• 2687 Citations
  • 31 Scopus h-Index
20092020

Research output per year

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Research Output

2020

Extracellular vesicles released by adipose tissue-derived mesenchymal stromal/stem cells from obese pigs fail to repair the injured kidney

Eirin, A., Ferguson, C. M., Zhu, X. Y., Saadiq, I. M., Tang, H., Lerman, A. & Lerman, L. O., Aug 2020, In : Stem Cell Research. 47, 101877.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Mesenchymal stem cell–derived extracellular vesicles induce regulatory T cells to ameliorate chronic kidney injury

Song, T., Eirin, A., Zhu, X., Zhao, Y., Krier, J. D., Tang, H., Jordan, K. L., Woollard, J. R., Taner, T., Lerman, A. & Lerman, L. O., Jan 1 2020, (Accepted/In press) In : Hypertension. p. 1223-1232 10 p.

Research output: Contribution to journalArticle

Metabolic Syndrome Impairs 3D Mitochondrial Structure, Dynamics, and Function in Swine Mesenchymal Stem Cells

Farahani, R. A., Farah, M. C., Zhu, X. Y., Tang, H., Saadiq, I. M., Lerman, L. O. & Eirin, A., 2020, (Accepted/In press) In : Stem Cell Reviews and Reports.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Selective intrarenal delivery of mesenchymal stem cell-derived extracellular vesicles attenuates myocardial injury in experimental metabolic renovascular disease

Zhang, L., Zhu, X. Y., Zhao, Y., Eirin, A., Liu, L., Ferguson, C. M., Tang, H., Lerman, A. & Lerman, L. O., Mar 1 2020, In : Basic Research in Cardiology. 115, 2, 16.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome

Pawar, A. S., Eirin, A., Krier, J. D., Woollard, J. R., Zhu, X. Y., Lerman, A., van Wijnen, A. J. & Lerman, L. O., May 1 2019, In : Stem Cell Research. 37, 101423.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman, L. O., Kurtz, T. W., Touyz, R. M., Ellison, D. H., Chade, A. R., Crowley, S. D., Mattson, D. L., Mullins, J. J., Osborn, J., Eirin, A., Reckelhoff, J. F., Iadecola, C. & Coffman, T. M., Jun 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 6, p. e87-e120

Research output: Contribution to journalReview article

19 Scopus citations

Coexisting renal artery stenosis and metabolic syndrome magnifies mitochondrial damage, aggravating poststenotic kidney injury in pigs

Nargesi, A. A., Zhang, L., Tang, H., Jordan, K. L., Saadiq, I. M., Textor, S. C., Lerman, L. O. & Eirin, A., Oct 1 2019, In : Journal of hypertension. 37, 10, p. 2061-2073 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: Role of podocyte mitochondria

Zhang, L. H., Zhu, X. Y., Eirin, A., Nargesi, A. A., Woollard, J. R., Santelli, A., Sun, I. O., Textor, S. C. & Lerman, L. O., 2019, In : American Journal of Physiology - Renal Physiology. 317, 1, p. F12-F22

Research output: Contribution to journalArticle

3 Scopus citations
Open Access
2 Scopus citations

Metabolic Syndrome Induces Release of Smaller Extracellular Vesicles from Porcine Mesenchymal Stem Cells

Conley, S. M., Shook, J. E., Zhu, X. Y., Eirin, A., Jordan, K. L., Woollard, J. R., Isik, B., Hickson, L. T. J., Puranik, A. S. & Lerman, L. O., Sep 1 2019, In : Cell Transplantation. 28, 9-10, p. 1271-1278 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Metabolic Syndrome Interferes with Packaging of Proteins within Porcine Mesenchymal Stem Cell-Derived Extracellular Vesicles

Eirin, A., Zhu, X. Y., Woollard, J. R., Tang, H., Dasari, S., Lerman, A. & Lerman, L. O., May 2019, In : Stem Cells Translational Medicine. 8, 5, p. 430-440 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells

Aghajani Nargesi, A., Zhu, X. Y., Hickson, L. T. J., Conley, S. M., van Wijnen, A. J., Lerman, L. O. & Eirin, A., Jun 15 2019, In : Stem Cell Reviews and Reports. 15, 3, p. 427-438 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
Open Access
5 Scopus citations

Novel therapeutic strategies for renovascular disease

Eirin, A., Textor, S. C. & Lerman, L. O., Jul 1 2019, In : Current opinion in nephrology and hypertension. 28, 4, p. 383-389 7 p.

