Charles Howard Adler, MD, PhD

  • 23576 Citations
  • 69 Scopus h-Index
1977 …2020

Research output per year

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Research Output

2020

Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report

Ornelas, A. S., Adler, C. H., Serrano, G. E., Curry, J. R., Shill, H. A., Kopyov, O. & Beach, T. G., Feb 2020, In : Parkinsonism and Related Disorders. 71, p. 36-39 4 p.

Research output: Contribution to journalArticle

Do Parkinson disease subject and caregiver-reported Epworth sleepiness scale reponses correlate?

Shprecher, D. R., Adler, C. H., Zhang, N., Shill, H. A., Belden, C. M., Driver-Dunckley, E., Mehta, S. H., Davis, K. J., Sue, L. I., Zamrini, E. & Beach, T. G., May 2020, In : Clinical Neurology and Neurosurgery. 192, 105728.

Research output: Contribution to journalArticle

Neuropathological Findings in Parkinson's Disease With Mild Cognitive Impairment

Knox, M. G., Adler, C. H., Shill, H. A., Driver-Dunckley, E., Mehta, S. A., Belden, C., Zamrini, E., Serrano, G., Sabbagh, M. N., Caviness, J. N., Sue, L. I., Davis, K. J., Dugger, B. N. & Beach, T. G., Jan 1 2020, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer’s disease dementia

Beach, T. G., Adler, C. H., Zhang, N., Serrano, G. E., Sue, L. I., Driver-Dunckley, E., Mehta, S. H., Zamrini, E. E., Sabbagh, M. N., Shill, H. A., Belden, C. M., Shprecher, D. R., Caselli, R. J., Reiman, E. M., Davis, K. J., Long, K. E., Nicholson, L. R., Intorcia, A. J., Glass, M. J., Walker, J. E. & 4 others, Callan, M. M., Oliver, J. C., Arce, R. & Gerkin, R. C., Apr 2020, In : PloS one. 15, 4, e0231720.

Research output: Contribution to journalArticle

Open Access
2019

Brain Lewy-Type Synucleinopathy Density Is Associated with a Lower Prevalence of Atherosclerotic Cardiovascular Disease Risk Factors in Patients with Parkinson's Disease

Driver-Dunckley, E. M., Zhang, N., Adler, C. H., Serrano, G. E., Sue, L. I., Shill, H. A., Mehta, S., Belden, C. M., Zamrini, E. Y., Davis, K. & Beach, T. G., Jan 1 2019, In : Journal of Parkinson's disease. 9, 3, p. 543-552 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Contrast Acuity With Different Colors in Parkinson's Disease

Gupta, H. V., Zhang, N., Driver-Dunckley, E. M., Mehta, S., Beach, T. G. & Adler, C. H., Jan 1 2019, (Accepted/In press) In : Movement Disorders Clinical Practice.

Research output: Contribution to journalArticle

Corrigendum: Guidance for switching from off-label antipsychotics to pimavanserin for Parkinson's disease psychosis: An expert consensus (CNS Spectrums (2018) 23:6 (402-413) DOI: 10.1017/S1092852918001359)

Black, K. J., Nasrallah, H., Isaacson, S., Stacy, M., Pahwa, R., Adler, C. H., Alva, G., Cooney, J. W., Kremens, D., Menza, M. A., Meyer, J. M., Patkar, A. A., Simuni, T., Morrissette, D. A. & Stahl, S. M., Oct 1 2019, In : CNS Spectrums. 24, 5, p. 574-575 2 p.

Research output: Contribution to journalComment/debate

Open Access

Faster cognitive decline in dementia due to Alzheimer disease with clinically undiagnosed Lewy body disease

Malek-Ahmadi, M., Beach, T. G., Zamrini, E., Adler, C. H., Sabbagh, M. N., Shill, H. A., Jacobson, S. A., Belden, C. M., Caselli, R. J., Woodruff, B. K., Rapscak, S. Z., Ahern, G. L., Shi, J., Caviness, J. N., Driver-Dunckley, E., Mehta, S. H., Shprecher, D. R., Spann, B. M., Tariot, P., Davis, K. J. & 16 others, Long, K. E., Nicholson, L. R., Intorcia, A., Glass, M. J., Walker, J. E., Callan, M., Curry, J., Cutler, B., Oliver, J., Arce, R., Walker, D. G., Lue, L. F., Serrano, G. E., Sue, L. I., Chen, K. & Reiman, E. M., Jan 1 2019, In : PloS one. 14, 6, e0217566.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Feasibility of repeat and bilateral submandibular gland needle biopsies in Parkinson's disease

Adler, C. H., Serrano, G. E., Zhang, N., Hinni, M. L., Lott, D. G., Mehta, S. H., Sue, L. I., Intorcia, A. & Beach, T. G., Nov 2019, In : Parkinsonism and Related Disorders. 68, p. 69-72 4 p.

