• 1033 Citations
  • 18 Scopus h-Index
19992020

Research output per year

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Research Output

2020

MicroRNA overexpression in slow transit constipation leads to reduced Na v 1.5 current and altered smooth muscle contractility

Mazzone, A., Strege, P. R., Gibbons, S. J., Alcaino, C., Joshi, V., Haak, A. J., Tschumperlin, D. J., Bernard, C. E., Cima, R. R., Larson, D. W., Chua, H. K., Graham, R. P., El Refaey, M., Mohler, P. J., Hayashi, Y., Ordog, T., Calder, S., Du, P., Farrugia, G. & Beyder, A., May 1 2020, In : Gut. 69, 5, p. 868-876 9 p.

Research output: Contribution to journalArticle

Open Access
2019

A Method for Multi-day Tracking of Gastrointestinal Smooth Muscle Contractile Patterns in Organotypic Culture

Du, P., Mazzone, A., Calder, S., Qian, A., Gibbons, S. J., Farrugia, G. & Beyder, A., Jul 2019, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., p. 4791-4794 4 p. 8857365. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation

Aghababaie, Z., Chan, C. H. A., Paskaranandavadivel, N., Beyder, A., Farrugia, G., Asirvatham, S., O'Grady, G., Cheng, L. K. & Angeli, T. R., Jul 2019, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., p. 170-173 4 p. 8856406. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

In pursuit of the epithelial mechanosensitivity mechanisms

Beyder, A., 2019, In : Frontiers in Endocrinology. 10, JAN

Research output: Contribution to journalShort survey

Open Access

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D., Yaqoob, U., Cao, S., Revzin, A., Beyder, A., Wang, R. A., Kamath, P. S., Kubes, P. & Shah, V., Jul 1 2019, In : Gastroenterology. 157, 1, p. 193-209.e9

Research output: Contribution to journalArticle

15 Scopus citations

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R. D., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

Strege, P. R., Mercado-Perez, A., Mazzone, A., Saito Loftus, Y. A., Bernard, C. E., Farrugia, G. & Beyder, A., Dec 1 2019, In : Channels (Austin, Tex.). 13, 1, p. 287-298 12 p.

Research output: Contribution to journalArticle

Open Access

Telocytes express ANO-1-encoded chloride channels in canine ventricular myocardium

DeSimone, C. V., McLeod, C. J., Gomez Pinilla, P. J., Beyder, A., Farrugia, G., Asirvatham, S. J. & Kapa, S., Jun 1 2019, In : journal of arrhythmia. 35, 3, p. 515-521 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

TRPPing up bronchiectasis

Mercado-Perez, A. & Beyder, A., Oct 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 4, p. L464-L465

Research output: Contribution to journalComment/debate

2018

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G. & Beyder, A., Aug 7 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7632-E7641

Research output: Contribution to journalArticle

24 Scopus citations

Gut development on a full stomach

Beyder, A., Apr 20 2018, (Accepted/In press) In : Nature Reviews Gastroenterology and Hepatology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Na v 1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journalArticle

11 Scopus citations

The touchy business of gastrointestinal (GI) mechanosensitivity

Treichel, A. J., Farrugia, G. & Beyder, A., Aug 15 2018, In : Brain Research. 1693, p. 197-200 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Whole cell electrophysiology of primary cultured murine enterochromaffin cells

Knutson, K., Strege, P. R., Li, J., Leiter, A. B., Farrugia, G. & Beyder, A., Sep 26 2018, In : Journal of Visualized Experiments. 2018, 139, e58112.

Research output: Contribution to journalArticle

2 Scopus citations
2017

47-Year-Old Man With Abdominal Pain and Diarrhea

Codipilly, D. C., Chedid, V. & Beyder, A., Jan 1 2017, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journalArticle

EAVK segment “c” sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1

Strege, P. R., Gibbons, S. J., Mazzone, A., Bernard, C. E., Beyder, A. & Farrugia, G., Jun 1 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G572-G579

Research output: Contribution to journalArticle

3 Scopus citations
27 Scopus citations

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Wang, F., Knutson, K., Alcaino, C., Linden, D. R., Gibbons, S. J., Kashyap, P., Grover, M., Oeckler, R., Gottlieb, P. A., Li, H. J., Leiter, A. B., Farrugia, G. & Beyder, A., Jan 1 2017, In : Journal of Physiology. 595, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4

Alcaino, C., Knutson, K., Gottlieb, P. A., Farrugia, G. & Beyder, A., Feb 7 2017, (Accepted/In press) In : Channels. p. 1-9 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release

Strege, P. R., Knutson, K., Eggers, S. J., Li, J. H., Wang, F., Linden, D., Szurszewski, J. H., Milescu, L., Leiter, A. B., Farrugia, G. & Beyder, A., Dec 1 2017, In : Scientific reports. 7, 1, 15650.

