• 5078 Citations
  • 40 Scopus h-Index
1990 …2020

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Article
2020

The role of the BCL-2 family of proteins in HIV-1 pathogenesis and persistence

Chandrasekar, A. P., Cummins, N. W. & Badleya, A. D., Jan 2020, In : Clinical Microbiology Reviews. 33, 1, e00107-19.

Research output: Contribution to journalArticle

1 Scopus citations
2019

HIV elite control is associated with reduced TRAILshort expression

Paim, A. C., Cummins, N. W., Natesampillai, S., Garcia-Rivera, E., Kogan, N., Neogi, U., Sönnerborg, A., Sperk, M., Bren, G. D., Deeks, S., Polley, E. & Badley, A. D., Sep 1 2019, In : AIDS. 33, 11, p. 1757-1763 7 p.

Research output: Contribution to journalArticle

Trailshort protects against CD4 T cell death during acute HIV infection

Natesampillai, S., Paim, A. C., Cummins, N. W., Chandrasekar, A. P., Bren, G. D., Lewin, S. R., Kiem, H. P. & Badley, A. D., Aug 1 2019, In : Journal of Immunology. 203, 3, p. 718-724 7 p.

Research output: Contribution to journalArticle

2018

Both HIV-Infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment

Nie, Z., Aboulnasr, F., Natesampillai, S., Burke, S. P., Krogman, A., Bren, G. D., Chung, T. D. Y., Anderson, J. R., Smart, M. K., Katzmann, D. J., Rajagopalan, G., Cummins, N. W. & Badley, A. D., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1110-1123 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

HIV protease-generated Casp8p41, when bound and inactivated by Bcl2, is degraded by the proteasome

Natesampillai, S., Cummins, N. W., Nie, Z., Sampath, R., Baker, J. V., Henry, K., Pinzone, M., O'Doherty, U., Polley, E., Bren, G. D., Katzmann, D. J. & Badley, A. D., Jul 1 2018, In : Journal of Virology. 92, 13, e00037-18.

Research output: Contribution to journalArticle

5 Scopus citations

The TRAIL: TRAILshort Axis in HIV Immunopathology

Aboulnasr, F., Paranjape, G. & Badley, A. D., Jan 1 2018, In : Critical reviews in immunology. 38, 6, p. 491-503 13 p.

Research output: Contribution to journalArticle

Transient Loss of HIV-1 DNA in an HIV-1 Positive Patient After Kidney Transplantation: A Case Report

Paim, A. C., Rizza, S., Badley, A. D., Prieto, M., Taler, S. J., Chong, P. P. & Cummins, N. W., Jan 1 2018, (Accepted/In press) In : American Journal of Medicine.

Research output: Contribution to journalArticle

2017

Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission

Sampath, R., Patel, R., Cunningham, S. A., Arif, S., Daly, R. C., Badley, A. D. & Wylam, M., May 1 2017, In : EBioMedicine. 19, p. 84-90 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

Cummins, N. W., Rizza, S., Litzow, M. R., Hua, S., Lee, G. Q., Einkauf, K., Chun, T. W., Rhame, F., Baker, J. V., Busch, M. P., Chomont, N., Dean, P. G., Fromentin, R., Haase, A. T., Hampton, D., Keating, S. M., Lada, S. M., Lee, T. H., Natesampillai, S., Richman, D. D. & 7 others, Schacker, T. W., Wietgrefe, S., Yu, X. G., Yao, J. D., Zeuli, J., Lichterfeld, M. & Badley, A. D., Nov 2017, In : PLoS Medicine. 14, 11, e1002461.

Research output: Contribution to journalArticle

20 Scopus citations

Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells

Sampath, R., Cummins, N. W., Natesampillai, S., Bren, G. D., Chung, T. D., Baker, J., Henry, K., Pagliuzza, A. & Badley, A. D., Jun 2017, In : PloS one. 12, 6, e0179327.

Research output: Contribution to journalArticle

2 Scopus citations

Maintenance of the HIV reservoir is antagonized by selective BCL2 inhibition

Cummins, N. W., Sainski-Nguyen, A. M., Natesampillai, S., Aboulnasr, F., Kaufmann, S. H. & Badley, A. D., Jun 1 2017, In : Journal of Virology. 91, 11, e00012-17.

