Arthur Beyder

2023

Intestinal enteroendocrine cells rely on ryanodine and IP₃ calcium store receptors for mechanotransduction

Knutson, K. R., Whiteman, S. T., Alcaino, C., Mercado-Perez, A., Finholm, I., Serlin, H. K., Bellampalli, S. S., Linden, D. R., Farrugia, G. & Beyder, A., Jan 15 2023, In: Journal of Physiology. 601, 2, p. 287-305 19 p.

Research output: Contribution to journal › Article › peer-review

2022

Capsaicin as an amphipathic modulator of Na_V1.5 mechanosensitivity

Cowan, L. M., Strege, P. R., Rusinova, R., Andersen, O. S., Farrugia, G. & Beyder, A., 2022, In: Channels. 16, 1, p. 9-26 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model

Aghababaie, Z., O'Grady, G., Nisbet, L. A., Modesto, A. E., Chan, C. H. A., Matthee, A., Amirapu, S., Beyder, A., Farrugia, G., Asirvatham, S. J., Sands, G. B., Paskaranandavadivel, N., Cheng, L. K. & Angeli-Gordon, T. R., Dec 2022, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 323, 6, p. G640-G652

Research output: Contribution to journal › Article › peer-review

Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer

Katsuta, E., Takabe, K., Vujcic, M., Gottlieb, P. A., Dai, T., Mercado-Perez, A., Beyder, A., Wang, Q. & Opyrchal, M., Sep 2022, In: International journal of molecular sciences. 23, 17, 9909.

Research output: Contribution to journal › Article › peer-review

Open Access

Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity

Treichel, A. J., Finholm, I., Knutson, K. R., Alcaino, C., Whiteman, S. T., Brown, M. R., Matveyenko, A., Wegner, A., Kacmaz, H., Mercado-Perez, A., Gajdos, G. B., Ordog, T., Grover, M., Szurszewski, J., Linden, D. R., Farrugia, G. & Beyder, A., Feb 2022, In: Gastroenterology. 162, 2, p. 535-547.e13

Research output: Contribution to journal › Article › peer-review

Studying Murine Small Bowel Mechanosensing of Luminal Particulates

Mercado-Perez, A., Wegner, A., Knutson, K., Zumchak, M. & Beyder, A., Mar 1 2022, In: Journal of Visualized Experiments. 2022, 181, e63697.

Research output: Contribution to journal › Article › peer-review

Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model

Aghababaie, Z., Cheng, L. K., Paskaranandavadivel, N., Avci, R., Chan, C. H. A., Matthee, A., Amirapu, S., Asirvatham, S. J., Farrugia, G., Beyder, A., O’Grady, G. & Angeli-Gordon, T. R., Apr 2022, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 322, 4, p. G431-G445

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A simple automated approach to measure mouse whole gut transit

Kacmaz, H., Alto, A., Knutson, K., Linden, D. R., Gibbons, S. J., Farrugia, G. & Beyder, A., Feb 2021, In: Neurogastroenterology and Motility. 33, 2, e13994.

Research output: Contribution to journal › Article › peer-review

Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach

Aghababaie, Z., Paskaranandavadivel, N., Amirapu, S., Chan, C. H. A., Du, P., Asirvatham, S. J., Farrugia, G., Beyder, A., O’Grady, G., Cheng, L. K. & Angeli-Gordon, T. R., Apr 2021, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 320, 4, p. G573-G585

