• 11829 Citations
  • 62 Scopus h-Index
1969 …2019
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Research Output 1969 2019

  • 11829 Citations
  • 62 Scopus h-Index
  • 208 Article
  • 2 Review article
  • 1 Conference contribution
  • 1 Short survey
2019
Open Access
Pregnancy-Associated Plasma Protein-A
Insulin-Like Growth Factor I
Cardiac Myocytes
Adipose Tissue
Insulin-Like Growth Factor Binding Protein 4

PAPP-A and the IGF system in atherosclerosis: what's up, what's down?

Steffensen, L. B., Conover, C. A. & Oxvig, C., Nov 1 2019, In : American journal of physiology. Heart and circulatory physiology. 317, 5, p. H1039-H1049

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Atherosclerosis
Somatomedins
Insulin-Like Growth Factor Binding Protein 4
Insulin-Like Growth Factor Binding Protein 2

Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion

Heitzeneder, S., Sotillo, E., Shern, J. F., Sindiri, S., Xu, P., Jones, R., Pollak, M., Noer, P. R., Lorette, J., Fazli, L., Alag, A., Meltzer, P., Lau, C., Conover, C. A., Oxvig, C., Sorensen, P. H., Maris, J. M., Khan, J. & Mackall, C. L., Sep 1 2019, In : Journal of the National Cancer Institute. 111, 9, p. 970-982 13 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Tumor Escape
Ewing's Sarcoma
Growth
Intercellular Signaling Peptides and Proteins
2018
2 Citations (Scopus)

40 years of IGF1: PAPP-A and cancer

Conover, C. A. & Oxvig, C., Jul 1 2018, In : Journal of Molecular Endocrinology. 61, 1, p. T1-T10

Research output: Contribution to journalReview article

Pregnancy-Associated Plasma Protein-A
Somatomedin Receptors
Somatomedins
Lung Neoplasms
Neoplasms
1 Citation (Scopus)

Characterization of mouse pericardial fat: regulation by PAPP-A

Bale, L. K., West, S. A. & Conover, C. A., Oct 1 2018, In : Growth Hormone and IGF Research. 42-43, p. 1-7 7 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Fats
Intra-Abdominal Fat
Groin
Adipocytes
2017

Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span

Bale, L. K., West, S. A. & Conover, C. A., Aug 1 2017, In : Aging Cell. 16, 4, p. 895-897 3 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Gene Expression
Tamoxifen
Mortality
Homologous Recombination
5 Citations (Scopus)

The IGF-p53 connection in cancer

Conover, C. A., Jan 1 2017, (Accepted/In press) In : Growth Hormone and IGF Research.

Research output: Contribution to journalArticle

Somatomedins
Apoptosis
Cell Cycle Checkpoints
Tumor Suppressor Genes
Oncogenes
2016
4 Citations (Scopus)

Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients

Bieghs, L., Brohus, M., Kristensen, I. B., Abildgaard, N., Bøgsted, M., Johnsen, H. E., Conover, C. A., De Bruyne, E., Vanderkerken, K., Overgaard, M. T. & Nyegaard, M., Apr 1 2016, In : PLoS One. 11, 4, e0154256.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Proteins
insulin-like growth factor binding proteins
myeloma
Multiple Myeloma
bone marrow
5 Citations (Scopus)
Pregnancy-Associated Plasma Protein-A
Gene expression
Muscle
Skeletal Muscle
Phenotype
8 Citations (Scopus)

Discrepancies in insulin-like growth factor signaling? No, not really

Conover, C. A., Oct 1 2016, In : Growth Hormone and IGF Research. 30-31, p. 42-44 3 p.

Research output: Contribution to journalShort survey

Somatomedins
Animal Models
53 Citations (Scopus)

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

Dauber, A., Muñoz-Calvo, M. T., Barrios, V., Domené, H. M., Kloverpris, S., Serra-Juhé, C., Desikan, V., Pozo, J., Muzumdar, R., Martos-Moreno, G. A., Hawkins, F., Jasper, H. G., Conover, C. A., Frystyk, J., Yakar, S., Hwa, V., Chowen, J. A., Oxvig, C., Rosenfeld, R. G., Pérez-Jurado, L. A. & 1 others, Argente, J., 2016, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
varespladib methyl
Blood Proteins
Pregnancy
Mutation
6 Citations (Scopus)

PAPP-A: A promising therapeutic target for healthy longevity

Conover, C. A. & Oxvig, C., 2016, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Somatomedins
Somatomedin Receptors
Insulin-Like Growth Factor Binding Proteins
Peptide Hydrolases
5 Citations (Scopus)

PAPP-A in normal human mesangial cells: Effect of inflammation and factors related to diabetic nephropathy

Donegan, D., Bale, L. K. & Conover, C. A., 2016, In : Journal of Endocrinology. 231, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

Mesangial Cells
Staphylococcal Protein A
Diabetic Nephropathies
Somatomedins
Blood Proteins
202 Citations (Scopus)

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J. & Van Deursen, J., Oct 28 2016, In : Science. 354, 6311, p. 472-477 6 p.

