Charles L Howe, PhD

  • 3953 Citations
  • 31 Scopus h-Index
19942019

Research output per year

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Research Output

2019

Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome

Clarkson, B. D. S., LaFrance-Corey, R. G., Kahoud, R. J., Farias-Moeller, R., Payne, E. T. & Howe, C. L., Jan 1 2019, In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

IgM natural autoantibodies in physiology and the treatment of disease

Fereidan-Esfahani, M., Nayfeh, T., Warrington, A., Howe, C. L. & Rodriguez, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 53-81 29 p. (Methods in Molecular Biology; vol. 1904).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
2018

Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection-related epilepsy syndrome

Farias-Moeller, R., LaFrance-Corey, R., Bartolini, L., Wells, E. M., Baker, M., Doslea, A., Suslovic, W., Greenberg, J., Carpenter, J. L. & Howe, C. L., Sep 1 2018, In : Epilepsia. 59, 9, p. 1753-1763 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Neuromyelitis Optica and Herpes Simplex Virus 2

Vanessa Marin Collazo, I., Howe, C. L., Lucchinetti, C. F. & Tobin, W., Jan 1 2018, In : Neurologist. 23, 3, p. 92-93 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Inflammatory cytokine-induced changes in neural network activity measured by waveform analysis of high-content calcium imaging in murine cortical neurons

Clarkson, B. D. S., Kahoud, R. J., McCarthy, C. B. & Howe, C. L., Dec 1 2017, In : Scientific Reports. 7, 1, 9037.

Research output: Contribution to journalArticle

8 Scopus citations

Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

Howe, C. L., LaFrance-Corey, R. G., Goddery, E. N., Johnson, R. K. & Mirchia, K., Dec 4 2017, In : Journal of Neuroinflammation. 14, 1, 238.

Research output: Contribution to journalArticle

14 Scopus citations

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

Guo, Y., Weigand, S. D., Popescu, B. F., Lennon, V. A., Parisi, J. E., Pittock, S. J., Parks, N. E., Clardy, S. L., Howe, C. L. & Lucchinetti, C. F., Feb 9 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons

Clarkson, B. D. S., Patel, M. S., Lafrance-Corey, R. G. & Howe, C. L., Jan 1 2017, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Febrile infection-related epilepsy syndrome treated with anakinra

Kenney-Jung, D. L., Vezzani, A., Kahoud, R. J., LaFrance-Corey, R. G., Ho, M. L., Muskardin, T. W., Wirrell, E. C., Howe, C. L. & Payne, E. T., Dec 1 2016, In : Annals of Neurology. 80, 6, p. 939-945 7 p.

Research output: Contribution to journalArticle

70 Scopus citations

Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

Wang, Y., Cao, Y., Mangalam, A. K., Guo, Y., LaFrance-Corey, R. G., Gamez, J. D., Atanga, P. A., Clarkson, B. D., Zhang, Y., Wang, E., Angom, R. S., Dutta, K., Ji, B. D., Pirko, I., Lucchinetti, C. F., Howe, C. L. & Mukhopadhyay, D., 2016, In : Journal of Cell Science. 129, 20, p. 3911-3921 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Neuroprotection mediated by inhibition of calpain during acute viral encephalitis

Howe, C. L., Lafrance-Corey, R. G., Mirchia, K., Sauer, B. M., McGovern, R. M., Reid, J. M. & Buenz, E. J., Jun 27 2016, In : Scientific Reports. 6, 28699.

Research output: Contribution to journalArticle

8 Scopus citations
2015

NFΚB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG

Walker-Caulfield, M. E., Guo, Y., Johnson, R. K., McCarthy, C. B., Fitz-Gibbon, P. D., Lucchinetti, C. F. & Howe, C. L., Sep 30 2015, In : Journal of Neuroinflammation. 12, 1, 185.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures

Howe, C. L., Kaptzan, T., Magaña, S. M., Ayers-Ringler, J. R., Lafrance-Corey, R. G. & Lucchinetti, C. F., May 2014, In : Glia. 62, 5, p. 692-708 17 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice

Bergstrom, R. A., Choi, J. H., Manduca, A., Shin, H. S., Worrell, G. A. & Howe, C. L., Apr 9 2013, In : Scientific reports. 3, 1483.

Research output: Contribution to journalArticle

34 Scopus citations

Axons are injured by antigen-specific CD8+ T cells through a MHC class I- and granzyme B-dependent mechanism

Sauer, B. M., Schmalstieg, W. F. & Howe, C. L., Nov 1 2013, In : Neurobiology of Disease. 59, p. 194-205 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Influenza vaccine and Guillain-Barré syndrome: Making informed decisions

Poland, G. A., Poland, C. M. & Howe, C. L., May 13 2013, In : The Lancet. 381, 9876, p. 1437-1439 3 p.

