• 973 Citations
  • 17 Scopus h-Index
19992019

Research output per year

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Research Output

2019

In pursuit of the epithelial mechanosensitivity mechanisms

Beyder, A., Jan 1 2019, In : Frontiers in Endocrinology. 10, JAN

Research output: Contribution to journalShort survey

Open Access

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D., Yaqoob, U., Cao, S., Revzin, A., Beyder, A., Wang, R. A., Kamath, P. S., Kubes, P. & Shah, V., Jul 1 2019, In : Gastroenterology. 157, 1, p. 193-209.e9

Research output: Contribution to journalArticle

8 Scopus citations

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R. D., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

Strege, P. R., Mercado-Perez, A., Mazzone, A., Saito Loftus, Y. A., Bernard, C. E., Farrugia, G. & Beyder, A., Dec 1 2019, In : Channels (Austin, Tex.). 13, 1, p. 287-298 12 p.

Research output: Contribution to journalArticle

Open Access

TRPPing up bronchiectasis

Mercado-Perez, A. & Beyder, A., Oct 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 4, p. L464-L465

Research output: Contribution to journalComment/debate

2018

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G. & Beyder, A., Aug 7 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7632-E7641

Research output: Contribution to journalArticle

19 Scopus citations

Gut development on a full stomach

Beyder, A., Apr 20 2018, (Accepted/In press) In : Nature Reviews Gastroenterology and Hepatology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Nav1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito Loftus, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 1 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journalArticle

9 Scopus citations

The touchy business of gastrointestinal (GI) mechanosensitivity

Treichel, A. J., Farrugia, G. & Beyder, A., Aug 15 2018, In : Brain Research. 1693, p. 197-200 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Whole cell electrophysiology of primary cultured murine enterochromaffin cells

Knutson, K., Strege, P. R., Li, J., Leiter, A. B., Farrugia, G. & Beyder, A., Sep 26 2018, In : Journal of Visualized Experiments. 2018, 139, e58112.

Research output: Contribution to journalArticle

1 Scopus citations
2017

47-Year-Old Man With Abdominal Pain and Diarrhea

Codipilly, D. C., Chedid, V. & Beyder, A., Jan 1 2017, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journalArticle

EAVK segment “c” sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1

Strege, P. R., Gibbons, S. J., Mazzone, A., Bernard, C. E., Beyder, A. & Farrugia, G., Jun 1 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G572-G579

Research output: Contribution to journalArticle

3 Scopus citations
23 Scopus citations

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4

Alcaino, C., Knutson, K., Gottlieb, P. A., Farrugia, G. & Beyder, A., Feb 7 2017, (Accepted/In press) In : Channels. p. 1-9 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release

Strege, P. R., Knutson, K., Eggers, S. J., Li, J. H., Wang, F., Linden, D. R., Szurszewski, J. H., Milescu, L., Leiter, A. B., Farrugia, G. & Beyder, A., Dec 1 2017, In : Scientific Reports. 7, 1, 15650.

Research output: Contribution to journalArticle

13 Scopus citations

XIVth Little Brain Big Brain: Next-generation enteric neuroscience

Beyder, A., De Lartigue, G., Ghia, J. E. & Hoffman, J. M., Mar 1 2017, In : Nature Reviews Gastroenterology and Hepatology. 14, 3, p. 135-136 2 p.

Research output: Contribution to journalComment/debate

2016

39-Year-Old Man With Dysphagia

Pestana, L., Puckett, J. & Beyder, A., Jun 1 2016, In : Mayo Clinic Proceedings. 91, 6, p. 808-811 4 p.

Research output: Contribution to journalShort survey

Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV1.5 in the rat jejunum

Beyder, A., Gibbons, S. J., Mazzone, A., Strege, P. R., Saravanaperumal, S. A., Sha, L., Higgins, S., Eisenman, S. T., Bernard, C. E., Geurts, A., Kline, C. F., Mohler, P. J. & Farrugia, G., Jan 1 2016, In : Neurogastroenterology and Motility. 28, 1, p. 64-73 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P. J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ordog, T., Camp, J. J., Ge, X., Bharucha, A. E., Linden, D. R., Szurszewski, J. H., Kashyap, P. C. & Farrugia, G., Jul 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 4, p. 454-467 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Ion channelopathies in functional GI disorders

Beyder, A. & Farrugia, G., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 4, p. G581-G586

Research output: Contribution to journalReview article

19 Scopus citations

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Wang, F., Knutson, K., Alcaino, C., Linden, D. R., Gibbons, S. J., Kashyap, P. C., Grover, M., Oeckler, R., Gottlieb, P. A., Li, H. J., Leiter, A. B., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

44 Scopus citations

Mechanosensitive Piezo Channels in the Gastrointestinal Tract

Alcaino, C., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Current Topics in Membranes.

