Cheryl A Conover

2020

Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity

DiToro, D., Harbour, S. N., Bando, J. K., Benavides, G., Witte, S., Laufer, V. A., Moseley, C., Singer, J. R., Frey, B., Turner, H., Bruning, J., Darley-Usmar, V., Gao, M., Conover, C., Hatton, R. D., Frank, S., Colonna, M. & Weaver, C. T., Apr 14 2020, In : Immunity. 52, 4, p. 650-667.e10

Research output: Contribution to journal › Article

Metalloproteinase PAPP - A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Kashyap, S., Hein, K. Z., Chini, C. C. S., Lika, J., Warner, G. M., Bale, L. K., Torres, V. E., Harris, P. C., Oxvig, C., Conover, C. A. & Chini, E. N., Feb 27 2020, In : JCI Insight. 5, 4, e135700.

Research output: Contribution to journal › Article

Open Access

2019

Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes

Conover, C. A., Bale, L. K., Frye, R. L. & Schaff, H. V., Feb 1 2019, In : Physiological reports. 7, 4, e14006.

Research output: Contribution to journal › Article

Open Access

1 Scopus citations

Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A

Torres, D., Hou, X., Bale, L., Heinzen, E. P., Maurer, M. J., Zanfagnin, V., Oberg, A. L., Conover, C. & Weroha, S. J., Jan 1 2019, In : PloS one. 14, 11, e0224564.

Research output: Contribution to journal › Article

Open Access

PAPP-A and the IGF system in atherosclerosis: what's up, what's down?

Steffensen, L. B., Conover, C. A. & Oxvig, C., Nov 1 2019, In : American journal of physiology. Heart and circulatory physiology. 317, 5, p. H1039-H1049

Research output: Contribution to journal › Review article

1 Scopus citations

Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion

Heitzeneder, S., Sotillo, E., Shern, J. F., Sindiri, S., Xu, P., Jones, R., Pollak, M., Noer, P. R., Lorette, J., Fazli, L., Alag, A., Meltzer, P., Lau, C., Conover, C. A., Oxvig, C., Sorensen, P. H., Maris, J. M., Khan, J. & Mackall, C. L., Sep 1 2019, In : Journal of the National Cancer Institute. 111, 9, p. 970-982 13 p.

Research output: Contribution to journal › Article

4 Scopus citations

2018

40 years of IGF1: PAPP-A and cancer

Conover, C. A. & Oxvig, C., Jul 1 2018, In : Journal of Molecular Endocrinology. 61, 1, p. T1-T10

Research output: Contribution to journal › Review article

5 Scopus citations

Characterization of mouse pericardial fat: regulation by PAPP-A

Bale, L. K., West, S. A. & Conover, C. A., Oct 1 2018, In : Growth Hormone and IGF Research. 42-43, p. 1-7 7 p.

Research output: Contribution to journal › Article

3 Scopus citations

2017

Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span

Bale, L. K., West, S. A. & Conover, C. A., Aug 1 2017, In : Aging Cell. 16, 4, p. 895-897 3 p.

Research output: Contribution to journal › Article

2 Scopus citations

The IGF-p53 connection in cancer

Conover, C. A., Jan 1 2017, (Accepted/In press) In : Growth Hormone and IGF Research.

Research output: Contribution to journal › Article

6 Scopus citations

2016

Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients

Bieghs, L., Brohus, M., Kristensen, I. B., Abildgaard, N., Bøgsted, M., Johnsen, H. E., Conover, C. A., De Bruyne, E., Vanderkerken, K., Overgaard, M. T. & Nyegaard, M., Apr 2016, In : PloS one. 11, 4, e0154256.

Research output: Contribution to journal › Article

4 Scopus citations

Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice

Conover, C. A., Bale, L. K. & Nair, K. S., Jul 1 2016, In : Experimental Gerontology. 80, p. 36-42 7 p.

Research output: Contribution to journal › Article

5 Scopus citations

Discrepancies in insulin-like growth factor signaling? No, not really

Conover, C. A., Oct 1 2016, In : Growth Hormone and IGF Research. 30-31, p. 42-44 3 p.

Research output: Contribution to journal › Short survey

8 Scopus citations

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

Dauber, A., Muñoz-Calvo, M. T., Barrios, V., Domené, H. M., Kloverpris, S., Serra-Juhé, C., Desikan, V., Pozo, J., Muzumdar, R., Martos-Moreno, G. A., Hawkins, F., Jasper, H. G., Conover, C. A., Frystyk, J., Yakar, S., Hwa, V., Chowen, J. A., Oxvig, C., Rosenfeld, R. G., Pérez-Jurado, L. A. & 1 others, Argente, J., 2016, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journal › Article

67 Scopus citations

PAPP-A: A promising therapeutic target for healthy longevity

Conover, C. A. & Oxvig, C., 2016, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journal › Article

8 Scopus citations

PAPP-A in normal human mesangial cells: Effect of inflammation and factors related to diabetic nephropathy

Donegan, D., Bale, L. K. & Conover, C. A., 2016, In : Journal of Endocrinology. 231, 1, p. 71-80 10 p.

