• 2535 Citations
  • 30 Scopus h-Index
20092019

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2019

Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome

Pawar, A. S., Eirin, A., Krier, J. D., Woollard, J. R., Zhu, X. Y., Lerman, A., van Wijnen, A. J. & Lerman, L. O., May 1 2019, In : Stem Cell Research. 37, 101423.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Coexisting renal artery stenosis and metabolic syndrome magnifies mitochondrial damage, aggravating poststenotic kidney injury in pigs

Nargesi, A. A., Zhang, L., Tang, H., Jordan, K. L., Saadiq, I. M., Textor, S. C., Lerman, L. O. & Eirin, A., Oct 1 2019, In : Journal of hypertension. 37, 10, p. 2061-2073 13 p.

Research output: Contribution to journalArticle

Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: Role of podocyte mitochondria

Zhang, L. H., Zhu, X. Y., Eirin, A., Nargesi, A. A., Woollard, J. R., Santelli, A., Sun, I. O., Textor, S. C. & Lerman, L. O., Jan 1 2019, In : American Journal of Physiology - Renal Physiology. 317, 7, p. F12-F22

Research output: Contribution to journalArticle

3 Scopus citations
Open Access
2 Scopus citations

Metabolic Syndrome Induces Release of Smaller Extracellular Vesicles from Porcine Mesenchymal Stem Cells

Conley, S. M., Shook, J. E., Zhu, X. Y., Eirin, A., Jordan, K. L., Woollard, J. R., Isik, B., Hickson, L. T. J., Puranik, A. S. & Lerman, L. O., Sep 1 2019, In : Cell Transplantation. 28, 9-10, p. 1271-1278 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Metabolic Syndrome Interferes with Packaging of Proteins within Porcine Mesenchymal Stem Cell-Derived Extracellular Vesicles

Eirin, A., Zhu, X. Y., Woollard, J. R., Tang, H., Dasari, S., Lerman, A. & Lerman, L. O., May 2019, In : Stem Cells Translational Medicine. 8, 5, p. 430-440 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells

Aghajani Nargesi, A., Zhu, X. Y., Hickson, L. T. J., Conley, S. M., van Wijnen, A. J., Lerman, L. O. & Eirin, A., Jun 15 2019, In : Stem Cell Reviews and Reports. 15, 3, p. 427-438 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
Open Access
3 Scopus citations

Renal Adiposity Does not Preclude Quantitative Assessment of Renal Function Using Dual-Energy Multidetector CT in Mildly Obese Human Subjects

Ferguson, C. M., Eirin, A., Michalak, G. J., Hedayat, F., Abumoawad, A. M., Hedayat, A. F., Zhu, X., Textor, S. C., McCollough, C. H. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Academic Radiology.

Research output: Contribution to journalArticle

2 Scopus citations

Renal artery stenosis alters gene expression in swine scattered tubular-like cells

Nargesi, A. A., Zhu, X. Y., Liu, Y., Tang, H., Jordan, K. L., Lerman, L. O. & Eirin, A., Oct 2 2019, In : International journal of molecular sciences. 20, 20, 5069.

Research output: Contribution to journalArticle

Open Access

Renovascular disease induces mitochondrial damage in swine scattered tubular cells

Nargesi, A. A., Zhu, X. Y., Conley, S. M., Woollard, J. R., Saadiq, I. M., Lerman, L. O. & Eirin, A., Nov 1 2019, In : American journal of physiology. Renal physiology. 317, 5, p. F1142-F1153

Research output: Contribution to journalArticle

2 Scopus citations

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

Santelli, A., Sun, I. O., Eirin, A., Abumoawad, A. M., Woollard, J. R., Lerman, A., Textor, S. C., Puranik, A. S. & Lerman, L. O., Jun 4 2019, In : Journal of the American Heart Association. 8, 11, e012584.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Tissue hypoxia, inflammation, and loss of glomerular filtration rate in human atherosclerotic renovascular disease

Abumoawad, A., Saad, A., Ferguson, C. M., Eirin, A., Woollard, J. R., Herrmann, S. M., Hickson, L. T. J., Bendel, E. C., Misra, S., Glockner, J., Lerman, L. O. & Textor, S. C., Apr 2019, In : Kidney international. 95, 4, p. 948-957 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
3 Scopus citations
2018

Emerging Paradigms in Chronic Kidney Ischemia

Eirin, A., Textor, S. C. & Lerman, L. O., Nov 1 2018, In : Hypertension (Dallas, Tex. : 1979). 72, 5, p. 1023-1030 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Intrarenal fat deposition does not interfere with the measurement of single-kidney perfusion in obese swine using multi-detector computed tomography

Ferguson, C. M., Eirin, A., Michalak, G. J., Hedayat, A. F., Abumoawad, A., Saad, A., Zhu, X., Textor, S. C., McCollough, C. H. & Lerman, L. O., Jan 1 2018, (Accepted/In press) In : Journal of Cardiovascular Computed Tomography.

