Charles L Howe, PhD &ndash; Research Output

2019

Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome

Clarkson, B. D. S., LaFrance-Corey, R. G., Kahoud, R. J., Farias-Moeller, R., Payne, E. T. & Howe, C. L., Jan 1 2019, In : Annals of neurology.

Research output: Contribution to journal › Article

Open Access

Interleukin-1 Receptors

Epilepsy

Fever

Infection

Protein Isoforms

2 Citations (Scopus)

IgM natural autoantibodies in physiology and the treatment of disease

Fereidan-Esfahani, M., Nayfeh, T., Warrington, A., Howe, C. L. & Rodriguez, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 53-81 29 p. (Methods in Molecular Biology; vol. 1904).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Autoantibodies

Immunoglobulin M

Autoantigens

Autoimmune Diseases

Antibodies

2018

2 Citations (Scopus)

Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection-related epilepsy syndrome

Farias-Moeller, R., LaFrance-Corey, R., Bartolini, L., Wells, E. M., Baker, M., Doslea, A., Suslovic, W., Greenberg, J., Carpenter, J. L. & Howe, C. L., Sep 1 2018, In : Epilepsia. 59, 9, p. 1753-1763 11 p.

Research output: Contribution to journal › Article

Hemophagocytic Lymphohistiocytosis

Epilepsy

Fever

Infection

Critical Illness

1 Citation (Scopus)

Neuromyelitis Optica and Herpes Simplex Virus 2

Vanessa Marin Collazo, I., Howe, C. L., Lucchinetti, C. F. & Tobin, W., Jan 1 2018, In : Neurologist. 23, 3, p. 92-93 2 p.

Research output: Contribution to journal › Article

Aquaporin 4

Neuromyelitis Optica

Human Herpesvirus 2

Antibodies

Virus Diseases

2017

4 Citations (Scopus)

Inflammatory cytokine-induced changes in neural network activity measured by waveform analysis of high-content calcium imaging in murine cortical neurons

Clarkson, B. D. S., Kahoud, R. J., McCarthy, C. B. & Howe, C. L., Dec 1 2017, In : Scientific Reports. 7, 1, 9037.

Research output: Contribution to journal › Article

Cytokines

Calcium

Neurons

Neuroglia

Autoimmune Diseases of the Nervous System

11 Citations (Scopus)

Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

Howe, C. L., LaFrance-Corey, R. G., Goddery, E. N., Johnson, R. K. & Mirchia, K., Dec 4 2017, In : Journal of Neuroinflammation. 14, 1, 238.

Research output: Contribution to journal › Article

Virus Diseases

Theilovirus

Monocytes

Brain

Neurons

12 Citations (Scopus)

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

Guo, Y., Weigand, S. D., Popescu, B. F., Lennon, V. A., Parisi, J. E., Pittock, S. J., Parks, N. E., Clardy, S. L., Howe, C. L. & Lucchinetti, C. F., Feb 9 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journal › Article

Neuromyelitis Optica

Aquaporin 4

Cerebrospinal Fluid

Pathology

Choroid Plexus

1 Citation (Scopus)

Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons

Clarkson, B. D. S., Patel, M. S., Lafrance-Corey, R. G. & Howe, C. L., Jan 1 2017, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journal › Article

Induced Pluripotent Stem Cells

Histocompatibility

Interferon-gamma

Axons

Neurons

2016

58 Citations (Scopus)

Febrile infection-related epilepsy syndrome treated with anakinra

Kenney-Jung, D. L., Vezzani, A., Kahoud, R. J., LaFrance-Corey, R. G., Ho, M. L., Muskardin, T. W., Wirrell, E. C., Howe, C. L. & Payne, E. T., Dec 1 2016, In : Annals of Neurology. 80, 6, p. 939-945 7 p.

Research output: Contribution to journal › Article

Interleukin 1 Receptor Antagonist Protein

Epilepsy

Fever

Infection

Interleukin-1 Receptors

7 Citations (Scopus)

Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

Wang, Y., Cao, Y., Mangalam, A. K., Guo, Y., LaFrance-Corey, R. G., Gamez, J. D., Atanga, P. A., Clarkson, B. D., Zhang, Y., Wang, E., Angom, R. S., Dutta, K., Ji, B. D., Pirko, I., Lucchinetti, C. F., Howe, C. L. & Mukhopadhyay, D., 2016, In : Journal of Cell Science. 129, 20, p. 3911-3921 11 p.

