• 5004 Citations
  • 40 Scopus h-Index
1990 …2020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1990 2020

2020

The role of the BCL-2 family of proteins in HIV-1 pathogenesis and persistence

Chandrasekar, A. P., Cummins, N. W. & Badleya, A. D., Jan 2020, In : Clinical Microbiology Reviews. 33, 1, e00107-19.

Research output: Contribution to journalArticle

HIV-1
Proteins
Therapeutics
Apoptosis
Infection
2019

HIV elite control is associated with reduced TRAILshort expression

Paim, A. C., Cummins, N. W., Natesampillai, S., Garcia-Rivera, E., Kogan, N., Neogi, U., Sönnerborg, A., Sperk, M., Bren, G. D., Deeks, S., Polley, E. & Badley, A. D., Sep 1 2019, In : AIDS. 33, 11, p. 1757-1763 7 p.

Research output: Contribution to journalArticle

HIV-1
HIV
Blood Cells
Cell Death
HIV Infections
1 Citation (Scopus)
Hematopoietic Stem Cell Transplantation
Hematologic Neoplasms
HIV Infections
Graft vs Host Disease
Survival

Trailshort protects against CD4 T cell death during acute HIV infection

Natesampillai, S., Paim, A. C., Cummins, N. W., Chandrasekar, A. P., Bren, G. D., Lewin, S. R., Kiem, H. P. & Badley, A. D., Aug 1 2019, In : Journal of Immunology. 203, 3, p. 718-724 7 p.

Research output: Contribution to journalArticle

HIV Infections
Cell Death
T-Lymphocytes
HIV-1
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Translation to Practice: Accelerating the Cycle of Innovation to Impact

Anderson, J. R., Chung, T. D. Y., Clark, L., Weis, J. A., Danielsen, A. J., Khosla, S., Gores, G. J. & Badley, A. D., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalReview article

Biological Factors
Practice Guidelines
Physicians
Equipment and Supplies
Pharmaceutical Preparations
2018

Allogeneic stem cell transplantation alone is unlikely to provide the HIV-1 cure

Cummins, N. W. & Badley, A. D., Jan 1 2018, In : Future Virology. 13, 5, p. 307-308 2 p.

Research output: Contribution to journalEditorial

Stem Cell Transplantation
HIV-1
5 Citations (Scopus)

Both HIV-Infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment

Nie, Z., Aboulnasr, F., Natesampillai, S., Burke, S. P., Krogman, A., Bren, G. D., Chung, T. D. Y., Anderson, J. R., Smart, M. K., Katzmann, D. J., Rajagopalan, G., Cummins, N. W. & Badley, A. D., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1110-1123 14 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Cellular Microenvironment
HIV
TNF-Related Apoptosis-Inducing Ligand Receptors
Proteasome Endopeptidase Complex
1 Citation (Scopus)

Corrections: Both HIV-infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment (Journal of Immunology (2008) 200 (1110-1123) DOI: 10.4049/jimmunol.1701113)

Nie, Z., Aboulnasr, F., Natesampillai, S., Burke, S. P., Krogman, A., Bren, G. D., Chung, T. D. Y., Anderson, J. R., Smart, M. K., Katzmann, D. J., Rajagopalan, G., Cummins, N. W. & Badley, A. D., Feb 1 2018, In : Journal of Immunology. 201, 5, 1 p.

Research output: Contribution to journalComment/debate

Cellular Microenvironment
Allergy and Immunology
HIV
Jurkat Cells
HeLa Cells
3 Citations (Scopus)

HIV protease-generated Casp8p41, when bound and inactivated by Bcl2, is degraded by the proteasome

Natesampillai, S., Cummins, N. W., Nie, Z., Sampath, R., Baker, J. V., Henry, K., Pinzone, M., O'Doherty, U., Polley, E., Bren, G. D., Katzmann, D. J. & Badley, A. D., Jul 1 2018, In : Journal of Virology. 92, 13, e00037-18.

Research output: Contribution to journalArticle

HIV Protease
proteasome endopeptidase complex
Proteasome Endopeptidase Complex
cell death
Cell Death

The TRAIL: TRAILshort Axis in HIV Immunopathology

Aboulnasr, F., Paranjape, G. & Badley, A. D., Jan 1 2018, In : Critical reviews in immunology. 38, 6, p. 491-503 13 p.

