Charles L Howe, PhD

  • 3847 Citations
  • 31 Scopus h-Index
19942019
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Research Output 1994 2019

  • 3847 Citations
  • 31 Scopus h-Index
  • 75 Article
  • 2 Chapter
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Article
2019
4 Citations (Scopus)

Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome

Clarkson, B. D. S., LaFrance-Corey, R. G., Kahoud, R. J., Farias-Moeller, R., Payne, E. T. & Howe, C. L., Jan 1 2019, In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access
Interleukin-1 Receptors
Epilepsy
Fever
Infection
Protein Isoforms
2018
2 Citations (Scopus)

Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection-related epilepsy syndrome

Farias-Moeller, R., LaFrance-Corey, R., Bartolini, L., Wells, E. M., Baker, M., Doslea, A., Suslovic, W., Greenberg, J., Carpenter, J. L. & Howe, C. L., Sep 1 2018, In : Epilepsia. 59, 9, p. 1753-1763 11 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Epilepsy
Fever
Infection
Critical Illness
1 Citation (Scopus)

Neuromyelitis Optica and Herpes Simplex Virus 2

Vanessa Marin Collazo, I., Howe, C. L., Lucchinetti, C. F. & Tobin, W., Jan 1 2018, In : Neurologist. 23, 3, p. 92-93 2 p.

Research output: Contribution to journalArticle

Aquaporin 4
Neuromyelitis Optica
Human Herpesvirus 2
Antibodies
Virus Diseases
2017
4 Citations (Scopus)

Inflammatory cytokine-induced changes in neural network activity measured by waveform analysis of high-content calcium imaging in murine cortical neurons

Clarkson, B. D. S., Kahoud, R. J., McCarthy, C. B. & Howe, C. L., Dec 1 2017, In : Scientific Reports. 7, 1, 9037.

Research output: Contribution to journalArticle

Cytokines
Calcium
Neurons
Neuroglia
Autoimmune Diseases of the Nervous System
11 Citations (Scopus)

Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

Howe, C. L., LaFrance-Corey, R. G., Goddery, E. N., Johnson, R. K. & Mirchia, K., Dec 4 2017, In : Journal of Neuroinflammation. 14, 1, 238.

Research output: Contribution to journalArticle

Virus Diseases
Theilovirus
Monocytes
Brain
Neurons
12 Citations (Scopus)

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

Guo, Y., Weigand, S. D., Popescu, B. F., Lennon, V. A., Parisi, J. E., Pittock, S. J., Parks, N. E., Clardy, S. L., Howe, C. L. & Lucchinetti, C. F., Feb 9 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Aquaporin 4
Cerebrospinal Fluid
Pathology
Choroid Plexus
1 Citation (Scopus)

Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons

Clarkson, B. D. S., Patel, M. S., Lafrance-Corey, R. G. & Howe, C. L., Jan 1 2017, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Histocompatibility
Interferon-gamma
Axons
Neurons
2016
58 Citations (Scopus)

Febrile infection-related epilepsy syndrome treated with anakinra

Kenney-Jung, D. L., Vezzani, A., Kahoud, R. J., LaFrance-Corey, R. G., Ho, M. L., Muskardin, T. W., Wirrell, E. C., Howe, C. L. & Payne, E. T., Dec 1 2016, In : Annals of Neurology. 80, 6, p. 939-945 7 p.

Research output: Contribution to journalArticle

Interleukin 1 Receptor Antagonist Protein
Epilepsy
Fever
Infection
Interleukin-1 Receptors
7 Citations (Scopus)

Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

Wang, Y., Cao, Y., Mangalam, A. K., Guo, Y., LaFrance-Corey, R. G., Gamez, J. D., Atanga, P. A., Clarkson, B. D., Zhang, Y., Wang, E., Angom, R. S., Dutta, K., Ji, B. D., Pirko, I., Lucchinetti, C. F., Howe, C. L. & Mukhopadhyay, D., 2016, In : Journal of Cell Science. 129, 20, p. 3911-3921 11 p.

