• 20671 Citations
  • 82 Scopus h-Index
1976 …2019

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Article
2010

BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells

Haddad-Weber, M., Prager, P., Kunz, M., Seefried, L., Jakob, F., Murray, M. M., Evans, C. H., Nöth, U. & Steinert, A. F., Jul 2010, In : Cytotherapy. 12, 4, p. 505-513 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Non-destructive evaluation of human mesenchymal progenitor cell transcriptional activity within osteochondral defects

Porter, R. M., Liu, F. J., Ferreira, E., Shen, Z. & Evans, C. H., Jul 2010, In : European Cells and Materials. 20, SUPPL.2, 1 p.

Research output: Contribution to journalArticle

Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage

Evans, C. H., Liu, F. J., Glatt, V., Hoyland, J. A., Kirker-Head, C., Walsh, A., Betz, O., Wells, J. W., Betz, V., Porter, R. M., Saad, F. A., Gerstenfeld, L. C., Einhorn, T. A., Harris, M. B. & Vrahas, M. S., Jan 1 2010, In : European Cells and Materials. 19, p. 96-111 16 p.

Research output: Contribution to journalArticle

67 Scopus citations
2009

Ability of recombinant human bone morphogenetic protein 2 to enhance bone healing in the presence of tobramycin: Evaluation in a rat segmental defect model

Glatt, V., Kwong, F. N., Park, K., Parry, N., Griffin, D., Vrahas, M., Evans, C. H. & Harris, M., Nov 1 2009, In : Journal of orthopaedic trauma. 23, 10, p. 693-701 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Accelerated healing of the rat Achilles tendon in response to autologous conditioned serum

Majewski, M., Ochsner, P. E., Liu, F., Flückiger, R. & Evans, C. H., Dec 2 2009, In : American Journal of Sports Medicine. 37, 11, p. 2117-2125 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion

Kwong, F. N. K., Hoyland, J. A., Freemont, A. J. & Evans, C. H., Jun 1 2009, In : Journal of Orthopaedic Research. 27, 6, p. 752-757 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis

Wehling, P., Reinecke, J., Baltzer, A. W. A., Granrath, M., Schulitz, K. P., Schultz, C., Krauspe, R., Whiteside, T. W., Elder, E., Ghivizzani, S. C., Robbins, P. D. & Evans, C. H., Feb 1 2009, In : Human gene therapy. 20, 2, p. 97-101 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer

Steinert, A. F., Palmer, G. D., Pilapil, C., Nöth, U., Evans, C. H. & Ghivizzani, S. C., May 1 2009, In : Tissue Engineering - Part A. 15, 5, p. 1127-1139 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer

Steinert, A. F., Proffen, B., Kunz, M., Hendrich, C., Ghivizzani, S. C., Nöth, U., Rethwilm, A., Eulert, J. & Evans, C. H., Oct 2 2009, In : Arthritis Research and Therapy. 11, 5, R148.

Research output: Contribution to journalArticle

101 Scopus citations

In situ modification of progenitor cells for the expedited regeneration of skeletal tissues

Evans, C. H., Aug 1 2009, In : European Cells and Materials. 18, SUPPL. 1, 1 p.

Research output: Contribution to journalArticle

Interleukin-1β and tumor necrosis factor α inhibit chondrogenesis by human mesenchymal stem cells through NF-κB-dependent pathways

Wehling, N., Palmer, G. D., Pilapil, C., Liu, F., Wells, J. W., Müller, P. E., Evans, C. H. & Porter, R. M., Mar 1 2009, In : Arthritis and rheumatism. 60, 3, p. 801-812 12 p.

Research output: Contribution to journalArticle

149 Scopus citations

Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus

Kay, J. D., Gouze, E., Oligino, T. J., Gouze, J. N., Watson, R. S., Levings, P. P., Bush, M. L., Dacanay, A., Nickerson, D. M., Robbins, P. D., Evans, C. H. & Ghivizzani, S. C., Oct 2 2009, In : Journal of Gene Medicine. 11, 7, p. 605-614 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty

Porter, R. M., Liu, F., Pilapil, C., Betz, O. B., Vrahas, M. S., Harris, M. B. & Evans, C. H., Jan 1 2009, In : Journal of Orthopaedic Research. 27, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures

Kwong, F. N. K., Hoyland, J. A., Evans, C. H. & Freemont, A. J., Feb 1 2009, In : International Orthopaedics. 33, 1, p. 281-288 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

Lefèvre, S., Knedla, A., Tennie, C., Kampmann, A., Wunrau, C., Dinser, R., Korb, A., Schnäker, E. M., Tarner, I. H., Robbins, P. D., Evans, C. H., Stürz, H., Steinmeyer, J., Gay, S., Schölmerich, J., Pap, T., Müller-Ladner, U. & Neumann, E., Dec 1 2009, In : Nature Medicine. 15, 12, p. 1414-1420 7 p.

Research output: Contribution to journalArticle

342 Scopus citations
2008

Arthritis gene therapy's first death

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Feb 27 2008, In : Arthritis Research and Therapy. 10, 3, 110.