Research output: Contribution to journalArticle

Minimal clinically important change in patients with cervical dystonia: Results from the CD PROBE study

Dashtipour, K., Mari, Z., Jankovic, J., Adler, C. H., Schwartz, M. & Brin, M. F., Oct 15 2019, In : Journal of the neurological sciences. 405, 116413.

Research output: Contribution to journalArticle

Open Access

Regional neuropathology distribution and verbal fluency impairments in Parkinson's disease

El-Nazer, R., Adler, C. H., Beach, T. G., Belden, C. M., Artz, J., Shill, H. A., Driver-Dunckley, E., Mehta, S. H., Sabbagh, M. N., Serrano, G. E., Sue, L. I., Zamrini, E. & Benge, J. F., Aug 2019, In : Parkinsonism and Related Disorders. 65, p. 73-78 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Risk of Parkinson's disease dementia related to level I MDS PD-MCI

on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”, Mar 2019, In : Movement Disorders. 34, 3, p. 430-435 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Tau immunoreactivity in peripheral tissues of human aging and select tauopathies

Dugger, B. N., Hoffman, B. R., Scroggins, A., Serrano, G. E., Adler, C. H., Shill, H. A., Belden, C. M., Sabbagh, M. N., Caviness, J. N., Driver-Dunckley, E. M. & Beach, T. G., Mar 23 2019, In : Neuroscience Letters. 696, p. 132-139 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tau positron-emission tomography in former national football league players

Stern, R. A., Adler, C. H., Chen, K., Navitsky, M., Luo, J., Dodick, D. W., Alosco, M. L., Tripodis, Y., Goradia, D. D., Martin, B., Mastroeni, D., Fritts, N. G., Jarnagin, J., Devous, M. D., Mintun, M. A., Pontecorvo, M. J., Shenton, M. E. & Reiman, E. M., May 2 2019, In : New England Journal of Medicine. 380, 18, p. 1716-1725 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Unified staging system for Lewy body disorders: Clinicopathologic correlations and comparison to Braak staging

Adler, C. H., Beach, T. G., Zhang, N., Shill, H. A., Driver-Dunckley, E., Caviness, J. N., Mehta, S. H., Sabbagh, M. N., Serrano, G. E., Sue, L. I., Belden, C. M., Powell, J., Jacobson, S. A., Zamrini, E., Shprecher, D., Davis, K. J., Dugger, B. N. & Hentz, J. G., Oct 1 2019, In : Journal of Neuropathology and Experimental Neurology. 78, 10, p. 891-899 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Using global team science to identify genetic parkinson's disease worldwide

MJFF Global Genetic Parkinson's Disease Study Group, Aug 2019, In : Annals of neurology. 86, 2, p. 153-157 5 p.

Research output: Contribution to journalEditorial

1 Scopus citations
2018

Characterization of the symptoms of neurogenic orthostatic hypotension and their impact from a survey of patients and caregivers

Claassen, D. O., Adler, C. H., Hewitt, L. A. & Gibbons, C., Aug 25 2018, In : BMC Neurology. 18, 1, 125.

Research output: Contribution to journalArticle

9 Scopus citations

Consensus-based attributes for identifying patients with spasmodic dysphonia and other voice disorders

Ludlow, C. L., Domangue, R., Sharma, D., Jinnah, H. A., Perlmutter, J. S., Berke, G., Sapienza, C., Smith, M. E., Blumin, J. H., Kalata, C. E., Blindauer, K., Johns, M., Hapner, E., Harmon, A., Paniello, R., Adler, C. H., Crujido, L., Lott, D. G., Bansberg, S. F., Barone, N. & 2 others, Drulia, T. & Stebbins, G., Aug 2018, In : JAMA Otolaryngology - Head and Neck Surgery. 144, 8, p. 657-665 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson's disease

Ortuño-Lizarán, I., Esquiva, G., Beach, T. G., Serrano, G. E., Adler, C. H., Lax, P. & Cuenca, N., Feb 23 2018, In : Acta Neuropathologica Communications. 6, 1, 90.

