Aleksandar Denic, MD, PhD

  • 905 Citations
  • 15 Scopus h-Index
20042019
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Research Output 2004 2019

2019
1 Citation (Scopus)

Global Glomerulosclerosis in Kidney Biopsies With Differing Amounts of Cortex: A Clinical-Pathologic Correlation Study

Niznik, R. S., Lopez, C. L., Kremers, W. K., Denic, A., Sethi, S. M., Stegall, M. D., Augustine, J. J. & Rule, A. D., Jul 1 2019, In : Kidney Medicine. 1, 4, p. 153-161 9 p.

Research output: Contribution to journalArticle

Open Access
Kidney
Biopsy
Arteriosclerosis
Large-Core Needle Biopsy
Fibrosis
4 Citations (Scopus)

Glomerular Volume and Glomerulosclerosis at Different Depths within the Human Kidney

Denic, A., Ricaurte, L., Lopez, C. L., Narasimhan, R., Lerman, L. O., Lieske, J. C., Thompson, R. H., Kremers, W. K. & Rule, A. D., Aug 1 2019, In : Journal of the American Society of Nephrology : JASN. 30, 8, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

Kidney
Obesity
Arteriosclerosis
Nephrectomy
Proteinuria
1 Citation (Scopus)

In-vivo techniques for determining nephron number

Denic, A., Elsherbiny, H. & Rule, A. D., Jan 1 2019, (Accepted/In press) In : Current opinion in nephrology and hypertension.

Research output: Contribution to journalArticle

Nephrons
Glomerular Filtration Rate
Kidney
Biopsy
Nephrology
6 Citations (Scopus)
Nephrosclerosis
Nephrons
Kidney
Biopsy
Living Donors
1 Citation (Scopus)
Allografts
Biomarkers
Transplants
Kidney
Biopsy
2018
3 Citations (Scopus)

Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume

Denic, A., Mathew, J., Nagineni, V. V., Thompson, R. H., Leibovich, B. C., Lerman, L. O., Lieske, J. C., Alexander, M. P., Augustine, J. J., Kremers, W. K. & Rule, A. D., Jul 1 2018, In : Journal of the American Society of Nephrology. 29, 7, p. 1960-1969 10 p.

Research output: Contribution to journalArticle

Clinical Pathology
Kidney
Biopsy
Proteinuria
Comorbidity
2017

Reply to Letter to the Editor

Glassock, R. J., Denic, A. & Rule, A. D., Jul 1 2017, In : Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia. 39, 3, p. 347-348 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Risk of hypertension among first-time symptomatic kidney stone formers

Kittanamongkolchai, W., Mara, K. C., Mehta, R. A., Vaughan, L. E., Denic, A., Knoedler, J. J., Enders, F. T., Lieske, J. C. & Rule, A. D., 2017, In : Clinical Journal of the American Society of Nephrology. 12, 3, p. 476-482 7 p.

Research output: Contribution to journalArticle

Kidney Calculi
Hypertension
Confidence Intervals
Sodium Chloride Symporter Inhibitors
Safety Management
61 Citations (Scopus)

Single-nephron glomerular filtration rate in healthy adults

Denic, A., Mathew, J., Lerman, L. O., Lieske, J. C., Larson, J. J., Alexander, M. P., Poggio, E., Glassock, R. J. & Rule, A. D., Jun 15 2017, In : New England Journal of Medicine. 376, 24, p. 2349-2357 9 p.

Research output: Contribution to journalArticle

Nephrons
Glomerular Filtration Rate
Kidney
Tissue Donors
Biopsy
3 Citations (Scopus)

The authors reply

Denic, A., Glassock, R. J. & Rule, A. D., Sep 21 2017, In : New England Journal of Medicine. 377, 12, p. 1203-1204 2 p.

Research output: Contribution to journalLetter

12 Citations (Scopus)

The conundrums of chronic kidney disease and aging

Glassock, R. J., Denic, A. & Rule, A. D., Aug 1 2017, In : Journal of Nephrology. 30, 4, p. 477-483 7 p.

