Charles L Howe

2022

Inflammatory monocytes and microglia play independent roles in inflammatory ictogenesis

Howe, C. L., LaFrance-Corey, R. G., Overlee, B. L., Johnson, R. K., Clarkson, B. D. S. & Goddery, E. N., Dec 2022, In: Journal of Neuroinflammation. 19, 1, 22.

Research output: Contribution to journal › Article › peer-review

Open Access

Insula and the Immune System: More than mere Co-existence?

Kerezoudis, P., Howe, C. L., Wu, L. J., Lundstrom, B. N. & Van Gompel, J. J., Oct 2022, In: Neuroscience Bulletin. 38, 10, p. 1271-1273 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation

Clarkson, B. D. S., Grund, E., David, K., Johnson, R. K. & Howe, C. L., Dec 2022, In: Journal of Neuroinflammation. 19, 1, 258.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular Mechanisms in the Genesis of Seizures and Epilepsy Associated With Viral Infection

Löscher, W. & Howe, C. L., May 9 2022, In: Frontiers in Molecular Neuroscience. 15, 870868.

Research output: Contribution to journal › Review article › peer-review

Open Access

Preservation of antigen-specific responses in cryopreserved CD4⁺ and CD8⁺ T cells expanded with IL-2 and IL-7

Clarkson, B. DS., Johnson, R. K., Bingel, C., Lothaller, C. & Howe, C. L., Jan 2022, In: Journal of Translational Autoimmunity. 5, 100173.

Research output: Contribution to journal › Article › peer-review

Open Access

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

Zhang, X., Pearsall, V. M., Carver, C. M., Atkinson, E. J., Clarkson, B. D. S., Grund, E. M., Baez-Faria, M., Pavelko, K. D., Kachergus, J. M., White, T. A., Johnson, R. K., Malo, C. S., Gonzalez-Suarez, A. M., Ayasoufi, K., Johnson, K. O., Tritz, Z. P., Fain, C. E., Khadka, R. H., Ogrodnik, M., Jurk, D., & 9 othersZhu, Y., Tchkonia, T., Revzin, A., Kirkland, J. L., Johnson, A. J., Howe, C. L., Thompson, E. A., LeBrasseur, N. K. & Schafer, M. J., Dec 2022, In: Nature communications. 13, 1, 5671.

Research output: Contribution to journal › Article › peer-review

Open Access

Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic Characteristics

Hinson, S. R., Honorat, J. A., Grund, E. M., Clarkson, B. D., Miske, R., Scharf, M., Zivelonghi, C., Al-Lozi, M. T., Bucelli, R. C., Budhram, A., Cho, T., Choi, E., Grell, J., Lopez-Chiriboga, A. S., Levin, M., Merati, M., Montalvo, M., Pittock, S. J., Wilson, M. R., Howe, C. L., & 1 othersMcKeon, A., Dec 2022, In: Annals of neurology. 92, 6, p. 1090-1101 12 p.

Research output: Contribution to journal › Article › peer-review

Spectrum of sublytic astrocytopathy in neuromyelitis optica

Guo, Y., Lennon, V. A., Parisi, J. E., Popescu, B., Vasquez, C., Pittock, S. J., Howe, C. L. & Lucchinetti, C. F., Apr 1 2022, In: Brain. 145, 4, p. 1379-1390 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Teriflunomide shifts the astrocytic bioenergetic profile from oxidative metabolism to glycolysis and attenuates TNFα-induced inflammatory responses

Kabiraj, P., Grund, E. M., Clarkson, B. D. S., Johnson, R. K., LaFrance-Corey, R. G., Lucchinetti, C. F. & Howe, C. L., Dec 2022, In: Scientific reports. 12, 1, 3049.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Citrullinated myelin induces microglial TNFα and inhibits endogenous repair in the cuprizone model of demyelination

Standiford, M. M., Grund, E. M. & Howe, C. L., Dec 2021, In: Journal of Neuroinflammation. 18, 1, 305.

