• 20712 Citations
  • 82 Scopus h-Index
1976 …2019

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Article
2004

Enhanced repair of the anterior cruciate ligament by in situ gene transfer: Evaluation in an in vitro model

Pascher, A., Steinert, A. F., Palmer, G. D., Betz, O., Gouze, J. N., Gouze, E., Pilapil, C., Ghivizzani, S. C., Evans, C. H. & Murray, M. M., Aug 1 2004, In : Molecular Therapy. 10, 2, p. 327-336 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model

Southwood, L. L., Frisbie, D. D., Kawcak, C. E., Ghivizzani, S. C., Evans, C. H. & McIlwraith, C. W., Jan 1 2004, In : Journal of Orthopaedic Research. 22, 1, p. 66-72 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Feasibility of percutaneous gene transfer to an atrophic nonunion in a rabbit

Lattermann, C., Baltzer, A. W., Zelle, B. A., Whalen, J. D., Niyibizi, C., Robbins, P. D., Evans, C. H. & Gruen, G. S., Aug 2004, In : Clinical orthopaedics and related research. 425, p. 237-243 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Gene delivery to cartilage defects using coagulated bone marrow aspirate

Pascher, A., Palmer, G. D., Steinert, A., Oligino, T., Gouze, E., Gouze, J. N., Betz, O., Spector, M., Robbins, P. D., Evans, C. H. & Ghivizzani, S. C., Jan 1 2004, In : Gene Therapy. 11, 2, p. 133-141 9 p.

Research output: Contribution to journalArticle

82 Scopus citations

Gene transfer to the tendon-bone insertion site

Lattermann, C., Zelle, B. A., Whalen, J. D., Baltzer, A. W. A., Robbins, P. D., Niyibizi, C., Evans, C. H. & Fu, F. H., Sep 1 2004, In : Knee Surgery, Sports Traumatology, Arthroscopy. 12, 5, p. 510-515 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors.

Gouze, J. N., Stoddart, M. J., Gouze, E., Palmer, G. D., Ghivizzani, S. C., Grodzinsky, A. J. & Evans, C. H., 2004, In : Methods in molecular medicine. 100, p. 147-164 18 p.

Research output: Contribution to journalArticle

15 Scopus citations

Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis

Yang, S. Y., Wu, B., Mayton, L., Mukherjee, P., Robbins, P. D., Evans, C. H. & Wooley, P. H., Mar 1 2004, In : Gene Therapy. 11, 5, p. 483-491 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Role of NF-κB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals

Agarwal, S., Deschner, J., Long, P., Verma, A., Hofman, C., Evans, C. H. & Piesco, N., Nov 1 2004, In : Arthritis and rheumatism. 50, 11, p. 3541-3548 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

The effect of AdBMP-2 on ovine osteoblasts and BMSC including a comparison to human and murine cells

Blum, R., Alini, M., Evans, C., Schneider, E. & Egermann, M., Jun 1 2004, In : European Cells and Materials. 7, SUPPL.1, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations
2003

A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer.

Gouze, J. N., Gouze, E., Palmer, G. D., Liew, V. S., Pascher, A., Betz, O. B., Thornhill, T. S., Evans, C. H., Grodzinsky, A. J. & Ghivizzani, S. C., 2003, In : Arthritis research & therapy. 5, 5, p. R301-309

Research output: Contribution to journalArticle

38 Scopus citations

Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees.

Mi, Z., Ghivizzani, S. C., Lechman, E., Glorioso, J. C., Evans, C. H. & Robbins, P. D., 2003, In : Arthritis research & therapy. 5, 3, p. R132-139

Research output: Contribution to journalArticle

92 Scopus citations

Gene transfer to articular chondrocytes with recombinant adenovirus.