Research output: Contribution to journalArticle

Neuropilin-1
Interferons
Endothelial Cells
Blood-Brain Barrier
Brain
7 Citations (Scopus)

Neuroprotection mediated by inhibition of calpain during acute viral encephalitis

Howe, C. L., Lafrance-Corey, R. G., Mirchia, K., Sauer, B. M., McGovern, R. M., Reid, J. M. & Buenz, E. J., Jun 27 2016, In : Scientific Reports. 6, 28699.

Research output: Contribution to journalArticle

Viral Encephalitis
Calpain
Ritonavir
Neurons
Picornaviridae Infections
2015
11 Citations (Scopus)

NFΚB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG

Walker-Caulfield, M. E., Guo, Y., Johnson, R. K., McCarthy, C. B., Fitz-Gibbon, P. D., Lucchinetti, C. F. & Howe, C. L., Sep 30 2015, In : Journal of Neuroinflammation. 12, 1, 185.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Immunoglobulin G
Astrocytes
Aquaporin 4
Aquaporins
2014
26 Citations (Scopus)

Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures

Howe, C. L., Kaptzan, T., Magaña, S. M., Ayers-Ringler, J. R., Lafrance-Corey, R. G. & Lucchinetti, C. F., 2014, In : GLIA. 62, 5, p. 692-708 17 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Astrocytes
Immunoglobulin G
Aquaporin 4
Serum
2013
34 Citations (Scopus)

Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice

Bergstrom, R. A., Choi, J. H., Manduca, A., Shin, H. S., Worrell, G. A. & Howe, C. L., 2013, In : Scientific Reports. 3, 1483.

Research output: Contribution to journalArticle

Electroencephalography
Seizures
Absence Epilepsy
Kainic Acid
Electrodes
18 Citations (Scopus)

Axons are injured by antigen-specific CD8+ T cells through a MHC class I- and granzyme B-dependent mechanism

Sauer, B. M., Schmalstieg, W. F. & Howe, C. L., Nov 2013, In : Neurobiology of Disease. 59, p. 194-205 12 p.

Research output: Contribution to journalArticle

CD8 Antigens
Granzymes
Axons
T-Lymphocytes
Wounds and Injuries
6 Citations (Scopus)

Influenza vaccine and Guillain-Barré syndrome: Making informed decisions

Poland, G. A., Poland, C. M. & Howe, C. L., 2013, In : The Lancet. 381, 9876, p. 1437-1439 3 p.

Research output: Contribution to journalArticle

H1N1 Subtype Influenza A Virus
Guillain-Barre Syndrome
Influenza Vaccines
Pandemics
Human Influenza
2012
30 Citations (Scopus)

Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection

Howe, C. L., Lafrance-Corey, R. G., Sundsbak, R. S., Sauer, B. M., Lafrance, S. J., Buenz, E. J. & Schmalstieg, W. F., 2012, In : Scientific Reports. 2, 545.

Research output: Contribution to journalArticle

Picornaviridae Infections
Monocytes
Brain
Theilovirus
Adoptive Transfer
37 Citations (Scopus)

Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain

Howe, C. L., LaFrance-Corey, R. G., Sundsbak, R. S. & LaFrance, S. J., Mar 9 2012, In : Journal of Neuroinflammation. 9, 50.

Research output: Contribution to journalArticle

Picornaviridae Infections
Monocytes
Hippocampus
Neutrophils
Brain
2011
Encephalitis Viruses
Receptors, Tumor Necrosis Factor, Type II
Receptors, Tumor Necrosis Factor, Type I
Hippocampus
Tumor Necrosis Factor-alpha
21 Citations (Scopus)

Isolation of brain-infiltrating leukocytes

Lafrance-Corey, R. G. & Howe, C. L., Jun 2011, In : Journal of Visualized Experiments. 52, e2747.