Research output: Contribution to journalArticle

15 Scopus citations

Mechanosensory signaling in enterochromaffin cells and 5-HT release: Potential implications for gut inflammation

Linan-Rico, A., Ochoa-Cortes, F., Beyder, A., Soghomonyan, S., Zuleta-Alarcon, A., Coppola, V. & Christofi, F. L., 2016, In : Frontiers in Neuroscience. 10, DEC, 564.

Research output: Contribution to journalReview article

15 Scopus citations

TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Henström, M., Hadizadeh, F., Beyder, A., Bonfiglio, F., Zheng, T., Assadi, G., Rafter, J., Bujanda, L., Agreus, L., Andreasson, A., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Talley, N. J., Simren, M., Walter, S., Wouters, M., Farrugia, G. & 1 others, D'Amato, M., Dec 14 2016, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

10 Scopus citations
2015

A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2+

Strege, P. R., Bernard, C. E., Mazzone, A., Linden, D. R., Beyder, A., Gibbons, S. J. & Farrugia, G., Nov 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 9, p. G743-G749

Research output: Contribution to journalArticle

10 Scopus citations

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces

Simonetto, D., Yang, H. Y., Yin, M., de Assuncao, T. M., Kwon, J. H., Hilscher, M., Pan, S., Yang, L., Bi, Y., Beyder, A., Cao, S., Simari, R. D., Ehman, R. L., Kamath, P. S. & Shah, V., Feb 1 2015, In : Hepatology. 61, 2, p. 648-659 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells

Neshatian, L., Strege, P. R., Rhee, P. L., Kraichely, R. E., Mazzone, A., Bernard, C. E., Cima, R. R., Larson, D., Dozois, E., Kline, C. F., Mohler, P. J., Beyder, A. & Farrugia, G., Sep 15 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 6, p. G506-G512

Research output: Contribution to journalArticle

10 Scopus citations
2014

84-year-old man with night sweats, weight loss, and diarrhea

Ngwa, T. N., Beyder, A. & Vege, S. S., 2014, In : Mayo Clinic Proceedings. 89, 3, p. 409-413 5 p.

Research output: Contribution to journalArticle

Loss-of-function of the voltage-gated sodium channel NaV1.5 (Channelopathies) in patients with irritable bowel syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito Loftus, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., Lindberg, G., Karling, P., Ohlsson, B., Gazouli, M., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P. & 8 others, Bellini, M., Barbara, G., Camilleri, M., Locke, G. R., Talley, N. J., D'Amato, M., Ackerman, M. J. & Farrugia, G., 2014, In : Gastroenterology. 146, 7, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
2013

Acute polyarticular gout presenting as Delirium

Wilson, M., Wan, S. H., Beyder, A., Osborn, T. & Beckman, T. J., Jun 2013, In : Journal of Clinical Rheumatology. 19, 4, p. 221-222 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Role of ion channel mechanosensitivity in the gut: Mechano-electrical feedback exemplified by stretch-dependence of Nav1.5

Beyder, A., Lees-Green, R. & Farrugia, G., Jan 1 2013, Lecture Notes in Computational Vision and Biomechanics. Springer Netherlands, p. 7-27 21 p. (Lecture Notes in Computational Vision and Biomechanics; vol. 10).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings

Angeli, T. R., Du, P., Paskaranandavadivel, N., Janssen, P. W. M., Beyder, A., Lentle, R. G., Bissett, I. P., Cheng, L. K. & O'Grady, G., Sep 2013, In : Journal of Physiology. 591, 18, p. 4567-4579 13 p.

