• 5030 Citations
  • 40 Scopus h-Index
1990 …2020
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Research Output 1990 2020

Article

26-year-old man with HIV infection and abdominal pain

MacMorran, W. S., Badley, A. D. & Wilson, W. R., 1995, In : Mayo Clinic Proceedings. 70, 9, p. 885-888 4 p.

Research output: Contribution to journalArticle

Abdominal Pain
HIV Infections
24 Citations (Scopus)

Acquired T-cell sensitivity to TRAIL mediated killing during HIV infection is regulated by CXCR4-gp120 interactions

Lum, J. J., Schnepple, D. J. & Badley, A. D., Jul 22 2005, In : AIDS. 19, 11, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
HIV Infections
Death Domain Receptors
T-Lymphocytes
Jurkat Cells
38 Citations (Scopus)

Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number

Dockrell, D. H., Badley, A. D., Algeciras-Schimnich, A., Simpson, M., Schut, R., Lynch, D. H. & Paya, C. V., Nov 20 1999, In : AIDS Research and Human Retroviruses. 15, 17, p. 1509-1518 10 p.

Research output: Contribution to journalArticle

CD4 Lymphocyte Count
Pokeweed Mitogens
Cell Death
HIV
T-Lymphocytes
6 Citations (Scopus)

Activity of the combination of nelfinavir and saquinavir against human immunodeficiency virus after failure of prior protease inhibitor therapy

Kravcik, S., Victor, G., Angel, J. B., Badley, A. D., Garber, G. E. & Cameron, D. W., 1999, In : Clinical Infectious Diseases. 29, 3, p. 702-703 2 p.

Research output: Contribution to journalArticle

Nelfinavir
Saquinavir
HIV Protease Inhibitors
Salvage Therapy
Combination Drug Therapy
7 Citations (Scopus)

A drug interaction between fusidic acid and a combination of ritonavir and saquinavir

Khaliq, Y., Gallicano, K., Leger, R., Foster, B. & Badley, A. D., 2000, In : British Journal of Clinical Pharmacology. 50, 1, p. 82-83 2 p.

Research output: Contribution to journalArticle

Saquinavir
Fusidic Acid
HIV Protease Inhibitors
Ritonavir
Liver Function Tests
Retroviridae Infections
Opportunistic Infections
Chronic Hepatitis C
Virus Diseases
Hepacivirus
44 Citations (Scopus)

Altering cell death pathways as an approach to cure HIV infection

Badley, A. D., Sainski, A., Wightman, F. & Lewin, S. R., Jul 2013, In : Cell Death and Disease. 4, 7, e718.

Research output: Contribution to journalArticle

Virus Diseases
Cell Death
HIV
Apoptosis
Infection
70 Citations (Scopus)
Listeriosis
Listeria monocytogenes
Sprague Dawley Rats
acidity
Stomach

Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria

Algeciras-Schimnich, A., Belzacq-Casagrande, A. S., Bren, G. D., Nie, Z., Taylor, J. A., Rizza, S., Brenner, C. & Badley, A. D., Dec 27 2007, In : The open virology journal. 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Caspase 8
Cytochromes c
Mitochondria
Peptide Hydrolases
Cell Death
14 Citations (Scopus)

Anti-apoptotic activity of the glutathione peroxidase homologue encoded by HIV-1

Cohen, I., Boya, P., Zhao, L., Métivier, D., Andreau, K., Perfettini, J. L., Weaver, J. G., Badley, A. D., Taylor, E. W. & Kroemer, G., Mar 2004, In : Apoptosis. 9, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

Glutathione Peroxidase
HIV-1
Cell death
Reactive Oxygen Species
Genes
93 Citations (Scopus)

Antiapoptotic mechanism of HIV protease inhibitors: Preventing mitochondrial transmembrane potential loss

Phenix, B. N., Lum, J. J., Nie, Z., Sanchez-Dardon, J. & Badley, A. D., Aug 15 2001, In : Blood. 98, 4, p. 1078-1085 8 p.

Research output: Contribution to journalArticle

Nelfinavir
HIV Protease Inhibitors
Membrane Potentials
Apoptosis
Caspases
13 Citations (Scopus)

Anti-apoptotic mechanisms of HIV: Lessons and novel approaches to curing HIV

Cummins, N. W. & Badley, A. D., Sep 2013, In : Cellular and Molecular Life Sciences. 70, 18, p. 3355-3363 9 p.