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease

Zheng, T., Ellinghaus, D., Juzenas, S., Cossais, F., Burmeister, G., Mayr, G., Jørgensen, I. F., Teder-Laving, M., Skogholt, A. H., Chen, S., Strege, P. R., Ito, G., Banasik, K., Becker, T., Bokelmann, F., Brunak, S., Buch, S., Clausnitzer, H., Datz, C., Degenhardt, F., & 65 othersDoniec, M., Erikstrup, C., Esko, T., Forster, M., Frey, N., Fritsche, L. G., Gabrielsen, M. E., Gräßle, T., Gsur, A., Gross, J., Hampe, J., Hendricks, A., Hinz, S., Hveem, K., Jongen, J., Junker, R., Karlsen, T. H., Hemmrich-Stanisak, G., Kruis, W., Kupcinskas, J., Laubert, T., Rosenstiel, P. C., Röcken, C., Laudes, M., Leendertz, F. H., Lieb, W., Limperger, V., Margetis, N., Mätz-Rensing, K., Németh, C. G., Ness-Jensen, E., Nowak-Göttl, U., Pandit, A., Pedersen, O. B., Peleikis, H. G., Peuker, K., Rodriguez, C. L., Rühlemann, M. C., Schniewind, B., Schulzky, M., Skieceviciene, J., Tepel, J., Thomas, L., Uellendahl-Werth, F., Ullum, H., Vogel, I., Volzke, H., Von Fersen, L., Von Schönfels, W., Vanderwerff, B., Wilking, J., Wittig, M., Zeissig, S., Zobel, M., Zawistowski, M., Vacic, V., Sazonova, O., Noblin, E. S., Farrugia, G., Beyder, A., Wedel, T., Kahlke, V., Schafmayer, C., D'Amato, M. & Franke, A., Aug 1 2021, In: Gut. 70, 8, p. 1538-1549 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor

Mazzaferro, S., Whiteman, S. T., Alcaino, C., Beyder, A. & Sine, S. M., Feb 2021, In: Cellular and Molecular Life Sciences. 78, 4, p. 1565-1575 11 p.

Research output: Contribution to journal › Article › peer-review

2020

Identification of intrinsic primary afferent neurons in mouse jejunum

Melo, C. G. D. S., Nicolai, E. N., Alcaino, C., Cassmann, T. J., Whiteman, S. T., Wright, A. M., Miller, K. E., Gibbons, S. J., Beyder, A. & Linden, D. R., Dec 2020, In: Neurogastroenterology and Motility. 32, 12, e13989.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

MicroRNA overexpression in slow transit constipation leads to reduced Na v 1.5 current and altered smooth muscle contractility

Mazzone, A., Strege, P. R., Gibbons, S. J., Alcaino, C., Joshi, V., Haak, A. J., Tschumperlin, D. J., Bernard, C. E., Cima, R. R., Larson, D. W., Chua, H. K., Graham, R. P., El Refaey, M., Mohler, P. J., Hayashi, Y., Ordog, T., Calder, S., Du, P., Farrugia, G. & Beyder, A., May 1 2020, In: Gut. 69, 5, p. 868-876 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2019

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D. A., Yaqoob, U., Cao, S., Revzin, A., Beyder, A., Wang, R. A., Kamath, P. S., Kubes, P. & Shah, V. H., Jul 2019, In: Gastroenterology. 157, 1, p. 193-209.e9

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R. D., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In: Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

SCN5A mutation G615E results in Na_V1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

Strege, P. R., Mercado-Perez, A., Mazzone, A., Saito, Y. A., Bernard, C. E., Farrugia, G. & Beyder, A., Jan 1 2019, In: Channels. 13, 1, p. 287-298 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Telocytes express ANO-1-encoded chloride channels in canine ventricular myocardium

DeSimone, C. V., McLeod, C. J., Gomez Pinilla, P. J., Beyder, A., Farrugia, G., Asirvatham, S. J. & Kapa, S., Jun 1 2019, In: journal of arrhythmia. 35, 3, p. 515-521 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2018

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G. & Beyder, A., Aug 7 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7632-E7641

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Gut development on a full stomach

Beyder, A., Jul 1 2018, In: Nature Reviews Gastroenterology and Hepatology. 15, 7, p. 394-395 2 p.

