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Arthur Beyder, MD, PhD

  • 908 Citations
  • 17 Scopus h-Index
19992019
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Research Output 1999 2019

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Article
2019
3 Citations (Scopus)

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D., Yaqoob, U., Cao, S., Revzin, A., Beyder, A., Wang, R. A., Kamath, P. S., Kubes, P. & Shah, V., Jul 1 2019, In : Gastroenterology. 157, 1, p. 193-209.e9

Research output: Contribution to journal › Article

Portal Hypertension
Neutrophils
Endothelial Cells
Liver
RNA Sequence Analysis
10 Citations (Scopus)

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R. D., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journal › Article

Genomic Instability
Wound Healing
Neutrophils
Homologous Recombination
Inflammation

SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

Strege, P. R., Mercado-Perez, A., Mazzone, A., Saito Loftus, Y. A., Bernard, C. E., Farrugia, G. & Beyder, A., Dec 1 2019, In : Channels (Austin, Tex.). 13, 1, p. 287-298 12 p.

Research output: Contribution to journal › Article

Open Access
NAV1.5 Voltage-Gated Sodium Channel
Cardiac Myocytes
Smooth Muscle
Channelopathies
Pressure
2018
12 Citations (Scopus)

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G. & Beyder, A., Aug 7 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7632-E7641

Research output: Contribution to journal › Article

Enterochromaffin Cells
Enteroendocrine Cells
Serotonin
Epithelial Cells
Population

Gut development on a full stomach

Beyder, A., Apr 20 2018, (Accepted/In press) In : Nature Reviews Gastroenterology and Hepatology. p. 1-2 2 p.

Research output: Contribution to journal › Article

Enteroendocrine Cells
Stomach
Epithelial Cells
Ion Channels
Drosophila
8 Citations (Scopus)

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Nav1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito Loftus, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 1 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journal › Article

Channelopathies
Irritable Bowel Syndrome
Mutation
Missense Mutation
Smooth Muscle
2 Citations (Scopus)

The touchy business of gastrointestinal (GI) mechanosensitivity

Treichel, A. J., Farrugia, G. & Beyder, A., Aug 15 2018, In : Brain Research. 1693, p. 197-200 4 p.

Research output: Contribution to journal › Article

Sensory Receptor Cells
Enterochromaffin Cells
Gastrointestinal Tract
Aptitude
Epithelial Cells
1 Citation (Scopus)

Whole cell electrophysiology of primary cultured murine enterochromaffin cells

Knutson, K., Strege, P. R., Li, J., Leiter, A. B., Farrugia, G. & Beyder, A., Sep 26 2018, In : Journal of Visualized Experiments. 2018, 139, e58112.

Research output: Contribution to journal › Article

Enterochromaffin Cells
Electrophysiology
Clamping devices
Enteroendocrine Cells
Cell culture
2017

47-Year-Old Man With Abdominal Pain and Diarrhea

Codipilly, D. C., Chedid, V. & Beyder, A., Jan 1 2017, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journal › Article

Abdominal Pain
Diarrhea
2 Citations (Scopus)

EAVK segment “c” sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1

Strege, P. R., Gibbons, S. J., Mazzone, A., Bernard, C. E., Beyder, A. & Farrugia, G., Jun 1 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G572-G579

Research output: Contribution to journal › Article

Exons
Interstitial Cells of Cajal
Stomach
Calcium
Chloride Channels
22 Citations (Scopus)

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production

Bhattarai, Y., Schmidt, B. A., Linden, D. R., Larson, E. D., Grover, M., Beyder, A., Farrugia, G. & Kashyap, P. C., 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 313, 1, p. G80-G87

Research output: Contribution to journal › Article

Receptors, Serotonin, 5-HT3
Serotonin
Acetates
Intestinal Secretions
Ondansetron
10 Citations (Scopus)

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4

Alcaino, C., Knutson, K., Gottlieb, P. A., Farrugia, G. & Beyder, A., Feb 7 2017, (Accepted/In press) In : Channels. p. 1-9 9 p.

Research output: Contribution to journal › Article

Ion Channels
Serotonin
Spiders
HEK293 Cells
Peptides
11 Citations (Scopus)

Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release

Strege, P. R., Knutson, K., Eggers, S. J., Li, J. H., Wang, F., Linden, D. R., Szurszewski, J. H., Milescu, L., Leiter, A. B., Farrugia, G. & Beyder, A., Dec 1 2017, In : Scientific Reports. 7, 1, 15650.