Research output: Contribution to journalArticle

Tunica Intima
Foam Cells
Atherosclerosis
Elastic Tissue
LDL Receptors
11 Citations (Scopus)

Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice

Steffensen, L. B., Conover, C. A., Bjørklund, M. M., Ledet, T., Bentzon, J. F. & Oxvig, C., May 1 2016, In : Atherosclerosis. 248, p. 36-43 8 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Atherosclerosis
teleocalcin
Dependovirus
Aptitude
18 Citations (Scopus)
Pregnancy-Associated Plasma Protein-A
Atherosclerotic Plaques
High Fat Diet
Metalloproteases
Apolipoproteins E
13 Citations (Scopus)

The insulin-like growth factor system in Multiple Myeloma: Diagnostic and therapeutic potential

Bieghs, L., Johnsen, H. E., Maes, K., Menu, E., Van Valckenborgh, E., Overgaard, M. T., Nyegaard, M., Conover, C. A., Vanderkerken, K. & De Bruyne, E., 2016, In : Oncotarget. 7, 30, p. 48732-48752 21 p.

Research output: Contribution to journalReview article

Somatomedins
Multiple Myeloma
Therapeutics
Drug Resistance
Insulin-Like Growth Factor Binding Proteins
2015
25 Citations (Scopus)

A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts

Becker, M. A., Haluska, P., Bale, L. K., Oxvig, C. & Conover, C. A., 2015, In : Molecular Cancer Therapeutics. 14, 4, p. 973-981 9 p.

Research output: Contribution to journalArticle

Staphylococcal Protein A
Neutralizing Antibodies
Ascites
Ovarian Neoplasms
Blood Proteins

Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

Steffensen, L. B., Poulsen, C. B., Shim, J., Bek, M., Jacobsen, K., Conover, C. A., Bentzon, J. F. & Oxvig, C., Dec 1 2015, In : Journal of Cardiovascular Translational Research. 8, 9, p. 528-535 8 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Myocardial Ischemia
Swine
Acute Coronary Syndrome
Ligation
1 Citation (Scopus)

PAPP-A affects tendon structure and mechanical properties

Yang, T. H., Thoreson, A. R., An, K. N., Zhao, C. D., Conover, C. A. & Amadio, P. C., 2015, In : Journal of Structural Biology. 192, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Tendons
Tail
Knockout Mice
Transgenic Mice
13 Citations (Scopus)

PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

Thomsen, J., Hjortebjerg, R., Espelund, U., Ørtoft, G., Vestergaard, P., Magnusson, N. E., Conover, C. A., Tramm, T., Hager, H., Høgdall, C., Høgdall, E., Oxvig, C. & Frystyk, J., 2015, In : Oncotarget. 6, 31, p. 32266-32278 13 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Somatomedins
Ascites
Insulin-Like Growth Factor Binding Protein 4
Carcinoma
4 Citations (Scopus)

Pregnancy-associated plasma protein-A deficiency improves survival of mice on a high fat diet

Conover, C. A., Bale, L. K. & Marler, R. J., Oct 1 2015, In : Experimental Gerontology. 70, p. 131-134 4 p., 9677.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Protein Deficiency
High Fat Diet
Nutrition
Fats
4 Citations (Scopus)

Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone

Clifton, K. B. & Conover, C. A., Dec 1 2015, In : Bone. 81, p. 413-416 4 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Anabolic Agents
Parathyroid Hormone
Somatomedins
Bone and Bones
6 Citations (Scopus)

The insulin-like growth factor system in the long-lived naked mole-rat

Brohus, M., Gorbunova, V., Faulkes, C. G., Overgaard, M. T. & Conover, C. A., Dec 1 2015, In : PLoS One. 10, 12, e0145587.