Research output: Contribution to journalArticle

HIV
Viral Cytopathogenic Effect
Cell Death
Viruses
Infection
10 Citations (Scopus)

Antiretroviral therapy influences cellular susceptibility to apoptosis in vivo

Cooper, C. L., Phenix, B., Mbisa, G., Lum, J. J., Parato, K., Hawley, N., Angel, J. B. & Badley, A. D., 2004, In : Frontiers in Bioscience. 9, p. 338-341 4 p.

Research output: Contribution to journalArticle

Post-Exposure Prophylaxis
Apoptosis
HIV
Nelfinavir
Lamivudine
24 Citations (Scopus)

Apoptosis in AIDS

Badley, A. D., Dockrell, D. & Paya, C. V., 1997, In : Advances in Pharmacology. 41, C, p. 271-294 24 p.

Research output: Contribution to journalArticle

Acquired Immunodeficiency Syndrome
HIV
Apoptosis
T-Lymphocytes
37 Citations (Scopus)

Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients

Zhang, X., Lalezari, J. P., Badley, A. D., Dorr, A., Kolis, S. J., Kinchelow, T. & Patel, I. H., Jun 2004, In : Clinical Pharmacology and Therapeutics. 75, 6, p. 558-568 11 p.

Research output: Contribution to journalArticle

Drug Interactions
HIV-1
Confidence Intervals
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2E1
17 Citations (Scopus)

Attenuated T-lymphocyte response to HIV therapy in individuals receiving HMG-CoA reductase inhibitors

Narayan, S., Hawley, N., Giguère, P. & Badley, A. D., May 2003, In : HIV Clinical Trials. 4, 3, p. 164-169 6 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
HIV
T-Lymphocytes
Lamivudine
Fibric Acids

A typical atypical pneumonia

Mikhael, J. R., Humphrey, S., Jabi, M. & Badley, A. D., 2002, In : Canadian Journal of Infectious Diseases. 13, 1

Research output: Contribution to journalArticle

Pneumonia
9 Citations (Scopus)

Beneficial effect of TRAIL on HIV burden, without detectable immune consequences

Shepard, B. D., De Forni, D., McNamara, D. R., Foli, A., Rizza, S., Abraham, R. S., Knutson, K. L., Wettstein, P. J., Lori, F. & Badley, A. D., Aug 28 2008, In : PLoS One. 3, 8, e3096.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
apoptosis
HIV
Lymphocytes
Viral Load
96 Citations (Scopus)

Blockade of HERG channels by HIV protease inhibitors

Anson, B. D., Weaver, J. G. R., Ackerman, M. J., Akinsete, O., Henry, K., January, C. T. & Badley, A. D., Feb 19 2005, In : Lancet. 365, 9460, p. 682-686 5 p.

Research output: Contribution to journalArticle

HIV Protease Inhibitors
Protease Inhibitors
Ether
Lopinavir
Torsades de Pointes
5 Citations (Scopus)

Both HIV-Infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment

Nie, Z., Aboulnasr, F., Natesampillai, S., Burke, S. P., Krogman, A., Bren, G. D., Chung, T. D. Y., Anderson, J. R., Smart, M. K., Katzmann, D. J., Rajagopalan, G., Cummins, N. W. & Badley, A. D., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1110-1123 14 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Cellular Microenvironment
HIV
TNF-Related Apoptosis-Inducing Ligand Receptors
Proteasome Endopeptidase Complex

Can HIV be cured and should we try?

Cummins, N. W. & Badley, A. D., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 705-709 5 p.

Research output: Contribution to journalArticle

Virus Latency
Anti-Retroviral Agents
AIDS Vaccines
Viral Load
HIV Infections
7 Citations (Scopus)

Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission

Sampath, R., Patel, R., Cunningham, S. A., Arif, S., Daly, R. C., Badley, A. D. & Wylam, M., May 1 2017, In : EBioMedicine. 19, p. 84-90 7 p.

Research output: Contribution to journalArticle

Mycoplasma hominis
Transplantation (surgical)
Transplants
Tissue Donors
Infection
3 Citations (Scopus)

Casp8p41 and HIV

Cummins, N. W. & Badley, A. D., 2015, In : Oncotarget. 6, 27, p. 23042-23043 2 p.