Research output: Contribution to journal › Article

Neuropilin-1

Interferons

Endothelial Cells

Blood-Brain Barrier

Brain

7 Citations (Scopus)

Neuroprotection mediated by inhibition of calpain during acute viral encephalitis

Howe, C. L., Lafrance-Corey, R. G., Mirchia, K., Sauer, B. M., McGovern, R. M., Reid, J. M. & Buenz, E. J., Jun 27 2016, In : Scientific Reports. 6, 28699.

Research output: Contribution to journal › Article

Viral Encephalitis

Calpain

Ritonavir

Neurons

Picornaviridae Infections

2015

11 Citations (Scopus)

NFΚB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG

Walker-Caulfield, M. E., Guo, Y., Johnson, R. K., McCarthy, C. B., Fitz-Gibbon, P. D., Lucchinetti, C. F. & Howe, C. L., Sep 30 2015, In : Journal of Neuroinflammation. 12, 1, 185.

Research output: Contribution to journal › Article

Neuromyelitis Optica

Immunoglobulin G

Astrocytes

Aquaporin 4

Aquaporins

2014

26 Citations (Scopus)

Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures

Howe, C. L., Kaptzan, T., Magaña, S. M., Ayers-Ringler, J. R., Lafrance-Corey, R. G. & Lucchinetti, C. F., 2014, In : GLIA. 62, 5, p. 692-708 17 p.

Research output: Contribution to journal › Article

Neuromyelitis Optica

Astrocytes

Immunoglobulin G

Aquaporin 4

Serum

2013

34 Citations (Scopus)

Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice

Bergstrom, R. A., Choi, J. H., Manduca, A., Shin, H. S., Worrell, G. A. & Howe, C. L., 2013, In : Scientific Reports. 3, 1483.

Research output: Contribution to journal › Article

Electroencephalography

Seizures

Absence Epilepsy

Kainic Acid

Electrodes

18 Citations (Scopus)

Axons are injured by antigen-specific CD8⁺ T cells through a MHC class I- and granzyme B-dependent mechanism

Sauer, B. M., Schmalstieg, W. F. & Howe, C. L., Nov 2013, In : Neurobiology of Disease. 59, p. 194-205 12 p.

Research output: Contribution to journal › Article

CD8 Antigens

Granzymes

Axons

T-Lymphocytes

Wounds and Injuries

6 Citations (Scopus)

Influenza vaccine and Guillain-Barré syndrome: Making informed decisions

Poland, G. A., Poland, C. M. & Howe, C. L., 2013, In : The Lancet. 381, 9876, p. 1437-1439 3 p.

Research output: Contribution to journal › Article

H1N1 Subtype Influenza A Virus

Guillain-Barre Syndrome

Influenza Vaccines

Pandemics

Human Influenza

2012

30 Citations (Scopus)

Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection

Howe, C. L., Lafrance-Corey, R. G., Sundsbak, R. S., Sauer, B. M., Lafrance, S. J., Buenz, E. J. & Schmalstieg, W. F., 2012, In : Scientific Reports. 2, 545.

Research output: Contribution to journal › Article

Picornaviridae Infections

Monocytes

Brain

Theilovirus

Adoptive Transfer

37 Citations (Scopus)

Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain

Howe, C. L., LaFrance-Corey, R. G., Sundsbak, R. S. & LaFrance, S. J., Mar 9 2012, In : Journal of Neuroinflammation. 9, 50.

Research output: Contribution to journal › Article

Picornaviridae Infections

Monocytes

Hippocampus

Neutrophils

Brain

2011

Erratum: Tumor necrosis factor α is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis (Brain Pathology (2009) 19 (12-26))

Rodriguez, M., Zoecklein, L., Papke, L., Gamez, J., Denic, A., Macura, S. I. & Howe, C. L., Jul 2011, In : Brain Pathology. 21, 4, p. 477 1 p.

Research output: Contribution to journal › Article

Encephalitis Viruses

Receptors, Tumor Necrosis Factor, Type II

Receptors, Tumor Necrosis Factor, Type I

Hippocampus

Tumor Necrosis Factor-alpha

20 Citations (Scopus)

Isolation of brain-infiltrating leukocytes

Lafrance-Corey, R. G. & Howe, C. L., Jun 2011, In : Journal of Visualized Experiments. 52, e2747.

