the contribution: The effect of cytokines on regeneration of compressed nerve roots and transsected peripheral nervesWehling, P., Wirths, J. & Evans, C. H., Jan 1 1993, In : Zeitschrift fur Orthopadie und Ihre Grenzgebiete. 131, 1, p. 83-93 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer

Bandara, G., Mueller, G. M., Galea-Lauri, J., Tindal, M. H., Georgescu, H. I., Suchanek, M. K., Hung, G. L., Glorioso, J. C., Robbins, P. D. & Evans, C. H., Nov 15 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 22, p. 10764-10768 5 p.

Research output: Contribution to journalArticle

267 Scopus citations

Nitric oxide and arthritis

Stefanovic‐Racic, M., Stadler, J. & Evans, C. H., Sep 1993, In : Arthritis & Rheumatism. 36, 8, p. 1036-1044 9 p.

Research output: Contribution to journalArticle

269 Scopus citations

The induction of IL-1 by freeze-dried ethylene oxide-treated bone-patellar tendon-bone allograft wear particles: An in vitro study

Silvaggio, V. J., Fu, F. H., Georgescu, H. I. & Evans, C. H., Jan 1 1993, In : Arthroscopy. 9, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

16 Scopus citations