Arthur Beyder

2019

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D., Yaqoob, U., Cao, S., Revzin, A., Beyder, A., Wang, R. A., Kamath, P. S., Kubes, P. & Shah, V., Jul 1 2019, In : Gastroenterology. 157, 1, p. 193-209.e9

Research output: Contribution to journal › Article

8 Scopus citations

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R. D., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journal › Article

13 Scopus citations

SCN5A mutation G615E results in Na_V1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

Strege, P. R., Mercado-Perez, A., Mazzone, A., Saito Loftus, Y. A., Bernard, C. E., Farrugia, G. & Beyder, A., Dec 1 2019, In : Channels (Austin, Tex.). 13, 1, p. 287-298 12 p.

Research output: Contribution to journal › Article

Open Access

2018

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G. & Beyder, A., Aug 7 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7632-E7641

Research output: Contribution to journal › Article

19 Scopus citations

Gut development on a full stomach

Beyder, A., Apr 20 2018, (Accepted/In press) In : Nature Reviews Gastroenterology and Hepatology. p. 1-2 2 p.

Research output: Contribution to journal › Article

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Na_v1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito Loftus, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 1 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journal › Article

9 Scopus citations

The touchy business of gastrointestinal (GI) mechanosensitivity

Treichel, A. J., Farrugia, G. & Beyder, A., Aug 15 2018, In : Brain Research. 1693, p. 197-200 4 p.

Research output: Contribution to journal › Article

2 Scopus citations

Whole cell electrophysiology of primary cultured murine enterochromaffin cells

Knutson, K., Strege, P. R., Li, J., Leiter, A. B., Farrugia, G. & Beyder, A., Sep 26 2018, In : Journal of Visualized Experiments. 2018, 139, e58112.

Research output: Contribution to journal › Article

1 Scopus citations

2017

47-Year-Old Man With Abdominal Pain and Diarrhea

Codipilly, D. C., Chedid, V. & Beyder, A., Jan 1 2017, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journal › Article

EAVK segment “c” sequence confers Ca²⁺-dependent changes to the kinetics of full-length human Ano1

Strege, P. R., Gibbons, S. J., Mazzone, A., Bernard, C. E., Beyder, A. & Farrugia, G., Jun 1 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G572-G579

Research output: Contribution to journal › Article

3 Scopus citations

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT₃ receptor expression via acetate production

Bhattarai, Y., Schmidt, B. A., Linden, D. R., Larson, E. D., Grover, M., Beyder, A., Farrugia, G. & Kashyap, P. C., 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 313, 1, p. G80-G87

Research output: Contribution to journal › Article

23 Scopus citations

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4

Alcaino, C., Knutson, K., Gottlieb, P. A., Farrugia, G. & Beyder, A., Feb 7 2017, (Accepted/In press) In : Channels. p. 1-9 9 p.

Research output: Contribution to journal › Article

11 Scopus citations

Sodium channel Na_V1.3 is important for enterochromaffin cell excitability and serotonin release

Strege, P. R., Knutson, K., Eggers, S. J., Li, J. H., Wang, F., Linden, D. R., Szurszewski, J. H., Milescu, L., Leiter, A. B., Farrugia, G. & Beyder, A., Dec 1 2017, In : Scientific Reports. 7, 1, 15650.

Research output: Contribution to journal › Article

13 Scopus citations

2016

Expression and function of the Scn5a-encoded voltage-gated sodium channel Na_V1.5 in the rat jejunum

Beyder, A., Gibbons, S. J., Mazzone, A., Strege, P. R., Saravanaperumal, S. A., Sha, L., Higgins, S., Eisenman, S. T., Bernard, C. E., Geurts, A., Kline, C. F., Mohler, P. J. & Farrugia, G., Jan 1 2016, In : Neurogastroenterology and Motility. 28, 1, p. 64-73 10 p.

Research output: Contribution to journal › Article

6 Scopus citations

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P. J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ordog, T., Camp, J. J., Ge, X., Bharucha, A. E., Linden, D. R., Szurszewski, J. H., Kashyap, P. C. & Farrugia, G., Jul 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 4, p. 454-467 14 p.

Research output: Contribution to journal › Article

12 Scopus citations

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Wang, F., Knutson, K., Alcaino, C., Linden, D. R., Gibbons, S. J., Kashyap, P. C., Grover, M., Oeckler, R., Gottlieb, P. A., Li, H. J., Leiter, A. B., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journal › Article

44 Scopus citations

Mechanosensitive Piezo Channels in the Gastrointestinal Tract

Alcaino, C., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Current Topics in Membranes.

