Amit Mahipal, MBBS

  • 1038 Citations
  • 16 Scopus h-Index
20052019
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Research Output 2005 2019

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Article
2019

A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms

Wolin, E., Mita, A., Mahipal, A., Meyer, T., Bendell, J., Nemunaitis, J., Munster, P. N., Paz-Ares, L., Filvaroff, E. H., Li, S., Hege, K., de Haan, H. & Mita, M., Jan 1 2019, In : PloS one. 14, 9, e0221994.

Research output: Contribution to journalArticle

Open Access
Neuroendocrine Tumors
Carcinoid Tumor
signs and symptoms (animals and humans)
Tumors
mouth

Clinicopathological features and outcomes of fibrolamellar hepatocellular carcinoma

Chakrabarti, S., Tella, S. H., Kommalapati, A., Huffman, B. M., Yadav, S., Riaz, I. B., Goyal, G., Mody, K., Borad, M. J., Cleary, S., Smoot, R. & Mahipal, A., Jan 1 2019, In : Journal of Gastrointestinal Oncology. 10, 3, p. 554-561 8 p.

Research output: Contribution to journalArticle

Survival
Recurrence
Fibrolamellar hepatocellular carcinoma
Cell Death
Phosphotransferases
2 Citations (Scopus)

First-in-human phase 1 dose-escalating trial of G305 in patients with advanced solid tumors expressing NY-ESO-1

Mahipal, A., Ejadi, S., Gnjatic, S., Kim-Schulze, S., Lu, H., ter Meulen, J. H., Kenney, R. & Odunsi, K., Jan 1 2019, In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalArticle

Neoplasms
Emulsions
Vaccines
T-Lymphocytes
Safety

Local excision for patients with stage I anal canal squamous cell carcinoma can be curative

Chakrabarti, S., Jin, Z., Huffman, B. M., Yadav, S., Graham, R., Lam-Himlin, D. M., Lightner, A., Hallemeier, C. & Mahipal, A., Apr 1 2019, In : Journal of Gastrointestinal Oncology. 10, 2, p. 171-178 8 p.

Research output: Contribution to journalArticle

Anal Canal
Squamous Cell Carcinoma
Recurrence
Disease-Free Survival
Salvage Therapy
3 Citations (Scopus)

Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis

Yadav, S., Xie, H., Bin-Riaz, I., Sharma, P., Durani, U., Goyal, G., Borah, B. J., Borad, M. J., Smoot, R., Roberts, L. R., Go, R. S., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Propensity Score
Cholangiocarcinoma
Adjuvant Chemotherapy
Drug Therapy
Survival

Novel Prognostic Factors in Resected Small Bowel Adenocarcinoma

Huffman, B. M., Jin, Z., Yadav, S., Patel, S., Nagorney, D. M., Truty, M., Mc Williams, R. R., Halfdanarson, T. R. & Mahipal, A., Jan 1 2019, In : Clinical colorectal cancer.

Research output: Contribution to journalArticle

Adenocarcinoma
Survival
Adjuvant Chemotherapy
Monocytes
Neoplasms

Survival and prognostic factors in patients with pancreatic squamous cell carcinoma

Tella, S. H., Kommalapati, A., Yadav, S., Bergquist, J. R., Truty, M., Durgin, L., Ma, W. W., Cleary, S. P., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Survival
Neoplasms
Drug Therapy
Survival Analysis
2018
1 Citation (Scopus)

Association between treatment facility volume, therapy types and overall survival in patients with intrahepatic cholangiocarcinoma

Kommalapati, A., Tella, S. H., Goyal, G., Borad, M. J., Alberts, S. R., Roberts, L. R., Hubbard, J. M., Durgin, L., Cleary, S. & Mahipal, A., Jan 1 2018, (Accepted/In press) In : HPB.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Survival
Liver
Therapeutics
Insurance
2 Citations (Scopus)

Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials

Denson, A., Burke, N., Wapinsky, G., Bertels, B., Juan, T. H., Lee, J., Springett, G. M., Strosberg, J. R., Kim, R. D., Sullivan, D. M. & Mahipal, A., Jan 1 2018, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 41, 2, p. 133-139 7 p.