Research output: Contribution to journalReview article

2 Scopus citations

Renal Adiposity Does not Preclude Quantitative Assessment of Renal Function Using Dual-Energy Multidetector CT in Mildly Obese Human Subjects

Ferguson, C. M., Eirin, A., Michalak, G. J., Hedayat, A. F., Abumoawad, A. M., Saad, A., Zhu, X., Textor, S. C., McCollough, C. H. & Lerman, L. O., Nov 2019, In : Academic radiology. 26, 11, p. 1488-1494 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Renal artery stenosis alters gene expression in swine scattered tubular-like cells

Nargesi, A. A., Zhu, X. Y., Liu, Y., Tang, H., Jordan, K. L., Lerman, L. O. & Eirin, A., Oct 2 2019, In : International journal of molecular sciences. 20, 20, 5069.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Renovascular disease induces mitochondrial damage in swine scattered tubular cells

Nargesi, A. A., Zhu, X. Y., Conley, S. M., Woollard, J. R., Saadiq, I. M., Lerman, L. O. & Eirin, A., Nov 2019, In : American Journal of Physiology - Renal Physiology. 317, 5, p. F1142-F1153

Research output: Contribution to journalArticle

5 Scopus citations

Senescence marker activin A is increased in human diabetic kidney disease: Association with kidney function and potential implications for therapy

Bian, X., Griffin, T. P., Zhu, X., Islam, M. N., Conley, S. M., Eirin, A., Tang, H., O'Shea, P. M., Palmer, A. K., McCoy, R. G., Herrmann, S. M., Mehta, R. A., Woollard, J. R., Rule, A. D., Kirkland, J. L., Tchkonia, T., Textor, S. C., Griffin, M. D., Lerman, L. O. & Hickson, L. T. J., Dec 15 2019, In : BMJ Open Diabetes Research and Care. 7, 1, e000720.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

Santelli, A., Sun, I. O., Eirin, A., Abumoawad, A. M., Woollard, J. R., Lerman, A., Textor, SC., Puranik, A. S. & Lerman, L. O., Jun 4 2019, In : Journal of the American Heart Association. 8, 11, e012584.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Tissue hypoxia, inflammation, and loss of glomerular filtration rate in human atherosclerotic renovascular disease

Abumoawad, A., Saad, A., Ferguson, C. M., Eirin, A., Woollard, J. R., Herrmann, S. M., Hickson, L. T. J., Bendel, E. C., Misra, S., Glockner, J., Lerman, L. O. & Textor, S. C., Apr 2019, In : Kidney international. 95, 4, p. 948-957 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
5 Scopus citations
2018

Emerging Paradigms in Chronic Kidney Ischemia

Eirin, A., Textor, S. C. & Lerman, L. O., Nov 1 2018, In : Hypertension (Dallas, Tex. : 1979). 72, 5, p. 1023-1030 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Enhancing Mitochondrial Health to Treat Hypertension

Eirin, A., Lerman, A. & Lerman, L. O., Oct 1 2018, In : Current Hypertension Reports. 20, 10, 89.

Research output: Contribution to journalReview article

5 Scopus citations

Intrarenal fat deposition does not interfere with the measurement of single-kidney perfusion in obese swine using multi-detector computed tomography

Ferguson, C. M., Eirin, A., Michalak, G. J., Hedayat, A. F., Abumoawad, A., Saad, A., Zhu, X., Textor, S. C., McCollough, C. H. & Lerman, L. O., Jan 1 2018, (Accepted/In press) In : Journal of Cardiovascular Computed Tomography.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of renal peritubular capillaries in hypertensive patients is detectable by urinary endothelial microparticle levels

Sun, I. O., Santelli, A., Abumoawad, A., Eirin, A., Ferguson, C. M., Woollard, J. R., Lerman, A., Textor, S. C., Puranik, A. S. & Lerman, L. O., Jan 1 2018, In : Hypertension. 72, 5, p. 1180-1188 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mesenchymal stem cell-Based therapy for chronic kidney disease

Irazabal, M. V., Hickson, L. T. J. & Eirin, A., Jan 1 2018, A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic. Elsevier, p. 275-296 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine

Eirin, A., Zhu, X. Y., Jonnada, S., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Jul 1 2018, In : Cell Transplantation. 27, 7, p. 1080-1095 16 p.

Research output: Contribution to journalArticle

25 Scopus citations

Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway

Meng, Y., Eirin, A., Zhu, X. Y., Tang, H., Hickson, L., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Oct 1 2018, In : Cell Transplantation. 27, 10, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mitochondrial targeted peptides preserve mitochondrial organization and decrease reversible myocardial changes in early swine metabolic syndrome

Yuan, F., Woollard, J. R., Jordan, K. L., Lerman, A., Lerman, L. O. & Eirin, A., Mar 1 2018, In : Cardiovascular Research. 114, 3, p. 431-442 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mitoprotection attenuates myocardial vascular impairment in porcine metabolic syndrome

Yuan, F., Hedayat, A. F., Ferguson, C. M., Lerman, A., Lerman, L. O. & Eirin, A., Apr 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 3, p. H669-H680

Research output: Contribution to journalArticle

5 Scopus citations

Mitoprotection preserves the renal vasculature in porcine metabolic syndrome

Eirin, A., Hedayat, A. F., Ferguson, C. M., Textor, S. C., Lerman, A. & Lerman, L. O., Jan 1 2018, (Accepted/In press) In : Experimental Physiology.

