Aleksandar Denic, MD, PhD

  • 1082 Citations
  • 16 Scopus h-Index
20042020

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Abbreviated Exposure to Hypoxia Is Sufficient to Induce CNS Dysmyelination, Modulate Spinal Motor Neuron Composition, and Impair Motor Development in Neonatal Mice

Watzlawik, J. O., Kahoud, R. J., O'Toole, R. J., White, K. A. M., Ogden, A. R., Painter, M. M., Wootla, B., Papke, L. M., Denic, A., Weimer, J. M., Carey, W. A. & Rodriguez, M., May 28 2015, In : PloS one. 10, 5, e0128007.

Research output: Contribution to journalArticle

10 Scopus citations

A monoclonal natural human IgM protects axons in the absence of remyelination

Wootla, B., Denic, A., Warrington, A. E. & Rodriguez, M., Apr 28 2016, In : Journal of Neuroinflammation. 13, 1, 94.

Research output: Contribution to journalArticle

7 Scopus citations

AMP-activated protein kinase suppresses autoimmune central nervous system disease by regulating M1-type macrophage-Th17 axis

Mangalam, A. K., Rattan, R., Suhail, H., Singh, J., Hoda, M. N., Deshpande, M., Fulzele, S., Denic, A., Shridhar, V., Kumar, A., Viollet, B., Rodriguez, M. & Giri, S., Aug 1 2016, In : Journal of Immunology. 197, 3, p. 747-760 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis

Xu, X., Denic, A., Jordan, L. R., Wittenberg, N. J., Warrington, A. E., Wootla, B., Papke, L. M., Zoecklein, L. J., Yoo, D., Shaver, J., Oh, S. H., Pease, L. R. & Rodriguez, M., Aug 1 2015, In : DMM Disease Models and Mechanisms. 8, 8, p. 831-842 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection

Buenz, E. J., Sauer, B. M., LaFrance-Corey, R. G., Deb, C., Denic, A., German, C. L. & Howe, C. L., Aug 2009, In : American Journal of Pathology. 175, 2, p. 668-684 17 p.

Research output: Contribution to journalArticle

48 Scopus citations
10 Scopus citations

A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination

Denic, A., Macura, S. I., Warrington, A. E., Pirko, I., Grossardt, B. R., Pease, L. R. & Rodriguez, M., Oct 12 2011, In : PloS one. 6, 10, e26001.

Research output: Contribution to journalArticle

18 Scopus citations

Basics of cancer pharmacogenomics

Denić, A. & Radulović, S., Jul 1 2004, In : Journal of B.U.ON.. 9, 3, p. 233-241 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Brainstem 1H Nuclear Magnetic Resonance (NMR) spectroscopy: Marker of demyelination and repair in spinal cord

Denic, A., Bieber, A., Warrington, A., Mishra, P. K., Macura, S. & Rodriguez, M., 2009, In : Annals of neurology. 66, 4, p. 559-564 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume

Denic, A., Mathew, J., Nagineni, V. V., Thompson, R. H., Leibovich, B. C., Lerman, L. O., Lieske, J. C., Alexander, M. P., Augustine, J. J., Kremers, W. K. & Rule, A. D., Jul 2018, In : Journal of the American Society of Nephrology. 29, 7, p. 1960-1969 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
3 Scopus citations

Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis

Denic, A., Pirko, I., Wootla, B., Bieber, A., MacUra, S. & Rodriguez, M., Sep 2012, In : Brain Pathology. 22, 5, p. 698-708 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
29 Scopus citations
38 Scopus citations

Global Glomerulosclerosis in Kidney Biopsies With Differing Amounts of Cortex: A Clinical-Pathologic Correlation Study

Niznik, R. S., Lopez, C. L., Kremers, W. K., Denic, A., Sethi, S., Stegall, M. D., Augustine, J. J. & Rule, A. D., Jul 1 2019, In : Kidney Medicine. 1, 4, p. 153-161 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Glomerular volume and glomerulosclerosis at different depths within the human kidney

Denic, A., Ricaurte, L., Lopez, C. L., Narasimhan, R., Lerman, L. O., Lieske, J. C., Houston Thompson, R., Kremers, W. K. & Rule, A. D., Aug 2019, In : Journal of the American Society of Nephrology. 30, 8, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human class I major histocompatibility complex alleles determine central nervous system injury versus repair

Wootla, B., Denic, A., Watzlawik, J. O., Warrington, A. E., Zoecklein, L. J., Papke-Norton, L. M., David, C. & Rodriguez, M., Nov 17 2016, In : Journal of Neuroinflammation. 13, 1, 293.

Research output: Contribution to journalArticle

In-vivo techniques for determining nephron number

Denic, A., Elsherbiny, H. & Rule, A. D., Nov 1 2019, In : Current opinion in nephrology and hypertension. 28, 6, p. 545-551 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Kidney structural features from living donors predict graft failure in the recipient

Issa, N., Lopez, C. L., Denic, A., Taler, S. J., Larson, J. J., Kremers, W. K., Ricaurte, L., Merzkani, M. A., Alexander, M. P., Chakkera, H. A., Stegall, M. D., Augustine, J. J. & Rule, A. D., 2020, In : Journal of the American Society of Nephrology. 31, 2, p. 415-423 9 p.