Research output: Contribution to journal › Article

Enterochromaffin Cells
Sodium Channels
Serotonin
NAV1.3 Voltage-Gated Sodium Channel
Action Potentials
2016
4 Citations (Scopus)

Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV1.5 in the rat jejunum

Beyder, A., Gibbons, S. J., Mazzone, A., Strege, P. R., Saravanaperumal, S. A., Sha, L., Higgins, S., Eisenman, S. T., Bernard, C. E., Geurts, A., Kline, C. F., Mohler, P. J. & Farrugia, G., Jan 1 2016, In : Neurogastroenterology and Motility. 28, 1, p. 64-73 10 p.

Research output: Contribution to journal › Article

NAV1.5 Voltage-Gated Sodium Channel
Jejunum
Smooth Muscle
Electrophysiology
Small Interfering RNA
12 Citations (Scopus)

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P. J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ordog, T., Camp, J. J., Ge, X., Bharucha, A. E., Linden, D. R., Szurszewski, J. H., Kashyap, P. C. & Farrugia, G., Jul 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 4, p. 454-467 14 p.

Research output: Contribution to journal › Article

Interstitial Cells of Cajal
Gastric Emptying
Interleukin-10
Heme Oxygenase-1
Stomach
39 Citations (Scopus)

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Wang, F., Knutson, K., Alcaino, C., Linden, D. R., Gibbons, S. J., Kashyap, P. C., Grover, M., Oeckler, R., Gottlieb, P. A., Li, H. J., Leiter, A. B., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journal › Article

Enterochromaffin Cells
Ion Channels
Serotonin
Epithelium
Jejunum
14 Citations (Scopus)

Mechanosensitive Piezo Channels in the Gastrointestinal Tract

Alcaino, C., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Current Topics in Membranes.

Research output: Contribution to journal › Article

Ion Channels
Gastrointestinal Tract
Enterochromaffin Cells
Interstitial Cells of Cajal
Voltage-Gated Sodium Channels
8 Citations (Scopus)

TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Henström, M., Hadizadeh, F., Beyder, A., Bonfiglio, F., Zheng, T., Assadi, G., Rafter, J., Bujanda, L., Agreus, L., Andreasson, A., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Talley, N. J., Simren, M., Walter, S., Wouters, M., Farrugia, G. & 1 others, D'Amato, M., Dec 14 2016, (Accepted/In press) In : Gut.

Research output: Contribution to journal › Article

Irritable Bowel Syndrome
Constipation
Ion Channels
2015
9 Citations (Scopus)

A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2+

Strege, P. R., Bernard, C. E., Mazzone, A., Linden, D. R., Beyder, A., Gibbons, S. J. & Farrugia, G., Nov 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 9, p. G743-G749

Research output: Contribution to journal › Article

Exons
Anions
Protein Isoforms
Niflumic Acid
Interstitial Cells of Cajal
54 Citations (Scopus)

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces

Simonetto, D., Yang, H. Y., Yin, M., de Assuncao, T. M., Kwon, J. H., Hilscher, M., Pan, S., Yang, L., Bi, Y., Beyder, A., Cao, S., Simari, R. D., Ehman, R. L., Kamath, P. S. & Shah, V., Feb 1 2015, In : Hepatology. 61, 2, p. 648-659 12 p.

Research output: Contribution to journal › Article

Hyperemia
Thrombosis
Liver
Fibrosis
Hepatic Stellate Cells
8 Citations (Scopus)

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells

Neshatian, L., Strege, P. R., Rhee, P. L., Kraichely, R. E., Mazzone, A., Bernard, C. E., Cima, R. R., Larson, D., Dozois, E., Kline, C. F., Mohler, P. J., Beyder, A. & Farrugia, G., Sep 15 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 6, p. G506-G512

Research output: Contribution to journal › Article

Voltage-Gated Sodium Channels
Smooth Muscle Myocytes
Colon
Smooth Muscle
Ascending Colon
2014

84-year-old man with night sweats, weight loss, and diarrhea

Ngwa, T. N., Beyder, A. & Vege, S. S., 2014, In : Mayo Clinic Proceedings. 89, 3, p. 409-413 5 p.

Research output: Contribution to journal › Article

Serositis
Sweating
Sweat
Systemic Lupus Erythematosus
Weight Loss
55 Citations (Scopus)

Loss-of-function of the voltage-gated sodium channel NaV1.5 (Channelopathies) in patients with irritable bowel syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito Loftus, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., Lindberg, G., Karling, P., Ohlsson, B., Gazouli, M., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P. & 8 others, Bellini, M., Barbara, G., Camilleri, M., Locke, G. R., Talley, N. J., D'Amato, M., Ackerman, M. J. & Farrugia, G., 2014, In : Gastroenterology. 146, 7, p. 1659-1668 10 p.

