• 18466 Citations
  • 69 Scopus h-Index
1976 …2019
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Research Output 1985 2019

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Review article
2019

Antibody-Drug Conjugates for the Therapy of Thoracic Malignancies

Xie, H. & Adjei, A., Mar 1 2019, In : Journal of Thoracic Oncology. 14, 3, p. 358-376 19 p.

Research output: Contribution to journalReview article

Thorax
Drug Therapy
Antibodies
Neoplasms
Pharmaceutical Preparations

A Proposed System Toward Standardizing Surgical-Based Treatments for Malignant Pleural Mesothelioma, From the Joint National Cancer Institute–International Association for the Study of Lung Cancer–Mesothelioma Applied Research Foundation Taskforce

Friedberg, J. S., Culligan, M. J., Tsao, A. S., Rusch, V., Sepesi, B., Pass, H. I., Bueno, R., Burt, B., Sugarbaker, D. J., de Perrot, M., Adjei, A., Adusumilli, P. S., Hirsch, F. R., Malik, S. M. & Harpole, D. J., Aug 1 2019, In : Journal of Thoracic Oncology. 14, 8, p. 1343-1353 11 p.

Research output: Contribution to journalReview article

Joints
Mesothelioma
Lung
Research
Neoplasms
33 Citations (Scopus)

Control of confounding and reporting of results in causal inference studies

Lederer, D. J., Bell, S. C., Branson, R. D., Chalmers, J. D., Marshall, R., Maslove, D. M., Ost, D. E., Punjabi, N. M., Schatz, M., Smyth, A. R., Stewart, P. W., Suissa, S., Adjei, A., Akdis, C. A., Azoulay, É., Bakker, J., Ballas, Z. K., Bardin, P. G., Barreiro, E., Bellomo, R. & 28 others, Bernstein, J. A., Brusasco, V., Buchman, T. G., Chokroverty, S., Collop, N. A., Crapo, J. D., Fitzgerald, D. A., Hale, L., Hart, N., Herth, F. J., Iwashyna, T. J., Jenkins, G., Kolb, M., Marks, G. B., Mazzone, P., Moorman, J. R., Murphy, T. M., Noah, T. L., Reynolds, P., Riemann, D., Russell, R. E., Sheikh, A., Sotgiu, G., Swenson, E. R., Szczesniak, R., Szymusiak, R., Teboul, J. L. & Vincent, J. L., Jan 1 2019, In : Annals of the American Thoracic Society. 16, 1, p. 22-28 7 p.

Research output: Contribution to journalReview article

Critical Care
Causality
Sleep
Epidemiology
Research Design

Current Diagnosis and Management of Small-Cell Lung Cancer

Wang, S., Zimmermann, S., Parikh, K., Mansfield, A. & Adjei, A., Aug 1 2019, In : Mayo Clinic proceedings. 94, 8, p. 1599-1622 24 p.

Research output: Contribution to journalReview article

Open Access
Small Cell Lung Carcinoma
Immunotherapy
Cranial Irradiation
Topotecan
Carboplatin

The Use of Radiation Therapy for the Treatment of Malignant Pleural Mesothelioma: Expert Opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation

Gomez, D. R., Rimner, A., Simone, C. B., Cho, B. C. J., de Perrot, M., Adjei, A., Bueno, R., Gill, R. R., Harpole, D. H., Hesdorffer, M., Hirsch, F. R., Jackson, A. A., Pass, H. I., Rice, D. C., Rusch, V. W., Tsao, A. S., Yorke, E. & Rosenzweig, K., Jul 1 2019, In : Journal of Thoracic Oncology. 14, 7, p. 1172-1183 12 p.

Research output: Contribution to journalReview article

Open Access
National Cancer Institute (U.S.)
Mesothelioma
Expert Testimony
Radiotherapy
Thorax
2018
2 Citations (Scopus)

Biomarker Clinical Trials in Lung Cancer: Design, Logistics, Challenges, and Practical Considerations

Le-Rademacher, J., Dahlberg, S., Lee, J. J., Adjei, A. & Mandrekar, S. J., Nov 1 2018, In : Journal of Thoracic Oncology. 13, 11, p. 1625-1637 13 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Biomarkers
Clinical Trials
Precision Medicine
Standard of Care
13 Citations (Scopus)

Representation of minorities and women in oncology clinical trials: Review of the past 14 years

Duma, N., Aguilera, J. V., Paludo, J., Haddox, C. L., Velez, M. G., Wang, Y., Leventakos, K., Hubbard, J. M., Mansfield, A., Go, R. S. & Adjei, A., Jan 1 2018, In : Journal of Oncology Practice. 14, 1, p. e1-e10

Research output: Contribution to journalReview article

Clinical Trials
Hispanic Americans
African Americans
Neoplasms
Pancreatic Neoplasms
2016
27 Citations (Scopus)

FGFR signaling as a target for Lung cancer therapy

Desai, A. & Adjei, A., Jan 1 2016, In : Journal of Thoracic Oncology. 11, 1, p. 9-20 12 p.