Research output: Contribution to journalComment/debate

6 Scopus citations
2012

Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection

Howe, C. L., Lafrance-Corey, R. G., Sundsbak, R. S., Sauer, B. M., Lafrance, S. J., Buenz, E. J. & Schmalstieg, W. F., Aug 15 2012, In : Scientific reports. 2, 545.

Research output: Contribution to journalArticle

30 Scopus citations

Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain

Howe, C. L., LaFrance-Corey, R. G., Sundsbak, R. S. & LaFrance, S. J., Mar 9 2012, In : Journal of Neuroinflammation. 9, 50.

Research output: Contribution to journalArticle

37 Scopus citations
2011

Erratum: Tumor necrosis factor α is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis (Brain Pathology (2009) 19 (12-26))

Rodriguez, M., Zoecklein, L., Papke, L., Gamez, J., Denic, A., Macura, S. & Howe, C., Jul 1 2011, In : Brain Pathology. 21, 4, 1 p.

Research output: Contribution to journalComment/debate

Isolation of brain-infiltrating leukocytes

Lafrance-Corey, R. G. & Howe, C. L., Jun 1 2011, In : Journal of Visualized Experiments. 52, e2747.

Research output: Contribution to journalArticle

23 Scopus citations

Neuromyelitis optica unique area postrema lesions: Nausea, vomiting, and pathogenic implications

Popescu, B. F. G., Lennon, V. A., Parisi, J. E., Howe, C. L., Weigand, S. D., Cabrera-Gómez, J. A., Newell, K., Mandler, R. N., Pittock, S. J., Weinshenker, B. G. & Lucchinetti, C. F., Apr 5 2011, In : Neurology. 76, 14, p. 1229-1237 9 p.

Research output: Contribution to journalArticle

170 Scopus citations

Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice

Nageswara Rao, A. A., Ye, H., Decker, P. A., Howe, C. L. & Wetmore, C., Jan 1 2011, In : Journal of Neuro-Oncology. 105, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures

German, C. L., Sauer, B. M. & Howe, C. L., Aug 15 2011, In : Experimental Cell Research. 317, 14, p. 1955-1969 15 p.

Research output: Contribution to journalArticle

21 Scopus citations
2010

CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis

Deb, C., Lafrance-Corey, R. G., Schmalstieg, W. F., Sauer, B. M., Wang, H., German, C. L., Windebank, A. J., Rodriguez, M. & Howe, C. L., Oct 21 2010, In : PloS one. 5, 8, e12478.

Research output: Contribution to journalArticle

25 Scopus citations

Erratum: Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC (The FASEB Journal (2006) 20, 13 (2408-2410) DOI: 10.1096/fj.06-6171fje)

Blocki, F. A., Radhakrishnan, S., Van Keulen, V. P., Heckman, K. L., Ciric, B., Howe, C. L., Rodriguez, M., Kwon, E. & Pease, L. R., Jun 2010, In : FASEB Journal. 24, 6, p. 2135-2136 2 p.

Research output: Contribution to journalComment/debate

Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Lacerda-Queiroz, N., Rodrigues, D. H., Vilela, M. C., Miranda, A. S. D., Amaral, D. C. G., Camargos, E. R. D. S., Carvalho, L. J. D. M., Howe, C. L., Teixeira, M. M. & Teixeira, A. L., Jul 1 2010, In : Experimental Parasitology. 125, 3, p. 271-278 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells (The Journal of Immunology (2008) 181, (7863-7872))

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Rodriguez, M., Pease, L. R. & Colonna, M., Jun 1 2010, In : Journal of Immunology. 184, 11, 1 p.

Research output: Contribution to journalComment/debate

2009

Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection

Buenz, E. J., Sauer, B. M., LaFrance-Corey, R. G., Deb, C., Denic, A., German, C. L. & Howe, C. L., Aug 2009, In : American Journal of Pathology. 175, 2, p. 668-684 17 p.

Research output: Contribution to journalArticle

47 Scopus citations

Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis

Deb, C., LaFrance-Corey, R. G., Zoecklein, L., Papke, L., Rodriguez, M. & Howe, C. L., Sep 1 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 9, p. 1037-1048 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes

Deb, C. & Howe, C. L., Sep 29 2009, In : Journal of neuroimmunology. 214, 1-2, p. 33-42 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Preparation of biologically active subcellular fractions using the Balch homogenizer

German, C. L. & Howe, C. L., Nov 1 2009, In : Analytical Biochemistry. 394, 1, p. 117-124 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Subcutaneous IGF-1 is not beneficial in 2-year als trial

Howe, C. L., Bergstrom, R. A. & Horazdovsky, B. F., Oct 2009, In : Neurology. 73, 15, p. 1247-1248 2 p.