Research output: Contribution to journal › Article

NAV1.5 Voltage-Gated Sodium Channel
Channelopathies
Irritable Bowel Syndrome
Mutation
Mexiletine
2013
3 Citations (Scopus)

Acute polyarticular gout presenting as Delirium

Wilson, M., Wan, S. H., Beyder, A., Osborn, T. & Beckman, T. J., Jun 2013, In : Journal of Clinical Rheumatology. 19, 4, p. 221-222 2 p.

Research output: Contribution to journal › Article

37 Citations (Scopus)

The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings

Angeli, T. R., Du, P., Paskaranandavadivel, N., Janssen, P. W. M., Beyder, A., Lentle, R. G., Bissett, I. P., Cheng, L. K. & O'Grady, G., Sep 2013, In : Journal of Physiology. 591, 18, p. 4567-4579 13 p.

Research output: Contribution to journal › Article

Suction
Nifedipine
Artifacts
Biophysics
Video Recording
2012
3 Citations (Scopus)

Large atrial myxoma causing dynamic obstruction of the mitral valve and atrial fibrillation

Beyder, A. & Klarich, K. W., 2012, In : Mayo Clinic Proceedings. 87, 2

Research output: Contribution to journal › Article

Myxoma
Mitral Valve
Atrial Fibrillation
7 Citations (Scopus)

Membrane permeable local anesthetics modulate Na V1.5 mechanosensitivity

Beyder, A., Strege, P. R., Bernard, C. & Farrugia, G., Jul 2012, In : Channels. 6, 4

Research output: Contribution to journal › Article

Lidocaine
Local Anesthetics
Membranes
Pressure
Electric potential
17 Citations (Scopus)

Quantification of gastrointestinal sodium channelopathy

Poh, Y. C., Beyder, A., Strege, P. R., Farrugia, G. & Buist, M. L., Jan 21 2012, In : Journal of Theoretical Biology. 293, p. 41-48 8 p.

Research output: Contribution to journal › Article

Channelopathies
Interstitial Cells of Cajal
Sodium
Quantification
Smooth Muscle Myocytes
49 Citations (Scopus)

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action

Beyder, A., Strege, P. R., Reyes, S., Bernard, C. E., Terzic, A., Makielski, J., Ackerman, M. J. & Farrugia, G., Jun 5 2012, In : Circulation. 125, 22, p. 2698-2706 9 p.

Research output: Contribution to journal › Article

Voltage-Gated Sodium Channels
Sodium Channels
Pharmaceutical Preparations
Pressure
Lidocaine
15 Citations (Scopus)

Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells

Strege, P., Beyder, A., Bernard, C., Crespo-Diaz, R., Behfar, A., Terzic, A., Ackerman, M. J. & Farrugia, G., Nov 2012, In : Channels. 6, 6, p. 457-462 6 p.

Research output: Contribution to journal › Article

Action Potentials
Shear stress
Cardiac Myocytes
Baths
Cells
34 Citations (Scopus)

Targeting ion channels for the treatment of gastrointestinal motility disorders

Beyder, A. & Farrugia, G., Jan 2012, In : Therapeutic Advances in Gastroenterology. 5, 1, p. 5-21 17 p.

Research output: Contribution to journal › Article

Gastrointestinal Motility
Ion Channels
Interstitial Cells of Cajal
Smooth Muscle Myocytes
Enteric Nervous System
2011
66 Citations (Scopus)

Altered expression of ano1 variants in human diabetic gastroparesis

Mazzone, A., Bernard, C. E., Strege, P. R., Beyder, A., Galietta, L. J. V., Pasricha, P. J., Rae, J. L., Parkman, H. P., Linden, D. R., Szurszewski, J. H., Ordog, T., Gibbons, S. J. & Farrugia, G., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13393-13403 11 p.

Research output: Contribution to journal › Article

Gastroparesis
Interstitial Cells of Cajal
Exons
Alternative Splicing
Muscle
36 Citations (Scopus)

Biophysically based modeling of the interstitial cells of Cajal: Current status and future perspectives

Lees-Green, R., Du, P., O'Grady, G., Beyder, A., Farrugia, G. & Pullan, A. J., 2011, In : Frontiers in Physiology. JUL, Article 29.