Research output: Contribution to journalArticle

Larger nephron size, low nephron number, and nephrosclerosis on biopsy as predictors of kidney function after donating a kidney

Issa, N., Vaughan, L. E., Denic, A., Kremers, W. K., Chakkera, H. A., Park, W. D., Matas, A. J., Taler, S. J., Stegall, M. D., Augustine, J. J. & Rule, A. D., Jul 2019, In : American Journal of Transplantation. 19, 7, p. 1989-1998 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Naturally occurringmonoclonal antibodies and their therapeutic potential for neurologic diseases

Wootla, B., Watzlawik, J. O., Warrington, A. E., Wittenberg, N. J., Denic, A., Xu, X., Jordan, L. R., Papke, L. M., Zoecklein, L. J., Pierce, M. L., Oh, S. H., Kantarci, O. H. & Rodriguez, M., Nov 1 2015, In : JAMA Neurology. 72, 11, p. 1346-1353 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice

Perschbacher, K., Smestad, J. A., Peters, J. P., Standiford, M. M., Denic, A., Wootla, B., Warrington, A. E., Rodriguez, M. & Maher, L. J., Feb 1 2015, In : Nucleic Acid Therapeutics. 25, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reply to Letter to the Editor

Glassock, R. J., Denic, A. & Rule, A. D., Jul 1 2017, In : Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia. 39, 3, p. 347-348 2 p.

Research output: Contribution to journalArticle

Risk of hypertension among first-time symptomatic kidney stone formers

Kittanamongkolchai, W., Mara, K. C., Mehta, R. A., Vaughan, L. E., Denic, A., Knoedler, J. J., Enders, F. T., Lieske, J. C. & Rule, A. D., 2017, In : Clinical Journal of the American Society of Nephrology. 12, 3, p. 476-482 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Single-nephron glomerular filtration rate in healthy adults

Denic, A., Mathew, J., Lerman, L. O., Lieske, J. C., Larson, J. J., Alexander, M. P., Poggio, E., Glassock, R. J. & Rule, A. D., Jun 15 2017, In : New England Journal of Medicine. 376, 24, p. 2349-2357 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
23 Scopus citations

Therapeutics to promote CNS repair: A natural human neuron-binding igm regulates membrane-raft dynamics and improves motility in a mouse model of multiple sclerosis

Xu, X., Denic, A., Warrington, A. E., Bieber, A. J. & Rodriguez, M., Jan 2013, In : Journal of Clinical Immunology. 33, SUPPL.1, p. S50-S56

Research output: Contribution to journalArticle

9 Scopus citations

The relevance of animal models in multiple sclerosis research

Denic, A., Johnson, A. J., Bieber, A. J., Warrington, A. E., Rodriguez, M. & Pirko, I., Feb 2011, In : Pathophysiology. 18, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

166 Scopus citations
96 Scopus citations

Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination

Kerkvliet, J., Zoecklein, L., Papke, L., Denic, A., Bieber, A. J., Pease, L. R., David, C. S. & Rodriguez, M., Dec 2009, In : Journal of virology. 83, 23, p. 12279-12289 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis

Denic, A., Zoecklein, L., Kerkvliet, J., Papke, L., Edukulla, R., Warrington, A., Bieber, A., Pease, L. R., David, C. S. & Rodriguez, M., Sep 2011, In : Brain Pathology. 21, 5, p. 501-515 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Treatment with a recombinant human IgM that recognizes PSA-NCAM preserves brain pathology in MOG-induced experimental autoimmune encephalomyelitis

Lemus, H. N., Warrington, A. E., Denic, A., Wootla, B. & Rodriguez, M., Apr 24 2017, In : Human Antibodies. 25, 3-4, p. 121-129 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tubulointerstitial Fibrosis of Living Donor Kidneys Associates with Urinary Monocyte Chemoattractant Protein 1

Wang, X., Lieske, J. C., Alexander, M. P., Jayachandran, M., Denic, A., Mathew, J., Lerman, L. O., Kremers, W. K., Larson, J. J. & Rule, A. D., Jul 1 2016, In : American journal of nephrology. 43, 6, p. 454-459 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tumor necrosis factor α is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis

Rodriguez, M., Zoecklein, L., Papke, L., Gamez, J., Denic, A., Macura, S. & Howe, C., Jan 2009, In : Brain Pathology. 19, 1, p. 12-26 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Untargeted plasma metabolomics identifies endogenous metabolite with drug-like properties in chronic animal model of multiple sclerosis

Poisson, L. M., Suhail, H., Singh, J., Datta, I., Deni, A., Labuzek, K., Hoda, N., Shankar, A., Kumar, A., Cerghet, M., Elias, S., Mohney, R. P., Rodriguez, M., Rattan, R., Mangalam, A. K. & Giri, S., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30697-30712 16 p.

Research output: Contribution to journalArticle

28 Scopus citations

Using computer-assisted morphometrics of 5-year biopsies to identify biomarkers of late renal allograft loss

Denic, A., Morales, M. C., Park, W. D., Smith, B. H., Kremers, W. K., Alexander, M. P., Cosio, F. G., Rule, A. D. & Stegall, M. D., Oct 1 2019, In : American Journal of Transplantation. 19, 10, p. 2846-2854 9 p.

Research output: Contribution to journalArticle

2 Scopus citations