Palmer, G. D., Gouze, E., Gouze, J. N., Betz, O. B., Evans, C. H. & Ghivizzani, S. C., 2003, In : Methods in molecular biology (Clifton, N.J.). 215, p. 235-246 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium

Yao, Q., Wang, S., Gambotto, A., Glorioso, J. C., Evans, C. H., Robbins, P. D., Ghivizzani, S. C. & Oligino, T. J., Jun 1 2003, In : Gene Therapy. 10, 12, p. 1055-1060 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Lentiviral-mediated gene delivery to synovium: Potent intra-articular expression with amplification by inflammation

Gouze, E., Pawliuk, R., Gouze, J. N., Pilapil, C., Fleet, C., Palmer, G. D., Evans, C. H., Leboulch, P. & Ghivizzani, S. C., Apr 1 2003, In : Molecular Therapy. 7, 4, p. 460-466 7 p.

Research output: Contribution to journalArticle

77 Scopus citations
2002

Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices

Samuel, R. E., Lee, C. R., Ghivizzani, S. C., Evans, C. H., Yannas, I. V., Olsen, B. R. & Spector, M., May 1 2002, In : Human gene therapy. 13, 7, p. 791-802 12 p.

Research output: Contribution to journalArticle

61 Scopus citations

IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model

Yang, S., Wu, B., Mayton, L., Evans, C. H., Robbins, P. D. & Wooley, P. H., Jan 1 2002, In : Inflammation Research. 51, 7, p. 342-350 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

In vivo gene delivery to synovium by lentiviral vectors

Gouze, E., Pawliuk, R., Pilapil, C., Gouze, J. N., Fleet, C., Palmer, G. D., Evans, C. H., Leboulch, P. & Ghivizzani, S. C., Jan 1 2002, In : Molecular Therapy. 5, 4, p. 397-404 8 p.

Research output: Contribution to journalArticle

95 Scopus citations

Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

Frisbie, D. D., Ghivizzani, S. C., Robbins, P. D., Evans, C. H. & McIlwraith, C. W., Jan 1 2002, In : Gene Therapy. 9, 1, p. 12-20 9 p.

Research output: Contribution to journalArticle

246 Scopus citations

Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

Frisbie, D. D., Ghivizzani, S. C., Robbins, P. D., Evans, C. H. & McIlwraith, C. W., 2002, In : Gene Therapy. 9, 1, p. 12-20 9 p.

Research output: Contribution to journalArticle

2001

Approaches to enhancing the retroviral transduction of human synoviocytes

Del Vecchio, M. A., Georgescu, H. I., McCormack, J. E., Robbins, P. D. & Evans, C. H., Jul 19 2001, In : Arthritis Research. 3, 4, p. 259-263 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function

Brower-Toland, B. D., Saxer, R. A., Goodrich, L. R., Mi, Z., Robbins, P. D., Evans, C. H. & Nixon, A. J., Jan 20 2001, In : Human gene therapy. 12, 2, p. 117-129 13 p.

Research output: Contribution to journalArticle

78 Scopus citations

Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4

Kim, S. H., Kim, S., Evans, C. H., Ghivizzani, S. C., Oligino, T. & Robbins, P. D., Mar 1 2001, In : Journal of Immunology. 166, 5, p. 3499-3505 7 p.

Research output: Contribution to journalArticle

Open Access
178 Scopus citations

Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch

Sud, S., Yang, S. Y., Evans, C. H., Robbins, P. D. & Wooley, P. H., Dec 27 2001, In : Inflammation. 25, 6, p. 361-372 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Gene mediated insulin-like growth factor-I delivery to the synovium

Saxer, R. A., Bent, S. J., Brower-Toland, B. D., Mi, Z., Robbins, P. D., Evans, C. H. & Nixon, A. J., Sep 11 2001, In : Journal of Orthopaedic Research. 19, 5, p. 759-767 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Gene therapy for osteoporosis: Evaluation in a murine ovariectomy model

