• 12002 Citations
  • 63 Scopus h-Index
1969 …2019

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Article
2019
Open Access
1 Scopus citations

Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A

Torres, D., Hou, X., Bale, L., Heinzen, E. P., Maurer, M. J., Zanfagnin, V., Oberg, A. L., Conover, C. & Weroha, S. J., Jan 1 2019, In : PloS one. 14, 11, e0224564.

Research output: Contribution to journalArticle

Open Access

PAPP-A and the IGF system in atherosclerosis: what's up, what's down?

Steffensen, L. B., Conover, C. A. & Oxvig, C., Nov 1 2019, In : American journal of physiology. Heart and circulatory physiology. 317, 5, p. H1039-H1049

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion

Heitzeneder, S., Sotillo, E., Shern, J. F., Sindiri, S., Xu, P., Jones, R., Pollak, M., Noer, P. R., Lorette, J., Fazli, L., Alag, A., Meltzer, P., Lau, C., Conover, C. A., Oxvig, C., Sorensen, P. H., Maris, J. M., Khan, J. & Mackall, C. L., Sep 1 2019, In : Journal of the National Cancer Institute. 111, 9, p. 970-982 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Characterization of mouse pericardial fat: regulation by PAPP-A

Bale, L. K., West, S. A. & Conover, C. A., Oct 1 2018, In : Growth Hormone and IGF Research. 42-43, p. 1-7 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span

Bale, L. K., West, S. A. & Conover, C. A., Aug 1 2017, In : Aging Cell. 16, 4, p. 895-897 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

The IGF-p53 connection in cancer

Conover, C. A., Jan 1 2017, (Accepted/In press) In : Growth Hormone and IGF Research.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients

Bieghs, L., Brohus, M., Kristensen, I. B., Abildgaard, N., Bøgsted, M., Johnsen, H. E., Conover, C. A., De Bruyne, E., Vanderkerken, K., Overgaard, M. T. & Nyegaard, M., Apr 1 2016, In : PLoS One. 11, 4, e0154256.

Research output: Contribution to journalArticle

4 Scopus citations
5 Scopus citations

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

Dauber, A., Muñoz-Calvo, M. T., Barrios, V., Domené, H. M., Kloverpris, S., Serra-Juhé, C., Desikan, V., Pozo, J., Muzumdar, R., Martos-Moreno, G. A., Hawkins, F., Jasper, H. G., Conover, C. A., Frystyk, J., Yakar, S., Hwa, V., Chowen, J. A., Oxvig, C., Rosenfeld, R. G., Pérez-Jurado, L. A. & 1 others, Argente, J., 2016, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

63 Scopus citations

PAPP-A: A promising therapeutic target for healthy longevity

Conover, C. A. & Oxvig, C., 2016, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

7 Scopus citations

PAPP-A in normal human mesangial cells: Effect of inflammation and factors related to diabetic nephropathy

Donegan, D., Bale, L. K. & Conover, C. A., 2016, In : Journal of Endocrinology. 231, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J. & Van Deursen, J., Oct 28 2016, In : Science. 354, 6311, p. 472-477 6 p.

Research output: Contribution to journalArticle

235 Scopus citations

Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice

Steffensen, L. B., Conover, C. A., Bjørklund, M. M., Ledet, T., Bentzon, J. F. & Oxvig, C., May 1 2016, In : Atherosclerosis. 248, p. 36-43 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
18 Scopus citations
2015

A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts

Becker, M. A., Haluska, P., Bale, L. K., Oxvig, C. & Conover, C. A., 2015, In : Molecular Cancer Therapeutics. 14, 4, p. 973-981 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

Steffensen, L. B., Poulsen, C. B., Shim, J., Bek, M., Jacobsen, K., Conover, C. A., Bentzon, J. F. & Oxvig, C., Dec 1 2015, In : Journal of Cardiovascular Translational Research. 8, 9, p. 528-535 8 p.

Research output: Contribution to journalArticle

PAPP-A affects tendon structure and mechanical properties

Yang, T. H., Thoreson, A. R., An, K. N., Zhao, C. D., Conover, C. A. & Amadio, P. C., 2015, In : Journal of Structural Biology. 192, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

Thomsen, J., Hjortebjerg, R., Espelund, U., Ørtoft, G., Vestergaard, P., Magnusson, N. E., Conover, C. A., Tramm, T., Hager, H., Høgdall, C., Høgdall, E., Oxvig, C. & Frystyk, J., 2015, In : Oncotarget. 6, 31, p. 32266-32278 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Pregnancy-associated plasma protein-A deficiency improves survival of mice on a high fat diet

Conover, C. A., Bale, L. K. & Marler, R. J., Oct 1 2015, In : Experimental Gerontology. 70, p. 131-134 4 p., 9677.

Research output: Contribution to journalArticle

4 Scopus citations

Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone

Clifton, K. B. & Conover, C. A., Dec 1 2015, In : Bone. 81, p. 413-416 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

The insulin-like growth factor system in the long-lived naked mole-rat

Brohus, M., Gorbunova, V., Faulkes, C. G., Overgaard, M. T. & Conover, C. A., Dec 1 2015, In : PLoS One. 10, 12, e0145587.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Heparin-binding mechanism of the IGF2/IGF-binding protein 2 complex

Lund, J., Søndergaard, M. T., Conover, C. A. & Overgaard, M. T., Mar 6 2014, In : Journal of Molecular Endocrinology. 52, 3, p. 345-355 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity

Mikkelsen, J. H., Resch, Z. T., Kalra, B., Savjani, G., Kumar, A., Conover, C. A. & Oxvig, C., 2014, In : Oncotarget. 5, 4, p. 1014-1025 12 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice

Bale, L. K., Chakraborty, S. & Conover, C. A., Apr 1 2014, In : Endocrinology. 155, 4, p. 1184-1187 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Motor and memory testing of long-lived pregnancy-associated plasma protein-A knock-out mice

Mason, E. J., Grell, J. A., West, S. A. & Conover, C. A., Dec 1 2014, In : Growth Hormone and IGF Research. 24, 6, p. 251-255 5 p.