Research output: Contribution to journalArticle

Viral Drug Resistance
HIV Protease
CD4-Positive T-Lymphocytes
Enzyme Activation
Caspase 9
4 Citations (Scopus)

Casp8p41 expression in primary T cells induces a proinflammatory response

Taylor, J. A., Cummins, N. W., Bren, G. D., Rizza, S., Kolbert, C. P., Behrens, M. D., Knutson, K. L., Kahl, J. C., Asmann, Y. & Badley, A. D., Jun 1 2010, In : AIDS. 24, 9, p. 1251-1258 8 p.

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
NF-kappa B
Microarray Analysis
Cytokines
19 Citations (Scopus)

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
HIV
T-Lymphocytes
Caspase 8
Cell Death
89 Citations (Scopus)

Cerebrospinal fluid HIV RNA and drug levels with combination ritonavir and saquinavir

Kravcik, S., Gallicano, K., Roth, V., Cassol, S., Hawley-Foss, N., Badley, A. D. & Cameron, D. W., Aug 15 1999, In : Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 21, 5, p. 371-375 5 p.

Research output: Contribution to journalArticle

Saquinavir
Ritonavir
Cerebrospinal Fluid
HIV
RNA
1 Citation (Scopus)

Characteristics of hepatitis C virus infection in HIV-infected people

Cooper, C. L., Badley, A. D. & Angel, J. B., 2001, In : Canadian Journal of Infectious Diseases. 12, 3, p. 157-163 7 p.

Research output: Contribution to journalArticle

Virus Diseases
Hepacivirus
HIV
Highly Active Antiretroviral Therapy
Interferon-alpha
17 Citations (Scopus)

Comparative CD4 T-cell responses of reverse transcriptase inhibitor therapy with or without nelfinavir matched for viral exposure

Kravcik, S., Magill, A., Sanghvi, B., Ogden, R., Cameron, D. W., Lewis, R., Yu, G. & Badley, A. D., 2001, In : HIV Clinical Trials. 2, 2, p. 160-170 11 p.

Research output: Contribution to journalArticle

Nelfinavir
Reverse Transcriptase Inhibitors
T-Lymphocytes
Area Under Curve
Cell Count
20 Citations (Scopus)

Cordyceps sinensis extracts do not prevent Fas-receptor and hydrogen peroxide-induced T-cell apoptosis

Buenz, E. J., Weaver, J. G., Bauer, B. A., Chalpin, S. D. & Badley, A. D., Jan 2004, In : Journal of Ethnopharmacology. 90, 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

Cordyceps
CD95 Antigens
Hydrogen Peroxide
Apoptosis
T-Lymphocytes
1 Citation (Scopus)

Correction to Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation [Journal of Cell Biology, 206, 7, (2014), 867-876]

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Wei Meng, X., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 207, 1, p. 159 1 p.

Research output: Contribution to journalArticle

HIV Protease
Cell Biology
T-Lymphocytes
83 Citations (Scopus)

Decreased HIV-associated T cell apoptosis by HIV protease inhibitors

Phenix, B. N., Angel, J. B., Mandy, F., Kravcik, S., Parato, K., Chambers, K. A., Gallicano, K., Hawley-Foss, N., Cassol, S., William Cameron, D. & Badley, A. D., Apr 10 2000, In : AIDS Research and Human Retroviruses. 16, 6, p. 559-567 9 p.

Research output: Contribution to journalArticle

HIV Protease Inhibitors
Protease Inhibitors
HIV
Apoptosis
T-Lymphocytes
53 Citations (Scopus)

Development of monoclonal gammopathy precedes the development of Epstein-Barr virus-induced posttransplant lymphoproliferative disorder

Badley, A. D., Portela, D. F., Patel, R., Kyle, R. A., Habermann, T. M., Strickler, J. G., Ilstrup, D. M., Wiesner, R. H., De Groen, P., Walker, R. C. & Paya, C. V., 1996, In : Liver Transplantation and Surgery. 2, 5, p. 375-382 8 p.

Research output: Contribution to journalArticle

Paraproteinemias
Lymphoproliferative Disorders
Human Herpesvirus 4
Proteins
Urine
43 Citations (Scopus)

Differential effects of interleukin-7 and interleukin-15 on NK cell anti-human immunodeficiency virus activity

Lum, J. J., Schnepple, D. J., Nie, Z., Sanchez-Dardon, J., Mbisa, G. L., Mihowich, J., Hawley, N., Narayan, S., Kim, J. E., Lynch, D. H. & Badley, A. D., Jun 2004, In : Journal of Virology. 78, 11, p. 6033-6042 10 p.

