• 5095 Citations
  • 40 Scopus h-Index
1990 …2020

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Article
2006

Introduction

Silvestri, G., Lori, F., Foli, A., Montaner, L. J., Clotet, B., Barreiro, P., Gatell, J. M., Poli, G., Lederman, M., Perno, C. F., Wainberg, M. A., Lieberman, J., Bentwitch, Z., Cooper, D. A., Badley, A., Kinloch, S., Miller, S., Youle, M., Autran, B., Lisziewicz, J. & 6 others, Weiner, D. B., Ensoli, B., Franchini, G., Maserati, R., Pollard, R. B. & Lunzen, J. V., Jul 1 2006, In : Journal of Acquired Immune Deficiency Syndromes. 42, 3 SUPPL. 1, p. S1-S27

Research output: Contribution to journalArticle

1 Scopus citations
2005

Acquired T-cell sensitivity to TRAIL mediated killing during HIV infection is regulated by CXCR4-gp120 interactions

Lum, J. J., Schnepple, D. J. & Badley, A. D., Jul 22 2005, In : AIDS. 19, 11, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Blockade of HERG channels by HIV protease inhibitors

Anson, B. D., Weaver, J. G. R., Ackerman, M. J., Akinsete, O., Henry, K., January, C. T. & Badley, A. D., Feb 19 2005, In : Lancet. 365, 9460, p. 682-686 5 p.

Research output: Contribution to journalArticle

98 Scopus citations

Elimination of senescent neutrophils by TNF-related apopotosis-inducing ligand

Lum, J. J., Bren, G., McClure, R. & Badley, A. D., Jul 15 2005, In : Journal of Immunology. 175, 2, p. 1232-1238 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCα and PKCθ

Trushin, S. A., Bren, G. D., Asin, S., Pennington, K. N., Paya, C. V. & Badley, A. D., Aug 1 2005, In : Journal of virology. 79, 15, p. 9821-9830 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Increased thymic output in HIV-negative patients after antiretroviral therapy

Graham, D. B., Bell, M. P., Huntoon, C. J., Weaver, J. G. R., Hawley, N., Badley, A. D. & McKean, D. J., Sep 23 2005, In : AIDS. 19, 14, p. 1467-1472 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor

Weaver, J. G. R., Tarze, A., Moffat, T. C., Lebras, M., Deniaud, A., Brenner, C., Bren, G. D., Morin, M. Y., Phenix, B. N., Dong, L., Jiang, S. X., Sim, V. L., Zurakowski, B., Lallier, J., Hardin, H., Wettstein, P., Van Heeswijk, R. P. G., Douen, A., Kroemer, R. T., Hou, S. T. & 4 others, Bennett, S. A. L., Lynch, D. H., Kroemer, G. & Badley, A. D., Jul 1 2005, In : Journal of Clinical Investigation. 115, 7, p. 1828-1838 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates

Pittock, S. T., Norby, S. M., Grande, J. P., Croatt, A. J., Bren, G. D., Badley, A. D., Caplice, N. M., Griffin, M. D. & Nath, K. A., Aug 1 2005, In : Kidney international. 68, 2, p. 611-622 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

Rejection severity directly correlates with myocyte apoptosis in pig-to-baboon cardiac xenotransplantation

Weaver, J. G. R., McGregor, C. G. A., Tazelaar, H. D. & Badley, A. D., Jul 1 2005, In : Journal of Heart and Lung Transplantation. 24, 7, p. 841-847 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ritonavir does not inhibit calpain in vitro

Cuerrier, D., Nie, Z., Badley, A. D. & Davies, P. L., Feb 4 2005, In : Biochemical and Biophysical Research Communications. 327, 1, p. 208-211 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2004

Anti-apoptotic activity of the glutathione peroxidase homologue encoded by HIV-1

Cohen, I., Boya, P., Zhao, L., Métivier, D., Andreau, K., Perfettini, J. L., Weaver, J. G., Badley, A., Taylor, E. W. & Kroemer, G., Mar 1 2004, In : Apoptosis. 9, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Antiretroviral therapy influences cellular susceptibility to apoptosis in vivo

Cooper, C. L., Phenix, B., Mbisa, G., Lum, J. J., Parato, K., Hawley, N., Angel, J. B. & Badley, A. D., Jan 1 2004, In : Frontiers in Bioscience. 9, p. 338-341 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients

Zhang, X., Lalezari, J. P., Badley, A. D., Dorr, A., Kolis, S. J., Kinchelow, T. & Patel, I. H., Jun 1 2004, In : Clinical pharmacology and therapeutics. 75, 6, p. 558-568 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cordyceps sinensis extracts do not prevent Fas-receptor and hydrogen peroxide-induced T-cell apoptosis

Buenz, E. J., Weaver, J. G., Bauer, B. A., Chalpin, S. D. & Badley, A. D., Jan 2004, In : Journal of Ethnopharmacology. 90, 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Differential effects of interleukin-7 and interleukin-15 on NK cell anti-human immunodeficiency virus activity

Lum, J. J., Schnepple, D. J., Nie, Z., Sanchez-Dardon, J., Mbisa, G. L., Mihowich, J., Hawley, N., Narayan, S., Kim, J. E., Lynch, D. H. & Badley, A. D., Jun 1 2004, In : Journal of virology. 78, 11, p. 6033-6042 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Effect on CD4 T-cell count of replacing protease inhibitors in patients with successful HIV suppression: A meta-analysis

Owen, C., Kazim, F. & Badley, A. D., Mar 5 2004, In : AIDS. 18, 4, p. 693-695 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Impact of mitochondrial regulation of apoptosis on the pathogenesis and treatment of HIV-1-induced immunodeficiency

Buenz, E. J. & Badley, A. D., Jul 2004, In : Mitochondrion. 4, 2-3, p. 235-254 20 p.

Research output: Contribution to journalArticle

9 Scopus citations

Improved survival in experimental sepsis with an orally administered inhibitor of apoptosis

Weaver, J. G. R., Rouse, M. S., Steckelberg, J. M. & Badley, A. D., Aug 1 2004, In : FASEB Journal. 18, 11, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

63 Scopus citations
2003

Attenuated T-lymphocyte response to HIV therapy in individuals receiving HMG-CoA reductase inhibitors

Narayan, S., Hawley, N., Giguère, P. & Badley, A. D., May 1 2003, In : HIV Clinical Trials. 4, 3, p. 164-169 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Production of CD8+ T cell nonlytic suppressive factors by CD28, CD38, and HLA-DR subpopulations

Jiang, J. Q., Balasubramanian, S., Hawley-Foss, N. C., Badley, A. D., Rosenthal, K. L. & Copeland, K. F. T., Jun 1 2003, In : AIDS Research and Human Retroviruses. 19, 6, p. 497-502 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis

Lum, J. J., Cohen, O. J., Nie, Z., Weaver, J. G., Gomez, T. S., Yao, X. J., Lynch, D., Pilon, A. A., Hawley, N., Kim, J. E., Chen, Z., Montpetit, M., Sanchez-Dardon, J., Cohen, E. A. & Badley, A. D., May 2003, In : Journal of Clinical Investigation. 111, 10, p. 1547-1554 8 p.

Research output: Contribution to journalArticle

Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis

Lum, J. J., Cohen, O. J., Nie, Z., Weaver, J. G., Gomez, T. S., Yao, X. J., Lynch, D., Pilon, A. A., Hawley, N., Kim, J. E., Chen, Z., Montpetit, M., Sanchez-Dardon, J., Cohen, E. A. & Badley, A. D., May 2003, In : Journal of Clinical Investigation. 111, 10, p. 1547-1554 8 p.

Research output: Contribution to journalArticle

172 Scopus citations
2002

A typical atypical pneumonia

Mikhael, J., Humphrey, S., Jabi, M. & Badley, A. D., Jan 1 2002, In : Canadian Journal of Infectious Diseases. 13, 1, p. 20+71-72

Research output: Contribution to journalArticle

Open Access

HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation

Nie, Z., Phenix, B. N., Lum, J. J., Alam, A., Lynch, D. H., Beckett, B., Krammer, P. H., Sekaly, R. P. & Badley, A. D., Jan 1 2002, In : Cell Death and Differentiation. 9, 11, p. 1172-1184 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor

Pilon, A. A., Lum, J. J., Sanchez-Dardon, J., Phenix, B. N., Douglas, R. & Badley, A. D., Jan 1 2002, In : Antimicrobial Agents and Chemotherapy. 46, 8, p. 2687-2691 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Influence of mitochondrial control of apoptosis on the pathogenesis, complications and treatment of HIV infection

Phenix, B. N. & Badley, A. D., Jan 1 2002, In : Biochimie. 84, 2-3, p. 251-264 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Normalization of natural killer cell function and phenotype with effective anti-HIV therapy and the role of IL-10

