• 5095 Citations
  • 40 Scopus h-Index
1990 …2020

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26-Year-Old Man With HIV Infection and Abdominal Pain

MacMorran, W. S., Badley, A. D. & Wilson, W. R., Jan 1 1995, In : Mayo Clinic proceedings. 70, 9, p. 885-888 4 p.

Research output: Contribution to journalArticle

Open Access

Acquired T-cell sensitivity to TRAIL mediated killing during HIV infection is regulated by CXCR4-gp120 interactions

Lum, J. J., Schnepple, D. J. & Badley, A. D., Jul 22 2005, In : AIDS. 19, 11, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number

Dockrell, D. H., Badley, A. D., Algeciras-Schimnich, A., Simpson, M., Schut, R., Lynch, D. H. & Paya, C. V., Nov 20 1999, In : AIDS Research and Human Retroviruses. 15, 17, p. 1509-1518 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Activity of the combination of nelfinavir and saquinavir against human immunodeficiency virus after failure of prior protease inhibitor therapy

Kravcik, S., Victor, G., Angel, J. B., Badley, A. D., Garber, G. E. & Cameron, D. W., Sep 28 1999, In : Clinical Infectious Diseases. 29, 3, p. 702-703 2 p.

Research output: Contribution to journalArticle

6 Scopus citations
70 Scopus citations

Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria

Algeciras-Schimnich, A., Belzacq-Casagrande, A. S., Bren, G. D., Nie, Z., Taylor, J. A., Rizza, S., Brenner, C. & Badley, A. D., Dec 27 2007, In : The open virology journal. 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Anti-apoptotic activity of the glutathione peroxidase homologue encoded by HIV-1

Cohen, I., Boya, P., Zhao, L., Métivier, D., Andreau, K., Perfettini, J. L., Weaver, J. G., Badley, A., Taylor, E. W. & Kroemer, G., Mar 1 2004, In : Apoptosis. 9, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Antiapoptotic mechanism of HIV protease inhibitors: Preventing mitochondrial transmembrane potential loss

Phenix, B. N., Lum, J. J., Nie, Z., Sanchez-Dardon, J. & Badley, A. D., Aug 15 2001, In : Blood. 98, 4, p. 1078-1085 8 p.

Research output: Contribution to journalArticle

93 Scopus citations

Antiretroviral therapy influences cellular susceptibility to apoptosis in vivo

Cooper, C. L., Phenix, B., Mbisa, G., Lum, J. J., Parato, K., Hawley, N., Angel, J. B. & Badley, A. D., Jan 1 2004, In : Frontiers in Bioscience. 9, p. 338-341 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Apoptosis in AIDS

Badley, A. D., Dockrell, D. & Paya, C. V., Dec 1 1997, In : Advances in Pharmacology. 41, C, p. 271-294 24 p.

Research output: Contribution to journalArticle

24 Scopus citations

Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients

Zhang, X., Lalezari, J. P., Badley, A. D., Dorr, A., Kolis, S. J., Kinchelow, T. & Patel, I. H., Jun 1 2004, In : Clinical pharmacology and therapeutics. 75, 6, p. 558-568 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Attenuated T-lymphocyte response to HIV therapy in individuals receiving HMG-CoA reductase inhibitors

Narayan, S., Hawley, N., Giguère, P. & Badley, A. D., May 1 2003, In : HIV Clinical Trials. 4, 3, p. 164-169 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

A typical atypical pneumonia

Mikhael, J., Humphrey, S., Jabi, M. & Badley, A. D., Jan 1 2002, In : Canadian Journal of Infectious Diseases. 13, 1, p. 20+71-72

Research output: Contribution to journalArticle

Open Access

Beneficial effect of TRAIL on HIV burden, without detectable immune consequences

Shepard, B. D., De Forni, D., McNamara, D. R., Foli, A., Rizza, S. A., Abraham, R. S., Knutson, K., Wettstein, P. J., Lori, F. & Badley, A. D., Aug 28 2008, In : PloS one. 3, 8, e3096.