Research output: Contribution to journal › Article

8 Scopus citations

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J. & Van Deursen, J., Oct 28 2016, In : Science. 354, 6311, p. 472-477 6 p.

Research output: Contribution to journal › Article

257 Scopus citations

Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice

Steffensen, L. B., Conover, C. A., Bjørklund, M. M., Ledet, T., Bentzon, J. F. & Oxvig, C., May 1 2016, In : Atherosclerosis. 248, p. 36-43 8 p.

Research output: Contribution to journal › Article

12 Scopus citations

Targeted Inhibition of Pregnancy-Associated Plasma Protein-A Activity Reduces Atherosclerotic Plaque Burden in Mice

Conover, C. A., Bale, L. K. & Oxvig, C., Feb 1 2016, In : Journal of Cardiovascular Translational Research. 9, 1, p. 77-79 3 p.

Research output: Contribution to journal › Article

18 Scopus citations

The insulin-like growth factor system in Multiple Myeloma: Diagnostic and therapeutic potential

Bieghs, L., Johnsen, H. E., Maes, K., Menu, E., Van Valckenborgh, E., Overgaard, M. T., Nyegaard, M., Conover, C. A., Vanderkerken, K. & De Bruyne, E., Jan 1 2016, In : Oncotarget. 7, 30, p. 48732-48752 21 p.

Research output: Contribution to journal › Review article

15 Scopus citations

2015

A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts

Becker, M. A., Haluska, P., Bale, L. K., Oxvig, C. & Conover, C. A., 2015, In : Molecular Cancer Therapeutics. 14, 4, p. 973-981 9 p.

Research output: Contribution to journal › Article

26 Scopus citations

Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

Steffensen, L. B., Poulsen, C. B., Shim, J., Bek, M., Jacobsen, K., Conover, C. A., Bentzon, J. F. & Oxvig, C., Dec 1 2015, In : Journal of Cardiovascular Translational Research. 8, 9, p. 528-535 8 p.

Research output: Contribution to journal › Article

PAPP-A affects tendon structure and mechanical properties

Yang, T. H., Thoreson, A. R., An, K. N., Zhao, C. D., Conover, C. A. & Amadio, P. C., 2015, In : Journal of Structural Biology. 192, 1, p. 59-66 8 p.

Research output: Contribution to journal › Article

1 Scopus citations

PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

Thomsen, J., Hjortebjerg, R., Espelund, U., Ørtoft, G., Vestergaard, P., Magnusson, N. E., Conover, C. A., Tramm, T., Hager, H., Høgdall, C., Høgdall, E., Oxvig, C. & Frystyk, J., Jan 1 2015, In : Oncotarget. 6, 31, p. 32266-32278 13 p.

Research output: Contribution to journal › Article

14 Scopus citations

Pregnancy-associated plasma protein-A deficiency improves survival of mice on a high fat diet

Conover, C. A., Bale, L. K. & Marler, R. J., Oct 1 2015, In : Experimental Gerontology. 70, p. 131-134 4 p., 9677.

Research output: Contribution to journal › Article

4 Scopus citations

Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone

Clifton, K. B. & Conover, C. A., Dec 1 2015, In : Bone. 81, p. 413-416 4 p.

Research output: Contribution to journal › Article

4 Scopus citations

The insulin-like growth factor system in the long-lived naked mole-rat

Brohus, M., Gorbunova, V., Faulkes, C. G., Overgaard, M. T. & Conover, C. A., Dec 1 2015, In : PloS one. 10, 12, e0145587.

Research output: Contribution to journal › Article

8 Scopus citations

2014

Heparin-binding mechanism of the IGF2/IGF-binding protein 2 complex

Lund, J., Søndergaard, M. T., Conover, C. A. & Overgaard, M. T., Mar 6 2014, In : Journal of Molecular Endocrinology. 52, 3, p. 345-355 11 p.

Research output: Contribution to journal › Article

12 Scopus citations

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity

Mikkelsen, J. H., Resch, Z. T., Kalra, B., Savjani, G., Kumar, A., Conover, C. A. & Oxvig, C., 2014, In : Oncotarget. 5, 4, p. 1014-1025 12 p.

Research output: Contribution to journal › Article

Open Access

32 Scopus citations

Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice

Bale, L. K., Chakraborty, S. & Conover, C. A., Apr 1 2014, In : Endocrinology. 155, 4, p. 1184-1187 4 p.