Research output: Contribution to journalArticle

72 Scopus citations

A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors

Palmer, G. D., Stoddart, M. J., Gouze, E., Gouze, J. N., Ghivizzani, S. C., Porter, R. M. & Evans, C. H., Mar 1 2008, In : Gene Therapy. 15, 5, p. 357-363 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Characterization and utilization of mesenchymal progenitor cells recovered with the Reamer-Irrigator-Aspirator

Porter, R. M., Ivkovic, A., Wells, J., Glatt, V., Harris, M. B., Vrahas, M. S. & Evans, C., Jul 1 2008, In : European Cells and Materials. 16, SUPPL.2, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures

Kisiday, J. D., Kopesky, P. W., Evans, C. H., Grodzinsky, A. J., Mcllwraith, C. W. & Frisbie, D. D., Mar 1 2008, In : Journal of Orthopaedic Research. 26, 3, p. 322-331 10 p.

Research output: Contribution to journalArticle

160 Scopus citations

Expedited strategies for the restoration of bone

Evans, C. H., Glatt, V., Liu, F. J., Wells, J. W., Ferreira, E., Vrahas, M. S., Harris, M. B., Ivkovic, A. & Porter, R. M., Dec 1 2008, In : European Cells and Materials. 16, SUPPL. 4, 1 p.

Research output: Contribution to journalArticle

Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model

Majewski, M., Betz, O., Ochsner, P. E., Liu, F., Porter, R. M. & Evans, C. H., Aug 13 2008, In : Gene Therapy. 15, 16, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Gentherapie in der Knorpelregeneration

Translated title of the contribution: Gene therapy in cartilage repairPascher, A., Palmer, G., Evans, C. H., Steinert, A., Windhager, R. & Ghivizzani, S. C., Jun 16 2008, In : Sport-Orthopadie - Sport-Traumatologie. 24, 2, p. 74-77 4 p.

Research output: Contribution to journalArticle

Improving the osteogenic behavior of human mesenchymal stromal cells

Ivkovic, A., Porter, R. M., Wells, J. W. & Evans, C. H., Jul 1 2008, In : European Cells and Materials. 16, SUPPL.2, 1 p.

Research output: Contribution to journalArticle

Influence of the mechanical environment upon the healing of segmental bone defects in a rat model Studied with a Novel external fixator

Glatt, V., Matthys, R., Ivkovic, A. & Evans, C., Jul 1 2008, In : European Cells and Materials. 16, SUPPL.2, 1 p.

Research output: Contribution to journalArticle

In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament

Steinert, A. F., Weber, M., Kunz, M., Palmer, G. D., Nöth, U., Evans, C. H. & Murray, M. M., Mar 1 2008, In : Biomaterials. 29, 7, p. 904-916 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Pro-inflammatory cytokines inhibit chondrogenesis by human mesenchymal stem cells through NF-κB-dependent pathways

Porter, R. M., Wehling, N., Palmer, G. D., Wells, J. W., Müller, P. E. & Evans, C. H., Jul 1 2008, In : European Cells and Materials. 16, SUPPL.2, 1 p.

Research output: Contribution to journalArticle

2007

Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells

Kwong, F. N. K., Richardson, S. M. & Evans, C. H., Dec 20 2007, In : Arthritis Research and Therapy. 10, 3, R65.

Research output: Contribution to journalArticle

54 Scopus citations

Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects

Betz, O. B., Betz, V. M., Nazarian, A., Egermann, M., Gerstenfeld, L. C., Einhorn, T. A., Vrahas, M. S., Bouxsein, M. L. & Evans, C. H., Jul 1 2007, In : Gene Therapy. 14, 13, p. 1039-1044 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-β1 complementary deoxyribonucleic acid

Steinert, A. F., Palmer, G. D., Capito, R., Hofstaetter, J. G., Pilapil, C., Ghivizzani, S. C., Spector, M. & Evans, C. H., Sep 1 2007, In : Tissue Engineering. 13, 9, p. 2227-2237 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model

Goodrich, L. R., Hidaka, C., Robbins, P. D., Evans, C. H. & Nixon, A. J., May 1 2007, In : Journal of Bone and Joint Surgery - Series B. 89, 5, p. 672-685 14 p.

Research output: Contribution to journalArticle

136 Scopus citations

Healing of segmental bone defects by direct percutaneous gene delivery: Effect of vector dose

Betz, V. M., Betz, O. B., Glatt, V., Gerstenfeld, L. C., Einhorn, T. A., Bouxsein, M. L., Vrahas, M. S. & Evans, C. H., Oct 1 2007, In : Human gene therapy. 18, 10, p. 907-915 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

John Hunter and the origins of modern orthopaedic research

Evans, C. H., Apr 1 2007, In : Journal of Orthopaedic Research. 25, 4, p. 556-560 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

The facilitated endogenous repair of bone by gene transfer

Evans, C. H., Aug 1 2007, In : European Cells and Materials. 14, SUPPL.1, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transgene persistence and cell turnover in the diarthrodial joint: Implications for gene therapy of chronic joint diseases

Gouze, E., Gouze, J. N., Palmer, G. D., Pilapil, C., Evans, C. H. & Ghivizzani, S. C., Jun 1 2007, In : Molecular Therapy. 15, 6, p. 1114-1120 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2006

Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep

Egermann, M., Baltzer, A. W., Adamaszek, S., Evans, C., Robbins, P., Schneider, E. & Lill, C. A., May 1 2006, In : Human gene therapy. 17, 5, p. 507-517 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations

Goodrich, L. R., Brower-Toland, B. D., Warnick, L., Robbins, P. D., Evans, C. H. & Nixon, A. J., Sep 1 2006, In : Gene Therapy. 13, 17, p. 1253-1262 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Direct percutaneous gene delivery to enhance healing of segmental bone defects

Betz, O. B., Betz, V. M., Nazarian, A., Pilapil, C. G., Vrahas, M. S., Bouxsein, M. L., Gerstenfeld, L. C., Einhorn, T. A. & Evans, C. H., Feb 1 2006, In : Journal of Bone and Joint Surgery - Series A. 88, 2, p. 355-365 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

Effect of BMP-2 gene transfer on bone healing in sheep

Egermann, M., Lill, C. A., Griesbeck, K., Evans, C. H., Robbins, P. D., Schneider, E. & Baltzer, A. W., Sep 1 2006, In : Gene Therapy. 13, 17, p. 1290-1299 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Molecular approaches to cartilage repair

Evans, C. H., Palmer, G. D., Pascher, A., Steinert, A. & Ghivizzani, S. C., Aug 1 2006, In : European Cells and Materials. 12, SUPPL.1, 1 p.

Research output: Contribution to journalArticle

Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: Comparison of adenovirus mediated gene transfer and protein delivery of BMP-2

Meinel, L., Hofmann, S., Betz, O., Fajardo, R., Merkle, H. P., Langer, R., Evans, C. H., Vunjak-Novakovic, G. & Kaplan, D. L., Oct 1 2006, In : Biomaterials. 27, 28, p. 4993-5002 10 p.

Research output: Contribution to journalArticle

144 Scopus citations

Potential biologic therapies for the intervertebral disc

Evans, C., Apr 12 2006, In : Journal of Bone and Joint Surgery - Series A. 88, SUPPL. 2, p. 95-98 4 p.

Research output: Contribution to journalArticle

73 Scopus citations
2005

Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model

Haupt, J. L., Frisbie, D. D., McIlwraith, C. W., Robbins, P. D., Ghivizzani, S., Evans, C. H. & Nixon, A. J., Jan 1 2005, In : Journal of Orthopaedic Research. 23, 1, p. 118-126 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro

Palmer, G. D., Steinert, A., Pascher, A., Gouze, E., Gouze, J. N., Betz, O., Johnstone, B., Evans, C. H. & Ghivizzani, S. C., Aug 1 2005, In : Molecular Therapy. 12, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

120 Scopus citations

Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy

Nixon, A. J., Haupt, J. L., Frisbie, D. D., Morisset, S. S., McIlwraith, C. W., Robbins, P. D., Evans, C. H. & Ghivizzani, S., Jan 1 2005, In : Gene Therapy. 12, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Gene therapy: What have we accomplished and where do we go from here?

Evans, C. H., Jan 1 2005, In : Journal of Rheumatology. 32, SUPPL. 72, p. 17-20 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Gene transfer to human joints: Progress toward a gene therapy of arthritis

Evans, C. H., Robbins, P. D., Ghivizzani, S. C., Wasko, M. C., Tomaino, M. M., Kang, R., Muzzonigro, T. A., Vogt, M., Elder, E. M., Whiteside, T. L., Watkins, S. C. & Herndon, J. H., Jun 14 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 24, p. 8698-8703 6 p.

Research output: Contribution to journalArticle

155 Scopus citations

The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics

Evans, C. H., Ghivizzani, S. C., Gouze, E., Rediske, J. J., Schwarz, E. M. & Robbins, P. D., Dec 1 2005, In : Arthritis Research and Therapy. 7, 6, p. 273-278 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

The potential of gene therapy for fracture healing in osteoporosis

Egermann, M., Schneider, E., Evans, C. H. & Baltzer, A. W., Dec 1 2005, In : Osteoporosis International. 16, SUPPL. 2, p. S120-S128

Research output: Contribution to journalArticle

48 Scopus citations
2004

Adenovirus-mediated gene transfer of glutamine: Fructose-6-phosphate amidotransferase antagonizes the effects of interluekin-1β on rat chondrocytes

Gouze, J. N., Gouze, E., Palmer, G. D., Kaneto, H., Ghivizzani, S. C., Grodzinsky, A. J. & Evans, C. H., Mar 2004, In : Osteoarthritis and Cartilage. 12, 3, p. 217-224 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Effects of cyclic longitudinal mechanical strain and dexamethasone on osteogenic differentiation of human bone marrow stromal cells

Jagodzinski, M., Drescher, M., Zeichen, J., Hankemeier, S., Krettek, C., Bosch, U., Van Griensven, M., Martin, I. & Evans, C., Jan 1 2004, In : European Cells and Materials. 7, p. 35-41 7 p.

Research output: Contribution to journalArticle

Open Access
116 Scopus citations