Research output: Contribution to journalArticle

3 Scopus citations

Obesity-induced mitochondrial dysfunction in porcine adipose tissue-derived mesenchymal stem cells

Meng, Y., Eirin, A., Zhu, X. Y., Tang, H., Chanana, P., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

13 Scopus citations

Preserved endothelial progenitor cell angiogenic activity in African American essential hypertensive patients

Kim, S. R., Eirin, A., Herrmann, S., Saad, A., Juncos, L. A., Lerman, A., Textor, S. C. & Lerman, L. O., Mar 1 2018, In : Nephrology Dialysis Transplantation. 33, 3, p. 392-401 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells

Meng, Y., Eirin, A., Zhu, X. Y., O'Brien, D. R., Lerman, A., Van Wijnen, A. J. & Lerman, L. O., Jul 21 2018, In : Diabetology and Metabolic Syndrome. 10, 1, 58.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Glomerular Hyperfiltration in Obese African American Hypertensive Patients Is Associated with Elevated Urinary Mitochondrial-DNA Copy Number

Eirin, A., Saad, A., Woollard, J. R., Juncos, L. A., Calhoun, D. A., Tang, H., Lerman, A., Textor, S. C. & Lerman, L. O., Nov 1 2017, In : American Journal of Hypertension. 30, 11, p. 1112-1119 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hitching a ride to renal repair

Eirin, A., Feb 2 2017, In : American Journal of Physiology - Renal Physiology. 312, 2, p. F276-F277

Research output: Contribution to journalEditorial

2 Scopus citations

Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells

Eirin, A., Zhu, X. Y., Puranik, A. S., Woollard, J. R., Tang, H., Dasari, S., Lerman, A., Van Wijnen, A. J. & Lerman, L. O., Mar 2017, In : PloS one. 12, 3, e0174303.

Research output: Contribution to journalArticle

43 Scopus citations

Mesenchymal stem cell-derived extracellular vesicles for kidney repair: Current status and looming challenges

Aghajani Nargesi, A., Lerman, L. O. & Eirin, A., Dec 4 2017, In : Stem Cell Research and Therapy. 8, 1, 273.

Research output: Contribution to journalReview article

44 Scopus citations

Mesenchymal stem cell-derived extracellular vesicles for renal repair

Nargesi, A. A., Lerman, L. O. & Eirin, A., Feb 1 2017, In : Current Gene Therapy. 17, 1, p. 29-42 14 p.

Research output: Contribution to journalReview article

39 Scopus citations

Metabolic syndrome alters expression of insulin signaling-related genes in swine mesenchymal stem cells

Conley, S. M., Zhu, X. Y., Eirin, A., Tang, H., Lerman, A., van Wijnen, A. J. & Lerman, L. O., 2017, (Accepted/In press) In : Gene.

Research output: Contribution to journalArticle

12 Scopus citations
18 Scopus citations

The emerging role of mitochondrial targeting in kidney disease

Eirin, A., Lerman, A. & Lerman, L. O., 2017, Handbook of Experimental Pharmacology. Springer New York LLC, Vol. 240. p. 229-250 22 p. (Handbook of Experimental Pharmacology; vol. 240).

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations

The metabolic syndrome alters the miRNA signature of porcine adipose tissue-derived mesenchymal stem cells

Meng, Y., Eirin, A., Zhu, X. Y., Tang, H., Chanana, P., Lerman, A., van Wijnen, A. J. & Lerman, L. O., 2017, (Accepted/In press) In : Cytometry Part A.

Research output: Contribution to journalArticle

19 Scopus citations

The metabolic syndrome induces early changes in the swine renal medullary mitochondria

Eirin, A., Woollard, J. R., Ferguson, C. M., Jordan, K. L., Tang, H., Textor, S. C., Lerman, A. & Lerman, L. O., Jun 1 2017, In : Translational Research. 184, p. 45-56.e9

Research output: Contribution to journalArticle

17 Scopus citations
2016

Challenges and opportunities for stem cell therapy in patients with chronic kidney disease

Hickson, L. J., Eirin, A. & Lerman, L. O., Apr 1 2016, In : Kidney international. 89, 4, p. 767-778 12 p.

Research output: Contribution to journalReview article

45 Scopus citations