Research output: Contribution to journalArticle

4 Scopus citations

Loss of renal peritubular capillaries in hypertensive patients is detectable by urinary endothelial microparticle levels

Sun, I. O., Santelli, A., Abumoawad, A., Eirin, A., Ferguson, C. M., Woollard, J. R., Lerman, A., Textor, S. C., Puranik, A. S. & Lerman, L. O., Jan 1 2018, In : Hypertension. 72, 5, p. 1180-1188 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine

Eirin, A., Zhu, X. Y., Jonnada, S., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Jul 1 2018, In : Cell Transplantation. 27, 7, p. 1080-1095 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway

Meng, Y., Eirin, A., Zhu, X. Y., Tang, H., Hickson, L., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Oct 1 2018, In : Cell Transplantation. 27, 10, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mitochondrial targeted peptides preserve mitochondrial organization and decrease reversible myocardial changes in early swine metabolic syndrome

Yuan, F., Woollard, J. R., Jordan, K. L., Lerman, A., Lerman, L. O. & Eirin, A., Mar 1 2018, In : Cardiovascular Research. 114, 3, p. 431-442 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mitoprotection attenuates myocardial vascular impairment in porcine metabolic syndrome

Yuan, F., Hedayat, A. F., Ferguson, C. M., Lerman, A., Lerman, L. O. & Eirin, A., Apr 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 3, p. H669-H680

Research output: Contribution to journalArticle

5 Scopus citations

Mitoprotection preserves the renal vasculature in porcine metabolic syndrome

Eirin, A., Hedayat, A. F., Ferguson, C. M., Textor, S. C., Lerman, A. & Lerman, L. O., Jan 1 2018, (Accepted/In press) In : Experimental Physiology.

Research output: Contribution to journalArticle

2 Scopus citations

Obesity-induced mitochondrial dysfunction in porcine adipose tissue-derived mesenchymal stem cells

Meng, Y., Eirin, A., Zhu, X. Y., Tang, H., Chanana, P., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

10 Scopus citations

Preserved endothelial progenitor cell angiogenic activity in African American essential hypertensive patients

Kim, S. R., Eirin, A., Herrmann, S., Saad, A., Juncos, L. A., Lerman, A., Textor, S. C. & Lerman, L. O., Mar 1 2018, In : Nephrology Dialysis Transplantation. 33, 3, p. 392-401 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells

Meng, Y., Eirin, A., Zhu, X. Y., O'Brien, D. R., Lerman, A., Van Wijnen, A. J. & Lerman, L. O., Jul 21 2018, In : Diabetology and Metabolic Syndrome. 10, 1, 58.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Glomerular Hyperfiltration in Obese African American Hypertensive Patients Is Associated with Elevated Urinary Mitochondrial-DNA Copy Number

Eirin, A., Saad, A., Woollard, J. R., Juncos, L. A., Calhoun, D. A., Tang, H., Lerman, A., Textor, S. C. & Lerman, L. O., Nov 1 2017, In : American Journal of Hypertension. 30, 11, p. 1112-1119 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells

Eirin, A., Zhu, X. Y., Puranik, A. S., Woollard, J. R., Tang, H., Dasari, S., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Mar 1 2017, In : PLoS One. 12, 3, e0174303.

Research output: Contribution to journalArticle

37 Scopus citations

Metabolic syndrome alters expression of insulin signaling-related genes in swine mesenchymal stem cells

Conley, S. M., Zhu, X. Y., Eirin, A., Tang, H., Lerman, A., van Wijnen, A. J. & Lerman, L. O., 2017, (Accepted/In press) In : Gene.

Research output: Contribution to journalArticle

11 Scopus citations
16 Scopus citations

The metabolic syndrome alters the miRNA signature of porcine adipose tissue-derived mesenchymal stem cells

Meng, Y., Eirin, A., Zhu, X. Y., Tang, H., Chanana, P., Lerman, A., van Wijnen, A. J. & Lerman, L. O., 2017, (Accepted/In press) In : Cytometry Part A.