Research output: Contribution to journalArticle

9 Scopus citations

Blockade of HERG channels by HIV protease inhibitors

Anson, B. D., Weaver, J. G. R., Ackerman, M. J., Akinsete, O., Henry, K., January, C. T. & Badley, A. D., Feb 19 2005, In : Lancet. 365, 9460, p. 682-686 5 p.

Research output: Contribution to journalArticle

98 Scopus citations

Both HIV-Infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment

Nie, Z., Aboulnasr, F., Natesampillai, S., Burke, S. P., Krogman, A., Bren, G. D., Chung, T. D. Y., Anderson, J. R., Smart, M. K., Katzmann, D. J., Rajagopalan, G., Cummins, N. W. & Badley, A. D., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1110-1123 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Can HIV be cured and should we try?

Cummins, N. W. & Badley, A. D., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 705-709 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission

Sampath, R., Patel, R., Cunningham, S. A., Arif, S., Daly, R. C., Badley, A. D. & Wylam, M., May 1 2017, In : EBioMedicine. 19, p. 84-90 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Casp8p41 expression in primary T cells induces a proinflammatory response

Taylor, J. A., Cummins, N. W., Bren, G. D., Rizza, S. A., Kolbert, C. P., Behrens, M. D., Knutson, K. L., Kahl, J. C., Asmann, Y. W. & Badley, A. D., Jun 1 2010, In : AIDS. 24, 9, p. 1251-1258 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y. P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., Jan 1 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cerebrospinal fluid HIV RNA and drug levels with combination ritonavir and saquinavir

Kravcik, S., Gallicano, K., Roth, V., Cassol, S., Hawley-Foss, N., Badley, A. & Cameron, D. W., Aug 15 1999, In : Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 21, 5, p. 371-375 5 p.

Research output: Contribution to journalArticle

89 Scopus citations

Comparative CD4 T-cell responses of reverse transcriptase inhibitor therapy with or without nelfinavir matched for viral exposure

Kravcik, S., Magill, A., Sanghvi, B., Ogden, R., Cameron, D. W., Lewis, R., Yu, G. & Badley, A. D., Jan 1 2001, In : HIV Clinical Trials. 2, 2, p. 160-170 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cordyceps sinensis extracts do not prevent Fas-receptor and hydrogen peroxide-induced T-cell apoptosis

Buenz, E. J., Weaver, J. G., Bauer, B. A., Chalpin, S. D. & Badley, A. D., Jan 2004, In : Journal of Ethnopharmacology. 90, 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Decreased HIV-associated T cell apoptosis by HIV protease inhibitors

Phenix, B. N., Angel, J. B., Mandy, F., Kravcik, S., Parato, K., Chambers, K. A., Gallicano, K., Hawley-Foss, N., Cassol, S., William Cameron, D. & Badley, A. D., Apr 10 2000, In : AIDS Research and Human Retroviruses. 16, 6, p. 559-567 9 p.

Research output: Contribution to journalArticle

83 Scopus citations

Development of monoclonal gammopathy precedes the development of Epstein-Barr virus-induced posttransplant lymphoproliferative disorder

Badley, A. D., Portela, D. F., Patel, R., Kyle, R. A., Habermann, T. M., Strickler, J. G., Ilstrup, D. M., Wiesner, R. H., De Groen, P., Walker, R. C. & Paya, C. V., Jan 1 1996, In : Liver Transplantation and Surgery. 2, 5, p. 375-382 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Differential effects of interleukin-7 and interleukin-15 on NK cell anti-human immunodeficiency virus activity

Lum, J. J., Schnepple, D. J., Nie, Z., Sanchez-Dardon, J., Mbisa, G. L., Mihowich, J., Hawley, N., Narayan, S., Kim, J. E., Lynch, D. H. & Badley, A. D., Jun 1 2004, In : Journal of virology. 78, 11, p. 6033-6042 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Disseminated coccidioidomycosis in a liver transplant recipient with negative serology: Use of polymerase chain reaction

Assi, M. A., Binnicker, M. J., Wengenack, N. L., Deziel, P. J. & Badley, A. D., Aug 1 2006, In : Liver Transplantation. 12, 8, p. 1290-1292 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Disseminated mycobacterium Chimaera infection after cardiothoracic surgery

Tan, N., Sampath, R., Abu Saleh, O. M., Tweet, M., Jevremovic, D., Alniemi, S., Wengenack, N. L., Sampathkumar, P. & Badley, A. D., 2016, In : Open Forum Infectious Diseases. 3, 3, ofw131.