Research output: Contribution to journalArticle

Clinical Trials, Phase I
Neoplasms
Gastrointestinal Neoplasms
Survival
Therapeutics

Phase 1 trial of enzalutamide in combination with gemcitabine and nab-paclitaxel for the treatment of advanced pancreatic cancer

Mahipal, A., Tella, S. H., Kommalapati, A., Goyal, G., Soares, H., Neuger, A., Copolla, D., Kim, J. & Kim, R., Jan 1 2018, (Accepted/In press) In : Investigational New Drugs.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Pharmacokinetics
Androgen Receptor Antagonists
Therapeutics
3 Citations (Scopus)

Prognostic factors and benefits of adjuvant therapy after pancreatoduodenectomy for ampullary adenocarcinoma: Mayo Clinic experience

Jin, Z., Hartgers, M. L., Sanhueza, C. T., Shubert, C. R., Alberts, S. R., Truty, M., Muppa, P., Nagorney, D. M., Smyrk, T. C., Hassan, M. & Mahipal, A., Jan 1 2018, (Accepted/In press) In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Pancreaticoduodenectomy
Adenocarcinoma
Therapeutics
Survival
Multivariate Analysis
4 Citations (Scopus)

Survival and Prognostic Factors in Patients with Solid Pseudopapillary Neoplasms of the Pancreas

Huffman, B. M., Westin, G., Alsidawi, S., Alberts, S. R., Nagorney, D. M., Halfdanarson, T. R. & Mahipal, A., Sep 1 2018, In : Pancreas. 47, 8, p. 1003-1007 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Survival
Neoplasms
Multivariate Analysis
Databases
4 Citations (Scopus)

Use of Radiation Therapy in Locally Advanced Pancreatic Cancer Improves Survival

Sajjad, M., Batra, S., Hoffe, S., Kim, R., Springett, G. & Mahipal, A., Jan 1 2018, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 41, 3, p. 236-241 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Radiotherapy
Radiation
Survival
Propensity Score
2017
6 Citations (Scopus)

EGFR Inhibitors in Patients with Advanced Squamous Cell Anal Carcinomas: A Single-Institution Experience

Kim, D. W., Byer, J., Kothari, N., Mahipal, A., Chang, Y. D. & Kim, R. D., Apr 1 2017, In : Oncology (Switzerland). 92, 4, p. 190-196 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
irinotecan
Therapeutics
Disease-Free Survival
35 Citations (Scopus)

Phase I dose-escalation and -expansion study of the BRAF inhibitor encorafenib (LGX818) in metastatic BRAF-mutant melanoma

Delord, J. P., Robert, C., Nyakas, M., McArthur, G. A., Kudchakar, R., Mahipal, A., Yamada, Y., Sullivan, R., Arance, A., Kefford, R. F., Carlino, M. S., Hidalgo, M., Gomez-Roca, C., Michel, D., Seroutou, A., Aslanis, V., Caponigro, G., Stuart, D. D., Moutouh-De Parseval, L., Demuth, T. & 1 others, Dummer, R., Sep 15 2017, In : Clinical Cancer Research. 23, 18, p. 5339-5348 10 p.

Research output: Contribution to journalArticle

Melanoma
Disease-Free Survival
Proto-Oncogene Proteins B-raf
Confidence Intervals
Maximum Tolerated Dose
24 Citations (Scopus)

Phase i trial of the human double minute 2 inhibitor MK-8242 in patients with advanced solid tumors

Wagner, A. J., Banerji, U., Mahipal, A., Somaiah, N., Hirsch, H., Fancourt, C., Johnson-Levonas, A. O., Lam, R., Meister, A. K., Russo, G., Knox, C. D., Rose, S. & Hong, D. S., Apr 20 2017, In : Journal of Clinical Oncology. 35, 12, p. 1304-1311 8 p.