Research output: Contribution to journalArticle

HIV
TNF-Related Apoptosis-Inducing Ligand Receptors
HIV Infections
Apoptosis
T-Lymphocytes

Transient Loss of HIV-1 DNA in an HIV-1 Positive Patient After Kidney Transplantation: A Case Report

Paim, A. C., Rizza, S., Badley, A. D., Prieto, M., Taler, S. J., Chong, P. P. & Cummins, N. W., Jan 1 2018, (Accepted/In press) In : American Journal of Medicine.

Research output: Contribution to journalArticle

Kidney Transplantation
HIV-1
DNA
2017
7 Citations (Scopus)

Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission

Sampath, R., Patel, R., Cunningham, S. A., Arif, S., Daly, R. C., Badley, A. D. & Wylam, M., May 1 2017, In : EBioMedicine. 19, p. 84-90 7 p.

Research output: Contribution to journalArticle

Mycoplasma hominis
Transplantation (surgical)
Transplants
Tissue Donors
Infection
19 Citations (Scopus)

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

Cummins, N. W., Rizza, S., Litzow, M. R., Hua, S., Lee, G. Q., Einkauf, K., Chun, T. W., Rhame, F., Baker, J. V., Busch, M. P., Chomont, N., Dean, P. G., Fromentin, R., Haase, A. T., Hampton, D., Keating, S. M., Lada, S. M., Lee, T. H., Natesampillai, S., Richman, D. D. & 7 others, Schacker, T. W., Wietgrefe, S., Yu, X. G., Yao, J. D., Zeuli, J., Lichterfeld, M. & Badley, A. D., Nov 1 2017, In : PLoS Medicine. 14, 11, e1002461.

Research output: Contribution to journalArticle

HIV-1
Stem Cells
HIV
Transplants
Stem Cell Transplantation
1 Citation (Scopus)

Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells

Sampath, R., Cummins, N. W., Natesampillai, S., Bren, G. D., Chung, T. D., Baker, J., Henry, K., Pagliuzza, A. & Badley, A. D., Jun 1 2017, In : PLoS One. 12, 6, e0179327.

Research output: Contribution to journalArticle

Drug Repositioning
Caspase 8
Cell death
cell death
Cell Death
18 Citations (Scopus)

Maintenance of the HIV reservoir is antagonized by selective BCL2 inhibition

Cummins, N. W., Sainski-Nguyen, A. M., Natesampillai, S., Aboulnasr, F., Kaufmann, S. H. & Badley, A. D., Jun 1 2017, In : Journal of Virology. 91, 11, e00012-17.

Research output: Contribution to journalArticle

Maintenance
HIV
cells
Infection
deterioration
2016

Casp8p41: The protean mediator of death in CD4 T-cells that replicate HIV

Sampath, R., Cummins, N. W. & Badley, A. D., Sep 27 2016, In : Journal of Cell Death. 9, p. 9-17 9 p.

Research output: Contribution to journalReview article

Proviruses
T-cells
Caspase 8
Viral Proteins
Cell death
30 Citations (Scopus)

Disseminated mycobacterium Chimaera infection after cardiothoracic surgery

Tan, N., Sampath, R., Abu Saleh, O. M., Tweet, M., Jevremovic, D., Alniemi, S., Wengenack, N. L., Sampathkumar, P. & Badley, A. D., 2016, In : Open Forum Infectious Diseases. 3, 3, ofw131.

Research output: Contribution to journalArticle

Mycobacterium Infections
Transplants
Infection
34 Citations (Scopus)

Prime, shock, and kill: Priming CD4 T cells from HIV patients with a BCL-2 antagonist before HIV reactivation reduces HIV reservoir size

Cummins, N. W., Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., De Araujo Correia, M. C. M., Sampath, R., Rizza, S., O'Brien, D., Yao, J. D., Kaufmann, S. H. & Badley, A. D., Apr 1 2016, In : Journal of Virology. 90, 8, p. 4032-4048 17 p.

Research output: Contribution to journalArticle

antagonists
Shock
T-lymphocytes
HIV
T-Lymphocytes
2015

Can HIV be cured and should we try?