Parato, K. G., Kumar, A., Badley, A. D., Sanchez-Dardon, J. L., Chambers, K. A., Young, C. D., Lim, W. T., Kravcik, S., Cameron, D. W. & Angel, J. B., Jun 14 2002, In : AIDS. 16, 9, p. 1251-1256 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Selection of lymphocyte gating protocol has an impact on the level of reliability of T-cell subsets in aging specimens

Bergeron, M., Nicholson, J. K. A., Phaneuf, S., Ding, T., Soucy, N., Badley, A. D., Foss, N. C. H. & Mandy, F., Dec 1 2002, In : Clinical Cytometry. 50, 2, p. 53-61 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
2001

Antiapoptotic mechanism of HIV protease inhibitors: Preventing mitochondrial transmembrane potential loss

Phenix, B. N., Lum, J. J., Nie, Z., Sanchez-Dardon, J. & Badley, A. D., Aug 15 2001, In : Blood. 98, 4, p. 1078-1085 8 p.

Research output: Contribution to journalArticle

93 Scopus citations

Comparative CD4 T-cell responses of reverse transcriptase inhibitor therapy with or without nelfinavir matched for viral exposure

Kravcik, S., Magill, A., Sanghvi, B., Ogden, R., Cameron, D. W., Lewis, R., Yu, G. & Badley, A. D., Jan 1 2001, In : HIV Clinical Trials. 2, 2, p. 160-170 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Effect of cessation of highly active antiretroviral therapy during a discordant response: Implications for scheduled therapeutic interruptions

Hawley-Foss, N., Mbisa, G., Lum, J. J., Pilon, A. A., Angel, J. B., Garber, G. & Badley, A. D., Aug 1 2001, In : Clinical Infectious Diseases. 33, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Induction of cell death in human immunodeficiency virus-infected macrophages and resting memory CD4 T cells by trail/Apo2L

Lum, J. J., Pilon, A. A., Sanchez-Dardon, J., Phenix, B. N., Kim, J. E., Mihowich, J., Jamison, K., Hawley-Foss, N., Lynch, D. H. & Badley, A. D., Nov 15 2001, In : Journal of virology. 75, 22, p. 11128-11136 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

Modulation of HIV transcription by CD8+ cells is mediated via multiple elements of the long terminal repeat

Maslove, D. M., Ni, L. W., Hawley-Foss, N. C., Badley, A. D. & Copeland, K. F. T., Aug 14 2001, In : Clinical and Experimental Immunology. 125, 1, p. 102-109 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function

Teixeira, L., Valdez, H., McCune, J. M., Koup, R. A., Badley, A. D., Hellerstein, M. K., Napolitano, L. A., Douek, D. C., Mbisa, G., Deeks, S., Harris, J. M., Barbour, J. D., Gross, B. H., Francis, I. R., Halvorsen, R., Asaad, R. & Lederman, M. M., Sep 28 2001, In : AIDS. 15, 14, p. 1749-1756 8 p.

Research output: Contribution to journalArticle

199 Scopus citations

Progressive human immunodeficiency virus-specific immune recovery with prolonged viral suppression

Angel, J. B., Parato, K. G., Kumar, A., Kravcik, S., Badley, A. D., Fex, C., Ashby, D., Sun, E. & Cameron, D. W., Feb 15 2001, In : Journal of Infectious Diseases. 183, 4, p. 546-554 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2000

Decreased HIV-associated T cell apoptosis by HIV protease inhibitors

Phenix, B. N., Angel, J. B., Mandy, F., Kravcik, S., Parato, K., Chambers, K. A., Gallicano, K., Hawley-Foss, N., Cassol, S., William Cameron, D. & Badley, A. D., Apr 10 2000, In : AIDS Research and Human Retroviruses. 16, 6, p. 559-567 9 p.

Research output: Contribution to journalArticle

83 Scopus citations

Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease

Khaliq, Y., Gallicano, K., Seguin, I., Fyke, K., Carignan, G., Bulman, D., Badley, A. & Cameron, D. W., Aug 21 2000, In : British Journal of Clinical Pharmacology. 50, 2, p. 108-115 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

The economic impact of cytomegalovirus infection after liver transplantation

Kim, W. R., Badley, A. D., Wiesner, R. H., Porayko, M. K., Seaberg, E. C., Keating, M. R., Evans, R. W., Dickson, E. R., Krom, R. A. F. & Paya, C. V., Feb 15 2000, In : Transplantation. 69, 3, p. 357-361 5 p.