Research output: Contribution to journalReview article

Fibroblast Growth Factor Receptors
Lung Neoplasms
Molecular Targeted Therapy
Fibroblast Growth Factors
Therapeutics
3 Citations (Scopus)

Novel active agents in patients with advanced NSCLC without driver mutations who have progressed after first-line chemotherapy

Manegold, C., Adjei, A., Bussolino, F., Cappuzzo, F., Crino, L., Dziadziuszko, R., Ettinger, D., Fennell, D., Kerr, K., Le Chevalier, T., Leighl, N., Papotti, M., Paz-Ares, L., Pérol, M., Peters, S., Pirker, R., Quoix, E., Reck, M., Smit, E., Vokes, E. & 2 others, Van Zandwijk, N. & Zhou, C., Dec 1 2016, In : ESMO Open. 1, 6, e000118.

Research output: Contribution to journalReview article

Proxy
Non-Small Cell Lung Carcinoma
Drug Therapy
Mutation
Therapeutics
2015
38 Citations (Scopus)

BRAF alterations as therapeutic targets in non-small-cell lung cancer

Nguyen-Ngoc, T., Bouchaab, H., Adjei, A. & Peters, S., Oct 1 2015, In : Journal of Thoracic Oncology. 10, 10, p. 1396-1403 8 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Extracellular Signal-Regulated MAP Kinases
Oncogenes
Sarcoma
Proto-Oncogene Proteins B-raf
2014
111 Citations (Scopus)

ALK inhibitors in the treatment of advanced NSCLC

Gridelli, C., Peters, S., Sgambato, A., Casaluce, F., Adjei, A. & Ciardiello, F., Mar 1 2014, In : Cancer Treatment Reviews. 40, 2, p. 300-306 7 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Gene Rearrangement
Oncogene Proteins
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
99 Citations (Scopus)

Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer

Brechbiel, J., Miller-Moslin, K. & Adjei, A., Jan 1 2014, In : Cancer Treatment Reviews. 40, 6, p. 750-759 10 p.

Research output: Contribution to journalReview article

Mitogen-Activated Protein Kinase Kinases
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
HhAntag691
Phosphatidylinositol 3-Kinases
Stem Cells
77 Citations (Scopus)
Drug Interactions
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Pharmacokinetics
6 Citations (Scopus)

Targeting oncogenic drivers

Zhao, Y. & Adjei, A., Jan 1 2014, In : Progress in tumor research. 41, p. 1-14 14 p.

Research output: Contribution to journalReview article

Neoplasms
Inborn Genetic Diseases
Germ-Line Mutation
Oncogene Proteins
Oncogenes
183 Citations (Scopus)

The clinical development of MEK inhibitors

Zhao, Y. & Adjei, A., Jan 1 2014, In : Nature Reviews Clinical Oncology. 11, 7, p. 385-400 16 p.

Research output: Contribution to journalReview article

Mitogen-Activated Protein Kinase Kinases
Neoplasms
MAP Kinase Signaling System
Antineoplastic Agents
Melanoma
2013
18 Citations (Scopus)

Strategies for improving outcomes in NSCLC: A look to the future

Stahel, R., Peters, S., Baas, P., Brambilla, E., Cappuzzo, F., De Ruysscher, D., Eberhardt, W. E. E., Felip, E., Fennell, D., Marchetti, A., Paz-Ares, L. & Adjei, A., Dec 1 2013, In : Lung Cancer. 82, 3, p. 375-382 8 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Disease Management
Molecular Biology
Therapeutics
Survival Rate
2012
197 Citations (Scopus)

MET: A promising anticancer therapeutic target

Peters, S. & Adjei, A., Jun 1 2012, In : Nature Reviews Clinical Oncology. 9, 6, p. 314-326 13 p.