Research output: Contribution to journal › Article

15 Scopus citations

TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Henström, M., Hadizadeh, F., Beyder, A., Bonfiglio, F., Zheng, T., Assadi, G., Rafter, J., Bujanda, L., Agreus, L., Andreasson, A., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Talley, N. J., Simren, M., Walter, S., Wouters, M., Farrugia, G. & 1 others, D'Amato, M., Dec 14 2016, (Accepted/In press) In : Gut.

Research output: Contribution to journal › Article

10 Scopus citations

2015

A novel exon in the human Ca^2+-activated Cl^- channel Ano1 imparts greater sensitivity to intracellular Ca²⁺

Strege, P. R., Bernard, C. E., Mazzone, A., Linden, D. R., Beyder, A., Gibbons, S. J. & Farrugia, G., Nov 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 9, p. G743-G749

Research output: Contribution to journal › Article

10 Scopus citations

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces

Simonetto, D. A., Yang, H. Y., Yin, M., de Assuncao, T. M., Kwon, J. H., Hilscher, M., Pan, S., Yang, L., Bi, Y., Beyder, A., Cao, S., Simari, R. D., Ehman, R., Kamath, P. S. & Shah, V. H., Feb 1 2015, In : Hepatology. 61, 2, p. 648-659 12 p.

Research output: Contribution to journal › Article

57 Scopus citations

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells

Neshatian, L., Strege, P. R., Rhee, P. L., Kraichely, R. E., Mazzone, A., Bernard, C. E., Cima, R. R., Larson, D., Dozois, E., Kline, C. F., Mohler, P. J., Beyder, A. & Farrugia, G., Sep 15 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 6, p. G506-G512

Research output: Contribution to journal › Article

10 Scopus citations

2014

Loss-of-function of the voltage-gated sodium channel Na_V1.5 (Channelopathies) in patients with irritable bowel syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., Lindberg, G., Karling, P., Ohlsson, B., Gazouli, M., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P. & 8 others, Bellini, M., Barbara, G., Camilleri, M., Locke, G. R., Talley, N. J., D'Amato, M., Ackerman, M. J. & Farrugia, G., Jun 2014, In : Gastroenterology. 146, 7, p. 1659-1668 10 p.

Research output: Contribution to journal › Article

62 Scopus citations

2013

Acute polyarticular gout presenting as Delirium

Wilson, M. E., Wan, S. H., Beyder, A., Osborn, T. G. & Beckman, T. J., Jun 1 2013, In : Journal of Clinical Rheumatology. 19, 4, p. 221-222 2 p.

Research output: Contribution to journal › Article

3 Scopus citations

The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings

Angeli, T. R., Du, P., Paskaranandavadivel, N., Janssen, P. W. M., Beyder, A., Lentle, R. G., Bissett, I. P., Cheng, L. K. & O'Grady, G., Sep 1 2013, In : Journal of Physiology. 591, 18, p. 4567-4579 13 p.

Research output: Contribution to journal › Article

41 Scopus citations

2012

Large atrial myxoma causing dynamic obstruction of the mitral valve and atrial fibrillation

Beyder, A. & Klarich, K. W., Feb 2012, In : Mayo Clinic proceedings. 87, 2, p. e9

Research output: Contribution to journal › Article

3 Scopus citations

Membrane permeable local anesthetics modulate Na_V1.5 mechanosensitivity

Beyder, A., Strege, P. R., Bernard, C. & Farrugia, G., Jan 1 2012, In : Channels. 6, 4

Research output: Contribution to journal › Article

9 Scopus citations

Quantification of gastrointestinal sodium channelopathy

Poh, Y. C., Beyder, A., Strege, P. R., Farrugia, G. & Buist, M. L., Jan 21 2012, In : Journal of Theoretical Biology. 293, p. 41-48 8 p.

Research output: Contribution to journal › Article

17 Scopus citations

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action

Beyder, A., Strege, P. R., Reyes, S., Bernard, C. E., Terzic, A., Makielski, J., Ackerman, M. J. & Farrugia, G., Jun 5 2012, In : Circulation. 125, 22, p. 2698-2706 9 p.