Research output: Contribution to journalLetter

14 Scopus citations

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Colonna, M., Leibson, P. J., Rodriguez, M. & Pease, L. R., Dec 1 2009, In : Journal of Immunology. 181, 11, p. 7863-7872 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Tumor necrosis factor α is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis

Rodriguez, M., Zoecklein, L., Papke, L., Gamez, J., Denic, A., Macura, S. & Howe, C., Jan 1 2009, In : Brain Pathology. 19, 1, p. 12-26 15 p.

Research output: Contribution to journalArticle

18 Scopus citations
2008

Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down- Regulating EAAT2

Hinson, S. R., Roemer, S. F., Lucchinetti, C. F., Fryer, J. P., Kryzer, T. J., Chamberlain, J. L., Howe, C. L., Pittock, S. J. & Lennon, V. A., Oct 27 2008, In : Journal of Experimental Medicine. 205, 11, p. 2473-2481 9 p.

Research output: Contribution to journalArticle

220 Scopus citations

Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination

Rodriguez, M., Zoecklein, L., Kerkvliet, J. G., Pavelko, K. D., Papke, L., Howe, C. L., Pease, L. R. & David, C., Apr 1 2008, In : Journal of virology. 82, 7, p. 3369-3380 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Immunological aspects of axon injury in multiple sclerosis

Howe, C. L., Dec 1 2008, Advances in multiple Sclerosis and Experimental Demyelinating Diseases. Rodriguez, M. (ed.). p. 93-131 39 p. (Current Topics in Microbiology and Immunology; vol. 318).

Research output: Chapter in Book/Report/Conference proceedingChapter

NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain

Deb, C. & Howe, C. L., May 1 2008, In : Journal of NeuroVirology. 14, 3, p. 261-266 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse

Kahraman, A., Barreyro, F. J., Bronk, S. F., Werneburg, N. W., Mott, J. L., Akazawa, Y., Masuoka, H. C., Howe, C. L. & Gores, G. J., Apr 1 2008, In : Hepatology. 47, 4, p. 1317-1330 14 p.

Research output: Contribution to journalArticle

68 Scopus citations

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Colonna, M., Leibson, P. J., Rodriguez, M. & Pease, L. R., Dec 1 2008, In : Journal of immunology (Baltimore, Md. : 1950). 181, 11, p. 7863-7872 10 p.

Research output: Contribution to journalArticle

2007

Absence of perforin expression confers axonal protection despite demyelination

Howe, C. L., Adelson, J. D. & Rodriguez, M., Feb 1 2007, In : Neurobiology of Disease. 25, 2, p. 354-359 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

A high-throughput 3-parameter flow cytometry-based cell death assay

Buenz, E. J., Limburg, P. J. & Howe, C. L., Mar 1 2007, In : Cytometry Part A. 71, 3, p. 170-173 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

A randomized Phase I study of Atuna racemosa: A potential new anti-MRSA natural product extract

Buenz, E. J., Bauer, B. A., Schnepple, D. J., Wahner-Roedler, D. L., Vandell, A. G. & Howe, C. L., Dec 3 2007, In : Journal of Ethnopharmacology. 114, 3, p. 371-376 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Beta-methylamino-alanine (BMAA) injures hippocampal neurons in vivo

Buenz, E. J. & Howe, C. L., May 1 2007, In : NeuroToxicology. 28, 3, p. 702-704 3 p.

Research output: Contribution to journalArticle

43 Scopus citations

CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination

Howe, C. L., Ure, D., Adelson, J. D., LaFrance-Corey, R., Johnson, A. & Rodriguez, M., Aug 1 2007, In : Journal of neuroimmunology. 188, 1-2, p. 13-21 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Response to Buenz and Howe [2]

Buenz, E. J. & Howe, C. L., Mar 1 2007, In : Journal of Perinatology. 27, 3, 1 p.

Research output: Contribution to journalLetter

2006

Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1β

Howe, C. L., Mayoral, S. & Rodriguez, M., Sep 1 2006, In : Neurobiology of Disease. 23, 3, p. 731-739 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Coated glass and vicryl microfibers as artificial axons

Howe, C. L., Dec 1 2006, In : Cells Tissues Organs. 183, 4, p. 180-194 15 p.

Research output: Contribution to journalArticle

17 Scopus citations