Research output: Contribution to journalArticle

Liposarcoma
Neoplasms
Pharmacokinetics
Thrombocytopenia
Nausea
2016
292 Citations (Scopus)

Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results from the phase Ib KEYNOTE-012 expansion cohort

Chow, L. Q. M., Haddad, R., Gupta, S., Mahipal, A., Mehra, R., Tahara, M., Berger, R., Eder, J. P., Burtness, B., Lee, S. H., Keam, B., Kang, H., Muro, K., Weiss, J., Geva, R., Lin, C. C., Chung, H. C., Meister, A., Dolled-Filhart, M., Pathiraja, K. & 2 others, Cheng, J. D. & Seiwert, T. Y., Nov 10 2016, In : Journal of Clinical Oncology. 34, 32, p. 3838-3845 8 p.

Research output: Contribution to journalArticle

Biomarkers
Ligands
Disease-Free Survival
Carcinoma, squamous cell of head and neck
pembrolizumab
71 Citations (Scopus)

First-in-class, first-in-human phase I study of selinexor, a selective inhibitor of nuclear export, in patients with advanced solid tumors

Abdul Razak, A. R., Mau-Soerensen, M., Gabrail, N. Y., Gerecitano, J. F., Shields, A. F., Unger, T. J., Saint-Martin, J. R., Carlson, R., Landesman, Y., McCauley, D., Rashal, T., Lassen, U., Kim, R., Stayner, L. A., Mirza, M. R., Kauffman, M., Shacham, S. & Mahipal, A., Dec 1 2016, In : Journal of Clinical Oncology. 34, 34, p. 4142-4150 9 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Neoplasms
Fatigue
Leukocytes
Pharmacokinetics
1 Citation (Scopus)

Malignant transformation of biliary adenofibroma: A rare biliary cystic tumor

Thompson, S. M., Zendejas-Mummert, B., Hartgers, M. L., Venkatesh, S. K., Smyrk, T. C., Mahipal, A. & Smoot, R. L., 2016, In : Journal of Gastrointestinal Oncology. 7, 6, p. E107-E112

Research output: Contribution to journalArticle

Adenofibroma
Neoplasms
Cyclin-Dependent Kinase Inhibitor p16
Clinical Pathology
Tumor Suppressor Genes
16 Citations (Scopus)

Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites

Mahipal, A., Klapman, J., Vignesh, S., Yang, C. S., Neuger, A., Chen, D. T. & Malafa, M. P., Jul 1 2016, In : Cancer Chemotherapy and Pharmacology. 78, 1, p. 157-165 9 p.

Research output: Contribution to journalArticle

Tocotrienols
Pharmacokinetics
Metabolites
Vitamin E
Healthy Volunteers
2015
7 Citations (Scopus)

A Meta-analysis of Randomized Clinical Trials of Chemoradiation Therapy in Locally Advanced Pancreatic Cancer

Ambe, C., Fulp, W., Springett, G., Hoffe, S. & Mahipal, A., Oct 1 2015, In : Journal of Gastrointestinal Cancer. 46, 3, p. 284-290 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Meta-Analysis
Randomized Controlled Trials
Drug Therapy
Therapeutics
6 Citations (Scopus)

Effect of age on clinical outcomes in phase 1 trial participants

Mahipal, A., Denson, A. C., Djulbegovic, B., Lush, R., Kumar, A., Juan, T. H., Schell, M. J. & Sullivan, D. M., Apr 1 2015, In : Cancer Control. 22, 2, p. 235-241 7 p.