Baltzer, A. W. A., Whalen, J. D., Wooley, P., Latterman, C., Truchan, L. M., Robbins, P. D. & Evans, C. H., Jan 1 2001, In : Gene Therapy. 8, 23, p. 1770-1776 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Gene therapy for rheumatoid arthritis

Gouze, E., Ghivizzani, S. C., Palmer, G. D., Gouze, J. N., Robbins, P. D. & Evans, C. H., Nov 1 2001, In : Expert Opinion on Biological Therapy. 1, 6, p. 971-978 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
4 Scopus citations

Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation

Yao, Q., Wang, S., Glorioso, J. C., Evans, C. H., Robbins, P. D., Ghivizzani, S. C. & Oligino, T. J., Jan 1 2001, In : Molecular Therapy. 3, 6, p. 901-910 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: Evidence for involvement of genetically modified dendritic cells and macrophages

Whalen, J. D., Thomson, A. W., Lu, L., Robbins, P. D. & Evans, C. H., Jan 1 2001, In : Molecular Therapy. 4, 6, p. 543-550 8 p.

Research output: Contribution to journalArticle

36 Scopus citations
2000

Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining

Yao, Q., Glorioso, J. C., Evans, C. H., Robbins, P. D., Kovesdi, I., Oligino, T. J. & Ghivizzani, S. C., Jan 1 2000, In : Journal of Gene Medicine. 2, 3, p. 210-219 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints

Mi, Z., Ghivizzani, S. C., Lechman, E. R., Jaffurs, D., Glorioso, J. C., Evans, C. H. & Robbins, P. D., Nov 22 2000, In : Arthritis and rheumatism. 43, 11, p. 2563-2570 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Breakout session 8: Ligament and tendon

Hart, D. A. & Evans, C. H., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S260-S261

Research output: Contribution to journalArticle

6 Scopus citations

Breakout session 9: Gene therapy for rheumatoid arthritis

Ghivizzani, S. C. & Evans, C. H., 2000, In : Clinical Orthopaedics and Related Research. 379 SUPPL.

Research output: Contribution to journalArticle

Breakout session 9: Gene therapy for rheumatoid arthritis

Ghivizzani, S. C. & Evans, C. H., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S308-S310

Research output: Contribution to journalArticle

Clinical trials in the gene therapy of arthritis

Evans, C. H., Ghivizzani, S. C., Herndon, J. H., Wasko, M. C., Reinecke, J., Wehling, P. & Robbins, P. D., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S300-S307

Research output: Contribution to journalArticle

74 Scopus citations

Cyclic tensile strain acts as an antagonist of IL-1β actions in chondrocytes

Xu, Z., Buckley, M. J., Evans, C. H. & Agarwal, S., Jul 1 2000, In : Journal of Immunology. 165, 1, p. 453-460 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

Does nitric oxide help explain the differential healing capacity of the anterior cruciate, posterior cruciate, and medial collateral ligaments?

Cao, M., Stefanovic-Racic, M., Georgescu, H. I. & Evans, C. H., Apr 7 2000, In : American Journal of Sports Medicine. 28, 2, p. 176-182 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

GAG-augmented polysaccharide hydrogel: A novel biocompatible and biodegradable material to support chondrogenesis

Sechriest, V. F., Miao, Y. J., Niyibizi, C., Westerhausen-Larson, A., Matthew, H. W., Evans, C. H., Fu, F. H. & Suh, J. K., Mar 15 2000, In : Journal of Biomedical Materials Research. 49, 4, p. 534-541 8 p.

Research output: Contribution to journalArticle

242 Scopus citations

Gene therapy approaches for treating rheumatoid arthritis

Ghivizzani, S. C., Oligino, T. J., Glorioso, J. C., Robbins, P. D. & Evans, C. H., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S288-S299

Research output: Contribution to journalArticle

19 Scopus citations

Gene therapy for established murine collagen-induced arthritis bylocal and systemic adenovirus-madiated delivery of interleukin-4

Kim, S. H., Evans, C. H., Kim, S., Oligino, T., Ghivizzani, S. C. & Robbins, P. D., Dec 1 2000, In : Arthritis Research. 2, 4, p. 293-302 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Gene therapy for juvenile rheumatoid arthritis?