Research output: Contribution to journal › Article › peer-review

Open Access

Correction for: Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis

Wilkins, J. M., Gakh, O., Kabiraj, P., McCarthy, C. B., Tobin, W. O., Howe, C. L. & Lucchinetti, C. F., 2021, In: Aging. 13, 5, p. 7707 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Leucine Zipper 4 Autoantibody: A Novel Germ Cell Tumor and Paraneoplastic Biomarker

Dubey, D., Kryzer, T., Guo, Y., Clarkson, B., Cheville, J. C., Costello, B. A., Leibovich, B. C., Algeciras-Schimnich, A., Lucchinnetti, C., Hammami, M. B., Knight, A. M., Howe, C., Lennon, V. A., McKeon, A. & Pittock, S. J., May 2021, In: Annals of neurology. 89, 5, p. 1001-1010 10 p.

Research output: Contribution to journal › Article › peer-review

Methods for intratumoral microdialysis probe targeting and validation in murine brain tumor models

Rajani, K., Olson, I., Jacobs, J. J., Riviere-cazaux, C., Burns, K., Carlstrom, L., Schroeder, M., Oh, J., Howe, C. L., Rahman, M., Sarkaria, J. N., Elmquist, W. F. & Burns, T. C., Nov 1 2021, In: Journal of Neuroscience Methods. 363, 109321.

Research output: Contribution to journal › Article › peer-review

Microdialysis and microperfusion electrodes in neurologic disease monitoring

Stangler, L. A., Kouzani, A., Bennet, K. E., Dumee, L., Berk, M., Worrell, G. A., Steele, S., Burns, T. C. & Howe, C. L., Dec 2021, In: Fluids and barriers of the CNS. 18, 1, 52.

Research output: Contribution to journal › Review article › peer-review

Open Access

2020

Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis

Dubey, D., Wilson, M. R., Clarkson, B., Giannini, C., Gandhi, M., Cheville, J., Lennon, V. A., Eggers, S., Devine, M. F., Mandel-Brehm, C., Kryzer, T., Hinson, S. R., Khazaie, K., Hales, C., Kattah, J., Pavelko, K. D., Andrews, P., Eaton, J. E., Jitprapaikulsan, J., Mills, J. R., & 13 othersFlanagan, E. P., Zekeridou, A., Leibovich, B., Fryer, J., Torre, M., Kaufman, C., Thoreson, J. B., Sagen, J., Linnoila, J. J., Derisi, J. L., Howe, C. L., McKeon, A. & Pittock, S. J., Nov 2020, In: JAMA neurology. 77, 11, p. 1420-1429 10 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Remyelination-promoting dna aptamer conjugate myaptavin-3064 binds to adult oligodendrocytes in vitro

Fereidan-Esfahani, M., Yue, W. Y., Wilbanks, B., Johnson, A. J., Warrington, A. E., Howe, C. L., Rodriguez, M. & Maher, L. J., Nov 2020, In: Pharmaceuticals. 13, 11, p. 1-11 11 p., 0403.

Research output: Contribution to journal › Article › peer-review

Open Access

Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis

Wilkins, J. M., Gakh, O., Kabiraj, P., McCarthy, C. B., Tobin, W. O., Howe, C. L. & Lucchinetti, C. F., Jul 31 2020, In: Aging. 12, 14, p. 15134-15156 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2019

Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome

Clarkson, B. D. S., LaFrance-Corey, R. G., Kahoud, R. J., Farias-Moeller, R., Payne, E. T. & Howe, C. L., Apr 2019, In: Annals of neurology. 85, 4, p. 526-537 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

IgM natural autoantibodies in physiology and the treatment of disease

Fereidan-Esfahani, M., Nayfeh, T., Warrington, A., Howe, C. L. & Rodriguez, M., 2019, Methods in Molecular Biology. Humana Press Inc., p. 53-81 29 p. (Methods in Molecular Biology; vol. 1904).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Scopus citations

Systemic evidence of acute seizure-associated elevation in serum neuronal injury biomarker in patients with temporal lobe epilepsy

Kunda, S., Lafrance-Corey, R. G., Khadjevand, F., Worrell, G. A. & Howe, C. L., Jul 25 2019, In: Acta Epileptologica. 1, 1, 2.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection-related epilepsy syndrome

