• 48437 Citations
  • 100 h-Index
1974 …2019
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Research Output 1978 2019

2019
Heart Failure
LCZ 696
1 Citation (Scopus)

Between-day versus within-day imprecision using the Abbott high-sensitivity cardiac troponin I assay at concentrations around 5 ng/l

Kavsak, P. A., Millar, E., McLay, G., Clark, L. & Jaffe, A. S., Feb 1 2019, In : Clinica Chimica Acta. 489, p. 58-60 3 p.

Research output: Contribution to journalLetter

Troponin I
Assays

Cuarta definición universal del infarto de miocardio: ¿Cambiará la práctica de la medicina de urgencias y emergencias?

Alquézar-Arbé, A., Ordóñez-Llanos, J. & Jaffe, A. S., Feb 1 2019, In : Emergencias. 31, 1, p. 55-57 3 p.

Research output: Contribution to journalComment/debate

Emergency Medicine
Myocardial Infarction
70 Citations (Scopus)

Fourth universal definition of myocardial infarction (2018)

Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., Mickley, H., Crea, F., Van De Werf, F., Bucciarelli-Ducci, C., Katus, H. A., Pinto, F. J., Antman, E. M., Hamm, C. W., De Caterina, R., Januzzi, J. L., Apple, F. S., Garcia, M. A. A., Underwood, S. R. & 59 othersCanty, J. M., Lyon, A. R., Devereaux, P. J., Zamorano, J. L., Lindahl, B., Weintraub, W. S., Newby, L. K., Virmani, R., Vranckx, P., Cutlip, D., Gibbons, R. J., Smith, S. C., Atar, D., Luepker, R. V., Robertson, R. M., Bonow, R. O., Steg, P. G., O’Gara, P. T., Fox, K. A. A., Hasdai, D., Aboyans, V., Achenbach, S., Agewall, S., Alexander, T., Avezum, A., Barbato, E., Bassand, J. P., Bates, E., Bittl, J. A., Breithardt, G., Bueno, H., Bugiardini, R., Cohen, M. G., Dangas, G., De Lemos, J. A., Delgado, V., Filippatos, G., Fry, E., Granger, C. B., Halvorsen, S., Hlatky, M. A., Ibanez, B., James, S., Kastrati, A., Leclercq, C., Mahaffey, K. W., Mehta, L., Müller, C., Patrono, C., Piepoli, M. F., Piñeiro, D., Roffi, M., Rubboli, A., Sharma, S., Simpson, I. A., Tendera, M., Valgimigli, M., Van Der Wal, A. C. & Windecker, S., Jan 1 2019, In : European Heart Journal. 40, 3, p. 237-269 33 p.

Research output: Contribution to journalArticle

Myocardial Infarction

High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis

Samaha, E., Avila, A., Helwani, M. A., Ben Abdallah, A., Jaffe, A. S., Scott, M. G. & Nagele, P., Mar 19 2019, In : Journal of the American Heart Association. 8, 6, p. e008626

Research output: Contribution to journalArticle

Open Access
Troponin
Exercise Test
Myocardial Ischemia
Troponin T
Meta-Analysis

High-Sensitivity Cardiac Troponin I Levels in Normal and Hypertensive Pregnancy

Ravichandran, J., Woon, S. Y., Quek, Y. S., Lim, Y. C., Noor, E. M., Suresh, K., Vigneswaran, R., Vasile, V., Shah, A., Mills, N. L., Sickan, J., Beshiri, A. & Jaffe, A. S., Jan 1 2019, (Accepted/In press) In : American Journal of Medicine.

Research output: Contribution to journalArticle

Pregnancy Induced Hypertension
Troponin I
Pre-Eclampsia
Troponin
Pregnancy

High-sensitivity cardiac troponin T increases after stress echocardiography

Samaha, E., Brown, J., Brown, F., Martinez, S. C., Scott, M., Jaffe, A. S., Davila-Roman, V. G. & Nagele, P., Jan 1 2019, In : Clinical Biochemistry. 63, p. 18-23 6 p.