Londino, A. V., Rothman, D., Robbins, P. D. & Evans, C. H., Jun 20 2000, In : Journal of Rheumatology. 27, SUPPL. 58, p. 53-55 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gene therapy for meniscal injury: Enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFβ1 gene

Goto, H., Shuler, F. D., Niyibizi, C., Fu, F. H., Robbins, P. D. & Evans, C. H., Jul 2000, In : Osteoarthritis and Cartilage. 8, 4, p. 266-271 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene

Baltzer, A. W. A., Lattermann, C., Whalen, J. D., Wooley, P., Weiss, K., Grimm, M., Ghivizzani, S. C., Robbins, P. D. & Evans, C. H., May 2000, In : Gene Therapy. 7, 9, p. 734-739 6 p.

Research output: Contribution to journalArticle

Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene

Baltzer, A. W. A., Lattermann, C., Whalen, J. D., Wooley, P., Weiss, K., Grimm, M., Ghivizzani, S. C., Robbins, P. D. & Evans, C. H., Jan 1 2000, In : Gene Therapy. 7, 9, p. 734-739 6 p.

Research output: Contribution to journalArticle

258 Scopus citations

Genetic enhancement of matrix synthesis by articular chondrocytes: Comparison of different growth factor genes in the presence and absence of interleukin-1

Smith, P., Shuler, F. D., Georgescu, H. I., Ghivizzani, S. C., Johnstone, B., Niyibizi, C., Robbins, P. D. & Evans, C. H., May 1 2000, In : Arthritis and rheumatism. 43, 5, p. 1156-1164 9 p.

Research output: Contribution to journalArticle

154 Scopus citations

Gentherapie bei gelenkerkrankungen - Direkter eingriff in die zugrunde liegende pathophysiologie bald moglich?

Translated title of the contribution: Gene therapy of joint deseases - Direct intervention in the underlying pathophysiology soon possible?Wehling, P., Reinecke, J. A., Meijer, H., Granrath, M. & Evans, C. H., Oct 3 2000, In : Klinikarzt. 29, 8-9, p. 224-227 4 p.

Research output: Contribution to journalArticle

Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: Implications for the clinical management of intervertebral disc disorders

Moon, S. H., Gilbertson, L. G., Nishida, K., Knaub, M., Muzzonigro, T., Robbins, P. D., Evans, C. H. & Kang, J. D., Oct 15 2000, In : Spine. 25, 20, p. 2573-2579 7 p.

Research output: Contribution to journalArticle

94 Scopus citations

Increased matrix synthesis following adenoviral transfer of a transforming growth factor β1 gene into articular chondrocytes

Shuler, F. D., Georgescu, H. I., Niyibizi, C., Studer, R. K., Mi, Z., Johnstone, B., Robbins, P. D. & Evans, C. H., Jan 1 2000, In : Journal of Orthopaedic Research. 18, 4, p. 585-592 8 p.

Research output: Contribution to journalArticle

93 Scopus citations

Insulinlike growth factor-I gene therapy applications for cartilage repair

Nixon, A. J., Brower-Toland, B. D., Bent, S. J., Saxer, R. A., Wilke, M. J., Robbins, P. D. & Evans, C. H., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S201-S213

Research output: Contribution to journalArticle

121 Scopus citations

Interaction of strain and interleukin-1 in articular cartilage: Effects on proteoglycan synthesis in chondrocytes

Gassner, R. J., Buckley, M. J., Studer, R. K., Evans, C. H. & Agarwal, S., Oct 2000, In : International Journal of Oral and Maxillofacial Surgery. 29, 5, p. 389-394 6 p.

Research output: Contribution to journalArticle

21 Scopus citations