Research output: Contribution to journalArticle

Transplantation
Neoplasms
Survival Rate
Confidence Intervals
Clinical Trials, Phase I
5 Citations (Scopus)

Paradoxical effect of capecitabine in 5-fluorouracil-induced cardiotoxicity: A case vignette and literature review

Saneeymehri, S. S., Markey, K. R. & Mahipal, A., Jan 1 2015, In : Journal of Oncology Pharmacy Practice. 22, 3, p. 552-555 4 p.

Research output: Contribution to journalArticle

Fluorouracil
Chest Pain
Cardiotoxicity
Capecitabine
Therapeutics
13 Citations (Scopus)

PET/CT fusion scan prevents futile laparotomy in early stage pancreatic cancer

Kim, R., Prithviraj, G., Kothari, N., Springett, G., Malafa, M., Hodul, P., Kim, J., Yue, B., Morse, B. & Mahipal, A., Jan 1 2015, In : Clinical Nuclear Medicine. 40, 11, p. e501-e505

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Laparotomy
Positron Emission Tomography Computed Tomography
Unnecessary Procedures
Registries
5 Citations (Scopus)

Phase i study of combination of pasireotide LAR + gemcitabine in locally advanced or metastatic pancreatic cancer

Suleiman, Y., Mahipal, A., Shibata, D., Siegel, E. M., Jump, H., Fulp, W. J., Springett, G. M. & Kim, R., Sep 21 2015, In : Cancer Chemotherapy and Pharmacology. 76, 3, p. 481-487 7 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Somatostatin Receptors
Somatomedins
Toxicity
6 Citations (Scopus)

Phase i trial of combination of FOLFIRI and pasireotide, a somatostatin analogue, in advanced gastrointestinal malignancies

Mahipal, A., Shibata, D., Siegel, E., Springett, G., Almhanna, K., Fulp, W., Williams-Elson, I. & Kim, R., Oct 22 2015, In : Investigational New Drugs. 33, 5, p. 1093-1099 7 p.

Research output: Contribution to journalArticle

Somatostatin
Neoplasms
irinotecan
Maximum Tolerated Dose
Safety
29 Citations (Scopus)

Selective nuclear export inhibitor KPT-330 enhances the antitumor activity of gemcitabine in human pancreatic cancer

Kazim, S., Malafa, M. P., Coppola, D., Husain, K., Zibadi, S., Kashyap, T., Crochiere, M., Landesman, Y., Rashal, T., Sullivan, D. M. & Mahipal, A., Jul 1 2015, In : Molecular Cancer Therapeutics. 14, 7, p. 1570-1581 12 p.

Research output: Contribution to journalArticle

gemcitabine
Cell Nucleus Active Transport
Pancreatic Neoplasms
Growth
Nude Mice
48 Citations (Scopus)

Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor

Papadopoulos, K. P., Isaacs, R., Bilic, S., Kentsch, K., Huet, H. A., Hofmann, M., Rasco, D., Kundamal, N., Tang, Z., Cooksey, J. & Mahipal, A., May 1 2015, In : Cancer Chemotherapy and Pharmacology. 75, 5, p. 887-895 9 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
TNF-Related Apoptosis-Inducing Ligand Receptors
Pharmacodynamics
Pharmacokinetics
Antibodies
2014
17 Citations (Scopus)

Carboplatin and paclitaxel treatment is effective in advanced anal cancer

Kim, R., Byer, J., Fulp, W. J., Mahipal, A., Dinwoodie, W. & Shibata, D., Jan 1 2014, In : Oncology (Switzerland). 87, 2, p. 125-132 8 p.