Research output: Contribution to journalArticle

9 Scopus citations

Detecting Mild Cognitive Deficits in Parkinson's Disease: Comparison of Neuropsychological Tests

on behalf of the IPMDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”, Nov 2018, In : Movement Disorders. 33, 11, p. 1750-1759 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

Dong, X., Liao, Z., Gritsch, D., Hadzhiev, Y., Bai, Y., Locascio, J. J., Guennewig, B., Liu, G., Blauwendraat, C., Wang, T., Adler, C. H., Hedreen, J. C., Faull, R. L. M., Frosch, M. P., Nelson, P. T., Rizzu, P., Cooper, A. A., Heutink, P., Beach, T. G., Mattick, J. S. & 2 others, Müller, F. & Scherzer, C. R., Oct 1 2018, In : Nature Neuroscience. 21, 10, p. 1482-1492 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Erratum to: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease (Nature Neuroscience, (2018), 21, 10, (1482-1492), 10.1038/s41593-018-0223-0)

Dong, X., Liao, Z., Gritsch, D., Hadzhiev, Y., Bai, Y., Locascio, J. J., Guennewig, B., Liu, G., Blauwendraat, C., Wang, T., Adler, C. H., Hedreen, J. C., Faull, R. L. M., Frosch, M. P., Nelson, P. T., Rizzu, P., Cooper, A. A., Heutink, P., Beach, T. G., Mattick, J. S. & 2 others, Müller, F. & Scherzer, C. R., Jan 1 2018, (Accepted/In press) In : Nature Neuroscience.

Research output: Contribution to journalArticle

Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson's Disease: The Systemic Synuclein Sampling Study (S4)

Systemic sSynuclein Sampling study, Jan 1 2018, In : Journal of Parkinson's Disease. 8, 4, p. 517-527 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Guidance for switching from off-label antipsychotics to pimavanserin for Parkinson's disease psychosis: An expert consensus

Black, K. J., Nasrallah, H., Isaacson, S., Stacy, M., Pahwa, R., Adler, C. H., Alva, G., Cooney, J. W., Kremens, D., Menza, M. A., Meyer, J. M., Patkar, A. A., Simuni, T., Morrissette, D. A. & Stahl, S. M., Dec 1 2018, In : CNS Spectrums. 23, 6, p. 402-413 12 p.

Research output: Contribution to journalArticle

Immunohistochemical method and histopathology judging for the systemic synuclein sampling study (S4)

Beach, T. G., Serrano, G. E., Kremer, T., Canamero, M., Dziadek, S., Sade, H., Derkinderen, P., Corbillé, A. G., Letournel, F., Munoz, D. G., White, C. L., Schneider, J., Crary, J. F., Sue, L. I., Adler, C. H., Glass, M. J., Intorcia, A. J., Walker, J. E., Foroud, T., Coffey, C. S. & 13 others, Ecklund, D., Riss, H., Goßmann, J., König, F., Kopil, C. M., Arnedo, V., Riley, L., Linder, C., Dave, K. D., Jennings, D., Seibyl, J., Mollenhauer, B. & Chahine, L., Jan 1 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 9, p. 793-802 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Importance of low diagnostic Accuracy for early Parkinson's disease

Beach, T. G. & Adler, C. H., Jan 1 2018, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

9 Scopus citations

Lewy body pathology in Alzheimer's disease: A clinicopathological prospective study

Savica, R., Beach, T. G., Hentz, J. G., Sabbagh, M. N., Serrano, G. E., Sue, L. I., Dugger, B. N., Shill, H. A., Driver-Dunckley, E. M., Caviness, J. N., Mehta, S., Jacobson, S. A., Belden, C. M., Davis, K. J., Zamrini, E., Shprecher, D. R. & Adler, C. H., Jan 1 2018, (Accepted/In press) In : Acta Neurologica Scandinavica.