Research output: Contribution to journal › Article

Brain

Leukocytes

Flow cytometry

Isoflurane

Infection

163 Citations (Scopus)

Neuromyelitis optica unique area postrema lesions: Nausea, vomiting, and pathogenic implications

Popescu, B. F. G., Lennon, V. A., Parisi, J. E., Howe, C. L., Weigand, S. D., Cabrera-Gómez, J. A., Newell, K., Mandler, R. N., Pittock, S. J., Weinshenker, B. G. & Lucchinetti, C. F., Apr 5 2011, In : Neurology. 76, 14, p. 1229-1237 9 p.

Research output: Contribution to journal › Article

Neuromyelitis Optica

Area Postrema

Nausea

Vomiting

Aquaporin 4

31 Citations (Scopus)

Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice

Nageswara Rao, A. A., Ye, H., Decker, P. A., Howe, C. L. & Wetmore, C., Jan 1 2011, In : Journal of Neuro-Oncology. 105, 2, p. 191-198 8 p.

Research output: Contribution to journal › Article

Cranial Irradiation

Hippocampus

Radiation

Pediatrics

Stem Cell Niche

20 Citations (Scopus)

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures

German, C. L., Sauer, B. M. & Howe, C. L., Aug 15 2011, In : Experimental Cell Research. 317, 14, p. 1955-1969 15 p.

Research output: Contribution to journal › Article

STAT3 Transcription Factor

Endosomes

Interleukin-6

Mitogens

Protein Kinases

2010

23 Citations (Scopus)

CD8⁺ T cells cause disability and axon loss in a mouse model of multiple sclerosis

Deb, C., Lafrance-Corey, R. G., Schmalstieg, W. F., Sauer, B. M., Wang, H. D., German, C. L., Windebank, A. J., Rodriguez, M. & Howe, C. L., 2010, In : PLoS One. 5, 8, e12478.

Research output: Contribution to journal › Article

T-cells

sclerosis

axons

Multiple Sclerosis

Axons

Erratum to Preparation of biologically active subcellular fractions using the Balch homogenizer [Anal. Biochem. 394, (2009), 117-124]

German, C. L. & Howe, C. L., May 2010, In : Analytical Biochemistry. 400, 2, p. 310 1 p.

Research output: Contribution to journal › Article

Subcellular Fractions

Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC (The FASEB Journal (2006) 20, 13 (2408-2410) DOI: 10.1096/fj.06-6171fje)

Blocki, F. A., Radhakrishnan, S., Van Keulen, V. P., Heckman, K. L., Ciric, B., Howe, C. L., Rodriguez, M., Kwon, E. D. & Pease, L. R., Jun 2010, In : FASEB Journal. 24, 6, p. 2135-2136 2 p.

Research output: Contribution to journal › Article

B7 Antigens

Gene expression

Immunoglobulin M

Antibodies

Dendritic Cells

33 Citations (Scopus)

Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Lacerda-Queiroz, N., Rodrigues, D. H., Vilela, M. C., Miranda, A. S. D., Amaral, D. C. G., Camargos, E. R. D. S., Carvalho, L. J. D. M., Howe, C. L., Teixeira, M. M. & Teixeira, A. L., Jul 2010, In : Experimental Parasitology. 125, 3, p. 271-278 8 p.

Research output: Contribution to journal › Article

Plasmodium berghei

Leukocytes

Central Nervous System

Brain

Parasites

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells (The Journal of Immunology (2008) 181, (7863-7872))

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Rodriguez, M., Pease, L. R. & Colonna, M., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6557 1 p.

Research output: Contribution to journal › Article

Myeloid Cells

Allergy and Immunology

Dendritic Cells

Antigens

2009

47 Citations (Scopus)

Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection

Buenz, E. J., Sauer, B. M., LaFrance-Corey, R. G., Deb, C., Denic, A., German, C. L. & Howe, C. L., Aug 2009, In : American Journal of Pathology. 175, 2, p. 668-684 17 p.