Research output: Contribution to journalArticle

Echocardiography
Stress Echocardiography
Troponin T
Dobutamine
Exercise
Troponin
United States Food and Drug Administration
Myocardial Infarction

Type 2 Myocardial Infarction: JACC Review Topic of the Week

Sandoval, Y. & Jaffe, A. S., Apr 16 2019, In : Journal of the American College of Cardiology. 73, 14, p. 1846-1860 15 p.

Research output: Contribution to journalReview article

Myocardial Infarction
Troponin
Myocardial Ischemia
Oxygen
Therapeutics
1 Citation (Scopus)
Amyloidosis
Heart Failure
Light
Serum
Brain Natriuretic Peptide
2018
1 Citation (Scopus)

1-h High-Sensitivity Troponin Rule-Out and Rule-In Approach: Strengths and Potential Weaknesses

Alpert, J. S. & Jaffe, A. S., Aug 7 2018, In : Journal of the American College of Cardiology. 72, 6, p. 633-635 3 p.

Research output: Contribution to journalEditorial

Troponin
Acute Coronary Syndrome
Myocardial Infarction

Analytical performance of an immunoassay to measure proenkephalin

Donato, L. J., Meeusen, J. W., Lieske, J. C., Bergmann, D., Sparwaßer, A. & Jaffe, A. S., Jan 1 2018, (Accepted/In press) In : Clinical Biochemistry.

Research output: Contribution to journalArticle

Immunoassay
Assays
Glomerular Filtration Rate
Plasmas
Enkephalins

Are high-sensitivity cardiac troponin I values stable between preoperative visit and day of non-cardiac surgery?

Samaha, E., Helwani, M. A., Brown, J. C., Brown, F., Jaffe, A. S., Scott, M. G. & Nagele, P., Feb 1 2018, In : Clinical Biochemistry. 52, p. 171-172 2 p.

Research output: Contribution to journalArticle

Troponin I
Ambulatory Surgical Procedures
Surgery
Troponin
Ambulatory Care
56 Citations (Scopus)

Association for clinical chemistry and the task force on clinical applications of cardiac bio-Markers of the international federation of clinical chemistry and laboratory medicine

Wu, A. H. B., Christenson, R. H., Greene, D. N., Jaffe, A. S., Kavsak, P. A., Ordonez-Llanos, J. & Apple, F. S., Apr 1 2018, In : Clinical Chemistry. 64, 4, p. 645-655 11 p.

Research output: Contribution to journalArticle

Clinical laboratories
Clinical Chemistry
Troponin
Advisory Committees
Medicine
1 Citation (Scopus)
Diabetic Nephropathies
Biomarkers
3 Citations (Scopus)

Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)

Saenger, A. K., Jaffe, A. S., Body, R., Collinson, P. O., Kavsak, P. A., Lam, C. S. P., Lefèvre, G., Omland, T., Ordóñez-Llanos, J., Pulkki, K. & Apple, F. S., Jan 1 2018, (Accepted/In press) In : Clinical Chemistry and Laboratory Medicine.

Research output: Contribution to journalArticle

Natriuretic Peptides
Troponin
Biomarkers
Biotin
Hemolysis
1 Citation (Scopus)

Clarifying the Proper Definitions for Type 2 Myocardial Infarction

Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R. & White, H. D., Mar 20 2018, In : Journal of the American College of Cardiology. 71, 11, 1 p.

Research output: Contribution to journalLetter

Myocardial Infarction

Comparing analytical outliers and the percent of emergency department patients with results above the 99th percentile upper reference limit for 2 conventional and one high sensitivity troponin assay

Karon, B. S., Wockenfus, A. M., Hartung, K. J., Scott, R. J., Carter, S. D. & Jaffe, A. S., Jan 1 2018, (Accepted/In press) In : Clinical Biochemistry.