Research output: Contribution to journalArticle

interleukin-7
Interleukin-15
Interleukin-7
Human immunodeficiency virus
natural killer cells
16 Citations (Scopus)

Disseminated coccidioidomycosis in a liver transplant recipient with negative serology: Use of polymerase chain reaction

Assi, M. A., Binnicker, M. J., Wengenack, N. L., Deziel, P. J. & Badley, A. D., Aug 2006, In : Liver Transplantation. 12, 8, p. 1290-1292 3 p.

Research output: Contribution to journalArticle

Coccidioidomycosis
Serology
Coccidioides
Polymerase Chain Reaction
Liver
33 Citations (Scopus)

Disseminated mycobacterium Chimaera infection after cardiothoracic surgery

Tan, N., Sampath, R., Abu Saleh, O. M., Tweet, M., Jevremovic, D., Alniemi, S., Wengenack, N. L., Sampathkumar, P. & Badley, A. D., 2016, In : Open Forum Infectious Diseases. 3, 3, ofw131.

Research output: Contribution to journalArticle

Mycobacterium Infections
Transplants
Infection
88 Citations (Scopus)

Dynamic correlation of apoptosis and immune activation during treatment of HIV infection

Badley, A. D., Parato, K., Cameron, D. W., Kravcik, S., Phenix, B. N., Ashby, D., Kumar, A., Lynch, D. H., Tschopp, J. & Angel, J. B., May 1999, In : Cell Death and Differentiation. 6, 5, p. 420-432 13 p.

Research output: Contribution to journalArticle

HIV Infections
Apoptosis
HIV
Therapeutics
T-Lymphocytes
7 Citations (Scopus)

Early changes in T-cell activation predict antiretroviral success in salvage therapy of HIV infection

Shepard, B. D., Loutfy, M. R., Raboud, J., Mandy, F., Kovacs, C. M., Diong, C., Bergeron, M., Govan, V., Rizza, S., Angel, J. B. & Badley, A. D., Jun 1 2008, In : Journal of Acquired Immune Deficiency Syndromes. 48, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

Salvage Therapy
HIV Infections
T-Lymphocytes
Proportional Hazards Models
HIV
9 Citations (Scopus)

Effect of cessation of highly active antiretroviral therapy during a discordant response: Implications for scheduled therapeutic interruptions

Hawley-Foss, N., Mbisa, G., Lum, J. J., Pilon, A. A., Angel, J. B., Garber, G. & Badley, A. D., 2001, In : Clinical Infectious Diseases. 33, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
T-Lymphocytes
Anti-Retroviral Agents
Therapeutics
3 Citations (Scopus)

Effect on CD4 T-cell count of replacing protease inhibitors in patients with successful HIV suppression: A meta-analysis

Owen, C., Kazim, F. & Badley, A. D., Mar 5 2004, In : AIDS. 18, 4, p. 693-695 3 p.

Research output: Contribution to journalArticle

CD4 Lymphocyte Count
Protease Inhibitors
Meta-Analysis
HIV
T-Lymphocytes
55 Citations (Scopus)

Elimination of senescent neutrophils by TNF-related apopotosis-inducing ligand

Lum, J. J., Bren, G., McClure, R. & Badley, A. D., Jul 15 2005, In : Journal of Immunology. 175, 2, p. 1232-1238 7 p.

Research output: Contribution to journalArticle

Neutrophils
Ligands
Bone Marrow
Chemokine CXCL12
Apoptosis

Erratum: Elimination of senescent neutrophils by TNF-related apopotosis inducing ligand (Journal of Immunology (2005) 175 (1232-1238))

Lum, J. J., Bren, G., McClure, R. & Badley, A. D., Sep 1 2005, In : Journal of Immunology. 175, 5, p. 3446 1 p.

Research output: Contribution to journalArticle

Allergy and Immunology
Neutrophils
Ligands
19 Citations (Scopus)

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

Cummins, N. W., Rizza, S., Litzow, M. R., Hua, S., Lee, G. Q., Einkauf, K., Chun, T. W., Rhame, F., Baker, J. V., Busch, M. P., Chomont, N., Dean, P. G., Fromentin, R., Haase, A. T., Hampton, D., Keating, S. M., Lada, S. M., Lee, T. H., Natesampillai, S., Richman, D. D. & 7 others, Schacker, T. W., Wietgrefe, S., Yu, X. G., Yao, J. D., Zeuli, J., Lichterfeld, M. & Badley, A. D., Nov 1 2017, In : PLoS Medicine. 14, 11, e1002461.

