• 12216 Citations
  • 63 Scopus h-Index
1969 …2020

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Article
2008

Differential regulation of pregnancy associated plasma protein-A in human coronary artery endothelial cells and smooth muscle cells

Conover, C. A., Harrington, S. C. & Bale, L. K., Jun 1 2008, In : Growth Hormone and IGF Research. 18, 3, p. 213-220 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Impact of pregnancy-associated plasma protein-A deletion on the adult murine skeleton

Tanner, S. J., Hefferan, T. E., Rosen, C. J. & Conover, C. A., May 1 2008, In : Journal of Bone and Mineral Research. 23, 5, p. 655-662 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo

Ning, Y., Schuller, A. G. P., Conover, C. A. & Pintar, J. E., May 1 2008, In : Molecular Endocrinology. 22, 5, p. 1213-1225 13 p.

Research output: Contribution to journalArticle

80 Scopus citations

Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: Exploring possible relationship to the longevity phenotype

Conover, C. A., Mason, M. A., Levine, J. A. & Novak, C. M., Sep 2008, In : Journal of Endocrinology. 198, 3, p. 599-605 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Pregnancy-Associated Plasma Protein-A Elevation in Patients With Acute Coronary Syndrome and Subsequent Atorvastatin Therapy

Miedema, M. D., Conover, C. A., MacDonald, H., Harrington, S. C., Oberg, D., Wilson, D., Henry, T. D. & Schwartz, R. S., Jan 1 2008, In : American Journal of Cardiology. 101, 1, p. 35-39 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
2007

Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor

Glerup, S., Kløverpris, S., Laursen, L. S., Dagnæs-Hansen, F., Thiel, S., Conover, C. A. & Oxvig, C., Jan 19 2007, In : Journal of Biological Chemistry. 282, 3, p. 1769-1778 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
99 Scopus citations

Loss of pregnancy-associated plasma protein A extends lifespan in mice

Conover, C. A. & Bale, L. K., Oct 1 2007, In : Aging Cell. 6, 5, p. 727-729 3 p.

Research output: Contribution to journalArticle

110 Scopus citations

Pregnancy associated plasma protein-A and risk stratification of patients presenting with chest pain in the emergency department

Elesber, A. A., Lerman, A., Denktas, A. E., Resch, Z. T., Jared Bunch, T., Schwartz, R. S. & Conover, C. A., May 2 2007, In : International Journal of Cardiology. 117, 3, p. 365-369 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice

Miller, B. S., Bronk, J. T., Nishiyama, T., Yamagiwa, H., Srivastava, A., Bolander, M. E. & Conover, C. A., Mar 1 2007, In : Journal of Endocrinology. 192, 3, p. 505-513 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages

Conover, C. A., Harrington, S. C., Bale, L. K. & Oxvig, C., Feb 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 2, p. H994-H1000

Research output: Contribution to journalArticle

39 Scopus citations
2006

Cytokine stimulation of pregnancy-associated plasma protein A expression in human coronary artery smooth muscle cells: Inhibition by resveratrol

Conover, C. A., Bale, L. K., Harrington, S. C., Resch, Z. T., Overgaard, M. T. & Oxvig, C., Jan 1 2006, In : American Journal of Physiology - Cell Physiology. 290, 1, p. C183-C188

Research output: Contribution to journalArticle

53 Scopus citations

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417

Haluska, P., Carboni, J. M., Loegering, D. A., Lee, F. Y., Wittman, M., Saulnier, M. G., Frennesson, D. B., Kalli, K. R., Conover, C. A., Attar, R. M., Kaufmann, S. H., Gottardis, M. & Erlichman, C., Jan 1 2006, In : Cancer research. 66, 1, p. 362-371 10 p.

Research output: Contribution to journalArticle

161 Scopus citations

Pregnancy-Associated Plasma Protein-A Is Markedly Expressed by Monocyte-Macrophage Cells in Vulnerable and Ruptured Carotid Atherosclerotic Plaques. A Link Between Inflammation and Cerebrovascular Events

Sangiorgi, G., Mauriello, A., Bonanno, E., Oxvig, C., Conover, C. A., Christiansen, M., Trimarchi, S., Rampoldi, V., Holmes, D. R., Schwartz, R. S. & Spagnoli, L. G., Jun 6 2006, In : Journal of the American College of Cardiology. 47, 11, p. 2201-2211 11 p.