Research output: Contribution to journalArticle

37 Scopus citations

Dynamic correlation of apoptosis and immune activation during treatment of HIV infection

Badley, A. D., Parato, K., Cameron, D. W., Kravcik, S., Phenix, B. N., Ashby, D., Kumar, A., Lynch, D. H., Tschopp, J. & Angel, J. B., May 1999, In : Cell Death and Differentiation. 6, 5, p. 420-432 13 p.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations

Early changes in T-cell activation predict antiretroviral success in salvage therapy of HIV infection

Shepard, B. D., Loutfy, M. R., Raboud, J., Mandy, F., Kovacs, C. M., Diong, C., Bergeron, M., Govan, V., Rizza, S. A., Angel, J. B. & Badley, A. D., Jun 1 2008, In : Journal of Acquired Immune Deficiency Syndromes. 48, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effect of cessation of highly active antiretroviral therapy during a discordant response: Implications for scheduled therapeutic interruptions

Hawley-Foss, N., Mbisa, G., Lum, J. J., Pilon, A. A., Angel, J. B., Garber, G. & Badley, A. D., Aug 1 2001, In : Clinical Infectious Diseases. 33, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effect on CD4 T-cell count of replacing protease inhibitors in patients with successful HIV suppression: A meta-analysis

Owen, C., Kazim, F. & Badley, A. D., Mar 5 2004, In : AIDS. 18, 4, p. 693-695 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Elimination of senescent neutrophils by TNF-related apopotosis-inducing ligand

Lum, J. J., Bren, G., McClure, R. & Badley, A. D., Jul 15 2005, In : Journal of Immunology. 175, 2, p. 1232-1238 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

Cummins, N. W., Rizza, S., Litzow, M. R., Hua, S., Lee, G. Q., Einkauf, K., Chun, T. W., Rhame, F., Baker, J. V., Busch, M. P., Chomont, N., Dean, P. G., Fromentin, R., Haase, A. T., Hampton, D., Keating, S. M., Lada, S. M., Lee, T. H., Natesampillai, S., Richman, D. D. & 7 others, Schacker, T. W., Wietgrefe, S., Yu, X. G., Yao, J. D., Zeuli, J., Lichterfeld, M. & Badley, A. D., Nov 2017, In : PLoS Medicine. 14, 11, e1002461.

Research output: Contribution to journalArticle

22 Scopus citations

Flying in the face of resistance: Antiviral-independent benefit of HIV protease inhibitors on T-cell survival

Vlahakis, S. R., Bren, G. D., Algeciras-Schimnich, A., Trushin, S. A., Schnepple, D. J. & Badley, A. D., Sep 1 2007, In : Clinical pharmacology and therapeutics. 82, 3, p. 294-299 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Glycoprotein 120 binding to CXCR4 causes p38-dependent primary T cell death that is facilitated by, but does not require cell-associated CD4

Trushin, S. A., Algeciras-Schimnich, A., Vlahakis, S. R., Bren, G. D., Warren, S., Schnepple, D. J. & Badley, A. D., Apr 15 2007, In : Journal of Immunology. 178, 8, p. 4846-4853 8 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice

Cummins, N. W., Weaver, E. A., May, S. M., Croatt, A. J., Foreman, O., Kennedy, R. B., Poland, G. A., Barry, M. A., Nath, K. A. & Badley, A. D., Jul 1 2012, In : FASEB Journal. 26, 7, p. 2911-2918 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation

Nie, Z., Phenix, B. N., Lum, J. J., Alam, A., Lynch, D. H., Beckett, B., Krammer, P. H., Sekaly, R. P. & Badley, A. D., Jan 1 2002, In : Cell Death and Differentiation. 9, 11, p. 1172-1184 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