Research output: Contribution to journal › Article

Picornaviridae Infections

Pyramidal Cells

Apoptosis

Viruses

Picornaviridae

33 Citations (Scopus)

Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis

Deb, C., LaFrance-Corey, R. G., Zoecklein, L., Papke, L., Rodriguez, M. & Howe, C. L., Sep 1 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 9, p. 1037-1048 12 p.

Research output: Contribution to journal › Article

Perforin

Multiple Sclerosis

Axons

Demyelinating Diseases

Theilovirus

10 Citations (Scopus)

Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes

Deb, C. & Howe, C. L., Sep 29 2009, In : Journal of Neuroimmunology. 214, 1-2, p. 33-42 10 p.

Research output: Contribution to journal › Article

Spinal Cord

Lymphocytes

Theilovirus

Demyelinating Diseases

Immunophenotyping

8 Citations (Scopus)

Preparation of biologically active subcellular fractions using the Balch homogenizer

German, C. L. & Howe, C. L., Nov 1 2009, In : Analytical Biochemistry. 394, 1, p. 117-124 8 p.

Research output: Contribution to journal › Article

Subcellular Fractions

Centrifugation

Cell membranes

Animals

Cells

14 Citations (Scopus)

Subcutaneous IGF-1 is not beneficial in 2-year als trial

Howe, C. L., Bergstrom, R. A. & Horazdovsky, B. F., Oct 2009, In : Neurology. 73, 15, p. 1247-1248 2 p.

Research output: Contribution to journal › Article

Amyotrophic Lateral Sclerosis

Subcutaneous Injections

Insulin-Like Growth Factor I

12 Citations (Scopus)

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Colonna, M., Leibson, P. J., Rodriguez, M. & Pease, L. R., Dec 1 2009, In : Journal of Immunology. 181, 11, p. 7863-7872 10 p.

Research output: Contribution to journal › Article

Myeloid Cells

Dendritic Cells

Antigens

Animal Disease Models

Type C Phospholipases

18 Citations (Scopus)

Tumor necrosis factor α is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis

Rodriguez, M., Zoecklein, L., Papke, L., Gamez, J., Denic, A., Macura, S. I. & Howe, C. L., Jan 2009, In : Brain Pathology. 19, 1, p. 12-26 15 p.

Research output: Contribution to journal › Article

Encephalitis Viruses

Receptors, Tumor Necrosis Factor, Type II

Receptors, Tumor Necrosis Factor, Type I

Hippocampus

Tumor Necrosis Factor-alpha

2008

216 Citations (Scopus)

Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down- Regulating EAAT2

Hinson, S. R., Roemer, S. F., Lucchinetti, C. F., Fryer, J. P., Kryzer, T. J., Chamberlain, J. L., Howe, C. L., Pittock, S. J. & Lennon, V. A., Oct 27 2008, In : Journal of Experimental Medicine. 205, 11, p. 2473-2481 9 p.

Research output: Contribution to journal › Article

Excitatory Amino Acid Transporter 2

Aquaporin 4

Neuromyelitis Optica

Autoantibodies

Glutamic Acid

3 Citations (Scopus)

Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination

Rodriguez, M., Zoecklein, L., Kerkvliet, J. G., Pavelko, K. D., Papke, L., Howe, C. L., Pease, L. R. & David, C., Apr 2008, In : Journal of Virology. 82, 7, p. 3369-3380 12 p.

Research output: Contribution to journal › Article

Encephalomyelitis

Demyelinating Diseases

HLA-DR Antigens

encephalitis

Transgenes

9 Citations (Scopus)

Immunological aspects of axon injury in multiple sclerosis

Howe, C. L., 2008, In : Current Topics in Microbiology and Immunology. 318, p. 93-131 39 p.

Research output: Contribution to journal › Article

Demyelinating Diseases

Multiple Sclerosis

Axons

Wounds and Injuries

Research

8 Citations (Scopus)

NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain

Deb, C. & Howe, C. L., May 2008, In : Journal of NeuroVirology. 14, 3, p. 261-266 6 p.

Research output: Contribution to journal › Article

Picornaviridae

T-Lymphocytes

Brain

Central Nervous System Viral Diseases

Theilovirus

66 Citations (Scopus)

TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse

Kahraman, A., Barreyro, F. J., Bronk, S. F., Werneburg, N. W., Mott, J. L., Akazawa, Y., Masuoka, H. C., Howe, C. L. & Gores, G. J., Apr 2008, In : Hepatology. 47, 4, p. 1317-1330 14 p.