Research output: Contribution to journal › Article › peer-review

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Na _v 1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 2018, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Whole cell electrophysiology of primary cultured murine enterochromaffin cells

Knutson, K., Strege, P. R., Li, J., Leiter, A. B., Farrugia, G. & Beyder, A., Sep 26 2018, In: Journal of Visualized Experiments. 2018, 139, e58112.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2017

EAVK segment “c” sequence confers Ca²⁺-dependent changes to the kinetics of full-length human Ano1

Strege, P. R., Gibbons, S. J., Mazzone, A., Bernard, C. E., Beyder, A. & Farrugia, G., Jun 2017, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G572-G579

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT₃ receptor expression via acetate production

Bhattarai, Y., Schmidt, B. A., Linden, D. R., Larson, E. D., Grover, M., Beyder, A., Farrugia, G. & Kashyap, P. C., 2017, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 313, 1, p. G80-G87

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Wang, F., Knutson, K., Alcaino, C., Linden, D. R., Gibbons, S. J., Kashyap, P., Grover, M., Oeckler, R., Gottlieb, P. A., Li, H. J., Leiter, A. B., Farrugia, G. & Beyder, A., Jan 1 2017, In: Journal of Physiology. 595, 1, p. 79-91 13 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4

Alcaino, C., Knutson, K., Gottlieb, P. A., Farrugia, G. & Beyder, A., May 4 2017, In: Channels (Austin, Tex.). 11, 3, p. 245-253 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Mechanosensitive Piezo Channels in the Gastrointestinal Tract

Alcaino, C., Farrugia, G. & Beyder, A., 2017, In: Current Topics in Membranes. 79, p. 219-244 26 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Sodium channel Na_V1.3 is important for enterochromaffin cell excitability and serotonin release

Strege, P. R., Knutson, K., Eggers, S. J., Li, J. H., Wang, F., Linden, D., Szurszewski, J. H., Milescu, L., Leiter, A. B., Farrugia, G. & Beyder, A., Dec 1 2017, In: Scientific reports. 7, 1, 15650.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Henström, M., Hadizadeh, F., Beyder, A., Bonfiglio, F., Zheng, T., Assadi, G., Rafter, J., Bujanda, L., Agreus, L., Andreasson, A., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Talley, N. J., Simren, M., Walter, S., Wouters, M., Farrugia, G., & 1 othersD'Amato, M., Sep 1 2017, In: Gut. 66, 9, p. 1725-1727 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2016

Expression and function of the Scn5a-encoded voltage-gated sodium channel Na_V1.5 in the rat jejunum

Beyder, A., Gibbons, S. J., Mazzone, A., Strege, P. R., Saravanaperumal, S. A., Sha, L., Higgins, S., Eisenman, S. T., Bernard, C. E., Geurts, A., Kline, C. F., Mohler, P. J. & Farrugia, G., Jan 1 2016, In: Neurogastroenterology and Motility. 28, 1, p. 64-73 10 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P. J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ordog, T., Camp, J. J., Ge, X., Bharucha, A. E., Linden, D. R., Szurszewski, J. H., Kashyap, P. C. & Farrugia, G., Jul 1 2016, In: CMGH. 2, 4, p. 454-467 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2015

A novel exon in the human Ca^2+-activated Cl^- channel Ano1 imparts greater sensitivity to intracellular Ca²⁺

Strege, P. R., Bernard, C. E., Mazzone, A., Linden, D. R., Beyder, A., Gibbons, S. J. & Farrugia, G., Nov 1 2015, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 9, p. G743-G749

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces

Simonetto, D. A., Yang, H. Y., Yin, M., de Assuncao, T. M., Kwon, J. H., Hilscher, M., Pan, S., Yang, L., Bi, Y., Beyder, A., Cao, S., Simari, R. D., Ehman, R., Kamath, P. S. & Shah, V. H., Feb 1 2015, In: Hepatology. 61, 2, p. 648-659 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells

Neshatian, L., Strege, P. R., Rhee, P. L., Kraichely, R. E., Mazzone, A., Bernard, C. E., Cima, R. R., Larson, D. W., Dozois, E. J., Kline, C. F., Mohler, P. J., Beyder, A. & Farrugia, G., Sep 15 2015, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 6, p. G506-G512

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2014

Loss-of-function of the voltage-gated sodium channel Na_V1.5 (Channelopathies) in patients with irritable bowel syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., Lindberg, G., Karling, P., Ohlsson, B., Gazouli, M., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P., & 8 othersBellini, M., Barbara, G., Camilleri, M., Locke, G. R., Talley, N. J., D'Amato, M., Ackerman, M. J. & Farrugia, G., Jun 2014, In: Gastroenterology. 146, 7, p. 1659-1668 10 p.