Research output: Contribution to journalArticle

23 Scopus citations
2016

Disseminated mycobacterium Chimaera infection after cardiothoracic surgery

Tan, N., Sampath, R., Abu Saleh, O. M., Tweet, M., Jevremovic, D., Alniemi, S., Wengenack, N. L., Sampathkumar, P. & Badley, A. D., 2016, In : Open Forum Infectious Diseases. 3, 3, ofw131.

Research output: Contribution to journalArticle

37 Scopus citations

Prime, shock, and kill: Priming CD4 T cells from HIV patients with a BCL-2 antagonist before HIV reactivation reduces HIV reservoir size

Cummins, N. W., Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., De Araujo Correia, M. C. M., Sampath, R., Rizza, S., O'Brien, D., Yao, J. D., Kaufmann, S. H. & Badley, A. D., Apr 1 2016, In : Journal of Virology. 90, 8, p. 4032-4048 17 p.

Research output: Contribution to journalArticle

40 Scopus citations
2015

Can HIV be cured and should we try?

Cummins, N. W. & Badley, A. D., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 705-709 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis

Cummins, N. W., Neuhaus, J., Chu, H., Neaton, J., Wyen, C., Rockstroh, J. K., Skiest, D. J., Boyd, M. A., Khoo, S., Rotger, M., Telenti, A., Weinshilboum, R. M. & Badley, A. D., Jul 1 2015, In : EBioMedicine. 2, 7, p. 706-712 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y. P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., Jan 1 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of Casp8p41

Cummins, N. W., Neuhaus, J., Sainski, A. M., Strausbauch, M. A., Wettstein, P. J., Lewin, S. R., Plana, M., Rizza, S. A., Temesgen, Z., Touloumi, G., Freiberg, M., Neaton, J. & Badley, A. D., May 30 2014, In : AIDS Research and Human Retroviruses. 30, 5, p. 476-479 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013
2012

Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice

Cummins, N. W., Weaver, E. A., May, S. M., Croatt, A. J., Foreman, O., Kennedy, R. B., Poland, G. A., Barry, M. A., Nath, K. A. & Badley, A. D., Jul 1 2012, In : FASEB Journal. 26, 7, p. 2911-2918 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

HIV replication, inflammation, and the effect of starting antiretroviral therapy on plasma asymmetric dimethylarginine, a novel marker of endothelial dysfunction

Baker, J. V., Neuhaus, J., Duprez, D., Freiberg, M., Bernardino, J. I., Badley, A. D., Nixon, D. E., Lundgren, J. D., Tracy, R. P. & Neaton, J. D., Jun 1 2012, In : Journal of Acquired Immune Deficiency Syndromes. 60, 2, p. 128-134 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: Implications for the development of T cell memory

Trushin, S. A., Carena, A. A., Bren, G. D., Rizza, S. A., Dong, X., Abraham, R. S. & Badley, A. D., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1835-1842 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations

Cummins, N. W., Klicpera, A., Sainski, A. M., Bren, G. D., Khosla, S., Westendorf, J. J. & Badley, A. D., Sep 12 2011, In : PloS one. 6, 9, e24876.

Research output: Contribution to journalArticle

6 Scopus citations

Isolation of a TRAIL antagonist from the serum of HIV-infected patients

Schnepple, D. J., Shepard, B., Bren, G. D., Cummins, N. W., Natesampillai, S., Trushin, S., Algeciras-Schimnich, A., Meng, X. W., Sainski, A. M., Rizza, S. A., Kaufmann, S. H. & Badley, A. D., Oct 14 2011, In : Journal of Biological Chemistry. 286, 41, p. 35742-35754 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak

Sainski, A. M., Natesampillai, S., Cummins, N. W., Bren, G. D., Taylor, J., Saenz, D. T., Poeschla, E. M. & Badley, A. D., Aug 2011, In : Journal of virology. 85, 16, p. 7965-7975 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

TRAIL Dependent Fratricidal Killing of gp120 Primed Hepatocytes by HCV Core Expressing Hepatocytes

Rizza, S. A., Challagundla, K. B., Natesampillai, S., Bren, G. D., Sykora, J., Walczak, H. & Badley, A. D., Dec 1 2011, In : PloS one. 6, 11, e27171.