Research output: Contribution to journalArticle

6 Scopus citations

Movement disorder society criteria for clinically established early Parkinson's disease

Berg, D., Adler, C. H., Bloem, B. R., Chan, P., Gasser, T., Goetz, C. G., Halliday, G., Lang, A. E., Lewis, S., Li, Y., Liepelt-Scarfone, I., Litvan, I., Marek, K., Maetzler, C., Mi, T., Obeso, J., Oertel, W., Olanow, C. W., Poewe, W., Rios-Romenets, S. & 8 others, Schäffer, E., Seppi, K., Heim, B., Slow, E., Stern, M., Bledsoe, I. O., Deuschl, G. & Postuma, R. B., Oct 2018, In : Movement Disorders. 33, 10, p. 1643-1646 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Phosphorylated α-synuclein in the retina is a biomarker of Parkinson's disease pathology severity

Ortuño-Lizarán, I., Beach, T. G., Serrano, G. E., Walker, D. G., Adler, C. H. & Cuenca, N., Aug 1 2018, In : Movement Disorders. 33, 8, p. 1315-1324 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosis

Shprecher, D. R., Adler, C. H., Zhang, N., Hentz, J. G., Serrano, G. E., Dugger, B. N., Shill, H. A., Savica, R., Caviness, J. N., Sabbagh, M. N., Belden, C. M., Driver-Dunckley, E. M., Mehta, S., Sue, L. I., Davis, K. J., Zamrini, E. & Beach, T. G., Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

7 Scopus citations

Probing the striatal dopamine system for a putative neuroprotective effect of deep brain stimulation in Parkinson's disease

Pal, G., Ouyang, B., Verhagen, L., Serrano, G., Shill, H. A., Adler, C. H., Beach, T. G. & Kordower, J. H., Jan 1 2018, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

3 Scopus citations

Protein phosphatase 2A and its methylation modulating enzymes LCMT-1 and PME-1 are dysregulated in tauopathies of progressive supranuclear palsy and Alzheimer disease

Park, H. J., Lee, K. W., Oh, S., Yan, R., Zhang, J., Beach, T. G., Adler, C. H., Voronkov, M., Braithwaite, S. P., Stock, J. B. & Mouradian, M. M., Feb 1 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 2, p. 139-148 10 p., nlx110.

Research output: Contribution to journalArticle

7 Scopus citations

The Yips: Methods to Identify Golfers with a Dystonic Etiology/Golfer's Cramp

Adler, C. H., Temkit, MH., Crews, D., McDaniel, T., Tucker, J., Hentz, J. G., Marquardt, C., Abraham, D. & Caviness, J. N., Nov 1 2018, In : Medicine and Science in Sports and Exercise. 50, 11, p. 2226-2230 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Weight Loss in Parkinson's Disease: No Evidence for Role of Small Intestinal Bacterial Overgrowth

DiBaise, J. D., Crowell, M. D., Driver-Dunckley, E. M., Mehta, S., Hoffman-Snyder, C., Lin, T. & Adler, C. H., Jan 1 2018, In : Journal of Parkinson's Disease. 8, 4, p. 571-581 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Association Between Pathology and Electroencephalographic Activity in Parkinson’s Disease

Caviness, J. N., Beach, T. G., Hentz, J. G., Shill, H. A., Driver-Dunckley, E. M. & Adler, C. H., Feb 1 2017, (Accepted/In press) In : Clinical EEG and Neuroscience.

Research output: Contribution to journalArticle

Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology

Walker, D. G., Lue, L. F., Tang, T. M., Adler, C. H., Caviness, J. N., Sabbagh, M. N., Serrano, G. E., Sue, L. I. & Beach, T. G., Jun 1 2017, In : Neurobiology of Aging. 54, p. 175-186 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Does Parkinson’s disease start in the gut?

Lionnet, A., Leclair-Visonneau, L., Neunlist, M., Murayama, S., Takao, M., Adler, C. H., Derkinderen, P. & Beach, T. G., Oct 16 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-12 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Essential Tremor and Depression

Aslam, S., Zhang, N., Adler, C. H., Caviness, J. N., Driver-Dunckley, E. M., Mehta, S., Sabbagh, M. N., Belden, C., Zamrini, E., Beach, T. G. & Shill, H. A., Nov 1 2017, In : Movement Disorders Clinical Practice. 4, 6, p. 838-842 5 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

GBA mutations in Parkinson disease: earlier death but similar neuropathological features