Cummins, N. W. & Badley, A. D., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 705-709 5 p.

Research output: Contribution to journalArticle

Virus Latency
Anti-Retroviral Agents
AIDS Vaccines
Viral Load
HIV Infections
3 Citations (Scopus)

Casp8p41 and HIV

Cummins, N. W. & Badley, A. D., 2015, In : Oncotarget. 6, 27, p. 23042-23043 2 p.

Research output: Contribution to journalArticle

Viral Drug Resistance
HIV Protease
CD4-Positive T-Lymphocytes
Enzyme Activation
Caspase 9
12 Citations (Scopus)

Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis

Cummins, N. W., Neuhaus, J., Chu, H., Neaton, J., Wyen, C., Rockstroh, J. K., Skiest, D. J., Boyd, M. A., Khoo, S., Rotger, M., Telenti, A., Weinshilboum, R. M. & Badley, A. D., Jul 1 2015, In : EBioMedicine. 2, 7, p. 706-712 7 p.

Research output: Contribution to journalArticle

efavirenz
HIV
Population
Cytochrome P-450 CYP3A
Polymorphism
2014
17 Citations (Scopus)

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
HIV
T-Lymphocytes
Caspase 8
Cell Death
1 Citation (Scopus)

Correction to Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation [Journal of Cell Biology, 206, 7, (2014), 867-876]

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Wei Meng, X., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 207, 1, p. 159 1 p.

Research output: Contribution to journalArticle

HIV Protease
Cell Biology
T-Lymphocytes
1 Citation (Scopus)

Seeding Open Innovation Drug Discovery and Translational Collaborations to Leverage Government Funding: A Case Study of Strategic Partnership between Sanford-Burnham and Mayo Clinic

Chung, T. D. Y., Khosla, S., Badley, A. D. & Jackson, M. R., Apr 14 2014, Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships. Wiley Blackwell, p. 451-486 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Discovery
Innovation
Translational Medical Research
Drug products
Pharmaceutical Preparations
7 Citations (Scopus)

Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of Casp8p41

Cummins, N. W., Neuhaus, J., Sainski, A. M., Strausbauch, M. A., Wettstein, P. J., Lewin, S. R., Plana, M., Rizza, S., Temesgen, Z., Touloumi, G., Freiberg, M., Neaton, J. & Badley, A. D., May 30 2014, In : AIDS Research and Human Retroviruses. 30, 5, p. 476-479 4 p.

Research output: Contribution to journalArticle

Communication
T-Lymphocytes
HIV
Therapeutics
CD4 Lymphocyte Count
2013
Retroviridae Infections
Opportunistic Infections
Chronic Hepatitis C
Virus Diseases
Hepacivirus
43 Citations (Scopus)

Altering cell death pathways as an approach to cure HIV infection

Badley, A. D., Sainski, A., Wightman, F. & Lewin, S. R., Jul 2013, In : Cell Death and Disease. 4, 7, e718.

Research output: Contribution to journalArticle

Virus Diseases
Cell Death
HIV
Apoptosis
Infection
13 Citations (Scopus)

Anti-apoptotic mechanisms of HIV: Lessons and novel approaches to curing HIV

Cummins, N. W. & Badley, A. D., Sep 2013, In : Cellular and Molecular Life Sciences. 70, 18, p. 3355-3363 9 p.

Research output: Contribution to journalArticle

HIV
Viral Cytopathogenic Effect
Cell Death
Viruses
Infection
2012
26 Citations (Scopus)

Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice

Cummins, N. W., Weaver, E. A., May, S. M., Croatt, A. J., Foreman, O., Kennedy, R. B., Poland, G. A., Barry, M. A., Nath, K. A. & Badley, A. D., Jul 2012, In : FASEB Journal. 26, 7, p. 2911-2918 8 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Virus Diseases
Orthomyxoviridae
Viruses
Vaccination
21 Citations (Scopus)

HIV replication, inflammation, and the effect of starting antiretroviral therapy on plasma asymmetric dimethylarginine, a novel marker of endothelial dysfunction

Baker, J. V., Neuhaus, J., Duprez, D., Freiberg, M., Bernardino, J. I., Badley, A. D., Nixon, D. E., Lundgren, J. D., Tracy, R. P. & Neaton, J. D., Jun 1 2012, In : Journal of Acquired Immune Deficiency Syndromes. 60, 2, p. 128-134 7 p.