Research output: Contribution to journalArticle

89 Scopus citations

Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina

Elesber, A. A., Conover, C. A., Denktas, A. E., Lennon, R. J., Holmes, D. R., Overgaard, M. T., Christiansen, M., Oxvig, C., Lerman, L. O. & Lerman, A., Jul 1 2006, In : European heart journal. 27, 14, p. 1678-1684 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Stress-activated signaling pathways mediate the stimulation of pregnancy-associated plasma protein-A expression in cultured human fibroblasts

Resch, Z. T., Oxvig, C., Bale, L. K. & Conover, C. A., Feb 1 2006, In : Endocrinology. 147, 2, p. 885-890 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
51 Scopus citations
2005
45 Scopus citations

PAPP-A is involved in matrix mineralization of human adult mesenchymal stem cells and angiogenesis in the chick CAM

Jadlowiec, J., Dongell, D., Smith, J., Conover, C. & Campbell, P., Sep 1 2005, In : Endocrinology. 146, 9, p. 3765-3772 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
2004
14 Scopus citations

Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystic ovary syndrome patients

Phy, J. L., Conover, C. A., Abbott, D. H., Zschunke, M. A., Walker, D. L., Session, D. R., Tummon, I. S., Thornhill, A. R., Lesnick, T. G. & Dumesic, D. A., Jul 1 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 7, p. 3561-3566 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development

Conover, C. A., Bale, L. K., Overgaard, M. T., Johnstone, E. W., Laursen, U. L., Füchtbauer, E. M., Oxvig, C. & van Deursen, J., Mar 1 2004, In : Development. 131, 5, p. 1187-1194 8 p.

Research output: Contribution to journalArticle

204 Scopus citations

Pregnancy-Associated Plasma Protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells

Kalli, K. R., Chen, B. K., Bale, L. K., Gernand, E., Overgaard, M. T., Oxvig, C., Cliby, W. A. & Conover, C. A., Jul 10 2004, In : International Journal of Cancer. 110, 5, p. 633-640 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Pregnancy-Associated Plasma Protein a Gene Expression as a Target of Inflammatory Cytokines

Resch, Z. T., Chen, B. K., Bale, L. K., Oxvig, C., Overgaard, M. T. & Conover, C. A., Mar 1 2004, In : Endocrinology. 145, 3, p. 1124-1129 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Regulation of pregnancy-associated plasma protein-A expression in cultured human osteoblasts

Conover, C. A., Chen, B. K. & Resch, Z. T., Feb 2004, In : Bone. 34, 2, p. 297-302 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

The Lin12-Notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity

Boldt, H. B., Kjaer-Sorensen, K., Overgaard, M. T., Weyer, K., Poulsen, C. B., Sottrup-Jensen, L., Conover, C. A., Giudice, L. C. & Oxvig, C., Sep 10 2004, In : Journal of Biological Chemistry. 279, 37, p. 38525-38531 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
2003

Combined effects of insulin-like growth factor-1 and transforming growth factor-β1 on periosteal mesenchymal cells during chondrogenesis in vitro

Fukumoto, T., Sperling, J. W., Sanyal, A., Fitzsimmons, J. S., Reinholz, G. G., Conover, C. A. & O'Driscoll, S. W., Jan 1 2003, In : Osteoarthritis and Cartilage. 11, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

220 Scopus citations

Effects of insulin-like growth factor-I on cultured human coronary artery smooth muscle cells

Bayes-Genis, A., Schwartz, R. S., Bale, L. K. & Conover, C. A., Oct 2003, In : Growth Hormone and IGF Research. 13, 5, p. 246-253 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Heterogeneous Role of Caspase-8 in Fenretinide-Induced Apoptosis in Epithelial Ovarian Carcinoma Cell Lines

Kalli, K. R., Devine, K. E., Cabot, M. C., Arnt, C. R., Heldebrant, M. P., Svingen, P. A., Erlichman, C., Hartmann, L. C., Conover, C. A. & Kaufmann, S. H., Dec 1 2003, In : Molecular pharmacology. 64, 6, p. 1434-1443 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Hodgkin's lymphoma manifesting with hypoglycemia

Soares-Welch, C. V., Zeldenrust, S. R., Conover, C. A., Grant, C. S. & Service, F. J., Jan 1 2003, In : Endocrine Practice. 9, 1, p. 96-97 2 p.

Research output: Contribution to journalArticle

Localization and regulation of pregnancy-associated plasma protein A expression in healing human skin

Chen, B. K., Leiferman, K. M., Pittelkow, M. R., Overgaard, M. T., Oxvig, C. & Conover, C. A., Sep 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 9, p. 4465-4471 7 p.

Research output: Contribution to journalArticle

67 Scopus citations
40 Scopus citations

Transforming Growth Factor-β Regulation of the Insulin-Like Growth Factor Binding Protein-4 Protease System in Cultured Human Osteoblasts

Ortiz, C. O., Chen, B. K., Bale, L. K., Overgaard, M. T., Oxvig, C. & Conover, C. A., Jun 1 2003, In : Journal of Bone and Mineral Research. 18, 6, p. 1066-1072 7 p.

Research output: Contribution to journalArticle

64 Scopus citations
2002

Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity

Søe, R., Overgaard, M. T., Thomsen, A. R., Laursen, L. S., Olsen, I. M., Sottrup-Jensen, L., Haaning, J., Giudice, L. C., Conover, C. A. & Oxvig, C., May 6 2002, In : European Journal of Biochemistry. 269, 8, p. 2247-2256 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Functional insulin receptors on human epithelial ovarian carcinoma cells: Implications for IGF-II mitogenic signaling

Kalli, K. R., Falowo, O. I., Bale, L. K., Zschunke, M. A., Roche, P. C. & Conover, C. A., Sep 2002, In : Endocrinology. 143, 9, p. 3259-3267 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: Evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation

Giudice, L. C., Conover, C. A., Bale, L., Faessen, G. H., Ilg, K., Sun, I., Imani, B., Suen, L. F., Irwin, J. C., Christiansen, M., Overgaard, M. T. & Oxvig, C., Jan 1 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 5, p. 2359-2366 8 p.