HIV-1 tat protein suppresses cholangiocyte toll- like receptor 4 expression and defense against cryptosporidium parvum

O'Hara, S. P., Small, A. J., Gajdos, G. B., Badley, A. D., Chen, X. M. & LaRusso, N. F., Apr 15 2009, In : Journal of Infectious Diseases. 199, 8, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

HIV elite control is associated with reduced TRAILshort expression

Paim, A. C., Cummins, N. W., Natesampillai, S., Garcia-Rivera, E., Kogan, N., Neogi, U., Sönnerborg, A., Sperk, M., Bren, G. D., Deeks, S., Polley, E. & Badley, A. D., Sep 1 2019, In : AIDS. 33, 11, p. 1757-1763 7 p.

Research output: Contribution to journalArticle

HIV gp120 induces, NF-κB dependent, HIV replication that requires procaspase 8

Bren, G. D., Trushin, S. A., Whitman, J., Shepard, B. & Badley, A. D., Mar 16 2009, In : PloS one. 4, 3, e4875.

Research output: Contribution to journalArticle

13 Scopus citations

HIV induces TRAIL sensitivity in hepatocytes

Babu, C. K., Suwansrinon, K., Bren, G. D., Badley, A. D. & Rizza, S. A., Jan 1 2009, In : PloS one. 4, 2, e4623.

Research output: Contribution to journalArticle

41 Scopus citations

HIV protease-generated Casp8p41, when bound and inactivated by Bcl2, is degraded by the proteasome

Natesampillai, S., Cummins, N. W., Nie, Z., Sampath, R., Baker, J. V., Henry, K., Pinzone, M., O'Doherty, U., Polley, E., Bren, G. D., Katzmann, D. J. & Badley, A. D., Jul 1 2018, In : Journal of Virology. 92, 13, e00037-18.

Research output: Contribution to journalArticle

5 Scopus citations

HIV Protease inhibitors impact on apoptosis

Rizza, S. A. & Badley, A. D., Jan 1 2008, In : Medicinal Chemistry. 4, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice

Hisatomi, T., Nakazawa, T., Noda, K., Almulki, L., Miyahara, S., Nakao, S., Ito, Y., She, H., Kohno, R., Michaud, N., Ishibashi, T., Hafezi-Moghadam, A., Badley, A. D., Kroemer, G. & Miller, J. W., Jun 2 2008, In : Journal of Clinical Investigation. 118, 6, p. 2025-2038 14 p.

Research output: Contribution to journalArticle

52 Scopus citations

HIV replication, inflammation, and the effect of starting antiretroviral therapy on plasma asymmetric dimethylarginine, a novel marker of endothelial dysfunction

Baker, J. V., Neuhaus, J., Duprez, D., Freiberg, M., Bernardino, J. I., Badley, A. D., Nixon, D. E., Lundgren, J. D., Tracy, R. P. & Neaton, J. D., Jun 1 2012, In : Journal of Acquired Immune Deficiency Syndromes. 60, 2, p. 128-134 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

HIV VprR77Q mutation does not influence clinical response of individuals initiating highly active antiretroviral therapy

Chui, C., Cheung, P. K., Brumme, C. J., Mo, T., Brumme, Z. L., Montaner, J. S. G., Badley, A. D. & Harrigan, P. R., Jul 1 2006, In : AIDS Research and Human Retroviruses. 22, 7, p. 615-618 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations

Cummins, N. W., Klicpera, A., Sainski, A. M., Bren, G. D., Khosla, S., Westendorf, J. J. & Badley, A. D., Sep 12 2011, In : PloS one. 6, 9, e24876.

Research output: Contribution to journalArticle

6 Scopus citations

Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCα and PKCθ

Trushin, S. A., Bren, G. D., Asin, S., Pennington, K. N., Paya, C. V. & Badley, A. D., Aug 1 2005, In : Journal of virology. 79, 15, p. 9821-9830 10 p.

Research output: Contribution to journalArticle

40 Scopus citations