Research output: Contribution to journal › Article

Bile Ducts

Immune System

Liver

Wounds and Injuries

Wild Animals

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Colonna, M., Leibson, P. J., Rodriguez, M. & Pease, L. R., Dec 1 2008, In : Journal of immunology (Baltimore, Md. : 1950). 181, 11, p. 7863-7872 10 p.

Research output: Contribution to journal › Article

Myeloid Cells

Dendritic Cells

Antigens

Phospholipase C gamma

Animal Disease Models

2007

47 Citations (Scopus)

Absence of perforin expression confers axonal protection despite demyelination

Howe, C. L., Adelson, J. D. & Rodriguez, M., Feb 2007, In : Neurobiology of Disease. 25, 2, p. 354-359 6 p.

Research output: Contribution to journal › Article

Perforin

Demyelinating Diseases

Axons

Wounds and Injuries

Theilovirus

11 Citations (Scopus)

A high-throughput 3-parameter flow cytometry-based cell death assay

Buenz, E. J., Limburg, P. J. & Howe, C. L., Mar 1 2007, In : Cytometry Part A. 71, 3, p. 170-173 4 p.

Research output: Contribution to journal › Article

Flow Cytometry

Cell Death

Apoptosis

Mitochondrial Membrane Potential

Cell Cycle

12 Citations (Scopus)

A randomized Phase I study of Atuna racemosa: A potential new anti-MRSA natural product extract

Buenz, E. J., Bauer, B. A., Schnepple, D. J., Wahner-Roedler, D. L., Vandell, A. G. & Howe, C. L., Dec 3 2007, In : Journal of Ethnopharmacology. 114, 3, p. 371-376 6 p.

Research output: Contribution to journal › Article

Methicillin-Resistant Staphylococcus aureus

Biological Products

Gram-Positive Bacteria

Safety

Controlled Clinical Trials

40 Citations (Scopus)

Beta-methylamino-alanine (BMAA) injures hippocampal neurons in vivo

Buenz, E. J. & Howe, C. L., May 2007, In : NeuroToxicology. 28, 3, p. 702-704 3 p.

Research output: Contribution to journal › Article

beta-Alanine

Alanine

Neurons

Amyotrophic Lateral Sclerosis

Guam

31 Citations (Scopus)

CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination

Howe, C. L., Ure, D., Adelson, J. D., LaFrance-Corey, R., Johnson, A. J. & Rodriguez, M., Aug 2007, In : Journal of Neuroimmunology. 188, 1-2, p. 13-21 9 p.

Research output: Contribution to journal › Article

Axonal Transport

Demyelinating Diseases

Axons

T-Lymphocytes

Peptides

1 Citation (Scopus)

Mechanisms of action of IVIG in adult onset Rasmussen's encephalitis. Re: Can J. Neurol. Sci. 2006;33:302-305 Rasmussen's encephalitis in a 58-year-old female: Still a variant?

Buenz, E. J. & Howe, C. L., Feb 2007, In : Canadian Journal of Neurological Sciences. 34, 1, p. 108-109 2 p.

Research output: Contribution to journal › Article

Age Factors

Intravenous Immunoglobulins

Myasthenia Gravis

Glutamate Receptors

Encephalitis

Response to Buenz and Howe [2]

Buenz, E. J. & Howe, C. L., Mar 2007, In : Journal of Perinatology. 27, 3, p. 197 1 p.

Research output: Contribution to journal › Article

2006

21 Citations (Scopus)

Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1β

Howe, C. L., Mayoral, S. & Rodriguez, M., Sep 2006, In : Neurobiology of Disease. 23, 3, p. 731-739 9 p.

Research output: Contribution to journal › Article

Oligodendroglia

Microglia

Interleukin-1

Neuroglia

Up-Regulation

17 Citations (Scopus)

Coated glass and vicryl microfibers as artificial axons

Howe, C. L., Dec 2006, In : Cells Tissues Organs. 183, 4, p. 180-194 15 p.

Research output: Contribution to journal › Article

Polyglactin 910

Oligodendroglia

Glass

Axons

Myelin Sheath