Research output: Contribution to journalReview article

Neoplasms
Therapeutics
Drug Resistance
Radiotherapy
Biomarkers
2011
20 Citations (Scopus)

Improved response to nab-paclitaxel compared with cremophor-solubilized paclitaxel is independent of secreted protein acidic and rich in cysteine expression in non-small cell lung cancer

Shao, H., Tang, H., Salavaggione, O. E., Yu, C., Hylander, B., Tan, W., Repasky, E., Adjei, A. & Dy, G. K., Jan 1 2011, In : Journal of Thoracic Oncology. 6, 6, p. 998-1005 8 p.

Research output: Contribution to journalReview article

Paclitaxel
Non-Small Cell Lung Carcinoma
Cysteine
Proteins
Heterografts
42 Citations (Scopus)

In the clinic: Ongoing clinical trials evaluating c-MET-inhibiting drugs

Sharma, N. & Adjei, A., Jan 1 2011, In : Therapeutic Advances in Medical Oncology. 3, 1, p. S37-S50

Research output: Contribution to journalReview article

Clinical Trials
Pharmaceutical Preparations
Neoplasms
Proto-Oncogene Proteins c-met
Phase III Clinical Trials
2009
3 Citations (Scopus)

Cooperative group research efforts in thoracic malignancies 2009: A review from the 10th annual international lung cancer congress

Wakelee, H., Loo, B. W., Kernstine, K. H., Putnam, J. B., Edelman, M. J., Vokes, E. E., Schiller, J. H., Baas, P., Saijo, N., Adjei, A., Goss, G., Choy, H. & Gandara, D. R., Jan 1 2009, In : Clinical Lung Cancer. 10, 6, p. 395-404 10 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Thorax
Research
Neoplasms
Precision Medicine
4 Citations (Scopus)

Cooperative group research endeavors in small-cell lung cancer: Current and future directions

Sangha, R., Lara, P. N., Adjei, A., Baas, P., Choy, H., Gaspar, L. E., Goss, G., Saijo, N., Schiller, J. H., Vokes, E. E. & Gandara, D. R., Jan 1 2009, In : Clinical Lung Cancer. 10, 5, p. 322-330 9 p.

Research output: Contribution to journalReview article

Small Cell Lung Carcinoma
Lung Neoplasms
Research
North America
Radiotherapy
265 Citations (Scopus)

Novel agents on the horizon for cancer therapy

Ma, W. W. & Adjei, A., Mar 1 2009, In : CA Cancer Journal for Clinicians. 59, 2, p. 111-137 27 p.

Research output: Contribution to journalReview article

Neoplasms
Proto-Oncogene Proteins c-met
HSP90 Heat-Shock Proteins
Tumor Microenvironment
Growth Factor Receptors
2008
273 Citations (Scopus)

Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy

Friday, B. B. & Adjei, A., Jan 15 2008, In : Clinical Cancer Research. 14, 2, p. 342-346 5 p.

Research output: Contribution to journalReview article

Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Neoplasms
MAP Kinase Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
6 Citations (Scopus)

Cooperative group portfolio in locally advanced non-small-cell lung cancer: Are we making progress?

Langer, C. J., Wakelee, H., Schiller, J., Choy, H., Shepherd, F., Vokes, E. E., Adjei, A., Baas, P., Saijo, N. & Gandara, D. R., Jan 1 2008, In : Clinical Lung Cancer. 9, 2, p. 85-91 7 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Cytotoxins
Radiation
Pemetrexed
Image-Guided Radiotherapy
5 Citations (Scopus)

Cooperative group research efforts in lung cancer: Focus on early-stage non-small-cell lung cancer

Wakelee, H., Langer, C., Vokes, E., Schiller, J., Baas, P., Saijo, N., Adjei, A., Shepherd, F., Choy, H. & Gandara, D. R., Jan 1 2008, In : Clinical Lung Cancer. 9, 1, p. 9-15 7 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Research
Drug Therapy
Radiosurgery
34 Citations (Scopus)

K-ras as a target for lung cancer therapy

Adjei, A., Jan 1 2008, In : Journal of Thoracic Oncology. 3, 6 SUPPL 2

Research output: Contribution to journalReview article

Lung Neoplasms
Therapeutics
Oncogenes
Non-Small Cell Lung Carcinoma
Neoplasms
44 Citations (Scopus)

Systemic cancer therapy: Evolution over the last 60 years

Dy, G. K. & Adjei, A., Oct 1 2008, In : Cancer. 113, 7, p. 1857-1887 31 p.