Research output: Contribution to journalArticle

Anus Neoplasms
Carboplatin
Paclitaxel
Anal Canal
Squamous Cell Carcinoma
40 Citations (Scopus)

Epidermal growth factor receptor inhibitors: Coming of age

Mahipal, A., Kothari, N. & Gupta, S., Jan 1 2014, In : Cancer Control. 21, 1, p. 74-79 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Head and Neck Neoplasms
Protein-Tyrosine Kinases
Colorectal Neoplasms
50 Citations (Scopus)

Participation of the elderly population in clinical trials: Barriers and solutions

Denson, A. C. & Mahipal, A., Jan 1 2014, In : Cancer Control. 21, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

Clinical Trials
Population
Drug Tolerance
Patient Participation
Neoplasms
9 Citations (Scopus)

Risks and benefits of phase 1 clinical trial participation

Mahipal, A. & Nguyen, D., Jan 1 2014, In : Cancer Control. 21, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

Clinical Trials, Phase I
Therapeutics
Patient Safety
Poisons
Neoplasms
1 Citation (Scopus)

Selinexor

Riaz, W., Burke, N. & Mahipal, A., Oct 1 2014, In : Drugs of the Future. 39, 10, p. 685-692 8 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Tumor Suppressor Proteins
Hematologic Neoplasms
Neoplasms
Molecular Biology
2013
22 Citations (Scopus)

Role of systemic chemotherapy in urothelial urinary bladder cancer

Gupta, S. & Mahipal, A., Jan 1 2013, In : Cancer Control. 20, 3, p. 200-210 11 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Drug Therapy
Standard of Care
Cisplatin
Survival

Viral vector vaccines to treat colorectal cancer

Ashraf, N., Mahipal, A. & Kim, R., Dec 1 2013, In : Current Colorectal Cancer Reports. 9, 4, p. 398-405 8 p.

Research output: Contribution to journalArticle

Viral Vaccines
Colorectal Neoplasms
Cancer Vaccines
Clinical Trials
Neoplasm Antigens
2012
36 Citations (Scopus)

A pilot study of sunitinib malate in patients with metastatic uveal melanoma

Mahipal, A., Tijani, L., Chan, K., Laudadio, M., Mastrangelo, M. J. & Sato, T., Dec 1 2012, In : Melanoma Research. 22, 6, p. 440-446 7 p.

Research output: Contribution to journalArticle

Disease-Free Survival
Survival
Hand-Foot Syndrome
sunitinib
Uveal melanoma
14 Citations (Scopus)

Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma

Mahipal, A., McDonald, M. J., Witkiewicz, A. & Carr, B. I., Mar 1 2012, In : Medical Oncology. 29, 1, p. 134-139 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Adenocarcinoma
Cell Membrane
Pancreatic Neoplasms
Survival
2011
13 Citations (Scopus)

Small-cell carcinoma of the gallbladder: Report of a case and literature review

Mahipal, A. & Gupta, S., Jul 1 2011, In : Gastrointestinal Cancer Research. 4, 4, p. 135-136 2 p.

Research output: Contribution to journalArticle

Small Cell Carcinoma
Gallbladder
24 Citations (Scopus)

Tumor-derived interleukin-10 as a prognostic factor in stage III patients undergoing adjuvant treatment with an autologous melanoma cell vaccine

Mahipal, A., Terai, M., Berd, D., Chervoneva, I., Patel, K., Mastrangelo, M. J. & Sato, T., Jul 1 2011, In : Cancer Immunology, Immunotherapy. 60, 7, p. 1039-1045 7 p.

Research output: Contribution to journalArticle

Interleukin-10
Melanoma
Vaccines
Neoplasms
Therapeutics
2007
7 Citations (Scopus)

Fatal pulmonary toxicity after a single dose of cyclophosphamide

Gupta, S. & Mahipal, A., Apr 1 2007, In : Pharmacotherapy. 27, 4, p. 616-618 3 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Lung
Amiodarone
Radiation Pneumonitis
Non-Hodgkin's Lymphoma
2006
47 Citations (Scopus)

Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa Women's Health Study

Mahipal, A., Anderson, K. E., Limburg, P. J. & Folsom, A. R., Oct 2006, In : Cancer Epidemiology Biomarkers and Prevention. 15, 10, p. 1785-1790 6 p.

Research output: Contribution to journalArticle

Women's Health
Colorectal Neoplasms
Anti-Inflammatory Agents
Aspirin
Confidence Intervals