Research output: Contribution to journalArticle

16 Scopus citations

The metabolic syndrome induces early changes in the swine renal medullary mitochondria

Eirin, A., Woollard, J. R., Ferguson, C. M., Jordan, K. L., Tang, H., Textor, S. C., Lerman, A. & Lerman, L. O., Jun 1 2017, In : Translational Research. 184, p. 45-56.e9

Research output: Contribution to journalArticle

15 Scopus citations
2016

Changes in inflammatory biomarkers after renal revascularization in atherosclerotic renal artery stenosis

Wang, W., Saad, A., Herrmann, S., Eirin, A., McKusick, M. A., Misra, S., Lerman, L. O. & Textor, S. C., Sep 1 2016, In : Nephrology Dialysis Transplantation. 31, 9, p. 1437-1443 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Comparative proteomic analysis of extracellular vesicles isolated from porcine adipose tissue-derived mesenchymal stem/stromal cells

Eirin, A., Zhu, X. Y., Puranik, A. S., Woollard, J. R., Tang, H., Dasari, S., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Oct 27 2016, In : Scientific Reports. 6, 36120.

Research output: Contribution to journalArticle

53 Scopus citations
16 Scopus citations

Functional plasticity of adipose-derived stromal cells during development of obesity

Zhu, X. Y., Ma, S., Eirin, A., Woollard, J. R., Hickson, L. J., Sun, D., Lerman, A. & Lerman, L. O., Jan 1 2016, In : Stem Cells Translational Medicine. 5, 7, p. 893-900 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2 Scopus citations

Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation

Eirin, A., Zhu, X. Y., Puranik, A. S., Tang, H., McGurren, K. A., van Wijnen, A. J., Lerman, A. & Lerman, L. O., May 24 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

73 Scopus citations

Perirenal Fat Promotes Renal Arterial Endothelial Dysfunction in Obese Swine through Tumor Necrosis Factor-α

Ma, S., Zhu, X. Y., Eirin, A., Woollard, J. R., Jordan, K. L., Tang, H., Lerman, A. & Lerman, L. O., 2016, (Accepted/In press) In : Journal of Urology.

Research output: Contribution to journalArticle

22 Scopus citations

Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension

Eirin, A., Ebrahimi, B., Kwon, S. H., Fiala, J. A., Williams, B. J., Woollard, J. R., He, Q., Gupta, R. C., Sabbah, H. N., Prakash, Y. S., Textor, S. C., Lerman, A. & Lerman, L. O., Jun 1 2016, In : Journal of the American Heart Association. 5, 6, e003118.

