• 20671 Citations
  • 82 Scopus h-Index
1976 …2019

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2000

Nitric oxide inhibits chondrocyte response to IGF-I: Inhibition of IGF-IRβ tyrosine phosphorylation

Studer, R. K., Levicoff, E., Georgescu, H., Miller, L., Jaffurs, D. & Evans, C. H., Dec 7 2000, In : American Journal of Physiology - Cell Physiology. 279, 4 48-4, p. C961-C969

Research output: Contribution to journalArticle

74 Scopus citations

Optionen fur den einsatz einer gentherapie zur behandlung von knochentumoren

Translated title of the contribution: Potential applications of gene therapy in bone tumorsKoch, H., Baltzer, A. W. A., Liebau, C., Evans, C. H., Robbins, P. D., Merk, H. & Krauspe, R., Jan 1 2000, In : Osteologie. 9, 3, p. 200-205 6 p.

Research output: Contribution to journalArticle

Orthopaedic applications of gene therapy: From concept to clinic

Kang, R., Ghivizzani, S. C., Muzzonigro, T. S., Herndon, J. H., Robbins, P. D. & Evans, C. H., Jan 1 2000, In : Clinical orthopaedics and related research. 375, p. 324-337 14 p.

Research output: Contribution to journalArticle

38 Scopus citations

Orthopaedic gene therapy: Editorial comment

Evans, C. H. & Scully, S. P., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S2

Research output: Contribution to journalArticle

7 Scopus citations

Osteoprogenitor cells within skeletal muscle

Bosch, P., Musgrave, D. S., Joon, Cummins, J., Shuler, F., Ghivizzani, S. C., Evans, C., Robbins, P. D. & Huard, J., Jan 1 2000, In : Journal of Orthopaedic Research. 18, 6, p. 933-944 12 p.

Research output: Contribution to journalArticle

237 Scopus citations

Potential applications of gene therapy to the treatment of intervertebral disc disorders

Nishida, K., Gilbertson, L. G., Robbins, P. D., Evans, C. H. & Kang, J. D., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S234-S241

Research output: Contribution to journalArticle

52 Scopus citations

Potential applications of gene therapy to the treatment of spinal disorders

Nishida, K., Gilbertson, L. G., Evans, C. H. & Kang, J. D., May 15 2000, In : Spine. 25, 10, p. 1308-1314 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Potential of gene therapy for treating osteogenesis imperfecta

Niyibizi, C., Smith, P., Mi, Z., Robbins, P. & Evans, C., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S126-S133

Research output: Contribution to journalArticle

22 Scopus citations

Potential role of direct adenoviral gene transfer in enhancing fracture repair

Baltzer, A. W. A., Lattermann, C., Whalen, J. D., Ghivizzani, S., Wooley, P., Krauspe, R., Robbins, P. D. & Evans, C. H., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S120-S125

Research output: Contribution to journalArticle

60 Scopus citations

TGFβ-1-gentransfer in gelenkknorpelzellen. Stimulierende wirkung in der extrazellularen matrixsynthese

Translated title of the contribution: TGFβ-1 gene transfer in articular chondrocytesMöller, H. D., Fu, F. H., Niyibizi, C., Studer, R. K., Georgescu, H. J., Robbins, P. D. & Evans, C. H., Feb 1 2000, In : Orthopade. 29, 2, p. 75-79 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Using gene therapy to protect and restore cartilage

Evans, C. H., Ghivizzani, S. C., Smith, P., Shuler, F. D., Mi, Z. & Robbins, P. D., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S214-S219

Research output: Contribution to journalArticle

82 Scopus citations

Zytokininduzierte Stickstoffmonoxidproduktion von Gelenkknorpelzellen unter kontinuierlicher passiver Bewegung. Antientzündlicher Effekt von kontinuierlicher passiver Bewegung auf Chondrozyten: In-vitro-Nachweis.

Translated title of the contribution: Cytokine-induced nitric oxide production of joint cartilage cells in continuous passive movement. Anti-inflammatory effect of continuous passive movement on chondrocytes: in vitro studyGassner, R., Buckley, M. J., Piesco, N., Evans, C. & Agarwal, S., Sep 2000, In : Mund-, Kiefer- und Gesichtschirurgie : MKG. 4 Suppl 2, p. S479-484

Research output: Contribution to journalArticle

4 Scopus citations
1999

Adenoviral transduction of human osteoblastic cell cultures. A new perspective for gene therapy of bone diseases

Baltzer, A. W. A., Whalen, J. D., Stefanovic-Racic, M., Ziran, B., Robbins, P. D. & Evans, C. H., Oct 1999, In : Acta Orthopaedica Scandinavica. 70, 5, p. 419-424 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws

Whalen, J. D., Lechman, E. L., Carlos, C. A., Weiss, K., Kovesdi, I., Glorioso, J. C., Robbins, P. D. & Evans, C. H., Mar 15 1999, In : Journal of Immunology. 162, 6, p. 3625-3632 8 p.