Farias-Moeller, R., LaFrance-Corey, R., Bartolini, L., Wells, E. M., Baker, M., Doslea, A., Suslovic, W., Greenberg, J., Carpenter, J. L. & Howe, C. L., Sep 2018, In: Epilepsia. 59, 9, p. 1753-1763 11 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Neuromyelitis Optica and Herpes Simplex Virus 2

Vanessa Marin Collazo, I., Howe, C. L., Lucchinetti, C. F. & Oliver Tobin, W., 2018, In: Neurologist. 23, 3, p. 92-93 2 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons

Clarkson, B. D. S., Patel, M. S., LaFrance-Corey, R. G. & Howe, C. L., Feb 2018, In: Annals of Clinical and Translational Neurology. 5, 2, p. 172-185 14 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2017

Inflammatory cytokine-induced changes in neural network activity measured by waveform analysis of high-content calcium imaging in murine cortical neurons

Clarkson, B. D. S., Kahoud, R. J., McCarthy, C. B. & Howe, C. L., Dec 1 2017, In: Scientific reports. 7, 1, 9037.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

Howe, C. L., LaFrance-Corey, R. G., Goddery, E. N., Johnson, R. K. & Mirchia, K., Dec 4 2017, In: Journal of Neuroinflammation. 14, 1, 238.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

Guo, Y., Weigand, S. D., Popescu, B. F., Lennon, V. A., Parisi, J. E., Pittock, S. J., Parks, N. E., Clardy, S. L., Howe, C. L. & Lucchinetti, C. F., Apr 1 2017, In: Acta neuropathologica. 133, 4, p. 597-612 16 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2016

Febrile infection-related epilepsy syndrome treated with anakinra

Kenney-Jung, D. L., Vezzani, A., Kahoud, R. J., LaFrance-Corey, R. G., Ho, M. L., Muskardin, T. W., Wirrell, E. C., Howe, C. L. & Payne, E. T., Dec 1 2016, In: Annals of neurology. 80, 6, p. 939-945 7 p.

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

Wang, Y., Cao, Y., Mangalam, A. K., Guo, Y., LaFrance-Corey, R. G., Gamez, J. D., Atanga, P. A., Clarkson, B. D., Zhang, Y., Wang, E., Angom, R. S., Dutta, K., Ji, B., Pirko, I., Lucchinetti, C. F., Howe, C. L. & Mukhopadhyay, D., 2016, In: Journal of cell science. 129, 20, p. 3911-3921 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Neuroprotection mediated by inhibition of calpain during acute viral encephalitis

Howe, C. L., Lafrance-Corey, R. G., Mirchia, K., Sauer, B. M., McGovern, R. M., Reid, J. M. & Buenz, E. J., Jun 27 2016, In: Scientific reports. 6, 28699.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2015

NFΚB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG

Walker-Caulfield, M. E., Guo, Y., Johnson, R. K., McCarthy, C. B., Fitz-Gibbon, P. D., Lucchinetti, C. F. & Howe, C. L., Sep 30 2015, In: Journal of Neuroinflammation. 12, 1, 185.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2014

Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures

Howe, C. L., Kaptzan, T., Magaña, S. M., Ayers-Ringler, J. R., Lafrance-Corey, R. G. & Lucchinetti, C. F., May 2014, In: Glia. 62, 5, p. 692-708 17 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

2013

Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice

Bergstrom, R. A., Choi, J. H., Manduca, A., Shin, H. S., Worrell, G. A. & Howe, C. L., 2013, In: Scientific reports. 3, 1483.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Axons are injured by antigen-specific CD8⁺ T cells through a MHC class I- and granzyme B-dependent mechanism

Sauer, B. M., Schmalstieg, W. F. & Howe, C. L., Nov 2013, In: Neurobiology of Disease. 59, p. 194-205 12 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Influenza vaccine and Guillain-Barré syndrome: Making informed decisions

Poland, G. A., Poland, C. M. & Howe, C. L., 2013, In: The Lancet. 381, 9876, p. 1437-1439 3 p.