Research output: Contribution to journalArticle

HIV
Inflammation
CD40 Ligand
P-Selectin
Therapeutics
5 Citations (Scopus)

SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: Implications for the development of T cell memory

Trushin, S. A., Carena, A. A., Bren, G. D., Rizza, S., Dong, X., Abraham, R. S. & Badley, A. D., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1835-1842 8 p.

Research output: Contribution to journalArticle

Glycoproteins
Protein Isoforms
Up-Regulation
T-Lymphocytes
Ligation
2011
6 Citations (Scopus)

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations

Cummins, N. W., Klicpera, A., Sainski, A. M., Bren, G. D., Khosla, S., Westendorf, J. J. & Badley, A. D., Sep 12 2011, In : PLoS One. 6, 9, e24876.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus env Gene Products
osteoblasts
Osteoblasts
Human immunodeficiency virus
apoptosis
10 Citations (Scopus)

Isolation of a TRAIL antagonist from the serum of HIV-infected patients

Schnepple, D. J., Shepard, B., Bren, G. D., Cummins, N. W., Natesampillai, S., Trushin, S., Algeciras-Schimnich, A., Meng, X. W., Sainski, A. M., Rizza, S., Kaufmann, S. H. & Badley, A. D., Oct 14 2011, In : Journal of Biological Chemistry. 286, 41, p. 35742-35754 13 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
HIV
Serum
TNF-Related Apoptosis-Inducing Ligand Receptors
HIV Infections
15 Citations (Scopus)

The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak

Sainski, A. M., Natesampillai, S., Cummins, N. W., Bren, G. D., Taylor, J., Saenz, D. T., Poeschla, E. M. & Badley, A. D., Aug 2011, In : Journal of Virology. 85, 16, p. 7965-7975 11 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
caspase-9
HIV-1
cell death
Cell Death
5 Citations (Scopus)

TRAIL Dependent Fratricidal Killing of gp120 Primed Hepatocytes by HCV Core Expressing Hepatocytes

Rizza, S., Challagundla, K. B., Natesampillai, S., Bren, G. D., Sykora, J., Walczak, H. & Badley, A. D., 2011, In : PLoS One. 6, 11, e27171.

Research output: Contribution to journalArticle

hepatocytes
Hepatocytes
HIV Envelope Protein gp120
Biopsy
HIV
2010
4 Citations (Scopus)

Casp8p41 expression in primary T cells induces a proinflammatory response

Taylor, J. A., Cummins, N. W., Bren, G. D., Rizza, S., Kolbert, C. P., Behrens, M. D., Knutson, K. L., Kahl, J. C., Asmann, Y. & Badley, A. D., Jun 1 2010, In : AIDS. 24, 9, p. 1251-1258 8 p.

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
NF-kappa B
Microarray Analysis
Cytokines
16 Citations (Scopus)

How much Gp120 is there?

Cummins, N. W., Rizza, S. & Badley, A. D., Apr 15 2010, In : Journal of Infectious Diseases. 201, 8, p. 1273-1274 2 p.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
Lymphoid Tissue
Tissue Distribution
HIV Infections
11 Citations (Scopus)

Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Cummins, N. W., Jiang, W., McGinty, J., Bren, G. D., Bosch, R. J., Landay, A., Deeks, S. G., Martin, J. N., Douek, D., Lederman, M. M., Brenchley, J. & Badley, A. D., Aug 1 2010, In : Journal of Infectious Diseases. 202, 3, p. 386-391 6 p.

Research output: Contribution to journalArticle

CD4 Lymphocyte Count
T-Lymphocytes
HIV
Bacterial DNA
Caspase 8
120 Citations (Scopus)

Mechanisms of HIV-associated lymphocyte apoptosis: 2010

Cummins, N. W. & Badley, A. D., Nov 2010, In : Cell Death and Disease. 1, 11, e99.