Research output: Contribution to journalArticle

5 Scopus citations
2010

Casp8p41 expression in primary T cells induces a proinflammatory response

Taylor, J. A., Cummins, N. W., Bren, G. D., Rizza, S. A., Kolbert, C. P., Behrens, M. D., Knutson, K. L., Kahl, J. C., Asmann, Y. W. & Badley, A. D., Jun 1 2010, In : AIDS. 24, 9, p. 1251-1258 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Cummins, N. W., Jiang, W., McGinty, J., Bren, G. D., Bosch, R. J., Landay, A., Deeks, S. G., Martin, J. N., Douek, D., Lederman, M. M., Brenchley, J. & Badley, A. D., Aug 1 2010, In : Journal of Infectious Diseases. 202, 3, p. 386-391 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells

Natesampillai, S., Nie, Z., Cummins, N. W., Jochmans, D., Bren, G. D., Angel, J. B. & Badley, A. D., Nov 1 2010, In : PLoS pathogens. 6, 11, e1001213.

Research output: Contribution to journalArticle

12 Scopus citations
5 Scopus citations
2009

HIV-1 tat protein suppresses cholangiocyte toll- like receptor 4 expression and defense against cryptosporidium parvum

O'Hara, S. P., Small, A. J., Gajdos, G. B., Badley, A. D., Chen, X. M. & LaRusso, N. F., Apr 15 2009, In : Journal of Infectious Diseases. 199, 8, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

HIV gp120 induces, NF-κB dependent, HIV replication that requires procaspase 8

Bren, G. D., Trushin, S. A., Whitman, J., Shepard, B. & Badley, A. D., Mar 16 2009, In : PloS one. 4, 3, e4875.

Research output: Contribution to journalArticle

13 Scopus citations

HIV induces TRAIL sensitivity in hepatocytes

Babu, C. K., Suwansrinon, K., Bren, G. D., Badley, A. D. & Rizza, S. A., Jan 1 2009, In : PloS one. 4, 2, e4623.

Research output: Contribution to journalArticle

41 Scopus citations

Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis

Singh, V. P., Bren, G. D., Algeciras-Schimnich, A., Schnepple, D., Navina, S., Rizza, S. A., Dawra, R. K., Saluja, A. K., Chari, S. T., Vege, S. S. & Badley, A. D., May 1 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 5, p. G1040-G1046

Research output: Contribution to journalArticle

17 Scopus citations

The biology of TRAIL and the role of TRAIL-based therapeutics in infectious diseases

Shepard, B. D. & Badley, A. D., Jul 29 2009, In : Anti-Infective Agents in Medicinal Chemistry. 8, 2, p. 87-101 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2008

Beneficial effect of TRAIL on HIV burden, without detectable immune consequences

Shepard, B. D., De Forni, D., McNamara, D. R., Foli, A., Rizza, S. A., Abraham, R. S., Knutson, K., Wettstein, P. J., Lori, F. & Badley, A. D., Aug 28 2008, In : PloS one. 3, 8, e3096.

Research output: Contribution to journalArticle

9 Scopus citations

Early changes in T-cell activation predict antiretroviral success in salvage therapy of HIV infection

Shepard, B. D., Loutfy, M. R., Raboud, J., Mandy, F., Kovacs, C. M., Diong, C., Bergeron, M., Govan, V., Rizza, S. A., Angel, J. B. & Badley, A. D., Jun 1 2008, In : Journal of Acquired Immune Deficiency Syndromes. 48, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

HIV Protease inhibitors impact on apoptosis

Rizza, S. A. & Badley, A. D., Jan 1 2008, In : Medicinal Chemistry. 4, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice

Hisatomi, T., Nakazawa, T., Noda, K., Almulki, L., Miyahara, S., Nakao, S., Ito, Y., She, H., Kohno, R., Michaud, N., Ishibashi, T., Hafezi-Moghadam, A., Badley, A. D., Kroemer, G. & Miller, J. W., Jun 2 2008, In : Journal of Clinical Investigation. 118, 6, p. 2025-2038 14 p.