Research output: Contribution to journalArticle

Brain
Leukocytes
Flow cytometry
Isoflurane
Infection
163 Citations (Scopus)

Neuromyelitis optica unique area postrema lesions: Nausea, vomiting, and pathogenic implications

Popescu, B. F. G., Lennon, V. A., Parisi, J. E., Howe, C. L., Weigand, S. D., Cabrera-Gómez, J. A., Newell, K., Mandler, R. N., Pittock, S. J., Weinshenker, B. G. & Lucchinetti, C. F., Apr 5 2011, In : Neurology. 76, 14, p. 1229-1237 9 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Area Postrema
Nausea
Vomiting
Aquaporin 4
31 Citations (Scopus)

Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice

Nageswara Rao, A. A., Ye, H., Decker, P. A., Howe, C. L. & Wetmore, C., Jan 1 2011, In : Journal of Neuro-Oncology. 105, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

Cranial Irradiation
Hippocampus
Radiation
Pediatrics
Stem Cell Niche
20 Citations (Scopus)

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures

German, C. L., Sauer, B. M. & Howe, C. L., Aug 15 2011, In : Experimental Cell Research. 317, 14, p. 1955-1969 15 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Endosomes
Interleukin-6
Mitogens
Protein Kinases
2010
23 Citations (Scopus)

CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis

Deb, C., Lafrance-Corey, R. G., Schmalstieg, W. F., Sauer, B. M., Wang, H. D., German, C. L., Windebank, A. J., Rodriguez, M. & Howe, C. L., 2010, In : PLoS One. 5, 8, e12478.

Research output: Contribution to journalArticle

T-cells
sclerosis
axons
Multiple Sclerosis
Axons
Subcellular Fractions

Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC (The FASEB Journal (2006) 20, 13 (2408-2410) DOI: 10.1096/fj.06-6171fje)

Blocki, F. A., Radhakrishnan, S., Van Keulen, V. P., Heckman, K. L., Ciric, B., Howe, C. L., Rodriguez, M., Kwon, E. D. & Pease, L. R., Jun 2010, In : FASEB Journal. 24, 6, p. 2135-2136 2 p.

Research output: Contribution to journalArticle

B7 Antigens
Gene expression
Immunoglobulin M
Antibodies
Dendritic Cells
33 Citations (Scopus)

Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Lacerda-Queiroz, N., Rodrigues, D. H., Vilela, M. C., Miranda, A. S. D., Amaral, D. C. G., Camargos, E. R. D. S., Carvalho, L. J. D. M., Howe, C. L., Teixeira, M. M. & Teixeira, A. L., Jul 2010, In : Experimental Parasitology. 125, 3, p. 271-278 8 p.

Research output: Contribution to journalArticle

Plasmodium berghei
Leukocytes
Central Nervous System
Brain
Parasites

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells (The Journal of Immunology (2008) 181, (7863-7872))

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Rodriguez, M., Pease, L. R. & Colonna, M., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6557 1 p.

Research output: Contribution to journalArticle

Myeloid Cells
Allergy and Immunology
Dendritic Cells
Antigens
2009
47 Citations (Scopus)

Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection

Buenz, E. J., Sauer, B. M., LaFrance-Corey, R. G., Deb, C., Denic, A., German, C. L. & Howe, C. L., Aug 2009, In : American Journal of Pathology. 175, 2, p. 668-684 17 p.

Research output: Contribution to journalArticle

Picornaviridae Infections
Pyramidal Cells
Apoptosis
Viruses
Picornaviridae
33 Citations (Scopus)

Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis

Deb, C., LaFrance-Corey, R. G., Zoecklein, L., Papke, L., Rodriguez, M. & Howe, C. L., Sep 1 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 9, p. 1037-1048 12 p.