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

2013

Acute polyarticular gout presenting as Delirium

Wilson, M. E., Wan, S. H., Beyder, A., Osborn, T. G. & Beckman, T. J., Jun 1 2013, In: Journal of Clinical Rheumatology. 19, 4, p. 221-222 2 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings

Angeli, T. R., Du, P., Paskaranandavadivel, N., Janssen, P. W. M., Beyder, A., Lentle, R. G., Bissett, I. P., Cheng, L. K. & O'Grady, G., Sep 2013, In: Journal of Physiology. 591, 18, p. 4567-4579 13 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

2012

Large atrial myxoma causing dynamic obstruction of the mitral valve and atrial fibrillation

Beyder, A. & Klarich, K. W., Feb 2012, In: Mayo Clinic proceedings. 87, 2, p. e9

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Membrane permeable local anesthetics modulate Na_V1.5 mechanosensitivity

Beyder, A., Strege, P. R., Bernard, C. & Farrugia, G., 2012, In: Channels. 6, 4, p. 308-316 9 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Quantification of gastrointestinal sodium channelopathy

Poh, Y. C., Beyder, A., Strege, P. R., Farrugia, G. & Buist, M. L., Jan 21 2012, In: Journal of Theoretical Biology. 293, p. 41-48 8 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action

Beyder, A., Strege, P. R., Reyes, S., Bernard, C. E., Terzic, A., Makielski, J., Ackerman, M. J. & Farrugia, G., Jun 5 2012, In: Circulation. 125, 22, p. 2698-2706 9 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Ranolazine inhibits shear sensitivity of endogenous Na⁺ current and spontaneous action potentials in HL-1 cells

Strege, P., Beyder, A., Bernard, C., Crespo-Diaz, R., Behfar, A., Terzic, A., Ackerman, M. & Farrugia, G., 2012, In: Channels. 6, 6, p. 457-462 6 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2011

Altered expression of ano1 variants in human diabetic gastroparesis

Mazzone, A., Bernard, C. E., Strege, P. R., Beyder, A., Galietta, L. J. V., Pasricha, P. J., Rae, J. L., Parkman, H. P., Linden, D. R., Szurszewski, J. H., Ördög, T., Gibbons, S. J. & Farrugia, G., Apr 15 2011, In: Journal of Biological Chemistry. 286, 15, p. 13393-13403 11 p.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na⁺ channel, NA_v1.5

Strege, P. R., Bernard, C. E., Kraichely, R. E., Mazzone, A., Sha, L., Beyder, A., Gibbons, S. J., Linden, D. R., Kendrick, M. L., Sarr, M. G., Szurszewski, J. H. & Farrugia, G., Jun 2011, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6, p. G1105-G1114

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

2010

Lack of serotonin 5-HT_2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo

Tharayil, V. S., Wouters, M. M., Stanich, J. E., Roeder, J. L., Lei, S., Beyder, A., Gomez-Pinilla, P. J., Gershon, M. D., Maroteaux, L., Gibbons, S. J. & Farrugia, G., Apr 2010, In: Neurogastroenterology and Motility. 22, 4, p. 462-469+e109-e110

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Mechanosensitivity of Na_v1.5, a voltage-sensitive sodium channel

Beyder, A., Rae, J. L., Bernard, C., Strege, P. R., Sachs, F. & Farrugia, G., Dec 2010, In: Journal of Physiology. 588, 24, p. 4969-4985 17 p.

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

T-type Ca²⁺ channel modulation by otilonium bromide

Strege, P. R., Sha, L., Beyder, A., Bernard, C. E., Perez-Reyes, E., Evangelista, S., Gibbons, S. J., Szurszewski, J. H. & Farrugia, G., May 2010, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 5, p. G706-G713

Research output: Contribution to journal › Article › peer-review