Research output: Contribution to journalArticle

184 Scopus citations

Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone

Musgrave, D. S., Bosch, P., Ghivizzani, S., Robbins, P. D., Evans, C. H. & Huard, J., Jun 1 1999, In : Bone. 24, 6, p. 541-547 7 p.

Research output: Contribution to journalArticle

214 Scopus citations

A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model.

Baltzer, A. W., Lattermann, C., Whalen, J. D., Braunstein, S., Robbins, P. D. & Evans, C. H., 1999, In : Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 7, 3, p. 197-202 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Arthritis gene therapy

Robbins, P. D. & Evans, C. H., Jan 1 1999, In : Drugs of Today. 35, 4-5, p. 353-360 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Clinical gene therapy for arthritis

Ghivizzani, S. C., Muzzonigro, T. S., Kang, R., Evans, C. H. & Robbins, P. D., Jan 1 1999, In : Drugs of Today. 35, 4-5, p. 389-396 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cyclic tensile stress exerts antiinflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase

Gassner, R., Buckley, M. J., Georgescu, H., Studer, R., Stefanovich-Racic, M., Piesco, N. P., Evans, C. H. & Agarwal, S., Aug 15 1999, In : Journal of Immunology. 163, 4, p. 2187-2192 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees

Lechman, E. R., Jaffurs, D., Ghivizzani, S. C., Gambotto, A., Kovesdi, I., Mi, Z., Evans, C. H. & Robbins, P. D., Aug 15 1999, In : Journal of Immunology. 163, 4, p. 2202-2208 7 p.

Research output: Contribution to journalArticle

128 Scopus citations

Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: The use of different viral vectors and the effects of injury

Hildebrand, K. A., Deie, M., Allen, C. R., Smith, D. W., Georgescu, H. I., Evans, C. H., Robbins, P. D. & Woo, S. L. Y., Jan 1 1999, In : Journal of Orthopaedic Research. 17, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

Genetically augmented tissue engineering of the musculoskeletal system

Evans, C. H. & Robbins, P. D., Jan 1 1999, In : Clinical orthopaedics and related research. 367 SUPPL., p. S410-S418

Research output: Contribution to journalArticle

50 Scopus citations

Gene transfer of cytokine inhibitors into human synovial fibroblasts in the scid mouse model

Müller-Ladner, U., Evans, C. H., Franklin, B. N., Roberts, C. R., Gay, R. E., Robbins, P. D. & Gay, S., Mar 29 1999, In : Arthritis and rheumatism. 42, 3, p. 490-497 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Gentherapeutische ansatze in der arthrosebehandlung

Translated title of the contribution: Therapy of arthritis by gene transferMöller, H. D. & Evans, C. H., Jan 1999, In : Orthopade. 28, 1, p. 76-81 6 p.

Research output: Contribution to journalArticle

Inhibition of transforming growth factor β production by nitric oxide- treated chondrocytes

Studer, R. K., Georgescu, H. I., Miller, L. A. & Evans, C. H., Feb 1 1999, In : Arthritis and rheumatism. 42, 2, p. 248-257 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism

Suh, J. K., Baek, G. H., Arøen, A., Malin, C. M., Niyibizi, C., Evans, C. H. & Westerhausen-Larson, A., Jan 1999, In : Osteoarthritis and Cartilage. 7, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis

Oligino, T., Ghivizzani, S. C., Wolfe, D., Lechman, E. R., Krisky, D., Mi, Z., Evans, C. H., Robbins, P. D. & Glorioso, J. C., Oct 1 1999, In : Gene Therapy. 6, 10, p. 1713-1720 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

In vitro transduktion humaner osteoblastarer zellpopulationen mit retroviralen vektoren

Translated title of the contribution: In vitro transduction of human osteoblastic cells using retroviral vectorsBaltzer, A. W. A., Whalen, J. D., Muzzonegro, T., Georgescu, H. I., Robbins, P. D. & Evans, C. H., Apr 1 1999, In : Zeitschrift fur Rheumatologie. 58, 2, p. 88-94 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Joint efforts: Tackling arthritis using gene therapy

Evans, C. H., Rediske, J. J., Abramson, S. B. & Robbins, P. D., Jan 1 1999, In : Molecular Medicine Today. 5, 4, p. 148-151 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: An in vivo study of adenovirus-mediated transfer of the human transforming growth factor β1 encoding gene

Nishida, K., Kang, J. D., Gilbertson, L. G., Moon, S. H., Suh, J. K., Vogt, M. T., Robbins, P. D. & Evans, C. H., Dec 1 1999, In : Spine. 24, 23, p. 2419-2425 7 p.

Research output: Contribution to journalArticle

264 Scopus citations

Nitric oxide in osteoarthritis

Studer, R., Jaffurs, D., Stefanovic-Racic, M., Robbins, P. D. & Evans, C. H., Jul 1999, In : Osteoarthritis and Cartilage. 7, 4, p. 377-379 3 p.