Research output: Contribution to journalArticle

Preferential expression of PAPPA in human preadipocytes from omental fat

Davidge-Pitts, C., Escande, C. J. & Conover, C. A., 2014, In : Journal of Endocrinology. 222, 1, p. 87-97 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
15 Scopus citations

Tissue-specific changes in pregnancy associated plasma protein-A expression with age in mice

Harstad, S. L. & Conover, C. A., Sep 2014, In : Experimental Gerontology. 57, p. 13-17 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Constitutive expression of pregnancy-associated plasma protein-A in arterial smooth muscle reduces the vascular response to injury in vivo

Bale, L. K., Resch, Z. T., Harstad, S. L., Overgaard, M. T. & Conover, C. A., Jan 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 2, p. E139-E144

Research output: Contribution to journalArticle

8 Scopus citations

Effects of mutated pregnancy-associated plasma protein-A on atherosclerotic lesion development in mice

Boldt, H. B., Bale, L. K., Resch, Z. T., Oxvig, C., Overgaard, M. T. & Conover, C. A., Jan 1 2013, In : Endocrinology. 154, 1, p. 246-252 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: Effect on vascular injury response

Conover, C. A., Bale, L. K. & Powell, D. R., Aug 1 2013, In : Endocrinology. 154, 8, p. 2734-2738 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

Mader, J. R., Resch, Z. T., McLean, G. R., Mikkelsen, J. H., Oxvig, C., Marler, R. J. & Conover, C. A., Sep 20 2013, In : Journal of Endocrinology. 219, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
18 Scopus citations

Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity

Kjaer-Sorensen, K., Engholm, D. H., Kamei, H., Morch, M. G., Kristensen, A. O., Zhou, J., Conover, C. A., Duan, C. & Oxvig, C., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 9982-9992 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Role of PAPP-A in aging and age-related disease

Conover, C. A., Jul 1 2013, In : Experimental Gerontology. 48, 7, p. 612-613 2 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011

Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice

Mason, E. J., Grell, J. A., Wan, J., Cohen, P. & Conover, C. A., Oct 1 2011, In : Growth Hormone and IGF Research. 21, 5, p. 243-247 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo

Boldt, H. B. & Conover, C. A., Apr 1 2011, In : Endocrinology. 152, 4, p. 1470-1478 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Pregnancy-Associated Plasma Protein-A2 (PAPP-A2): Tissue expression and biological consequences of gene knockout in mice

Conover, C. A., Boldt, H. B., Bale, L. K., Clifton, K. B., Grell, J. A., Mader, J. R., Mason, E. J. & Powell, D. R., Jul 1 2011, In : Endocrinology. 152, 7, p. 2837-2844 8 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility

Nyegaard, M., Overgaard, M. T., Su, Y. Q., Hamilton, A. E., Kwintkiewicz, J., Hsieh, M., Nayak, N. R., Conti, M., Conover, C. A. & Giudice, L. C., Jun 1 2010, In : Biology of Reproduction. 82, 6, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-a

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P. & Marler, R. J., Jun 1 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Longevity is not influenced by prenatal programming of body size

Conover, C. A., Bale, L. K., Grell, J. A., Mader, J. R. & Mason, M. A., Aug 1 2010, In : Aging Cell. 9, 4, p. 647-649 3 p.

Research output: Contribution to journalArticle

8 Scopus citations
8 Scopus citations

Transforming growth factor-β1 modulates insulin-like growth factor binding protein-4 expression and proteolysis in cultured periosteal explants

Gonzalez, C., Auw Yang, K. G., Schwab, J. H., Fitzsimmons, J. S., Reinholz, M. M., Resch, Z. T., Bale, L. K., Clemens, V. R., Conover, C. A., O'Driscoll, S. W. & Reinholz, G. G., Apr 1 2010, In : Growth Hormone and IGF Research. 20, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development

Conover, C. A., Mason, M. A., Bale, L. K., Harrington, S. C., Nyegaard, M., Oxvig, C. & Overgaard, M. T., Aug 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 299, 2, p. H284-H291

Research output: Contribution to journalArticle

45 Scopus citations
2009

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice

Swindell, W. R., Masternak, M. M., Kopchick, J. J., Conover, C. A., Bartke, A. & Miller, R. A., Jun 1 2009, In : Mechanisms of Ageing and Development. 130, 6, p. 393-400 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

IGF system in children with congenital disorders of glycosylation

Miller, B. S., Khosravi, M. J., Patterson, M. C. & Conover, C. A., Jun 1 2009, In : Clinical Endocrinology. 70, 6, p. 892-897 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Regional variation in adipogenesis and IGF regulatory proteins in the fetal baboon

Tchoukalova, Y. D., Nathanielsz, P. W., Conover, C. A., Smith, S. R. & Ravussin, E., Mar 13 2009, In : Biochemical and Biophysical Research Communications. 380, 3, p. 679-683 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A

Vallejo, A. N., Michel, J. J., Bale, L. K., Lemster, B. H., Borghesi, L. & Conover, C. A., Jul 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 27, p. 11252-11257 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
2008

Differential regulation of pregnancy associated plasma protein-A in human coronary artery endothelial cells and smooth muscle cells

Conover, C. A., Harrington, S. C. & Bale, L. K., Jun 1 2008, In : Growth Hormone and IGF Research. 18, 3, p. 213-220 8 p.

Research output: Contribution to journalArticle

44 Scopus citations