Research output: Contribution to journalReview article

Folic Acid Antagonists
Drug Therapy
Mechlorethamine
Tumor Microenvironment
Hematologic Neoplasms
2007
17 Citations (Scopus)

Inhibitors of Raf kinase and MEK signaling

Ramnath, N. & Adjei, A., Sep 1 2007, In : Update on Cancer Therapeutics. 2, 3, p. 111-118 8 p.

Research output: Contribution to journalReview article

raf Kinases
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Platelet-Derived Growth Factor Receptors
Phase II Clinical Trials
11 Citations (Scopus)

Novel small-molecule inhibitors of the vascular endothelial growth factor receptor

Adjei, A., Jan 1 2007, In : Clinical Lung Cancer. 8, SUPPL. 2

Research output: Contribution to journalReview article

Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor A
Protein-Tyrosine Kinases
Carcinogenesis
Phosphotransferases
2006
20 Citations (Scopus)

Angiogenesis inhibitors in lung cancer: A promise fulfilled

Dy, G. K. & Adjei, A., Jan 1 2006, In : Clinical Lung Cancer. 7, SUPPL. 4

Research output: Contribution to journalReview article

Angiogenesis Inhibitors
Vascular Endothelial Growth Factor A
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Antibodies, Monoclonal, Humanized
5 Citations (Scopus)

Farnesyltransferase inhibitors

Adjei, A., Mar 1 2006, In : Update on Cancer Therapeutics. 1, 1, p. 17-23 7 p.

Research output: Contribution to journalReview article

Farnesyltranstransferase
ras Proteins
Neoplasms
Monomeric GTP-Binding Proteins
Hematologic Neoplasms
30 Citations (Scopus)

The Akt/mTOR and mitogen-activated protein kinase pathways in lung cancer therapy

Papadimitrakopoulou, V. & Adjei, A., Sep 1 2006, In : Journal of Thoracic Oncology. 1, 7, p. 749-751 3 p.

Research output: Contribution to journalReview article

Mitogen-Activated Protein Kinases
Lung Neoplasms
Intracellular Signaling Peptides and Proteins
TOR Serine-Threonine Kinases
MAP Kinase Kinase Kinases
2005
21 Citations (Scopus)

Farnesyltransferase inhibitors.

Adjei, A., Jan 1 2005, In : Cancer chemotherapy and biological response modifiers. 22, p. 123-133 11 p.

Research output: Contribution to journalReview article

Alkyl and Aryl Transferases
Protein Prenylation
Farnesyltranstransferase
Quinolones
Enzyme Inhibitors
145 Citations (Scopus)

Intracellular signal transduction pathway proteins as targets for cancer therapy

Adjei, A. & Hidalgo, M., Dec 1 2005, In : Journal of Clinical Oncology. 23, 23, p. 5386-5403 18 p.

Research output: Contribution to journalReview article

Signal Transduction
Neoplasms
Proteins
Intercellular Signaling Peptides and Proteins
Phosphotransferases
178 Citations (Scopus)

K-ras as a target for cancer therapy

Friday, B. B. & Adjei, A., Nov 25 2005, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1756, 2, p. 127-144 18 p.

Research output: Contribution to journalReview article

ras Proteins
Neoplasms
Therapeutics
Oncogenes
Cell Differentiation
8 Citations (Scopus)

Obstacles and opportunities in the clinical development of targeted therapeutics

Dy, G. K. & Adjei, A., Oct 12 2005, In : Progress in Drug Research. 63, p. 19-41 23 p.

Research output: Contribution to journalReview article

Antineoplastic Combined Chemotherapy Protocols
Drug Design
Antineoplastic Agents
Patient Selection
Research Design
4 Citations (Scopus)

Sequencing bortezomib with chemotherapy and targeted agents.

Adjei, A., Oct 1 2005, In : Clinical lung cancer.. 7 Suppl 2

Research output: Contribution to journalReview article

Drug Therapy
Antineoplastic Agents
Tumor Suppressor Proteins
Proteasome Inhibitors
Cyclins
17 Citations (Scopus)

Targeting multiple signal transduction pathways in lung cancer.

Adjei, A., Sep 1 2005, In : Clinical lung cancer.. 7 Suppl 1

Research output: Contribution to journalReview article

Signal Transduction
Lung Neoplasms
Phosphotransferases
Epidermal Growth Factor Receptor
Proto-Oncogene Proteins c-raf
27 Citations (Scopus)

The role of mitogen-activated ERK-kinase inhibitors in lung cancer therapy

Adjei, A., Jan 1 2005, In : Clinical Lung Cancer. 7, 3, p. 221-223 3 p.