Research output: Contribution to journalArticle

14 Scopus citations

TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Henström, M., Hadizadeh, F., Beyder, A., Bonfiglio, F., Zheng, T., Assadi, G., Rafter, J., Bujanda, L., Agreus, L., Andreasson, A., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Talley, N. J., Simren, M., Walter, S., Wouters, M., Farrugia, G. & 1 others, D'Amato, M., Sep 1 2017, In : Gut. 66, 9, p. 1725-1727 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

XIVth Little Brain Big Brain: Next-generation enteric neuroscience

Beyder, A., De Lartigue, G., Ghia, J. E. & Hoffman, J. M., Mar 1 2017, In : Nature Reviews Gastroenterology and Hepatology. 14, 3, p. 135-136 2 p.

Research output: Contribution to journalComment/debate

2016

39-Year-Old Man With Dysphagia

Pestana, L., Puckett, J. & Beyder, A., Jun 1 2016, In : Mayo Clinic proceedings. 91, 6, p. 808-811 4 p.

Research output: Contribution to journalShort survey

Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV1.5 in the rat jejunum

Beyder, A., Gibbons, S. J., Mazzone, A., Strege, P. R., Saravanaperumal, S. A., Sha, L., Higgins, S., Eisenman, S. T., Bernard, C. E., Geurts, A., Kline, C. F., Mohler, P. J. & Farrugia, G., Jan 1 2016, In : Neurogastroenterology and Motility. 28, 1, p. 64-73 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P. J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ordog, T., Camp, J. J., Ge, X., Bharucha, A. E., Linden, D. R., Szurszewski, J. H., Kashyap, P. C. & Farrugia, G., Jul 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 4, p. 454-467 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Ion channelopathies in functional GI disorders

Beyder, A. & Farrugia, G., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 4, p. G581-G586

Research output: Contribution to journalReview article

20 Scopus citations

Mechanosensitive Piezo Channels in the Gastrointestinal Tract

Alcaino, C., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Current Topics in Membranes.

Research output: Contribution to journalArticle

15 Scopus citations

Mechanosensory signaling in enterochromaffin cells and 5-HT release: Potential implications for gut inflammation

Linan-Rico, A., Ochoa-Cortes, F., Beyder, A., Soghomonyan, S., Zuleta-Alarcon, A., Coppola, V. & Christofi, F. L., 2016, In : Frontiers in Neuroscience. 10, DEC, 564.

Research output: Contribution to journalReview article

17 Scopus citations
2015

A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2+

Strege, P. R., Bernard, C. E., Mazzone, A., Linden, D. R., Beyder, A., Gibbons, S. J. & Farrugia, G., Nov 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 9, p. G743-G749

Research output: Contribution to journalArticle

12 Scopus citations

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces

Simonetto, D. A., Yang, H. Y., Yin, M., de Assuncao, T. M., Kwon, J. H., Hilscher, M., Pan, S., Yang, L., Bi, Y., Beyder, A., Cao, S., Simari, R. D., Ehman, R., Kamath, P. S. & Shah, V. H., Feb 1 2015, In : Hepatology. 61, 2, p. 648-659 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells

Neshatian, L., Strege, P. R., Rhee, P. L., Kraichely, R. E., Mazzone, A., Bernard, C. E., Cima, R. R., Larson, D. W., Dozois, E. J., Kline, C. F., Mohler, P. J., Beyder, A. & Farrugia, G., Sep 15 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 6, p. G506-G512

Research output: Contribution to journalArticle

10 Scopus citations
2014

84-year-old man with night sweats, weight loss, and diarrhea

Ngwa, T. N., Beyder, A. & Vege, S. S., Mar 2014, In : Mayo Clinic proceedings. 89, 3, p. 409-413 5 p.

Research output: Contribution to journalShort survey

Loss-of-function of the voltage-gated sodium channel NaV1.5 (Channelopathies) in patients with irritable bowel syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., Lindberg, G., Karling, P., Ohlsson, B., Gazouli, M., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P. & 8 others, Bellini, M., Barbara, G., Camilleri, M., Locke, G. R., Talley, N. J., D'Amato, M., Ackerman, M. J. & Farrugia, G., Jun 2014, In : Gastroenterology. 146, 7, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

64 Scopus citations
2013

Acute polyarticular gout presenting as Delirium

Wilson, M. E., Wan, S. H., Beyder, A., Osborn, T. G. & Beckman, T. J., Jun 1 2013, In : Journal of Clinical Rheumatology. 19, 4, p. 221-222 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Role of ion channel mechanosensitivity in the gut: Mechano-electrical feedback exemplified by stretch-dependence of Nav1.5

Beyder, A., Lees-Green, R. & Farrugia, G., Jan 1 2013, Lecture Notes in Computational Vision and Biomechanics. Springer Netherlands, p. 7-27 21 p. (Lecture Notes in Computational Vision and Biomechanics; vol. 10).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings

Angeli, T. R., Du, P., Paskaranandavadivel, N., Janssen, P. W. M., Beyder, A., Lentle, R. G., Bissett, I. P., Cheng, L. K. & O'Grady, G., Sep 1 2013, In : Journal of Physiology. 591, 18, p. 4567-4579 13 p.