Research output: Contribution to journalArticle

Troponin
Hospital Emergency Service
Assays
Troponin I
Troponin T
1 Citation (Scopus)

Comparison of high-sensitivity cardiac troponin I and T for the prediction of cardiac complications after non-cardiac surgery

TropoVasc and BASEL-PMI Investigators, Sep 1 2018, In : American Heart Journal. 203, p. 67-73 7 p.

Research output: Contribution to journalArticle

Troponin T
Troponin I
Confidence Intervals
Blood Vessels
Odds Ratio
1 Citation (Scopus)

Czwarta uniwersalna definicja zawalu serca (2018)

Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., Mickley, H., Crea, F., Van De Werf, F., Bucciarelli-Ducci, C., Katus, H. A., Pinto, F. J., Antman, E. M., Hamm, C. W., De Caterina, R., Januzzi, J. L., Apple, F. S., Garcia, M. A. A., Richard Underwood, S. & 19 othersCanty, J. M., Lyon, A. R., Devereaux, P. J., Zamorano, J. L., Lindahl, B., Weintraub, W. S., Kristin Newby, L., Virmani, R., Vranckx, P., Cutlip, D., Gibbons, R. J., Smith, S. C., Atar, D., Luepker, R. V., Robertson, R. M., Bonow, R. O., Gabriel Steg, P., O'Gara, P. T. & A Fox, K. A., Oct 16 2018, In : Kardiologia Polska. 76, 10, p. 1383-1415 33 p.

Research output: Contribution to journalArticle

Myocardial Infarction
5 Citations (Scopus)

Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., Bailey, S., Young, J. M., Cullen, L., Greenslade, J. H., Parsonage, W. A., Everett, B. M., Peacock, W. F., Jaffe, A. S. & Pickering, J. W., Jul 1 2018, In : Clinical Chemistry. 64, 7, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Troponin
Observational Studies
Hazards
Population
Assays
1 Citation (Scopus)

Diagnostic concordance between NT-proBNP and BNP for suspected heart failure

Farnsworth, C. W., Bailey, A. L., Jaffe, A. S. & Scott, M. G., Sep 1 2018, In : Clinical Biochemistry. 59, p. 50-55 6 p.

Research output: Contribution to journalArticle

Heart Failure
pro-brain natriuretic peptide (1-76)
Natriuretic Peptides
Testing
Chronic Renal Insufficiency
2 Citations (Scopus)

Evaluation of the Siemens ADVIA Centaur high-sensitivity cardiac troponin I assay in serum

Kavsak, P. A., Worster, A., Hill, S. A. & Jaffe, A. S., Dec 1 2018, In : Clinica Chimica Acta. 487, p. 216-221 6 p.

Research output: Contribution to journalArticle

Troponin I
Assays
Serum
Troponin
Testing
17 Citations (Scopus)

Fourth Universal Definition of Myocardial Infarction (2018)

Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction, Nov 13 2018, In : Circulation. 138, 20, p. e618-e651

Research output: Contribution to journalArticle

Takotsubo Cardiomyopathy
Myocardial Infarction
4 Citations (Scopus)

Fourth Universal Definition of Myocardial Infarction (2018)

Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction, Dec 1 2018, In : Global Heart. 13, 4, p. 305-338 34 p.

Research output: Contribution to journalArticle

Takotsubo Cardiomyopathy
Myocardial Infarction
76 Citations (Scopus)

Fourth Universal Definition of Myocardial Infarction (2018)

The Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction, Oct 30 2018, In : Journal of the American College of Cardiology. 72, 18, p. 2231-2264 34 p.