Research output: Contribution to journalReview article

Mitogens
Lung Neoplasms
Phosphotransferases
MAP Kinase Kinase Kinases
Mutation
11 Citations (Scopus)

Treating cancer by blocking cell signals

Adjei, A. & Hidalgo, M., Dec 1 2005, In : Journal of Clinical Oncology. 23, 23, p. 5279-5280 2 p.

Research output: Contribution to journalReview article

Benzamides
Calcium-Calmodulin-Dependent Protein Kinases
MAP Kinase Signaling System
Enzyme Inhibitors
Neoplasms
2004
96 Citations (Scopus)

Farnesyltransferase Inhibitors

Sebti, S. M. & Adjei, A., Jan 1 2004, In : Seminars in Oncology. 31, 1 SUPPL. 1, p. 28-39 12 p.

Research output: Contribution to journalReview article

Farnesyltranstransferase
ras Proteins
Urinary Bladder Neoplasms
Myelodysplastic Syndromes
Cytotoxins
52 Citations (Scopus)

Pharmacology and mechanism of action of pemetrexed

Adjei, A., Jan 1 2004, In : Clinical Lung Cancer. 5, SUPPL. 2

Research output: Contribution to journalReview article

Pemetrexed
Pharmacology
docetaxel
Folic Acid
Hydroxymethyl and Formyl Transferases
2003
9 Citations (Scopus)

Farnesyltransferase inhibitors.

Adjei, A., Jan 1 2003, In : Cancer chemotherapy and biological response modifiers. 21, p. 127-144 18 p.

Research output: Contribution to journalReview article

Alkyl and Aryl Transferases
Farnesyltranstransferase
Enzyme Inhibitors
Hematologic Neoplasms
Antineoplastic Agents
2 Citations (Scopus)

Immunohistochemical assays of farnesyltransferase inhibition in patient samples.

Adjei, A., Jan 1 2003, In : Methods in molecular medicine. 85, p. 141-145 5 p.

Research output: Contribution to journalReview article

Neoplasm Proteins
Molecular Sequence Data
HSP40 Heat-Shock Proteins
Alkyl and Aryl Transferases
Protein Prenylation
36 Citations (Scopus)

Novel anticancer agents in clinical development.

Adjei, A. & Rowinsky, E. K., Jul 1 2003, In : Cancer biology & therapy. 2, 4 Suppl 1

Research output: Contribution to journalReview article

Antineoplastic Agents
Neoplasms
Connective Tissue
Cellular Microenvironment
Therapeutics

Pemetrexed (Alimta): a novel multitargeted antifolate agent.

Adjei, A., Apr 1 2003, In : Expert Review of Anticancer Therapy. 3, 2, p. 145-156 12 p.

Research output: Contribution to journalReview article

Pemetrexed
Folic Acid Antagonists
gemcitabine
Cisplatin
Mesothelioma
72 Citations (Scopus)

Pemetrexed (Alimta®): A novel multitargeted antifolate agent

Adjei, A., Jan 1 2003, In : Expert Review of Anticancer Therapy. 3, 2, p. 145-156 12 p.

Research output: Contribution to journalReview article

Pemetrexed
Folic Acid Antagonists
gemcitabine
Cisplatin
Mesothelioma
2002
5 Citations (Scopus)

Farnesyltransferase inhibitors.

Adjei, A., Jan 1 2002, In : Cancer chemotherapy and biological response modifiers. 20, p. 151-167 17 p.

Research output: Contribution to journalReview article

Alkyl and Aryl Transferases
Farnesyltranstransferase
Enzyme Inhibitors
Antineoplastic Agents
Signal Transduction
23 Citations (Scopus)

Inhibitors of the ras oncogene as therapeutic targets

Ghobrial, I. M. & Adjei, A., Oct 1 2002, In : Hematology/Oncology Clinics of North America. 16, 5, p. 1065-1088 24 p.

Research output: Contribution to journalReview article

ras Genes
Therapeutics
Mutation
Clinical Trials
Neoplasms
89 Citations (Scopus)

Novel targets for lung cancer therapy: Part II

Dy, G. K. & Adjei, A., Jul 1 2002, In : Journal of Clinical Oncology. 20, 13, p. 3016-3028 13 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Neoplasms
Therapeutics
Protein Transport
Proteolysis