Research output: Contribution to journalArticle

Perforin
Multiple Sclerosis
Axons
Demyelinating Diseases
Theilovirus
10 Citations (Scopus)

Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes

Deb, C. & Howe, C. L., Sep 29 2009, In : Journal of Neuroimmunology. 214, 1-2, p. 33-42 10 p.

Research output: Contribution to journalArticle

Spinal Cord
Lymphocytes
Theilovirus
Demyelinating Diseases
Immunophenotyping
8 Citations (Scopus)

Preparation of biologically active subcellular fractions using the Balch homogenizer

German, C. L. & Howe, C. L., Nov 1 2009, In : Analytical Biochemistry. 394, 1, p. 117-124 8 p.

Research output: Contribution to journalArticle

Subcellular Fractions
Centrifugation
Cell membranes
Animals
Cells
14 Citations (Scopus)

Subcutaneous IGF-1 is not beneficial in 2-year als trial

Howe, C. L., Bergstrom, R. A. & Horazdovsky, B. F., Oct 2009, In : Neurology. 73, 15, p. 1247-1248 2 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Subcutaneous Injections
Insulin-Like Growth Factor I
12 Citations (Scopus)

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Colonna, M., Leibson, P. J., Rodriguez, M. & Pease, L. R., Dec 1 2009, In : Journal of Immunology. 181, 11, p. 7863-7872 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Dendritic Cells
Antigens
Animal Disease Models
Type C Phospholipases
18 Citations (Scopus)

Tumor necrosis factor α is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis

Rodriguez, M., Zoecklein, L., Papke, L., Gamez, J., Denic, A., Macura, S. I. & Howe, C. L., Jan 2009, In : Brain Pathology. 19, 1, p. 12-26 15 p.

Research output: Contribution to journalArticle

Encephalitis Viruses
Receptors, Tumor Necrosis Factor, Type II
Receptors, Tumor Necrosis Factor, Type I
Hippocampus
Tumor Necrosis Factor-alpha
2008
216 Citations (Scopus)

Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down- Regulating EAAT2

Hinson, S. R., Roemer, S. F., Lucchinetti, C. F., Fryer, J. P., Kryzer, T. J., Chamberlain, J. L., Howe, C. L., Pittock, S. J. & Lennon, V. A., Oct 27 2008, In : Journal of Experimental Medicine. 205, 11, p. 2473-2481 9 p.

Research output: Contribution to journalArticle

Excitatory Amino Acid Transporter 2
Aquaporin 4
Neuromyelitis Optica
Autoantibodies
Glutamic Acid
3 Citations (Scopus)

Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination

Rodriguez, M., Zoecklein, L., Kerkvliet, J. G., Pavelko, K. D., Papke, L., Howe, C. L., Pease, L. R. & David, C., Apr 2008, In : Journal of Virology. 82, 7, p. 3369-3380 12 p.

Research output: Contribution to journalArticle

Encephalomyelitis
Demyelinating Diseases
HLA-DR Antigens
encephalitis
Transgenes
9 Citations (Scopus)

Immunological aspects of axon injury in multiple sclerosis

Howe, C. L., 2008, In : Current Topics in Microbiology and Immunology. 318, p. 93-131 39 p.

Research output: Contribution to journalArticle

Demyelinating Diseases
Multiple Sclerosis
Axons
Wounds and Injuries
Research
8 Citations (Scopus)

NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain

Deb, C. & Howe, C. L., May 2008, In : Journal of NeuroVirology. 14, 3, p. 261-266 6 p.

Research output: Contribution to journalArticle

Picornaviridae
T-Lymphocytes
Brain
Central Nervous System Viral Diseases
Theilovirus
66 Citations (Scopus)

TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse

Kahraman, A., Barreyro, F. J., Bronk, S. F., Werneburg, N. W., Mott, J. L., Akazawa, Y., Masuoka, H. C., Howe, C. L. & Gores, G. J., Apr 2008, In : Hepatology. 47, 4, p. 1317-1330 14 p.