Research output: Contribution to journalArticle

29 Scopus citations

The MEST score provides earlier risk prediction in lgA nephropathy

Barbour, S. J., Espino-Hernandez, G., Reich, H. N., Coppo, R., Roberts, I. S. D., Feehally, J., Herzenberg, A. M., Cattran, D. C., Bavbek, N., Cook, T., Troyanov, S., Alpers, C., Amore, A., Barratt, J., Berthoux, F., Bonsib, S., Bruijn, J., D'Agati, V., D'Amico, G., Emancipator, S. & 163 others, Emmal, F., Ferrario, F., Fervenza, F., Florquin, S., Fogo, A., Geddes, C., Groene, H., Haas, M., Hill, P., Hogg, R., Hsu, S., Hunley, T., Hladunewich, M., Jennette, C., Joh, K., Julian, B., Kawamura, T., Lai, F., Leung, C., Li, L., Li, P., Liu, Z., Massat, A., Mackinnon, B., Mezzano, S., Schena, F., Tomino, Y., Walker, P., Wang, H., Weening, J., Yoshikawa, N., Zhang, H., Coppo, R., Troyanov, S., Cattran, D. C., Cook, H. T., Feehally, J., Roberts, I., Tesar, V., Maixnerova, D., Lundberg, S., Gesualdo, L., Emma, F., Fuiano, L., Beltrame, G., Rollino, C., Amore, A., Camilla, R., Peruzzi, L., Praga, M., Feriozzi, S., Polci, R., Segoloni, G., Colla, L., Pani, A., Angioi, A., Piras, L., Cancarini, G., Ravera, S., Durlik, M., Moggia, E., Ballarin, J., Di Giulio, S., Pugliese, F., Serriello, I., Caliskan, Y., Sever, M., Kilicaslan, I., Locatelli, F., Del Vecchio, L., Wetzels, J. F. M., Peters, H., Berg, U., Carvalho, F., Da Costa Ferreira, A. C., Maggio, M., Wiecek, A., Ots-Rosenberg, M., Magistroni, R., Topaloglu, R., Bilginer, Y., D'Amico, M., Stangou, M., Giacchino, F., Goumenos, D., Kalliakmani, P., Gerolymos, M., Galesic, K., Geddes, C., Siamopoulos, K., Balafa, O., Galliani, M., Stratta, P., Quaglia, M., Bergia, R., Cravero, R., Salvadori, M., Cirami, L., Fellstrom, B., Kloster Smerud, H., Ferrario, F., Stellato, T., Egido, J., Martin, C., Floege, J., Eitner, F., Lupo, A., Bernich, P., Menè, P., Morosetti, M., Van Kooten, C., Rabelink, T., Reinders, M. E. J., Boria Grinyo, J. M., Cusinato, S., Benozzi, L., Savoldi, S., Licata, C., Mizerska-Wasiak, M., Martina, G., Messuerotti, A., Dal Canton, A., Esposito, C., Migotto, C., Triolo, G., Mariano, F., Pozzi, C., Boero, R., Bellur, S., Mazzucco, G., Giannakakis, C., Honsova, E., Sundelin, B., Di Palma, A. M., Ferrario, F., Gutiérrez, E., Asunis, A. M., Barratt, J., Tardanico, R., Perkowska-Ptasinska, A., Arce Terroba, J., Fortunato, M., Pantzaki, A., Ozluk, Y., Steenbergen, E., Soderberg, M., Riispere, Z., Furci, L., Orhan, D., Kipgen, D., Casartelli, D., Galesic Ljubanovic, D., Gakiopoulou, H., Bertoni, E., Cannata Ortiz, P., Karkoszka, H., Groene, H. J., Stoppacciaro, A., Bajema, I., Bruijn, J., Fulladosa Oliveras, X., Maldyk, J. & Ioachim, E., Jan 1 2016, In : Kidney international. 89, 1, p. 167-175 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Urinary Mitochondrial DNA Copy Number Identifies Chronic Renal Injury in Hypertensive Patients

Eirin, A., Saad, A., Tang, H., Herrmann, S., Woollard, J. R., Lerman, A., Textor, S. C. & Lerman, L. O., Aug 1 2016, In : Hypertension. 68, 2, p. 401-410 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2015

Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesity

Pawar, A. S., Zhu, X. Y., Eirin, A., Tang, H., Jordan, K. L., Woollard, J. R., Lerman, A. & Lerman, L. O., Feb 1 2015, In : Obesity. 23, 2, p. 399-407 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

A Multicenter Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR)

Mentor Consortium group & Dillon, J. J., 2015, In : Nephron. 130, 3, p. 159-168 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
19 Scopus citations

Cardiac Metabolic Alterations in Hypertensive Obese Pigs

Zhang, X., Li, Z. L., Eirin, A., Ebrahimi, B., Pawar, A. S., Zhu, X. Y., Lerman, A. & Lerman, L. O., Aug 20 2015, In : Hypertension. 66, 2, p. 430-436 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
9 Scopus citations

Experimental coronary artery stenosis accelerates kidney damage in renovascular hypertensive swine

Sun, D., Eirin, A., Zhu, X. Y., Zhang, X., Crane, J. A., Woollard, J. R., Lerman, A. & Lerman, L. O., Apr 8 2015, In : Kidney International. 87, 4, p. 719-727 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Histiocytic glomerulopathy associated with macrophage activation syndrome

Eirin, A., Irazabal, M. V., Fervenza, F. C. & Sethi, S., Jan 1 2015, In : Clinical Kidney Journal. 8, 2, p. 157-160 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Intrarenal delivery of mesenchymal stem cells and endothelial progenitor cells attenuates hypertensive cardiomyopathy in experimental renovascular hypertension

Eirin, A., Zhu, X. Y., Ebrahimi, B., Krier, J. D., Riester, S. M., van Wijnen, A. J., Lerman, A. & Lerman, L. O., Oct 13 2015, In : Cell Transplantation. 24, 10, p. 2041-2053 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Intra-renal delivery of mesenchymal stem cells attenuates myocardial injury after reversal of hypertension in porcine renovascular disease

Eirin, A., Zhu, X. Y., Ferguson, C. M., Riester, S. M., van Wijnen, A. J., Lerman, A. & Lerman, L. O., Jan 19 2015, In : Stem Cell Research and Therapy. 6, 1, 7.

Research output: Contribution to journalArticle

20 Scopus citations