Adler, C. H., Beach, T. G., Shill, H. A., Caviness, J. N., Driver-Dunckley, E., Sabbagh, M. N., Patel, A., Sue, L. I., Serrano, G., Jacobson, S. A., Davis, K., Belden, C. M., Dugger, B. N., Paciga, S. A., Winslow, A. R., Hirst, W. D. & Hentz, J. G., Nov 2017, In : European Journal of Neurology. 24, 11, p. 1363-1368 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hypermethylation of synphilin-1, alpha-synuclein-interacting protein (SNCAIP) gene in the cerebral cortex of patients with sporadic Parkinson’s disease

Dashtipour, K., Tafreshi, A., Adler, C. H., Beach, T., Chen, X., Serrano, G., Tashiro, S. & Wang, C., Jul 1 2017, In : Brain Sciences. 7, 7, 74.

Research output: Contribution to journalArticle

3 Scopus citations

Improved diagnosis of Parkinson's disease from a detailed olfactory phenotype

Gerkin, R. C., Adler, C. H., Hentz, J. G., Shill, H. A., Driver-Dunckley, E. M., Mehta, S., Sabbagh, M. N., Caviness, J. N., Dugger, B. N., Serrano, G., Belden, C., Smith, B. H., Sue, L., Davis, K. J., Zamrini, E. & Beach, T. G., 2017, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

5 Scopus citations

Mild cognitive impairment as a risk factor for Parkinson's disease dementia

on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”, Jul 2017, In : Movement Disorders. 32, 7, p. 1056-1065 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Multicenter observational study of abobotulinumtoxinA neurotoxin in cervical dystonia: The ANCHOR-CD registry

Trosch, R. M., Espay, A. J., Truong, D., Gil, R., Singer, C., LeWitt, P. A., Lew, M. F., Tagliati, M., Adler, C. H., Chen, J. J., Marchese, D. & Comella, C. L., May 15 2017, In : Journal of the Neurological Sciences. 376, p. 84-90 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Peripheral synucleinopathy in early Parkinson's disease: Submandibular gland needle biopsy findings

Adler, C. H., Dugger, B. N., Hentz, J. G., Hinni, M. L., Lott, D. G., Driver-Dunckley, E. M., Mehta, S., Serrano, G., Sue, L. I., Duffy, A., Intorcia, A., Filon, J., Pullen, J., Walker, D. G. & Beach, T. G., May 1 2017, In : Movement Disorders. 32, 5, p. 722-723 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Spasmodic Dysphonia: A Review. Part 1: Pathogenic Factors

Hintze, J. M., Ludlow, C. L., Bansberg, S. F., Adler, C. H. & Lott, D. G., Oct 1 2017, In : Otolaryngology - Head and Neck Surgery (United States). 157, 4, p. 551-557 7 p.

Research output: Contribution to journalReview article

8 Scopus citations

Spasmodic Dysphonia: A Review. Part 2: Characterization of Pathophysiology

Hintze, J. M., Ludlow, C. L., Bansberg, S. F., Adler, C. H. & Lott, D. G., Oct 1 2017, In : Otolaryngology - Head and Neck Surgery (United States). 157, 4, p. 558-564 7 p.

Research output: Contribution to journalReview article

7 Scopus citations

The search for a peripheral biopsy indicator of a-synuclein pathology for Parkinson disease

Lee, J. M., Derkinderen, P., Kordower, J. H., Freeman, R., Munoz, D. G., Kremer, T., Zago, W., Hutten, S. J., Adler, C. H., Serrano, G. E. & Beach, T. G., 2017, In : Journal of Neuropathology and Experimental Neurology. 76, 1, p. 2-15 14 p.

Research output: Contribution to journalReview article

43 Scopus citations

The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease

Visanji, N. P., Mollenhauer, B., Beach, T. G., Adler, C. H., Coffey, C. S., Kopil, C. M., Dave, K. D., Foroud, T., Chahine, L. & Jennings, D., Apr 1 2017, In : Biomarkers in Medicine. 11, 4, p. 359-368 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2016

Abolishing the 1-year rule: How much evidence will be enough?

Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Marek, K., Litvan, I., Lang, A. E., Halliday, G., Goetz, C. G., Gasser, T., Dubois, B., Chan, P., Bloem, B. R., Adler, C. H. & Deuschl, G., Nov 1 2016, In : Movement Disorders. 31, 11, p. 1623-1627 5 p.

Research output: Contribution to journalArticle

27 Scopus citations