Research output: Contribution to journalArticle

Bile Ducts
Immune System
Liver
Wounds and Injuries
Wild Animals

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Colonna, M., Leibson, P. J., Rodriguez, M. & Pease, L. R., Dec 1 2008, In : Journal of immunology (Baltimore, Md. : 1950). 181, 11, p. 7863-7872 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Dendritic Cells
Antigens
Phospholipase C gamma
Animal Disease Models
2007
47 Citations (Scopus)

Absence of perforin expression confers axonal protection despite demyelination

Howe, C. L., Adelson, J. D. & Rodriguez, M., Feb 2007, In : Neurobiology of Disease. 25, 2, p. 354-359 6 p.

Research output: Contribution to journalArticle

Perforin
Demyelinating Diseases
Axons
Wounds and Injuries
Theilovirus
11 Citations (Scopus)

A high-throughput 3-parameter flow cytometry-based cell death assay

Buenz, E. J., Limburg, P. J. & Howe, C. L., Mar 1 2007, In : Cytometry Part A. 71, 3, p. 170-173 4 p.

Research output: Contribution to journalArticle

Flow Cytometry
Cell Death
Apoptosis
Mitochondrial Membrane Potential
Cell Cycle
12 Citations (Scopus)

A randomized Phase I study of Atuna racemosa: A potential new anti-MRSA natural product extract

Buenz, E. J., Bauer, B. A., Schnepple, D. J., Wahner-Roedler, D. L., Vandell, A. G. & Howe, C. L., Dec 3 2007, In : Journal of Ethnopharmacology. 114, 3, p. 371-376 6 p.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Biological Products
Gram-Positive Bacteria
Safety
Controlled Clinical Trials
40 Citations (Scopus)

Beta-methylamino-alanine (BMAA) injures hippocampal neurons in vivo

Buenz, E. J. & Howe, C. L., May 2007, In : NeuroToxicology. 28, 3, p. 702-704 3 p.

Research output: Contribution to journalArticle

beta-Alanine
Alanine
Neurons
Amyotrophic Lateral Sclerosis
Guam
31 Citations (Scopus)

CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination

Howe, C. L., Ure, D., Adelson, J. D., LaFrance-Corey, R., Johnson, A. J. & Rodriguez, M., Aug 2007, In : Journal of Neuroimmunology. 188, 1-2, p. 13-21 9 p.

Research output: Contribution to journalArticle

Axonal Transport
Demyelinating Diseases
Axons
T-Lymphocytes
Peptides
1 Citation (Scopus)
Age Factors
Intravenous Immunoglobulins
Myasthenia Gravis
Glutamate Receptors
Encephalitis

Response to Buenz and Howe [2]

Buenz, E. J. & Howe, C. L., Mar 2007, In : Journal of Perinatology. 27, 3, p. 197 1 p.

Research output: Contribution to journalArticle

2006
21 Citations (Scopus)

Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1β

Howe, C. L., Mayoral, S. & Rodriguez, M., Sep 2006, In : Neurobiology of Disease. 23, 3, p. 731-739 9 p.

Research output: Contribution to journalArticle

Oligodendroglia
Microglia
Interleukin-1
Neuroglia
Up-Regulation
17 Citations (Scopus)

Coated glass and vicryl microfibers as artificial axons

Howe, C. L., Dec 2006, In : Cells Tissues Organs. 183, 4, p. 180-194 15 p.

Research output: Contribution to journalArticle

Polyglactin 910
Oligodendroglia
Glass
Axons
Myelin Sheath
36 Citations (Scopus)

Disrupted spatial memory is a consequence of picornavirus infection

Buenz, E. J., Rodriguez, M. & Howe, C. L., Nov 2006, In : Neurobiology of Disease. 24, 2, p. 266-273 8 p.

Research output: Contribution to journalArticle

Picornaviridae Infections
Viruses
Rhinovirus
Enterovirus
Wounds and Injuries