Research output: Contribution to journalArticle

Takotsubo Cardiomyopathy
Myocardial Infarction
2 Citations (Scopus)

High-sensitivity cardiac troponin T in young, healthy adults undergoing non-cardiac surgery

Duma, A., Wagner, C., Titz, M., Maleczek, M., Hüpfl, M., Weihs, V. B., Samaha, E., Herkner, H., Szekeres, T., Mittlboeck, M., Scott, M. G., Jaffe, A. S. & Nagele, P., Feb 1 2018, In : British Journal of Anaesthesia. 120, 2, p. 291-298 8 p.

Research output: Contribution to journalArticle

Troponin T
Young Adult
Troponin
Wounds and Injuries
Physiological Phenomena

High-Sensitivity Troponin in Patients With Coronary Artery Endothelial Dysfunction

El Sabbagh, A., Prasad, M., Zack, C. J., Widmer, R. J., Karon, B. S., Lerman, A. & Jaffe, A. S., Nov 1 2018, In : The Journal of invasive cardiology. 30, 11, p. 406-410 5 p.

Research output: Contribution to journalArticle

Troponin
Troponin I
Coronary Vessels
Ischemia
Population
13 Citations (Scopus)

How is cardiac troponin released from injured myocardium?

Mair, J., Lindahl, B., Hammarsten, O., Müller, C., Giannitsis, E., Huber, K., Möckel, M., Plebani, M., Thygesen, K. & Jaffe, A. S., Sep 1 2018, In : European heart journal. Acute cardiovascular care. 7, 6, p. 553-560 8 p.

Research output: Contribution to journalReview article

Troponin
Myocardium
Necrosis
Myocardial Ischemia
Wounds and Injuries
9 Citations (Scopus)

ICare-ACS (Improving Care Processes for Patients with Suspected Acute Coronary Syndrome): A Study of Cross-System Implementation of a National Clinical Pathway

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., Allan, K. E., Ardagh, M. W., Bonning, J. W. N., Callender, R., Chapman, L. R. E., Christiansen, J. P., Cromhout, A. P. J., Cullen, L., Deely, J. M., Devlin, G. P., Ferrier, K. A., Florkowski, C. M., Frampton, C. M. A., George, P. M. & 20 othersHamilton, G. J., Jaffe, A. S., Kerr, A. J., Larkin, G. L., Makower, R. M., Matthews, T. J. E., Parsonage, W. A., Peacock, W. F., Peckler, B. F., Van Pelt, N. C., Poynton, L., Richards, A. M., Scott, A. G., Simmonds, M. B., Smyth, D., Thomas, O. P., To, A. C. Y., Du Toit, S. A., Troughton, R. W. & Yates, K. M., Jan 23 2018, In : Circulation. 137, 4, p. 354-363 10 p.

Research output: Contribution to journalArticle

Critical Pathways
Acute Coronary Syndrome
Patient Care
Troponin
Length of Stay

Improving the specificity of cardiac biomarkers—the early development of cardiac troponin I (cTnI) assays

Jaffe, A. S., Mar 1 2018, In : Clinical Chemistry. 64, 3, p. 609-610 2 p.

Research output: Contribution to journalComment/debate

Troponin I
Biomarkers
Assays
1 Citation (Scopus)

Meta-Analyses and Interpretation of Troponin Values in Heart Failure*

Jaffe, A. S. & Miller, W. L., Jan 1 2018, (Accepted/In press) In : JACC: Heart Failure.

Research output: Contribution to journalArticle

Troponin
Meta-Analysis
Heart Failure
8 Citations (Scopus)

Plasma Ceramides

Meeusen, J. W., Donato, L. J., Bryant, S. C., Baudhuin, L. M., Berger, P. B. & Jaffe, A. S., Aug 1 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 8, p. 1933-1939 7 p.

Research output: Contribution to journalArticle

Ceramides
Sphingosine
Coronary Artery Disease
Coronary Angiography
Sphingolipids
6 Citations (Scopus)

Possible mechanisms behind cardiac troponin elevations

Hammarsten, O., Mair, J., Möckel, M., Lindahl, B. & Jaffe, A. S., Nov 17 2018, In : Biomarkers. 23, 8, p. 725-734 10 p.