Research output: Contribution to journalArticle

HIV-1
Stem Cells
HIV
Transplants
Stem Cell Transplantation
10 Citations (Scopus)

FasL/Fas and TNF/TNFR interactions in the regulation of immune responses and disease.

Lynch, D. H., Campbell, K. A., Miller, R. E., Badley, A. D. & Paya, C. V., Oct 1996, In : Behring Institute Mitteilungen. 97, p. 175-184 10 p.

Research output: Contribution to journalArticle

CD95 Antigens
Fas Ligand Protein
T-cells
Tumor Necrosis Factor Receptors
Immune System Diseases
29 Citations (Scopus)

Flow cytometric measurement of telomere length

Lauzon, W., Dardon, J. S., Cameron, D. W. & Badley, A. D., Jun 15 2000, In : Communications in Clinical Cytometry. 42, 3, p. 159-164 6 p.

Research output: Contribution to journalArticle

Telomere
Southern Blotting
Fluorescence In Situ Hybridization
Centromere
Cell Aging
16 Citations (Scopus)

Flying in the face of resistance: Antiviral-independent benefit of HIV protease inhibitors on T-cell survival

Rizza, S., Bren, G. D., Algeciras-Schimnich, A., Trushin, S. A., Schnepple, D. J. & Badley, A. D., Sep 2007, In : Clinical Pharmacology and Therapeutics. 82, 3, p. 294-299 6 p.

Research output: Contribution to journalArticle

Protease Inhibitors
Antiviral Agents
Cell Survival
HIV
T-Lymphocytes
33 Citations (Scopus)

Glycoprotein 120 binding to CXCR4 causes p38-dependent primary T cell death that is facilitated by, but does not require cell-associated CD4

Trushin, S. A., Algeciras-Schimnich, A., Rizza, S., Bren, G. D., Warren, S., Schnepple, D. J. & Badley, A. D., Apr 15 2007, In : Journal of Immunology. 178, 8, p. 4846-4853 8 p.

Research output: Contribution to journalArticle

Glycoproteins
Cell Death
T-Lymphocytes
CXCR4 Receptors
CD4 Antigens
26 Citations (Scopus)

Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice

Cummins, N. W., Weaver, E. A., May, S. M., Croatt, A. J., Foreman, O., Kennedy, R. B., Poland, G. A., Barry, M. A., Nath, K. A. & Badley, A. D., Jul 2012, In : FASEB Journal. 26, 7, p. 2911-2918 8 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Virus Diseases
Orthomyxoviridae
Viruses
Vaccination
21 Citations (Scopus)

HIV-1 protease inhibitors and cytomegalovirus vMIA induce mitochondrial fragmentation without triggering apoptosis [2]

Roumier, T., Szabadkai, G., Simoni, A. M., Perfettini, J. L., Paulau, A. L., Castedo, M., Métivier, D., Badley, A. D., Rizzuto, R. & Kroemer, G., Feb 2006, In : Cell Death and Differentiation. 13, 2, p. 348-351 4 p.

Research output: Contribution to journalArticle

Immediate-Early Proteins
Nelfinavir
Saquinavir
Inhibitor of Apoptosis Proteins
HIV Protease Inhibitors
80 Citations (Scopus)

HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation

Nie, Z., Phenix, B. N., Lum, J. J., Alam, A., Lynch, D. H., Beckett, B., Krammer, P. H., Sekaly, R. P. & Badley, A. D., Nov 1 2002, In : Cell Death and Differentiation. 9, 11, p. 1172-1184 13 p.

Research output: Contribution to journalArticle

Caspase 8
Caspases
Cytochromes c
Apoptosis
T-Lymphocytes
20 Citations (Scopus)

HIV-1 tat protein suppresses cholangiocyte toll- like receptor 4 expression and defense against cryptosporidium parvum

O'Hara, S. P., Small, A. J., Gajdos, G. B., Badley, A. D., Chen, X. M. & La Russo, N. F., Apr 15 2009, In : Journal of Infectious Diseases. 199, 8, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

tat Gene Products
Cryptosporidium parvum
Toll-Like Receptor 4
HIV-1
Cryptosporidiosis