Research output

Research output per year 2008 2015 2016 2017 2018 2019 2020 2021 2022 2023 2023

• 70 Article
• 8 Review article
• 6 Comment/debate

Research output per year

Research output per year

Search results

• 2023

  An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells

  Raulin, A. C., Liu, C. C. & Bu, G., Mar 17 2023, In: STAR Protocols. 4, 1, 101976.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 100%
  • Cholesterol 55%
  • Apolipoprotein 15%
  • Apolipoproteins 12%
  • Disorder 10%

• Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

  Liu, C. C., Wang, N., Chen, Y., Inoue, Y., Shue, F., Ren, Y., Wang, M., Qiao, W., Ikezu, T. C., Li, Z., Zhao, J., Martens, Y., Doss, S. V., Rosenberg, C. L., Jeevaratnam, S., Jia, L., Raulin, A. C., Qi, F., Zhu, Y., Alnobani, A., & 9 othersKnight, J., Chen, Y., Linares, C., Kurti, A., Fryer, J. D., Zhang, B., Wu, L. J., Kim, B. Y. S. & Bu, G., Nov 2023, In: Nature immunology. 24, 11, p. 1854-1866 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Microglia 89%
  • Brain Diseases 83%
  • Apolipoproteins E 78%
  • Alzheimer Disease 68%

• Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology (Molecular Neurodegeneration, (2023), 18, 1, (8), 10.1186/s13024-023-00599-3)

  Qiao, W., Chen, Y., Zhong, J., Madden, B. J., Charlesworth, C. M., Martens, Y. A., Liu, C. C., Knight, J., Ikezu, T. C., Aishe, K., Zhu, Y., Meneses, A., Rosenberg, C. L., Kuchenbecker, L. A., Vanmaele, L. K., Li, F., Chen, K., Shue, F., Dacquel, M. V., Fryer, J., & 3 othersPandey, A., Zhao, N. & Bu, G., Dec 2023, In: Molecular neurodegeneration. 18, 1, 28.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Molecular Pathology 100%
  • Amyloid 82%

• Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

  for the Alzheimer's Disease Neuroimaging Initiative, Dec 2023, In: Molecular neurodegeneration. 18, 1, 2.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Alzheimer Disease 74%
  • Phenotype 57%
  • Brain 46%
  • Proteins 35%

• LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

  Oue, H., Yamazaki, Y., Qiao, W., Yuanxin, C., Ren, Y., Kurti, A., Shue, F., Parsons, T. M., Perkerson, R. B., Kawatani, K., Wang, N., Starling, S. C., Roy, B., Mosneag, I. E., Aikawa, T., Holm, M. L., Liu, C. C., Inoue, Y., Sullivan, P. M., Asmann, Y. W., & 3 othersKim, B. Y. S., Bu, G. & Kanekiyo, T., Apr 10 2023, In: JCI Insight. 8, 7, e163822.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipoprotein Receptors 100%
  • Blood Vessels 41%
  • Dementia 36%
  • Cognitive Dysfunction 28%
  • Proteins 25%

• Sex specific molecular networks and key drivers of Alzheimer’s disease

  Guo, L., Cao, J., Hou, J., Li, Y., Huang, M., Zhu, L., Zhang, L., Lee, Y., Duarte, M. L., Zhou, X., Wang, M., Liu, C. C., Martens, Y., Chao, M., Goate, A., Bu, G., Haroutunian, V., Cai, D. & Zhang, B., Dec 2023, In: Molecular neurodegeneration. 18, 1, 39.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alzheimer Disease 100%
  • Genotype 24%
  • Sex Characteristics 24%
  • Brain 12%
  • Brain Mapping 11%

• Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer’s Disease

  Macyczko, J. R., Wang, N., Zhao, J., Ren, Y., Lu, W., Ikezu, T. C., Zhao, N., Liu, C. C., Bu, G. & Li, Y., Jan 2023, In: Molecular Neurobiology. 60, 1, p. 26-35 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Porcupines 100%
  • Catenins 74%
  • Alzheimer Disease 45%
  • Down-Regulation 41%
  • Brain 21%

• Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

  Qiao, W., Chen, Y., Zhong, J., Madden, B. J., Charlesworth, C. M., Martens, Y. A., Liu, C. C., Knight, J., Ikezu, T. C., Aishe, K., Zhu, Y., Meneses, A., Rosenberg, C. L., Kuchenbecker, L. A., Vanmaele, L. K., Li, F., Chen, K., Shue, F., Dacquel, M. V., Fryer, J., & 3 othersPandey, A., Zhao, N. & Bu, G., Dec 2023, In: Molecular neurodegeneration. 18, 1, 8.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid Cells 100%
  • Amyloid 92%
  • Pathology 61%
  • Alzheimer Disease 23%
  • Mutation 13%

• Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology

  MacYczko, J. R., Wang, N., Lu, W., Jeevaratnam, S., Shue, F., Martens, Y., Liu, C. C., Kanekiyo, T., Bu, G. & Li, Y., 2023, In: Journal of Alzheimer's Disease. 95, 2, p. 399-405 7 p.

  Research output: Contribution to journal › Article › peer-review

  • dementia 100%
  • pathology 95%
  • Amyloid 94%
  • Up-Regulation 71%
  • Pathology 62%
• 2022

  ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease

  Li, Y., Macyczko, J. R., Liu, C. C. & Bu, G., Jul 2022, In: Neurobiology of aging. 115, p. 20-28 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Apolipoproteins E 78%
  • Alzheimer Disease 57%
  • Microglia 21%
  • Pathology 19%

• ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

  Martens, Y. A., Zhao, N., Liu, C. C., Kanekiyo, T., Yang, A. J., Goate, A. M., Holtzman, D. M. & Bu, G., Apr 20 2022, In: Neuron. 110, 8, p. 1304-1317 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Apolipoproteins E 100%
  • Dementia 78%
  • Alzheimer Disease 73%
  • Apolipoprotein E4 64%
  • Protein Isoforms 37%

• ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

  Raulin, A. C., Doss, S. V., Trottier, Z. A., Ikezu, T. C., Bu, G. & Liu, C. C., Dec 2022, In: Molecular neurodegeneration. 17, 1, 72.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Apolipoproteins E 100%
  • Alzheimer Disease 73%
  • Alleles 30%
  • Apolipoprotein E4 28%
  • Protein Isoforms 16%

• Clinicopathologic Factors Associated With Reversion to Normal Cognition in Patients With Mild Cognitive Impairment

  Li, Z., Heckman, M. G., Kanekiyo, T., Martens, Y. A., Day, G. S., Vassilaki, M., Liu, C. C., Bennett, D. A., Petersen, R. C., Zhao, N. & Bu, G., May 17 2022, In: Neurology. 98, 20, p. E2036-E2045

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cognitive Dysfunction 100%
  • Cognition 96%
  • Memory 71%
  • Amyloid 46%
  • Glucose 46%

• Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids (Acta Neuropathologica, (2021), 142, 5, (807-825), 10.1007/s00401-021-02361-9)

  Zhao, J., Lu, W., Ren, Y., Fu, Y., Martens, Y. A., Shue, F., Davis, M. D., Wang, X., Chen, K., Li, F., Liu, C. C., Graff-Radford, N. R., Wszolek, Z. K., Younkin, S. G., Brafman, D. A., Ertekin-Taner, N., Asmann, Y. W., Dickson, D. W., Xu, Z., Pan, M., & 3 othersHan, X., Kanekiyo, T. & Bu, G., Jan 2022, In: Acta neuropathologica. 143, 1, p. 119-121 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Synucleins 100%
  • Organoids 86%
  • Apolipoproteins E 70%
  • Lipid Metabolism 63%
  • Publications 54%

• Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia

  Zhao, N., Qiao, W., Li, F., Ren, Y., Zheng, J., Martens, Y. A., Wang, X., Li, L., Liu, C. C., Chen, K., Zhu, Y., Ikezu, T. C., Li, Z., Meneses, A. D., Jin, Y., Knight, J. A., Chen, Y., Bastea, L., Linares, C., Sonustun, B., & 11 othersJob, L., Smith, M. L., Xie, M., Liu, Y. U., Umpierre, A. D., Haruwaka, K., Quicksall, Z. S., Storz, P., Asmann, Y. W., Wu, L. J. & Bu, G., Dec 5 2022, In: Journal of Experimental Medicine. 219, 12, e20212479.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia 100%
  • Amyloid 93%
  • Alzheimer Disease 76%
  • RNA Sequence Analysis 22%
  • Antigen Presentation 21%

• LRP1 is a neuronal receptor for α-synuclein uptake and spread

  Chen, K., Martens, Y. A., Meneses, A., Ryu, D. H., Lu, W., Raulin, A. C., Li, F., Zhao, J., Chen, Y., Jin, Y., Linares, C., Goodwin, M., Li, Y., Liu, C. C., Kanekiyo, T., Holtzman, D. M., Golde, T. E., Bu, G. & Zhao, N., Dec 2022, In: Molecular neurodegeneration. 17, 1, 57.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Lipoprotein Receptors 94%
  • Proteins 24%
  • Neurons 18%
  • Lysine 14%

• Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

  Wang, N., Wang, M., Jeevaratnam, S., Rosenberg, C., Ikezu, T. C., Shue, F., Doss, S. V., Alnobani, A., Martens, Y. A., Wren, M., Asmann, Y. W., Zhang, B., Bu, G. & Liu, C. C., Dec 2022, In: Molecular neurodegeneration. 17, 1, 75.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E2 100%
  • Apolipoprotein E4 89%
  • Demyelinating Diseases 69%
  • Microglia 66%
  • Lipid Metabolism 63%

• Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function

  Liu, C. C., Zhao, J., Fu, Y., Inoue, Y., Ren, Y., Chen, Y., Doss, S. V., Shue, F., Jeevaratnam, S., Bastea, L., Wang, N., Martens, Y. A., Qiao, W., Wang, M., Zhao, N., Jia, L., Yamazaki, Y., Yamazaki, A., Rosenberg, C. L., Wang, Z., & 20 othersKong, D., Li, Z., Kuchenbecker, L. A., Trottier, Z. A., Felton, L., Rogers, J., Quicksall, Z. S., Linares, C., Knight, J., Chen, Y., Kurti, A., Kanekiyo, T., Fryer, J. D., Asmann, Y. W., Storz, P., Wang, X., Peng, J., Zhang, B., Kim, B. Y. S. & Bu, G., Aug 2022, In: Nature Neuroscience. 25, 8, p. 1020-1033 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Apolipoproteins E 78%
  • Cognition 58%
  • Pathology 46%
  • Apolipoprotein E3 36%

• TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

  Xie, M., Liu, Y. U., Zhao, S., Zhang, L., Bosco, D. B., Pang, Y. P., Zhong, J., Sheth, U., Martens, Y. A., Zhao, N., Liu, C. C., Zhuang, Y., Wang, L., Dickson, D. W., Mattson, M. P., Bu, G. & Wu, L. J., Jan 2022, In: Nature Neuroscience. 25, 1, p. 26-38 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA-Binding Proteins 100%
  • Neuroprotection 93%
  • Myeloid Cells 91%
  • Microglia 33%
  • human TDP-43 protein 22%
• 2021

  APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

  Liu, C. C., Murray, M. E., Li, X., Zhao, N., Wang, N., Heckman, M. G., Shue, F., Martens, Y., Li, Y., Raulin, A. C., Rosenberg, C. L., Doss, S. V., Zhao, J., Wren, M. C., Jia, L., Ren, Y., Ikezu, T. C., Lu, W., Fu, Y., Caulfield, T., & 27 othersTrottier, Z. A., Knight, J., Chen, Y., Linares, C., Wang, X., Kurti, A., Asmann, Y. W., Wszolek, Z. K., Smith, G. E., Vemuri, P., Kantarci, K., Knopman, D. S., Lowe, V. J., Jack, C. R., Parisi, J. E., Ferman, T. J., Boeve, B. F., Graff-Radford, N. R., Petersen, R. C., Younkin, S. G., Fryer, J. D., Wang, H., Han, X., Frieden, C., Dickson, D. W., Ross, O. A. & Bu, G., Sep 29 2021, In: Science translational medicine. 13, 613, eabc9375.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dementia 100%
  • Alzheimer Disease 92%
  • Lewy Bodies 66%
  • Apolipoproteins E 54%
  • Brain 25%

• Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

  Zhao, J., Lu, W., Ren, Y., Fu, Y., Martens, Y. A., Shue, F., Davis, M. D., Wang, X., Chen, K., Li, F., Liu, C. C., Graff-Radford, N. R., Wszolek, Z. K., Younkin, S. G., Brafman, D. A., Ertekin-Taner, N., Asmann, Y. W., Dickson, D. W., Xu, Z., Pan, M., & 3 othersHan, X., Kanekiyo, T. & Bu, G., Nov 2021, In: Acta neuropathologica. 142, 5, p. 807-825 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Organoids 86%
  • Apolipoproteins E 70%
  • Lipid Metabolism 63%
  • Lewy Bodies 42%

• Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids (Nature Communications, (2020), 11, 1, (5540), 10.1038/s41467-020-19264-0)

  Zhao, J., Fu, Y., Yamazaki, Y., Ren, Y., Davis, M. D., Liu, C. C., Lu, W., Wang, X., Chen, K., Cherukuri, Y., Jia, L., Martens, Y. A., Job, L., Shue, F., Nguyen, T. T., Younkin, S. G., Graff-Radford, N. R., Wszolek, Z. K., Brafman, D. A., Asmann, Y. W., & 3 othersErtekin-Taner, N., Kanekiyo, T. & Bu, G., Dec 1 2021, In: Nature communications. 12, 1, 2707.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Generation and validation of APOE knockout human iPSC-derived cerebral organoids

  Martens, Y. A., Xu, S., Tait, R., Li, G., Zhao, X. C., Lu, W., Liu, C. C., Kanekiyo, T., Bu, G. & Zhao, J., Jun 18 2021, In: STAR Protocols. 2, 2, 100571.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Induced Pluripotent Stem Cells 86%
  • Apolipoproteins E 80%
  • Apolipoprotein 31%
  • Alzheimer Disease 29%

• Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

  Hou, X., Watzlawik, J. O., Cook, C., Liu, C. C., Kang, S. S., Lin, W. L., DeTure, M., Heckman, M. G., Diehl, N. N., Al-Shaikh, F. S. H., Walton, R. L., Ross, O. A., Melrose, H. L., Ertekin-Taner, N., Bu, G., Petrucelli, L., Fryer, J. D., Murray, M. E., Dickson, D. W., Fiesel, F. C., & 1 othersSpringer, W., Mar 2021, In: Alzheimer's and Dementia. 17, 3, p. 417-430 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitophagy 100%
  • dementia 73%
  • pathology 70%
  • Alzheimer Disease 56%
  • brain 46%
  5 Scopus citations

• Preparation of single cell suspensions enriched in mouse brain vascular cells for single-cell RNA sequencing

  Yamazaki, A., Shue, F., Yamazaki, Y., Martens, Y. A., Bu, G. & Liu, C. C., Sep 17 2021, In: STAR Protocols. 2, 3, 100715.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • RNA Sequence Analysis 67%
  • Nutrient 64%
  • Heterogeneity 55%
  • Suspensions 52%

• Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function

  Yamazaki, Y., Liu, C. C., Yamazaki, A., Shue, F., Martens, Y. A., Chen, Y., Qiao, W., Kurti, A., Oue, H., Ren, Y., Li, Y., Aikawa, T., Cherukuri, Y., Fryer, J. D., Asmann, Y. W., Kim, B. Y. S., Kanekiyo, T. & Bu, G., Feb 3 2021, In: Neuron. 109, 3, p. 438-447.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Blood Vessels 43%
  • Apolipoprotein E3 36%
  • Apolipoproteins E 26%
  • Astrocytes 15%
  1 Scopus citations
• 2020

  Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ₄₂ in triggering receptor expressed on myeloid cells 2 loss-of-function murine models

  Rong, Z., Cheng, B., Zhong, L., Ye, X., Li, X., Jia, L., Li, Y., Shue, F., Wang, N., Cheng, Y., Huang, X., Liu, C. C., Fryer, J. D., Wang, X., Zhang, Y. W. & Zheng, H., Aug 1 2020, In: FASEB Journal. 34, 8, p. 10984-10997 14 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP Phosphohydrolases 100%
  • Myeloid Cells 89%
  • Mutation 73%
  • Alzheimer Disease 67%
  • Microglia 53%
  1 Scopus citations

• Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

  Zhao, N., Ren, Y., Yamazaki, Y., Qiao, W., Li, F., Felton, L. M., Mahmoudiandehkordi, S., Kueider-Paisley, A., Sonoustoun, B., Arnold, M., Shue, F., Zheng, J., Attrebi, O. N., Martens, Y. A., Li, Z., Bastea, L., Meneses, A. D., Chen, K., Thompson, J. W., St John-Williams, L., & 12 othersTachibana, M., Aikawa, T., Oue, H., Job, L., Yamazaki, A., Liu, C. C., Storz, P., Asmann, Y. W., Ertekin-Taner, N., Kanekiyo, T., Kaddurah-Daouk, R. & Bu, G., Jun 3 2020, In: Neuron. 106, 5, p. 727-742.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drive 100%
  • Metabolome 72%
  • Genotype 69%
  • Alzheimer Disease 50%
  • Apolipoprotein E2 49%
  17 Scopus citations

• APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

  Zhao, J., Fu, Y., Yamazaki, Y., Ren, Y., Davis, M. D., Liu, C. C., Lu, W., Wang, X., Chen, K., Cherukuri, Y., Jia, L., Martens, Y. A., Job, L., Shue, F., Nguyen, T. T., Younkin, S. G., Graff-Radford, N. R., Wszolek, Z. K., Brafman, D. A., Asmann, Y. W., & 3 othersErtekin-Taner, N., Kanekiyo, T. & Bu, G., Dec 1 2020, In: Nature communications. 11, 1, 5540.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • stem cells 83%
  • Organoids 79%
  • synapses 75%
  • Induced Pluripotent Stem Cells 68%
  15 Scopus citations

• APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

  Zhao, N., Attrebi, O. N., Ren, Y., Qiao, W., Sonustun, B., Martens, Y. A., Meneses, A. D., Li, F., Shue, F., Zheng, J., van Ingelgom, A. J., Davis, M. D., Kurti, A., Knight, J. A., Linares, C., Chen, Y., Delenclos, M., Liu, C. C., Fryer, J. D., Asmann, Y. W., & 4 othersMcLean, P. J., Dickson, D. W., Ross, O. A. & Bu, G., Feb 5 2020, In: Science translational medicine. 12, 529, eaay1809.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Amyloid 62%
  • Pathology 41%
  • Dementia 18%
  • Human ApoE protein 17%
  24 Scopus citations

• Astrocyte-derived clusterin suppresses amyloid formation in vivo

  Wojtas, A. M., Sens, J. P., Kang, S. S., Baker, K. E., Berry, T. J., Kurti, A., Daughrity, L., Jansen-West, K. R., Dickson, D. W., Petrucelli, L., Bu, G., Liu, C. C. & Fryer, J. D., Dec 2020, In: Molecular neurodegeneration. 15, 1, 71.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clusterin 100%
  • Amyloid 67%
  • Astrocytes 65%
  • Alzheimer Disease 19%
  • Gliosis 12%
  2 Scopus citations

• Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease

  Liu, C. C., Yamazaki, Y., Heckman, M. G., Martens, Y. A., Jia, L., Yamazaki, A., Diehl, N. N., Zhao, J., Zhao, N., DeTure, M., Davis, M. D., Felton, L. M., Qiao, W., Li, Y., Li, H., Fu, Y., Wang, N., Wren, M., Aikawa, T., Holm, M. L., & 10 othersOue, H., Linares, C., Allen, M., Carrasquillo, M. M., Murray, M. E., Petersen, R. C., Ertekin-Taner, N., Dickson, D. W., Kanekiyo, T. & Bu, G., Oct 1 2020, In: Alzheimer's and Dementia. 16, 10, p. 1372-1383 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cerebral Amyloid Angiopathy 100%
  • Tight Junctions 79%
  • Apolipoproteins E 75%
  • dementia 71%
  • integrity 60%
  5 Scopus citations
• 2019

  5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

  Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C. C., Kanekiyo, T. & Bu, G., Mar 2 2019, In: International journal of molecular sciences. 20, 6, 1488.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoproteins 100%
  • Ondansetron 81%
  • Serotonin 5-HT3 Receptor Antagonist 80%
  • secretions 69%
  • Serotonin 5-HT3 Receptor Antagonists 68%
  5 Scopus citations

• APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

  Tachibana, M., Holm, M. L., Liu, C. C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. & Kanekiyo, T., Mar 2019, In: Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • LDL Receptors 100%
  • oxidized low density lipoprotein 86%
  • Amyloid 81%
  • Apolipoprotein E4 77%
  • Pathology 54%
  31 Scopus citations

• Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

  Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C. C. & Bu, G., Sep 1 2019, In: Nature Reviews Neurology. 15, 9, p. 501-518 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Apolipoproteins E 100%
  • Alzheimer Disease 73%
  • Apolipoprotein E4 51%
  • Alleles 41%
  • Pathology 35%
  149 Scopus citations

• Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model (Nature Communications, (2019), 10, 1, (1365), 10.1038/s41467-019-09118-9)

  Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., Chen, K., Wang, N., Zhu, L., Can, D., Marten, Y., Shinohara, M., Liu, C. C., Du, D., Sun, H., Wen, L., & 3 othersXu, H., Bu, G. & Chen, X. F., Dec 1 2019, In: Nature communications. 10, 1, 2923.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • document markup languages 100%
  • phenotype 78%
  • Communication 50%
  • communication 46%
  • Alzheimer Disease 43%
  1 Scopus citations

• Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

  Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., Chen, K., Wang, N., Zhu, L., Can, D., Marten, Y., Shinohara, M., Liu, C. C., Du, D., Sun, H., Wen, L., & 3 othersXu, H., Bu, G. & Chen, X. F., Dec 1 2019, In: Nature communications. 10, 1, 1365.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • phenotype 100%
  • Neuroprotective 90%
  • Myeloid Cells 72%
  • Marker 62%
  • Protective 58%
  68 Scopus citations
• 2018

  Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease -conformist, nonconformist, and realistic prospects for AD pathogenesis

  Li, H., Liu, C. C., Zheng, H. & Huang, T. Y., Dec 24 2018, In: Translational Neurodegeneration. 7, 1, 34.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Amyloid 100%
  • Alzheimer Disease 81%
  • Infections 50%
  • Disease Progression 14%
  • Microbial Interactions 13%
  36 Scopus citations

• APOE ε2 is associated with increased tau pathology in primary tauopathy

  Zhao, N., Liu, C. C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff-Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R., Murray, M. E., Koga, S., & 3 othersDickson, D. W., Ross, O. A. & Bu, G., Dec 1 2018, In: Nature communications. 9, 1, 4388.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E2 100%
  • Tauopathies 89%
  • pathology 79%
  • mice 68%
  • Human ApoE protein 53%
  49 Scopus citations

• Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

  Zhao, N., Liu, C. C., Qiao, W. & Bu, G., Feb 15 2018, In: Biological psychiatry. 83, 4, p. 347-357 11 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Low Density Lipoprotein Receptor-Related Protein-1 100%
  • Apolipoproteins E 72%
  • Alzheimer Disease 53%
  • Lipids 19%
  • Amyloid 18%
  137 Scopus citations

• Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

  Kang, S. S., Kurti, A., Baker, K. E., Liu, C. C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. & Fryer, J. D., Jan 15 2018, In: Human molecular genetics. 27, 2, p. 211-223 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Knockout Mice 100%
  • Lipopolysaccharides 93%
  • Myeloid Cells 74%
  • Neurodegenerative Diseases 63%
  • Alleles 53%
  25 Scopus citations

• Lipocalin-2 protects the brain during inflammatory conditions

  Kang, S. S., Ren, Y., Liu, C. C., Kurti, A., Baker, K. E., Bu, G., Asmann, Y. & Fryer, J. D., Feb 1 2018, In: Molecular Psychiatry. 23, 2, p. 344-350 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipocalin-2 100%
  • Lipopolysaccharides 64%
  • Central Nervous System 46%
  • Brain 36%
  • Cytokines 23%
  49 Scopus citations

• Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

  Tachibana, M., Yamazaki, Y., Liu, C. C., Bu, G. & Kanekiyo, T., Feb 2018, In: Experimental Neurology. 300, p. 13-21 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pericytes 100%
  • Cerebrovascular Circulation 78%
  • Amyloid 77%
  • Pathology 51%
  • Brain 39%
  23 Scopus citations
• 2017

  ApoE4 Accelerates Early Seeding of Amyloid Pathology

  Liu, C. C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W. & Bu, G., Dec 6 2017, In: Neuron. 96, 5, p. 1024-1032.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Amyloid 69%
  • Pathology 46%
  • Apolipoprotein E3 32%
  • Apolipoproteins E 15%
  103 Scopus citations

• Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

  Zhao, N., Liu, C. C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M. & Bu, G., Sep 27 2017, In: Neuron. 96, 1, p. 115-129.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Insulin Receptor 82%
  • Endosomes 82%
  • Insulin 50%
  • Alzheimer Disease 25%
  104 Scopus citations

• Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

  Liu, C. C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G., Apr 12 2017, In: Journal of Neuroscience. 37, 15, p. 4023-4031 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipoprotein Receptors 100%
  • Amyloid 66%
  • Astrocytes 64%
  • Alzheimer Disease 43%
  • Brain 34%
  86 Scopus citations

• Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

  Wojtas, A. M., Kang, S. S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C. C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G., Carare, R. O. & Fryer, J. D., Aug 15 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clusterin 100%
  • Cerebral Amyloid Angiopathy 75%
  • Amyloid 67%
  • Drainage 60%
  • mouse presenilin 1 46%
  54 Scopus citations

• Soluble TREM2 induces inflammatory responses and enhances microglial survival

  Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G., 2017, In: Journal of Experimental Medicine. 214, 3, p. 597-607 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid Cells 100%
  • Microglia 99%
  • Pyroptosis 64%
  • Cytokines 60%
  • Cell Surface Receptors 53%
  106 Scopus citations

• Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

  Rogers, J. T., Liu, C. C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G., May 1 2017, In: Neurobiology of aging. 53, p. 112-121 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ibuprofen 100%
  • Cognition 50%
  • Neuronal Plasticity 40%
  • Astrocytes 39%
  • Anti-Inflammatory Agents 31%
  15 Scopus citations

• TREM2 promotes microglial survival by activating wnt/β-catenin pathway

  Zheng, H., Jia, L., Liu, C. C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G., Feb 15 2017, In: Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Catenins 100%
  • Wnt Signaling Pathway 89%
  • Myeloid Cells 80%
  • Microglia 33%
  • Alzheimer Disease 20%
  110 Scopus citations