Research output: Contribution to journal › Article

10 Scopus citations

Motor and memory testing of long-lived pregnancy-associated plasma protein-A knock-out mice

Mason, E. J., Grell, J. A., West, S. A. & Conover, C. A., Dec 1 2014, In : Growth Hormone and IGF Research. 24, 6, p. 251-255 5 p.

Research output: Contribution to journal › Article

Preferential expression of PAPPA in human preadipocytes from omental fat

Davidge-Pitts, C., Escande, C. J. & Conover, C. A., 2014, In : Journal of Endocrinology. 222, 1, p. 87-97 11 p.

Research output: Contribution to journal › Article

14 Scopus citations

Pregnancy-associated plasma protein-A expression in human breast cancer

Mansfield, A. S., Visscher, D. W., Hart, S. N., Wang, C., Goetz, M. P., Oxvig, C. & Conover, C. A., Dec 1 2014, In : Growth Hormone and IGF Research. 24, 6, p. 264-267 4 p.

Research output: Contribution to journal › Article

15 Scopus citations

Tissue-specific changes in pregnancy associated plasma protein-A expression with age in mice

Harstad, S. L. & Conover, C. A., Sep 2014, In : Experimental Gerontology. 57, p. 13-17 5 p.

Research output: Contribution to journal › Article

2 Scopus citations

2013

Constitutive expression of pregnancy-associated plasma protein-A in arterial smooth muscle reduces the vascular response to injury in vivo

Bale, L. K., Resch, Z. T., Harstad, S. L., Overgaard, M. T. & Conover, C. A., Jan 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 2, p. E139-E144

Research output: Contribution to journal › Article

8 Scopus citations

Effects of mutated pregnancy-associated plasma protein-A on atherosclerotic lesion development in mice

Boldt, H. B., Bale, L. K., Resch, Z. T., Oxvig, C., Overgaard, M. T. & Conover, C. A., Jan 1 2013, In : Endocrinology. 154, 1, p. 246-252 7 p.

Research output: Contribution to journal › Article

10 Scopus citations

Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: Effect on vascular injury response

Conover, C. A., Bale, L. K. & Powell, D. R., Aug 1 2013, In : Endocrinology. 154, 8, p. 2734-2738 5 p.

Research output: Contribution to journal › Article

12 Scopus citations

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

Mader, J. R., Resch, Z. T., McLean, G. R., Mikkelsen, J. H., Oxvig, C., Marler, R. J. & Conover, C. A., Sep 20 2013, In : Journal of Endocrinology. 219, 1, p. 51-58 8 p.

Research output: Contribution to journal › Article

17 Scopus citations

Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet

Conover, C. A., Harstad, S. L., Tchkonia, T. & Kirkland, J. L., Nov 1 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 9, p. E1145-E1153

Research output: Contribution to journal › Article

18 Scopus citations

Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity

Kjaer-Sorensen, K., Engholm, D. H., Kamei, H., Morch, M. G., Kristensen, A. O., Zhou, J., Conover, C. A., Duan, C. & Oxvig, C., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 9982-9992 11 p.

Research output: Contribution to journal › Article

13 Scopus citations

Role of PAPP-A in aging and age-related disease

Conover, C. A., Jul 1 2013, In : Experimental Gerontology. 48, 7, p. 612-613 2 p.

Research output: Contribution to journal › Article

16 Scopus citations

2012

Key questions and answers about pregnancy-associated plasma protein-A

Conover, C. A., May 1 2012, In : Trends in Endocrinology and Metabolism. 23, 5, p. 242-249 8 p.

Research output: Contribution to journal › Review article

86 Scopus citations

2011

Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice

Mason, E. J., Grell, J. A., Wan, J., Cohen, P. & Conover, C. A., Oct 1 2011, In : Growth Hormone and IGF Research. 21, 5, p. 243-247 5 p.

Research output: Contribution to journal › Article

12 Scopus citations

Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo

Boldt, H. B. & Conover, C. A., Apr 1 2011, In : Endocrinology. 152, 4, p. 1470-1478 9 p.

Research output: Contribution to journal › Article

45 Scopus citations

Pregnancy-Associated Plasma Protein-A2 (PAPP-A2): Tissue expression and biological consequences of gene knockout in mice

Conover, C. A., Boldt, H. B., Bale, L. K., Clifton, K. B., Grell, J. A., Mader, J. R., Mason, E. J. & Powell, D. R., Jul 1 2011, In : Endocrinology. 152, 7, p. 2837-2844 8 p.

Research output: Contribution to journal › Article

44 Scopus citations

2010

Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility

Nyegaard, M., Overgaard, M. T., Su, Y. Q., Hamilton, A. E., Kwintkiewicz, J., Hsieh, M., Nayak, N. R., Conti, M., Conover, C. A. & Giudice, L. C., Jun 1 2010, In : Biology of Reproduction. 82, 6, p. 1129-1138 10 p.

Research output: Contribution to journal › Article