Research output: Contribution to journalArticle

Virus Diseases
HIV
Lymphocytes
Apoptosis
Viral Proteins
12 Citations (Scopus)

Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells

Natesampillai, S., Nie, Z., Cummins, N. W., Jochmans, D., Bren, G. D., Angel, J. B. & Badley, A. D., Nov 2010, In : PLoS Pathogens. 6, 11, e1001213.

Research output: Contribution to journalArticle

HIV Protease
HIV
Cell Death
T-Lymphocytes
Peptide Hydrolases
5 Citations (Scopus)
Hepacivirus
Interferons
Tumor Necrosis Factor-alpha
HIV
Apoptosis

Pulmonary complications of bone-marrow and stem-cell transplantation

Afessa, B., Badley, A. D. & Peters, S. G., Jan 1 2010, Drug-Induced and Iatrogenic Respiratory Disease. CRC Press, p. 172-191 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

transplantation
Hematopoietic Stem Cell Transplantation
Stem Cell Transplantation
Bone Marrow Transplantation
bone
2009
20 Citations (Scopus)

HIV-1 tat protein suppresses cholangiocyte toll- like receptor 4 expression and defense against cryptosporidium parvum

O'Hara, S. P., Small, A. J., Gajdos, G. B., Badley, A. D., Chen, X. M. & La Russo, N. F., Apr 15 2009, In : Journal of Infectious Diseases. 199, 8, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

tat Gene Products
Cryptosporidium parvum
Toll-Like Receptor 4
HIV-1
Cryptosporidiosis
13 Citations (Scopus)

HIV gp120 induces, NF-κB dependent, HIV replication that requires procaspase 8

Bren, G. D., Trushin, S. A., Whitman, J., Shepard, B. & Badley, A. D., Mar 16 2009, In : PLoS One. 4, 3, e4875.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
caspase-8
Caspase 8
HIV
Chemical activation
41 Citations (Scopus)

HIV induces TRAIL sensitivity in hepatocytes

Babu, C. K., Suwansrinon, K., Bren, G. D., Badley, A. D. & Rizza, S., 2009, In : PLoS One. 4, 2, e4623.

Research output: Contribution to journalArticle

liver diseases
Liver
hepatocytes
Liver Diseases
Hepatocytes
17 Citations (Scopus)

Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis

Singh, V. P., Bren, G. D., Algeciras-Schimnich, A., Schnepple, D., Navina, S., Rizza, S., Dawra, R. K., Saluja, A. K., Chari, S. T., Vege, S. S. & Badley, A. D., May 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 5

Research output: Contribution to journalArticle

Nelfinavir
Ceruletide
Ritonavir
Pancreatitis
Inflammation
10 Citations (Scopus)

The biology of TRAIL and the role of TRAIL-based therapeutics in infectious diseases

Shepard, B. D. & Badley, A. D., 2009, In : Anti-Infective Agents in Medicinal Chemistry. 8, 2, p. 87-101 15 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Communicable Diseases
Apoptosis
Viruses
Therapeutics
28 Citations (Scopus)

The TRAIL to viral pathogenesis: The good, the bad and the ugly

Cummins, N. W. & Badley, A. D., 2009, In : Current Molecular Medicine. 9, 4, p. 495-505 11 p.

Research output: Contribution to journalArticle

Virus Diseases
Antiviral Agents
Apoptosis
Viruses
Cytokines
2008
9 Citations (Scopus)

Beneficial effect of TRAIL on HIV burden, without detectable immune consequences

Shepard, B. D., De Forni, D., McNamara, D. R., Foli, A., Rizza, S., Abraham, R. S., Knutson, K. L., Wettstein, P. J., Lori, F. & Badley, A. D., Aug 28 2008, In : PLoS One. 3, 8, e3096.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
apoptosis
HIV
Lymphocytes
Viral Load
7 Citations (Scopus)

Early changes in T-cell activation predict antiretroviral success in salvage therapy of HIV infection

Shepard, B. D., Loutfy, M. R., Raboud, J., Mandy, F., Kovacs, C. M., Diong, C., Bergeron, M., Govan, V., Rizza, S., Angel, J. B. & Badley, A. D., Jun 1 2008, In : Journal of Acquired Immune Deficiency Syndromes. 48, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

Salvage Therapy
HIV Infections
T-Lymphocytes
Proportional Hazards Models
HIV