Research output: Contribution to journalArticle

42 Scopus citations
2012

Large atrial myxoma causing dynamic obstruction of the mitral valve and atrial fibrillation

Beyder, A. & Klarich, K. W., Feb 2012, In : Mayo Clinic proceedings. 87, 2, p. e9

Research output: Contribution to journalArticle

3 Scopus citations

Membrane permeable local anesthetics modulate NaV1.5 mechanosensitivity

Beyder, A., Strege, P. R., Bernard, C. & Farrugia, G., Jan 1 2012, In : Channels. 6, 4

Research output: Contribution to journalArticle

9 Scopus citations

Quantification of gastrointestinal sodium channelopathy

Poh, Y. C., Beyder, A., Strege, P. R., Farrugia, G. & Buist, M. L., Jan 21 2012, In : Journal of Theoretical Biology. 293, p. 41-48 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action

Beyder, A., Strege, P. R., Reyes, S., Bernard, C. E., Terzic, A., Makielski, J., Ackerman, M. J. & Farrugia, G., Jun 5 2012, In : Circulation. 125, 22, p. 2698-2706 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells

Strege, P., Beyder, A., Bernard, C., Crespo-Diaz, R., Behfar, A., Terzic, A., Ackerman, M. & Farrugia, G., Jan 1 2012, In : Channels. 6, 6, p. 457-462 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeting ion channels for the treatment of gastrointestinal motility disorders

Beyder, A. & Farrugia, G., Jan 2012, In : Therapeutic Advances in Gastroenterology. 5, 1, p. 5-21 17 p.

Research output: Contribution to journalReview article

37 Scopus citations
2011

Altered expression of ano1 variants in human diabetic gastroparesis

Mazzone, A., Bernard, C. E., Strege, P. R., Beyder, A., Galietta, L. J. V., Pasricha, P. J., Rae, J. L., Parkman, H. P., Linden, D. R., Szurszewski, J. H., Ördög, T., Gibbons, S. J. & Farrugia, G., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13393-13403 11 p.

Research output: Contribution to journalArticle

71 Scopus citations

Biophysically based modeling of the interstitial cells of Cajal: Current status and future perspectives

Lees-Green, R., Du, P., O'Grady, G., Beyder, A., Farrugia, G. & Pullan, A. J., 2011, In : Frontiers in Physiology. JUL, Article 29.

Research output: Contribution to journalReview article

38 Scopus citations

Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, NAv1.5

Strege, P. R., Bernard, C. E., Kraichely, R. E., Mazzone, A., Sha, L., Beyder, A., Gibbons, S. J., Linden, D. R., Kendrick, M. L., Sarr, M. G., Szurszewski, J. H. & Farrugia, G., Jun 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6, p. G1105-G1114

Research output: Contribution to journalArticle

27 Scopus citations
2010

Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo

Tharayil, V. S., Wouters, M. M., Stanich, J. E., Roeder, J. L., Lei, S., Beyder, A., Gomez-Pinilla, P. J., Gershon, M. D., Maroteaux, L., Gibbons, S. J. & Farrugia, G., Apr 1 2010, In : Neurogastroenterology and Motility. 22, 4, p. 462-469+e109-e110

Research output: Contribution to journalArticle

39 Scopus citations

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

Beyder, A., Rae, J. L., Bernard, C., Strege, P. R., Sachs, F. & Farrugia, G., Dec 1 2010, In : Journal of Physiology. 588, 24, p. 4969-4985 17 p.

Research output: Contribution to journalArticle

104 Scopus citations

T-type Ca2+ channel modulation by otilonium bromide

Strege, P. R., Sha, L., Beyder, A., Bernard, C. E., Perez-Reyes, E., Evangelista, S., Gibbons, S. J., Szurszewski, J. H. & Farrugia, G., May 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 5, p. G706-G713

Research output: Contribution to journalArticle

14 Scopus citations
2009

Electromechanical coupling in the membranes of Shaker-transfected HEK cells

Beyder, A. & Sachs, F., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6626-6631 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

Atomic force microscopy analysis of cell volume regulation

Spagnoli, C., Beyder, A., Besch, S. & Sachs, F., Sep 22 2008, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 78, 3, 031916.

Research output: Contribution to journalArticle

45 Scopus citations