Research output: Contribution to journalReview article

Troponin
Wounds and Injuries
Necrosis
Myocardial Infarction
Troponin T
7 Citations (Scopus)

Prevalence of biotin supplement usage in outpatients and plasma biotin concentrations in patients presenting to the emergency department

Katzman, B. M., Lueke, A. J., Donato, L. J., Jaffe, A. S. & Baumann, N. A., Sep 1 2018, In : Clinical Biochemistry. 60, p. 11-16 6 p.

Research output: Contribution to journalArticle

Biotin
Hospital Emergency Service
Outpatients
Plasmas
Population
1 Citation (Scopus)

Rapid rule-out of suspected acute coronary syndrome in the Emergency Department by high-sensitivity cardiac troponin T levels at presentation

Fabbri, A., Bachetti, C., Ottani, F., Morelli, A., Benazzi, B., Spiezia, S., Cortigiani, M., Dorizzi, R., Jaffe, A. S. & Galvani, M., Jan 1 2018, (Accepted/In press) In : Internal and Emergency Medicine.

Research output: Contribution to journalArticle

Troponin T
Acute Coronary Syndrome
Hospital Emergency Service
Myocardial Infarction
Unstable Angina
1 Citation (Scopus)

Reply to letter by Trupp et al.

Apple, F. S., Saenger, A. K., Gunsolus, I. L., Love, S. A. & Jaffe, A. S., Feb 1 2018, In : Clinical Biochemistry. 52, 1 p.

Research output: Contribution to journalLetter

13 Citations (Scopus)

Safety of magnetic resonance imaging in patients with legacy pacemakers and defibrillators and abandoned leads

Padmanabhan, D., Kella, D. K., Mehta, R., Kapa, S., Deshmukh, A., Mulpuru, S., Jaffe, A. S., Felmlee, J. P., Jondal, M. L., Dalzell, C. M., Asirvatham, S. J., Cha, Y-M., Watson, R. E. & Friedman, P. A., Feb 1 2018, In : Heart Rhythm. 15, 2, p. 228-233 6 p.

Research output: Contribution to journalArticle

Defibrillators
Magnetic Resonance Imaging
Safety
Troponin T
Equipment and Supplies
2 Citations (Scopus)

Sample matrix and high-sensitivity cardiac troponin i assays

Kavsak, P. A., Roy, C., Malinowski, P., Clark, L., Lamers, S., Bamford, K., Hill, S., Worster, A. & Jaffe, A. S., Jan 1 2018, (Accepted/In press) In : Clinical Chemistry and Laboratory Medicine.

Research output: Contribution to journalArticle

Troponin
Assays
Plasmas
Lithium
Heparin
2 Citations (Scopus)

Science Moves Slowly

Jaffe, A. S. & Apple, F. S., Apr 10 2018, In : Journal of the American College of Cardiology. 71, 14, p. 1550-1552 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Significance of High-Sensitivity Troponin T After Elective External Direct Current Cardioversion for Atrial Fibrillation or Atrial Flutter

Lobo, R., Jaffe, A. S., Cahill, C., Blake, O., Abbas, S., Meany, T. B., Hennessy, T. & Kiernan, T. J., Jan 15 2018, In : American Journal of Cardiology. 121, 2, p. 188-192 5 p.

Research output: Contribution to journalArticle

Electric Countershock
Troponin T
Atrial Flutter
Atrial Fibrillation
Troponin
6 Citations (Scopus)

The prognostic impact of periprocedural myocardial infarction and injury

Thygesen, K. & Jaffe, A. S., Apr 1 2018, In : European Heart Journal. 39, 13, p. 1110-1112 3 p.