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

2012

Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection

Howe, C. L., Lafrance-Corey, R. G., Sundsbak, R. S., Sauer, B. M., Lafrance, S. J., Buenz, E. J. & Schmalstieg, W. F., 2012, In: Scientific reports. 2, 545.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain

Howe, C. L., LaFrance-Corey, R. G., Sundsbak, R. S. & LaFrance, S. J., Mar 9 2012, In: Journal of Neuroinflammation. 9, 560.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

2011

Erratum: Tumor necrosis factor α is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis (Brain Pathology (2009) 19 (12-26))

Rodriguez, M., Zoecklein, L., Papke, L., Gamez, J., Denic, A., Macura, S. & Howe, C., Jul 2011, In: Brain Pathology. 21, 4, p. 477 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Isolation of brain-infiltrating leukocytes

Lafrance-Corey, R. G. & Howe, C. L., Jun 2011, In: Journal of Visualized Experiments. 52, e2747.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Neuromyelitis optica unique area postrema lesions: Nausea, vomiting, and pathogenic implications

Popescu, B. F. G., Lennon, V. A., Parisi, J. E., Howe, C. L., Weigand, S. D., Cabrera-Gómez, J. A., Newell, K., Mandler, R. N., Pittock, S. J., Weinshenker, B. G. & Lucchinetti, C. F., Apr 5 2011, In: Neurology. 76, 14, p. 1229-1237 9 p.

Research output: Contribution to journal › Article › peer-review

190 Scopus citations

Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice

Nageswara Rao, A. A., Ye, H., Decker, P. A., Howe, C. L. & Wetmore, C., Nov 2011, In: Journal of neuro-oncology. 105, 2, p. 191-198 8 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures

German, C. L., Sauer, B. M. & Howe, C. L., Aug 15 2011, In: Experimental Cell Research. 317, 14, p. 1955-1969 15 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2010

CD8⁺ T cells cause disability and axon loss in a mouse model of multiple sclerosis

Deb, C., Lafrance-Corey, R. G., Schmalstieg, W. F., Sauer, B. M., Wang, H., German, C. L., Windebank, A. J., Rodriguez, M. & Howe, C. L., 2010, In: PloS one. 5, 8, e12478.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Erratum: Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC (The FASEB Journal (2006) 20, 13 (2408-2410) DOI: 10.1096/fj.06-6171fje)

Blocki, F. A., Radhakrishnan, S., Van Keulen, V. P., Heckman, K. L., Ciric, B., Howe, C. L., Rodriguez, M., Kwon, E. & Pease, L. R., Jun 2010, In: FASEB Journal. 24, 6, p. 2135-2136 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Erratum to Preparation of biologically active subcellular fractions using the Balch homogenizer [Anal. Biochem. 394, (2009), 117-124]

German, C. L. & Howe, C. L., May 2010, In: Analytical Biochemistry. 400, 2, p. 310 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Lacerda-Queiroz, N., Rodrigues, D. H., Vilela, M. C., Miranda, A. S. D., Amaral, D. C. G., Camargos, E. R. D. S., Carvalho, L. J. D. M., Howe, C. L., Teixeira, M. M. & Teixeira, A. L., Jul 2010, In: Experimental Parasitology. 125, 3, p. 271-278 8 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells (The Journal of Immunology (2008) 181, (7863-7872))

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Rodriguez, M., Pease, L. R. & Colonna, M., Jun 1 2010, In: Journal of Immunology. 184, 11, p. 6557 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

2009

Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection

Buenz, E. J., Sauer, B. M., LaFrance-Corey, R. G., Deb, C., Denic, A., German, C. L. & Howe, C. L., Aug 2009, In: American Journal of Pathology. 175, 2, p. 668-684 17 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis

Deb, C., LaFrance-Corey, R. G., Zoecklein, L., Papke, L., Rodriguez, M. & Howe, C. L., Sep 1 2009, In: Journal of Neuropathology and Experimental Neurology. 68, 9, p. 1037-1048 12 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes

Deb, C. & Howe, C. L., Sep 29 2009, In: Journal of neuroimmunology. 214, 1-2, p. 33-42 10 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Preparation of biologically active subcellular fractions using the Balch homogenizer

German, C. L. & Howe, C. L., Nov 1 2009, In: Analytical Biochemistry. 394, 1, p. 117-124 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Charles L Howe, PhD

Research output

Search results