Research output: Contribution to journalArticle

52 Scopus citations

Infected cell killing by HIV-1 protease promotes NF-κB dependent HIV-1 replication

Bren, G. D., Whitman, J., Cummins, N., Shepard, B., Rizz, S. A., Trushin, S. A. & Badley, A. D., May 7 2008, In : PloS one. 3, 5, e2112.

Research output: Contribution to journalArticle

22 Scopus citations

Insidious sinusitis leading to catastrophic cerebral aspergillosis in transplant recipients.

van de Beek, D., Patel, R., Campeau, N. G., Badley, A., Parisi, J. E., Rabinstein, A. A., Manno, E. M. & Wijdicks, E. F., Jun 10 2008, In : Neurology. 70, 24 Pt 2, p. 2411-2413 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nelfinavir monotherapy increases naïve T-cell numbers in HIV-negative healthy young adults

Rizza, S. A., Tangalos, E. G., McClees, M. D., Strausbauch, M. A., Targonski, P. V., McKean, D. J., Wettstein, P. J. & Badley, A. D., May 5 2008, In : Frontiers in Bioscience. 13, 5, p. 1605-1609 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2007

Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria

Algeciras-Schimnich, A., Belzacq-Casagrande, A. S., Bren, G. D., Nie, Z., Taylor, J. A., Rizza, S., Brenner, C. & Badley, A. D., Dec 27 2007, In : The open virology journal. 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Flying in the face of resistance: Antiviral-independent benefit of HIV protease inhibitors on T-cell survival

Vlahakis, S. R., Bren, G. D., Algeciras-Schimnich, A., Trushin, S. A., Schnepple, D. J. & Badley, A. D., Sep 1 2007, In : Clinical pharmacology and therapeutics. 82, 3, p. 294-299 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Glycoprotein 120 binding to CXCR4 causes p38-dependent primary T cell death that is facilitated by, but does not require cell-associated CD4

Trushin, S. A., Algeciras-Schimnich, A., Vlahakis, S. R., Bren, G. D., Warren, S., Schnepple, D. J. & Badley, A. D., Apr 15 2007, In : Journal of Immunology. 178, 8, p. 4846-4853 8 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo

Nie, Z., Bren, G. D., Vlahakis, S. R., Schimnich, A. A., Brenchley, J. M., Trushin, S. A., Warren, S., Schnepple, D. J., Kovacs, C. M., Loutfy, M. R., Douek, D. C. & Badley, A. D., Jul 1 2007, In : Journal of virology. 81, 13, p. 6947-6956 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Renal hemodynamic, inflammatory, and apoptotic responses to lipopolysaccharide in HO-1-/- mice

Tracz, M. J., Juncos, J. P., Grande, J. P., Croatt, A. J., Ackerman, A. W., Rajagopalan, G., Knutson, K. L., Badley, A. D., Griffin, M. D., Alam, J. & Nath, K. A., Jun 2007, In : American Journal of Pathology. 170, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: Implications for chronic kidney disease

Murali, N. S., Ackerman, A. W., Croatt, A. J., Cheng, J., Grande, J. P., Sutor, S. L., Bram, R. J., Bren, G. D., Badley, A. D., Alam, J. & Nath, K. A., Feb 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 2, p. F837-F844

Research output: Contribution to journalArticle

35 Scopus citations

The human immunodeficiency virus type 1 Tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism

O'Hara, S. P., Small, A. J., Nelson, J. B., Badley, A. D., Chen, X. M., Gores, G. J. & LaRusso, N. F., Feb 1 2007, In : Infection and Immunity. 75, 2, p. 684-696 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2006

Disseminated coccidioidomycosis in a liver transplant recipient with negative serology: Use of polymerase chain reaction

Assi, M. A., Binnicker, M. J., Wengenack, N. L., Deziel, P. J. & Badley, A. D., Aug 1 2006, In : Liver Transplantation. 12, 8, p. 1290-1292 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

HIV VprR77Q mutation does not influence clinical response of individuals initiating highly active antiretroviral therapy

Chui, C., Cheung, P. K., Brumme, C. J., Mo, T., Brumme, Z. L., Montaner, J. S. G., Badley, A. D. & Harrigan, P. R., Jul 1 2006, In : AIDS Research and Human Retroviruses. 22, 7, p. 615-618 4 p.

Research output: Contribution to journalArticle

10 Scopus citations