Research output: Contribution to journalArticle

41 Scopus citations
2012

Large atrial myxoma causing dynamic obstruction of the mitral valve and atrial fibrillation

Beyder, A. & Klarich, K. W., 2012, In : Mayo Clinic Proceedings. 87, 2

Research output: Contribution to journalArticle

3 Scopus citations

Membrane permeable local anesthetics modulate Na V1.5 mechanosensitivity

Beyder, A., Strege, P. R., Bernard, C. & Farrugia, G., Jul 2012, In : Channels. 6, 4

Research output: Contribution to journalArticle

9 Scopus citations

Quantification of gastrointestinal sodium channelopathy

Poh, Y. C., Beyder, A., Strege, P. R., Farrugia, G. & Buist, M. L., Jan 21 2012, In : Journal of Theoretical Biology. 293, p. 41-48 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action

Beyder, A., Strege, P. R., Reyes, S., Bernard, C. E., Terzic, A., Makielski, J., Ackerman, M. J. & Farrugia, G., Jun 5 2012, In : Circulation. 125, 22, p. 2698-2706 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells

Strege, P., Beyder, A., Bernard, C., Crespo-Diaz, R., Behfar, A., Terzic, A., Ackerman, M. J. & Farrugia, G., Nov 2012, In : Channels. 6, 6, p. 457-462 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
36 Scopus citations
2011

Altered expression of ano1 variants in human diabetic gastroparesis

Mazzone, A., Bernard, C. E., Strege, P. R., Beyder, A., Galietta, L. J. V., Pasricha, P. J., Rae, J. L., Parkman, H. P., Linden, D. R., Szurszewski, J. H., Ordog, T., Gibbons, S. J. & Farrugia, G., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13393-13403 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Biophysically based modeling of the interstitial cells of Cajal: Current status and future perspectives

Lees-Green, R., Du, P., O'Grady, G., Beyder, A., Farrugia, G. & Pullan, A. J., 2011, In : Frontiers in Physiology. JUL, Article 29.

Research output: Contribution to journalArticle

38 Scopus citations

Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, NAv1.5

Strege, P. R., Bernard, C. E., Kraichely, R. E., Mazzone, A., Sha, L., Beyder, A., Gibbons, S. J., Linden, D. R., Kendrick, M. L., Sarr, M. G., Szurszewski, J. H. & Farrugia, G., Jun 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6

Research output: Contribution to journalArticle

27 Scopus citations
2010

Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo

Tharayil, V. S., Wouters, M. M., Stanich, J. E., Roeder, J. L., Lei, S., Beyder, A., Gomez-Pinilla, P. J., Gershon, M. D., Maroteaux, L., Gibbons, S. J. & Farrugia, G., Apr 2010, In : Neurogastroenterology and Motility. 22, 4

Research output: Contribution to journalArticle

38 Scopus citations

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

Beyder, A., Rae, J. L., Bernard, C., Strege, P. R., Sachs, F. & Farrugia, G., Dec 2010, In : Journal of Physiology. 588, 24, p. 4969-4985 17 p.

Research output: Contribution to journalArticle

99 Scopus citations

T-type Ca2+ channel modulation by otilonium bromide

Strege, P. R., Sha, L., Beyder, A., Bernard, C. E., Perez-Reyes, E., Evangelista, S., Gibbons, S. J., Szurszewski, J. H. & Farrugia, G., May 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 5

Research output: Contribution to journalArticle

14 Scopus citations
2009

Electromechanical coupling in the membranes of Shaker-transfected HEK cells

Beyder, A. & Sachs, F., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6626-6631 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

Atomic force microscopy analysis of cell volume regulation

Spagnoli, C., Beyder, A., Besch, S. & Sachs, F., Sep 22 2008, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 78, 3, 031916.

Research output: Contribution to journalArticle

45 Scopus citations
2007

Drift-free atomic force microscopy measurements of cell height and mechanical properties

Spagnoli, C., Beyder, A., Besch, S. R. & Sachs, F., 2007, In : Review of Scientific Instruments. 78, 3, 036111.

Research output: Contribution to journalArticle

12 Scopus citations

Hydrodynamics of torsional probes for atomic force microscopy in liquids

Basak, S., Beyder, A., Spagnoli, C., Raman, A. & Sachs, F., 2007, In : Journal of Applied Physics. 102, 2, 024914.

Research output: Contribution to journalArticle

8 Scopus citations
2006

Microfabricated torsion levers optimized for low force and high-frequency operation in fluids

Beyder, A. & Sachs, F., Jun 2006, In : Ultramicroscopy. 106, 8-9, p. 838-846 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Reducing probe dependent drift in atomic force microscope with symmetrically supported torsion levers

Beyder, A., Spagnoli, C. & Sachs, F., May 2006, In : Review of Scientific Instruments. 77, 5, 056105.

Research output: Contribution to journalArticle

13 Scopus citations