Research output: Contribution to journalArticle

Open Access
108 Scopus citations

Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: Identification of a novel inducible inhibitor

Chen, B. K., Overgaard, M. T., Bale, L. K., Resch, Z. T., Christiansen, M., Oxvig, C. & Conover, C. A., 2002, In : Endocrinology. 143, 4, p. 1199-1205 7 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Subcutaneous administration of insulin-like growth (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., John Ballard, F., Doran, P. M. & Khosla, S., Jun 2002, In : Growth Hormone and IGF Research. 12, 3, p. 178-183 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: Substrate residues distant from the scissile bond are critical for proteolysis

Laursen, L. S., Overgaard, M. T., Nielsen, C. G., Boldt, H. B., Hopmann, K. H., Conover, C. A., Sottrup-Jensen, L., Giudice, L. C. & Oxvig, C., Oct 1 2002, In : Biochemical Journal. 367, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

63 Scopus citations
Open Access
27 Scopus citations
2001

Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty

Bayes-Genis, A., Schwartz, R. S., Lewis, D. A., Overgaard, M. T., Christiansen, M., Oxvig, C., Ashai, K., Holmes, D. R. & Conover, C. A., Jan 1 2001, In : Arteriosclerosis, thrombosis, and vascular biology. 21, 3, p. 335-341 7 p.

Research output: Contribution to journalArticle

Open Access
132 Scopus citations

Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: Implications for the mechanism of IGFBP-4 proteolysis by PAPP-A

Laursen, L. S., Overgaard, M. T., Soe, R., Boldt, H. B., Sottrup-Jensen, L., Giudice, L. C., Conover, C. A. & Oxvig, C., Aug 24 2001, In : FEBS Letters. 504, 1-2, p. 36-40 5 p.

Research output: Contribution to journalArticle

220 Scopus citations

Pregnancy-associated plasma protein-A (PAPP-A) in ovine, bovine, porcine, and equine ovarian follicles: Involvement in IGF binding protein-4 proteolytic degradation and mRNA expression during follicular development

Mazerbourg, S., Overgaard, M. T., Oxvig, C., Christiansen, M., Conover, C. A., Laurendeau, I., Vidaud, M., Tosser-Klopp, G., Zapf, J. & Monget, P., Jan 1 2001, In : Endocrinology. 142, 12, p. 5243-5253 11 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Pregnancy-associated Plasma Protein-A2 (PAPP-A2), a Novel Insulin-like Growth Factor-binding Protein-5 Proteinase

Overgaard, M. T., Bold, H. B., Laursen, L. S., Sottrup-Jensen, L., Conover, C. A. & Oxvig, C., Jun 15 2001, In : Journal of Biological Chemistry. 276, 24, p. 21849-21853 5 p.

Research output: Contribution to journalArticle

159 Scopus citations

Pregnancy-associated plasma protein A as a marker of acute coronary syndromes

Bayes-Genis, A., Conover, C. A., Overgaard, M. T., Bailey, K. R., Christiansen, M., Holmes, D. R., Virmani, R., Oxvig, C. & Schwartz, R. S., Oct 4 2001, In : New England Journal of Medicine. 345, 14, p. 1022-1029 8 p.

Research output: Contribution to journalArticle

497 Scopus citations

Pregnancy-associated plasma protein-A is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteum

Conover, C. A., Faessen, G. F., Ilg, K. E., Chandrasekher, Y. A., Christiansen, M., Overgaard, M. T., Oxvig, C. & Giudice, L. C., May 16 2001, In : Endocrinology. 142, 5, p. 2155-2158 4 p.

Research output: Contribution to journalArticle

100 Scopus citations
2000

Characterization of the enzymatic specificity of the IGF-dependent insulin-like growth factor binding protein-4 (IGFBP-4) protease

Chelius, D., Conover, C. A., Baldwin, M. A. & Spencer, E. M., Jan 1 2000, In : Growth Hormone and IGF Research. 10, 6, p. 360-366 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor

Overgaard, M. T., Haaning, J., Boldt, H. B., Olsen, I. M., Laursen, L. S., Christiansen, M., Gleich, G. J., Sottrup-Jensen, L., Conover, C. A. & Oxvig, C., Oct 6 2000, In : Journal of Biological Chemistry. 275, 40, p. 31128-31133 6 p.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations
Open Access
73 Scopus citations

Mechanisms of lysolipid phosphate effects on cellular survival and proliferation

Goetzl, E. J., Lee, H., Dolezalova, H., Kalli, K. R., Conover, C. A., Hu, Y. L., Azuma, T., Stossel, T. P., Karliner, J. S. & Jaffe, R. B., 2000, In : Annals of the New York Academy of Sciences. 905, p. 177-187 11 p.

Research output: Contribution to journalArticle

47 Scopus citations