Research output: Contribution to journalArticle

72 Scopus citations
1999

Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number

Dockrell, D. H., Badley, A. D., Algeciras-Schimnich, A., Simpson, M., Schut, R., Lynch, D. H. & Paya, C. V., Nov 20 1999, In : AIDS Research and Human Retroviruses. 15, 17, p. 1509-1518 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Activity of the combination of nelfinavir and saquinavir against human immunodeficiency virus after failure of prior protease inhibitor therapy

Kravcik, S., Victor, G., Angel, J. B., Badley, A. D., Garber, G. E. & Cameron, D. W., Sep 28 1999, In : Clinical Infectious Diseases. 29, 3, p. 702-703 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cerebrospinal fluid HIV RNA and drug levels with combination ritonavir and saquinavir

Kravcik, S., Gallicano, K., Roth, V., Cassol, S., Hawley-Foss, N., Badley, A. & Cameron, D. W., Aug 15 1999, In : Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 21, 5, p. 371-375 5 p.

Research output: Contribution to journalArticle

89 Scopus citations

Dynamic correlation of apoptosis and immune activation during treatment of HIV infection

Badley, A. D., Parato, K., Cameron, D. W., Kravcik, S., Phenix, B. N., Ashby, D., Kumar, A., Lynch, D. H., Tschopp, J. & Angel, J. B., May 1999, In : Cell Death and Differentiation. 6, 5, p. 420-432 13 p.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations
1998

In vivo analysis of Fas/FasL interactions in HIV-infected patients

Badley, A. D., Dockrell, D. H., Algeciras, A., Ziesmer, S., Landay, A., Lederman, M. M., Connick, E., Kessler, H., Kuritzkes, D., Lynch, D. H., Roche, P., Yagita, H. & Paya, C. V., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

Open Access
130 Scopus citations

Porphyria cutanea tarda and human immunodeficiency virus: Two cases associated with hepatitis C

O'Connor, W. J., Badley, A. D., Dicken, C. H. & Murphy, G. M., Jan 1 1998, In : Mayo Clinic proceedings. 73, 9, p. 895-897 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Significance of cytomegalovirus for long-term survival after orthotopic liver transplantation: A prospective derivation and validation cohort analysis

Falagas, M. E., Paya, C., Ruthazer, R., Badley, A., Patel, R., Wiesner, R., Griffith, J., Freeman, R., Rohrer, R., Werner, B. G. & Snydman, D. R., Oct 27 1998, In : Transplantation. 66, 8, p. 1020-1028 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

The expression of Fas ligand by macrophages and its upregulation by human immunodeficiency virus

Dockrell, D. H., Badley, A. D., Villacian, J. S., Heppelmann, C. J., Algeciras, A., Ziesmer, S., Yagita, H., Lynch, D. H., Roche, P. C., Leibson, P. J. & Paya, C. V., Jun 1 1998, In : Journal of Clinical Investigation. 101, 11, p. 2394-2405 12 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Transcriptional regulation of the human FasL promoter-enhancer region

Holtz-Heppelmann, C. J., Algeciras, A., Badley, A. D. & Paya, C. V., Feb 20 1998, In : Journal of Biological Chemistry. 273, 8, p. 4416-4423 8 p.

Research output: Contribution to journalArticle

130 Scopus citations
1997

Apoptosis in AIDS

Badley, A. D., Dockrell, D. & Paya, C. V., Dec 1 1997, In : Advances in Pharmacology. 41, C, p. 271-294 24 p.

Research output: Contribution to journalArticle

24 Scopus citations

Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor

Badley, A. D., Dockrell, D., Simpson, M., Schut, R., Lynch, D. H., Leibson, P. & Paya, C. V., Jan 6 1997, In : Journal of Experimental Medicine. 185, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

211 Scopus citations

Prophylaxis of cytomegalovirus infection in liver transplantation: A randomized trial comparing a combination of ganciclovir and acyclovir to acyclovir

Badley, A. D., Seaberg, E. C., Porayko, M. K., Wiesner, R. H., Keating, M. R., Wilhelm, M. P., Walker, R. C., Patel, R., Marshall, W. F., Debernardi, M., Zetterman, R., Steers, J. L. & Paya, C. V., Jul 15 1997, In : Transplantation. 64, 1, p. 66-73 8 p.

Research output: Contribution to journalArticle

80 Scopus citations