Research output: Contribution to journalArticle

Mole Rats
Heterocephalus glaber
somatomedins
Somatomedins
Rats
2014
11 Citations (Scopus)

Heparin-binding mechanism of the IGF2/IGF-binding protein 2 complex

Lund, J., Søndergaard, M. T., Conover, C. A. & Overgaard, M. T., Mar 6 2014, In : Journal of Molecular Endocrinology. 52, 3, p. 345-355 11 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Heparin
Insulin-Like Growth Factor Binding Proteins
A73025
Glycosaminoglycans
30 Citations (Scopus)

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity

Mikkelsen, J. H., Resch, Z. T., Kalra, B., Savjani, G., Kumar, A., Conover, C. A. & Oxvig, C., 2014, In : Oncotarget. 5, 4, p. 1014-1025 12 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Somatomedin Receptors
Somatomedins
Insulin-Like Growth Factor Binding Protein 4
Heterografts
10 Citations (Scopus)

Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice

Bale, L. K., Chakraborty, S. & Conover, C. A., Apr 2014, In : Endocrinology. 155, 4, p. 1184-1187 4 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Atherosclerotic Plaques
Gene Expression
Aorta
Arteries

Motor and memory testing of long-lived pregnancy-associated plasma protein-A knock-out mice

Mason, E. J., Grell, J. A., West, S. A. & Conover, C. A., Dec 1 2014, In : Growth Hormone and IGF Research. 24, 6, p. 251-255 5 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Knockout Mice
Learning
Insulin-Like Growth Factor Binding Proteins
Diabetic Nephropathies
13 Citations (Scopus)

Preferential expression of PAPPA in human preadipocytes from omental fat

Davidge-Pitts, C., Escande, C. J. & Conover, C. A., 2014, In : Journal of Endocrinology. 222, 1, p. 87-97 11 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Fats
Sirtuin 1
Cytokines
Adenylate Kinase
14 Citations (Scopus)

Pregnancy-associated plasma protein-A expression in human breast cancer

Mansfield, A., Visscher, D. W., Hart, S., Wang, C., Goetz, M. P., Oxvig, C. & Conover, C. A., Dec 1 2014, In : Growth Hormone and IGF Research. 24, 6, p. 264-267 4 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Breast Neoplasms
Estrogen Receptors
Neoplasms
Metalloproteases
2 Citations (Scopus)

Tissue-specific changes in pregnancy associated plasma protein-A expression with age in mice

Harstad, S. L. & Conover, C. A., 2014, In : Experimental Gerontology. 57, p. 13-17 5 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Tissue
Thymus
Gonads
Messenger RNA
2013
8 Citations (Scopus)
Pregnancy-Associated Plasma Protein-A
Vascular Smooth Muscle
Wounds and Injuries
Transgenic Mice
Insulin-Like Growth Factor I
10 Citations (Scopus)

Effects of mutated pregnancy-associated plasma protein-A on atherosclerotic lesion development in mice

Boldt, H. B., Bale, L. K., Resch, Z. T., Oxvig, C., Overgaard, M. T. & Conover, C. A., Jan 1 2013, In : Endocrinology. 154, 1, p. 246-252 7 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Insulin-Like Growth Factor Binding Protein 4
Apolipoproteins E
Knockout Mice
Transgenic Mice
11 Citations (Scopus)

Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: Effect on vascular injury response

Conover, C. A., Bale, L. K. & Powell, D. R., Aug 1 2013, In : Endocrinology. 154, 8, p. 2734-2738 5 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Vascular System Injuries
Blood Proteins
Gene Expression
Pregnancy
14 Citations (Scopus)

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

Mader, J. R., Resch, Z. T., McLean, G. R., Mikkelsen, J. H., Oxvig, C., Marler, R. J. & Conover, C. A., 2013, In : Journal of Endocrinology. 219, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Diabetic Nephropathies
Bowman Capsule
Kidney
Knockout Mice
18 Citations (Scopus)
Pregnancy-Associated Plasma Protein-A
Protein Deficiency
Intra-Abdominal Fat
High Fat Diet
Knockout Mice
12 Citations (Scopus)

Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity

Kjaer-Sorensen, K., Engholm, D. H., Kamei, H., Morch, M. G., Kristensen, A. O., Zhou, J., Conover, C. A., Duan, C. & Oxvig, C., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 9982-9992 11 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Zebrafish
Somatomedin Receptors
Insulin-Like Growth Factor Binding Proteins
Gastrulation
15 Citations (Scopus)