Research output: Contribution to journal › Article

Interstitial Cells of Cajal
Channelopathies
Cell Physiological Phenomena
Gastrointestinal Motility
Electrophysiology
27 Citations (Scopus)

Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, NAv1.5

Strege, P. R., Bernard, C. E., Kraichely, R. E., Mazzone, A., Sha, L., Beyder, A., Gibbons, S. J., Linden, D. R., Kendrick, M. L., Sarr, M. G., Szurszewski, J. H. & Farrugia, G., Jun 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6

Research output: Contribution to journal › Article

Hydrogen Sulfide
Jejunum
Oxidation-Reduction
Cystathionine
Dithiothreitol
2010
38 Citations (Scopus)

Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo

Tharayil, V. S., Wouters, M. M., Stanich, J. E., Roeder, J. L., Lei, S., Beyder, A., Gomez-Pinilla, P. J., Gershon, M. D., Maroteaux, L., Gibbons, S. J. & Farrugia, G., Apr 2010, In : Neurogastroenterology and Motility. 22, 4

Research output: Contribution to journal › Article

Receptor, Serotonin, 5-HT2B
Interstitial Cells of Cajal
Myenteric Plexus
97 Citations (Scopus)

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

Beyder, A., Rae, J. L., Bernard, C., Strege, P. R., Sachs, F. & Farrugia, G., Dec 2010, In : Journal of Physiology. 588, 24, p. 4969-4985 17 p.

Research output: Contribution to journal › Article

Sodium Channels
Mechanical Phenomena
HEK293 Cells
Ion Channels
Gastrointestinal Tract
14 Citations (Scopus)

T-type Ca2+ channel modulation by otilonium bromide

Strege, P. R., Sha, L., Beyder, A., Bernard, C. E., Perez-Reyes, E., Evangelista, S., Gibbons, S. J., Szurszewski, J. H. & Farrugia, G., May 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 5

Research output: Contribution to journal › Article

Parasympatholytics
Smooth Muscle
HEK293 Cells
Patch-Clamp Techniques
Muscle Contraction
2009
28 Citations (Scopus)

Electromechanical coupling in the membranes of Shaker-transfected HEK cells

Beyder, A. & Sachs, F., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6626-6631 6 p.

Research output: Contribution to journal › Article

Membranes
Surface Tension
Atomic Force Microscopy
HEK293 Cells
Membrane Potentials
2008
45 Citations (Scopus)

Atomic force microscopy analysis of cell volume regulation

Spagnoli, C., Beyder, A., Besch, S. & Sachs, F., Sep 22 2008, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 78, 3, 031916.

Research output: Contribution to journal › Article

Atomic Force Microscopy
atomic force microscopy
Cell
cells
Osmotic Stress
2007
12 Citations (Scopus)

Drift-free atomic force microscopy measurements of cell height and mechanical properties

Spagnoli, C., Beyder, A., Besch, S. R. & Sachs, F., 2007, In : Review of Scientific Instruments. 78, 3, 036111.

Research output: Contribution to journal › Article

Atomic force microscopy
atomic force microscopy
mechanical properties
Mechanical properties
cells
8 Citations (Scopus)

Hydrodynamics of torsional probes for atomic force microscopy in liquids

Basak, S., Beyder, A., Spagnoli, C., Raman, A. & Sachs, F., 2007, In : Journal of Applied Physics. 102, 2, 024914.

Research output: Contribution to journal › Article

hydrodynamics
atomic force microscopy
probes
liquids
levers
2006
17 Citations (Scopus)

Microfabricated torsion levers optimized for low force and high-frequency operation in fluids

Beyder, A. & Sachs, F., Jun 2006, In : Ultramicroscopy. 106, 8-9, p. 838-846 9 p.

Research output: Contribution to journal › Article

levers
Torsional stress
torsion
Fluids
probes
13 Citations (Scopus)

Reducing probe dependent drift in atomic force microscope with symmetrically supported torsion levers

Beyder, A., Spagnoli, C. & Sachs, F., May 2006, In : Review of Scientific Instruments. 77, 5, 056105.

Research output: Contribution to journal › Article

levers
Torsional stress
torsion
Microscopes
microscopes
1999
27 Citations (Scopus)

Spatially resolved detection of attomole quantities of organic molecules localized in picoliter vials using time-of-flight secondary ion mass spectrometry

Braun, R. M., Beyder, A., Xu, J., Wood, M. C., Ewing, A. G. & Winograd, N., Aug 15 1999, In : Analytical Chemistry. 71, 16, p. 3318-3324 7 p.

Research output: Contribution to journal › Article

Silicon
Secondary ion mass spectrometry
Dispensers
Molecules
Solenoids