Research output: Contribution to journalArticle

151 Scopus citations

Potential treatment of osteoarthritis by gene therapy

Evans, C. H. & Robbins, P. D., Jan 1 1999, In : Rheumatic Disease Clinics of North America. 25, 2, p. 333-344 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging

Oyama, M., Tatlock, A., Fukuta, S., Kavalkovich, K., Nishimura, K., Johnstone, B., Robbins, P. D., Evans, C. H. & Niyibizi, C., Mar 1 1999, In : Gene Therapy. 6, 3, p. 321-329 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

The role of gene therapy: Fact or fiction?

Muzzonigro, T. S., Ghivizzani, S. C., Robbins, P. D. & Evans, C. H., Jan 1 1999, In : Clinics in Sports Medicine. 18, 1, p. 223-239 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Transfer of LacZ marker gene to the meniscus

Goto, H., Shuler, F. D., Lamsam, C., Moller, H. D., Niyibizi, C., Fu, F. H., Robbins, P. D. & Evans, C. H., Jul 1 1999, In : Journal of Bone and Joint Surgery - Series A. 81, 7, p. 918-925 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Trisomy 7 in synovial fibroblasts obtained from arthritic joints

Weiss, K. R., Georgescu, H. I., Gollin, S. M., Kang, R. & Evans, C. H., Dec 1 1999, In : Inflammation Research. 48, SUPPL. 2, p. S132-S133

Research output: Contribution to journalArticle

3 Scopus citations
1998

A 1998 status report on orthopedic gene therapy

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 1 1998, In : Current Opinion in Orthopaedics. 9, 6, p. 75-80 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Adenovirus-mediated gene transfer to nucleus pulposus cells implications for the treatment of intervertebral disc degeneration

Nishida, K., Kang, J. D., Suh, J. K., Robbins, P. D., Evans, C. H. & Gilbertson, L. G., Nov 15 1998, In : Spine. 23, 22, p. 2437-2443 7 p.

Research output: Contribution to journalArticle

132 Scopus citations

Blocking cytokines with genes

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jul 1998, In : Journal of Leukocyte Biology. 64, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Differences in nitric oxide production by superficial and deep human articular chondrocytes: Implications for proteoglycan turnover in inflammatory joint diseases

Häuselmann, H. J., Stefanovic-Racic, M., Michel, B. A. & Evans, C. H., Feb 1 1998, In : Journal of Immunology. 160, 3, p. 1444-1448 5 p.

Research output: Contribution to journalArticle

65 Scopus citations
269 Scopus citations

Generation of nitric oxide by lapine meniscal cells and its effect on matrix metabolism: Stimulation of collagen production by arginine

Cao, M., Stefanovic-Racic, M., Georgescu, H. I., Miller, L. A. & Evans, C. H., Jan 1 1998, In : Journal of Orthopaedic Research. 16, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Gene therapy for rheumatoid arthritis

Robbins, P. D., Evans, C. H. & Chernajovsky, Y., Jan 1 1998, In : Springer Seminars in Immunopathology. 20, 1-2, p. 197-209 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Gene therapy in arthritis

Whalen, J. D., Robbins, P. D. & Evans, C. H., Nov 1 1998, In : IDrugs. 1, 7, p. 802-806 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gene therapy in sports medicine

Lattermann, C., Baltzer, A. W. A., Whalen, J. D., Evans, C. H., Robbins, P. D. & Fu, F. H., Jan 1 1998, In : Sports medicine and arthroscopy review. 6, 2, p. 83-88 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Potential role for gene therapy in the enhancement of fracture healing

Niyibizi, C., Baltzer, A., Lattermann, C., Oyama, M., Whalen, J. D., Robbins, P. D. & Evans, C. H., Jan 1 1998, In : Clinical orthopaedics and related research. 355 SUPPL., p. S148-S153

Research output: Contribution to journalArticle

76 Scopus citations
1997

Constitutive Intra-Articular Expression of Human IL-1β Following Gene Transfer to Rabbit Synovium Produces All Major Pathologies of Human Rheumatoid Arthritis

Ghivizzani, S. C., Kang, R., Georgescu, H. I., Lechman, E. R., Jaffurs, D., Engle, J. M., Watkins, S. C., Tindal, M. H., Suchanek, M. K., McKenzie, L. R., Evans, C. H. & Robbins, P. D., Oct 1 1997, In : Journal of Immunology. 159, 7, p. 3604-3612 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10

Doughty, L. A., Patrene, K. D., Evans, C. H., Boggs, S. S. & Robbins, P. D., Jan 1 1997, In : Gene Therapy. 4, 3, p. 252-257 6 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: Implications for arthritis gene therapy

Ghivizzani, S. C., Lechman, E. R., Tio, C., Mule, K. M., Chada, S., McCormack, J. E., Evans, C. H. & Robbins, P. D., Jan 1 1997, In : Gene Therapy. 4, 9, p. 977-982 6 p.

Research output: Contribution to journalArticle

Open Access
88 Scopus citations

Effect of growth factors on the proliferation of ligament fibroblasts from skeletally mature rabbits

Scherping, S. C., Schmidt, C. C., Georgescu, H. I., Kwoh, C. K., Evans, C. H. & Woo, S. L. Y., 1997, In : Connective Tissue Research. 36, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

101 Scopus citations