Role of PAPP-A in aging and age-related disease

Conover, C. A., Jul 2013, In : Experimental Gerontology. 48, 7, p. 612-613 2 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Aging of materials
Fetal Development
Names
Pregnancy
2012
82 Citations (Scopus)

Key questions and answers about pregnancy-associated plasma protein-A

Conover, C. A., May 2012, In : Trends in Endocrinology and Metabolism. 23, 5, p. 242-249 8 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Metalloproteases
Somatomedins
Placenta
Zinc
2011
12 Citations (Scopus)

Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice

Mason, E. J., Grell, J. A., Wan, J., Cohen, P. & Conover, C. A., Oct 2011, In : Growth Hormone and IGF Research. 21, 5, p. 243-247 5 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Knockout Mice
Phenotype
44 Citations (Scopus)

Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo

Boldt, H. B. & Conover, C. A., Apr 2011, In : Endocrinology. 152, 4, p. 1470-1478 9 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Ovarian Neoplasms
Growth
Neoplasms
Insulin-Like Growth Factor Binding Proteins
40 Citations (Scopus)

Pregnancy-Associated Plasma Protein-A2 (PAPP-A2): Tissue expression and biological consequences of gene knockout in mice

Conover, C. A., Boldt, H. B., Bale, L. K., Clifton, K. B., Grell, J. A., Mader, J. R., Mason, E. J. & Powell, D. R., Jul 2011, In : Endocrinology. 152, 7, p. 2837-2844 8 p.

Research output: Contribution to journalArticle

Gene Knockout Techniques
varespladib methyl
Knockout Mice
Blood Proteins
Pregnancy
2010
41 Citations (Scopus)

Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility

Nyegaard, M., Overgaard, M. T., Su, Y. Q., Hamilton, A. E., Kwintkiewicz, J., Hsieh, M., Nayak, N. R., Conti, M., Conover, C. A. & Giudice, L. C., Jun 2010, In : Biology of Reproduction. 82, 6, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Fertility
Insulin-Like Growth Factor Binding Proteins
Somatomedins
Knockout Mice
53 Citations (Scopus)

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-a

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P. & Marler, R. J., Jun 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Blood Proteins
Knockout Mice
Pathology
Pregnancy
8 Citations (Scopus)

Longevity is not influenced by prenatal programming of body size

Conover, C. A., Bale, L. K., Grell, J. A., Mader, J. R. & Mason, M. A., Aug 2010, In : Aging Cell. 9, 4, p. 647-649 3 p.

Research output: Contribution to journalArticle

Embryonic and Fetal Development
Pregnancy-Associated Plasma Protein-A
Body Size
Somatomedins
Fetal Development
22 Citations (Scopus)

PAPP-A: A new anti-aging target?

Conover, C. A., Dec 2010, In : Aging Cell. 9, 6, p. 942-946 5 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Somatomedins
Knockout Mice
History
8 Citations (Scopus)
Dermatitis
dermatitis
Nutrition
Dietary Supplements
Vitamins
5 Citations (Scopus)

Transforming growth factor-β1 modulates insulin-like growth factor binding protein-4 expression and proteolysis in cultured periosteal explants

Gonzalez, C., Auw Yang, K. G., Schwab, J. H., Fitzsimmons, J. S., Reinholz, M. M., Resch, Z. T., Bale, L. K., Clemens, V. R., Conover, C. A., O'Driscoll, S. W. & Reinholz, G. G., Apr 2010, In : Growth Hormone and IGF Research. 20, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 4
Transforming Growth Factors
Pregnancy-Associated Plasma Protein-A
Proteolysis
Transforming Growth Factor beta
43 Citations (Scopus)

Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development

Conover, C. A., Mason, M. A., Bale, L. K., Harrington, S. C., Nyegaard, M., Oxvig, C. & Overgaard, M. T., Aug 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 299, 2

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Smooth Muscle
Apolipoproteins E
Insulin-Like Growth Factor Binding Protein 4
Knockout Mice
2009
33 Citations (Scopus)

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice

Swindell, W. R., Masternak, M. M., Kopchick, J. J., Conover, C. A., Bartke, A. & Miller, R. A., Jun 2009, In : Mechanisms of Ageing and Development. 130, 6, p. 393-400 8 p.

Research output: Contribution to journalArticle

Heat-Shock Proteins
Messenger RNA
Liver
Caenorhabditis elegans
Insulin-Like Growth Factor I