Research output: Contribution to journal › Article

50 Scopus citations

Ranolazine inhibits shear sensitivity of endogenous Na⁺ current and spontaneous action potentials in HL-1 cells

Strege, P., Beyder, A., Bernard, C., Crespo-Diaz, R., Behfar, A., Terzic, A., Ackerman, M. & Farrugia, G., Jan 1 2012, In : Channels. 6, 6, p. 457-462 6 p.

Research output: Contribution to journal › Article

16 Scopus citations

2011

Altered expression of ano1 variants in human diabetic gastroparesis

Mazzone, A., Bernard, C. E., Strege, P. R., Beyder, A., Galietta, L. J. V., Pasricha, P. J., Rae, J. L., Parkman, H. P., Linden, D. R., Szurszewski, J. H., Ördög, T., Gibbons, S. J. & Farrugia, G., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13393-13403 11 p.

Research output: Contribution to journal › Article

69 Scopus citations

Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na⁺ channel, NA_v1.5

Strege, P. R., Bernard, C. E., Kraichely, R. E., Mazzone, A., Sha, L., Beyder, A., Gibbons, S. J., Linden, D. R., Kendrick, M. L., Sarr, M. G., Szurszewski, J. H. & Farrugia, G., Jun 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6, p. G1105-G1114

Research output: Contribution to journal › Article

27 Scopus citations

2010

Lack of serotonin 5-HT_2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo

Tharayil, V. S., Wouters, M. M., Stanich, J. E., Roeder, J. L., Lei, S., Beyder, A., Gomez-Pinilla, P. J., Gershon, M. D., Maroteaux, L., Gibbons, S. J. & Farrugia, G., Apr 1 2010, In : Neurogastroenterology and Motility. 22, 4, p. 462-469+e109-e110

Research output: Contribution to journal › Article

38 Scopus citations

Mechanosensitivity of Na_v1.5, a voltage-sensitive sodium channel

Beyder, A., Rae, J. L., Bernard, C., Strege, P. R., Sachs, F. & Farrugia, G., Dec 1 2010, In : Journal of Physiology. 588, 24, p. 4969-4985 17 p.

Research output: Contribution to journal › Article

99 Scopus citations

T-type Ca²⁺ channel modulation by otilonium bromide

Strege, P. R., Sha, L., Beyder, A., Bernard, C. E., Perez-Reyes, E., Evangelista, S., Gibbons, S. J., Szurszewski, J. H. & Farrugia, G., May 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 5, p. G706-G713

Research output: Contribution to journal › Article

14 Scopus citations

2009

Electromechanical coupling in the membranes of Shaker-transfected HEK cells

Beyder, A. & Sachs, F., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6626-6631 6 p.

Research output: Contribution to journal › Article

28 Scopus citations

2008

Atomic force microscopy analysis of cell volume regulation

Spagnoli, C., Beyder, A., Besch, S. & Sachs, F., Sep 22 2008, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 78, 3, 031916.

Research output: Contribution to journal › Article

45 Scopus citations

2007

Drift-free atomic force microscopy measurements of cell height and mechanical properties

Spagnoli, C., Beyder, A., Besch, S. R. & Sachs, F., Apr 8 2007, In : Review of Scientific Instruments. 78, 3, 036111.

Research output: Contribution to journal › Article

12 Scopus citations

Hydrodynamics of torsional probes for atomic force microscopy in liquids

Basak, S., Beyder, A., Spagnoli, C., Raman, A. & Sachs, F., Aug 7 2007, In : Journal of Applied Physics. 102, 2, 024914.

Research output: Contribution to journal › Article

8 Scopus citations

2006

Microfabricated torsion levers optimized for low force and high-frequency operation in fluids

Beyder, A. & Sachs, F., Jun 1 2006, In : Ultramicroscopy. 106, 8-9, p. 838-846 9 p.

Research output: Contribution to journal › Article

17 Scopus citations

Reducing probe dependent drift in atomic force microscope with symmetrically supported torsion levers

Beyder, A., Spagnoli, C. & Sachs, F., May 1 2006, In : Review of Scientific Instruments. 77, 5, 056105.

Research output: Contribution to journal › Article

13 Scopus citations

1999

Spatially resolved detection of attomole quantities of organic molecules localized in picoliter vials using time-of-flight secondary ion mass spectrometry

Braun, R. M., Beyder, A., Xu, J., Wood, M. C., Ewing, A. G. & Winograd, N., Aug 15 1999, In : Analytical Chemistry. 71, 16, p. 3318-3324 7 p.

Research output: Contribution to journal › Article

27 Scopus citations

Arthur Beyder, MD, PhD