Research output: Contribution to journalEditorial

Myocardial Infarction
Wounds and Injuries
9 Citations (Scopus)

Use of copeptin for rapid rule-out of acute myocardial infarction

ESC Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association, Sep 1 2018, In : European heart journal. Acute cardiovascular care. 7, 6, p. 570-576 7 p.

Research output: Contribution to journalReview article

Troponin
Myocardial Infarction
copeptins
Troponin
Chronic Obstructive Pulmonary Disease
Comorbidity
14 Citations (Scopus)

What to do when you question cardiac troponin values

Mair, J., Lindahl, B., Müller, C., Giannitsis, E., Huber, K., Möckel, M., Plebani, M., Thygesen, K. & Jaffe, A. S., Sep 1 2018, In : European heart journal. Acute cardiovascular care. 7, 6, p. 577-586 10 p.

Research output: Contribution to journalArticle

Troponin
Myocardial Infarction
Troponin T
Troponin I
Myocardial Ischemia
2017
9 Citations (Scopus)

Analytical comparison of three different versions of a high-sensitivity cardiac troponin I assay over 10 years

Kavsak, P. A., Worster, A., Hill, S. A., MacRae, A. R. & Jaffe, A. S., Dec 1 2017, In : Clinica Chimica Acta. 475, p. 51-55 5 p.

Research output: Contribution to journalArticle

Troponin I
Lithium
Heparin
Assays
Troponin
3 Citations (Scopus)

Another Unanswerable Question

Jaffe, A. S., Apr 1 2017, In : JACC: Basic to Translational Science. 2, 2, p. 115-117 3 p.

Research output: Contribution to journalEditorial

Troponin
Ischemia
Apoptosis
98 Citations (Scopus)

Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery

Devereaux, P. J., Biccard, B. M., Sigamani, A., Xavier, D., Chan, M. T. V., Srinathan, S. K., Walsh, M., Abraham, V., Pearse, R., Wang, C. Y., Sessler, D. I., Kurz, A., Szczeklik, W., Berwanger, O., Villar, J. C., Malaga, G., Garg, A. X., Chow, C. K., Ackland, G., Patel, A. & 33 othersBorges, F. K., Belley-Cote, E. P., Duceppe, E., Spence, J., Tandon, V., Williams, C., Sapsford, R. J., Polanczyk, C. A., Tiboni, M., Alonso-Coello, P., Faruqui, A., Heels-Ansdell, DI., Lamy, A., Whitlock, R., LeManach, Y., Roshanov, P. S., McGillion, M., Kavsak, P., McQueen, M. J., Thabane, L., Rodseth, R. N., Buse, G. A. L., Bhandari, M., Garutti, I., Jacka, M. J., Schünemann, H. J., Cortes, O. L., Coriat, P., Dvirnik, N., Botto, F., Pettit, S., Jaffe, A. S. & Guyatt, G. H., Apr 25 2017, In : JAMA - Journal of the American Medical Association. 317, 16, p. 1642-1651 10 p.

Research output: Contribution to journalArticle

Troponin T
Troponin
Mortality
Wounds and Injuries
Ambulatory Surgical Procedures
5 Citations (Scopus)

Best practices for monitoring cardiac troponin in detecting myocardial injury

Apple, F. S., Jaffe, A. S., Sharkey, S., Kavsak, P., Kontos, M. C., Saenger, A. K. & Smith, S., Jan 1 2017, In : Clinical Chemistry. 63, 1, p. 37-44 8 p.

Research output: Contribution to journalComment/debate

89 Citations (Scopus)

Cardiac troponin assays: Guide to understanding analytical characteristics and their impact on clinical care

Apple, F. S., Sandoval, Y., Jaffe, A. S. & Ordonez-Llanos, J., Jan 1 2017, In : Clinical Chemistry. 63, 1, p. 73-81 9 p.

Research output: Contribution to journalReview article

Troponin T
Troponin
Troponin I
Assays
Acute Coronary Syndrome