Research output: Contribution to journalReview article

Chronic Renal Insufficiency
Glomerular Filtration Rate
Kidney
Nephrons
Uncertainty
72 Citations (Scopus)
Nephrons
Kidney Glomerulus
Kidney
Tissue Donors
Biopsy
5 Citations (Scopus)

Treatment with a recombinant human IgM that recognizes PSA-NCAM preserves brain pathology in MOG-induced experimental autoimmune encephalomyelitis

Lemus, H. N., Warrington, A. E., Denic, A., Wootla, B. & Rodriguez, M., Apr 24 2017, In : Human Antibodies. 25, 3-4, p. 121-129 9 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Immunoglobulin M
Pathology
Brain
Nervous System Diseases
3 Citations (Scopus)
Glomerular Filtration Rate
Geriatrics
Kidney
Nephrons
Kidney Diseases
2016
7 Citations (Scopus)

A monoclonal natural human IgM protects axons in the absence of remyelination

Wootla, B., Denic, A., Warrington, A. E. & Rodriguez, M., Apr 28 2016, In : Journal of Neuroinflammation. 13, 1, 94.

Research output: Contribution to journalArticle

Theilovirus
Immunoglobulin M
Axons
Multiple Sclerosis
Spinal Cord
15 Citations (Scopus)

AMP-activated protein kinase suppresses autoimmune central nervous system disease by regulating M1-type macrophage-Th17 axis

Mangalam, A. K., Rattan, R., Suhail, H., Singh, J., Hoda, M. N., Deshpande, M., Fulzele, S., Denic, A., Shridhar, V., Kumar, A., Viollet, B., Rodriguez, M. & Giri, S., Aug 1 2016, In : Journal of Immunology. 197, 3, p. 747-760 14 p.

Research output: Contribution to journalArticle

Autoimmune Diseases of the Nervous System
AMP-Activated Protein Kinases
Central Nervous System Diseases
Autoimmune Experimental Encephalomyelitis
Interleukin-17
22 Citations (Scopus)
Nephrosclerosis
Nephrons
Hypertrophy
Kidney
Living Donors

Human class I major histocompatibility complex alleles determine central nervous system injury versus repair

Wootla, B., Denic, A., Watzlawik, J. O., Warrington, A. E., Zoecklein, L. J., Papke-Norton, L. M., David, C. & Rodriguez, M., Nov 17 2016, In : Journal of Neuroinflammation. 13, 1, 293.

Research output: Contribution to journalArticle

Nervous System Trauma
Major Histocompatibility Complex
Central Nervous System
Alleles
Theilovirus
19 Citations (Scopus)
Living Donors
Kidney
Nephrons
Nephrosclerosis
Hypertrophy
104 Citations (Scopus)

Structural and Functional Changes With the Aging Kidney

Denic, A., Glassock, R. J. & Rule, A. D., Jan 1 2016, In : Advances in Chronic Kidney Disease. 23, 1, p. 19-28 10 p.

Research output: Contribution to journalArticle

Kidney
Glomerular Filtration Rate
Nephrosclerosis
Arteriosclerosis
Nephrons
4 Citations (Scopus)

Tubulointerstitial Fibrosis of Living Donor Kidneys Associates with Urinary Monocyte Chemoattractant Protein 1

Wang, X., Lieske, J. C., Alexander, M. P., Jayachandran, M., Denic, A., Mathew, J., Lerman, L. O., Kremers, W. K., Larson, J. J. & Rule, A. D., Jul 1 2016, In : American Journal of Nephrology. 43, 6, p. 454-459 6 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Living Donors
Fibrosis
Urine
Kidney
2015
7 Citations (Scopus)

Abbreviated Exposure to Hypoxia Is Sufficient to Induce CNS Dysmyelination, Modulate Spinal Motor Neuron Composition, and Impair Motor Development in Neonatal Mice

Watzlawik, J. O., Kahoud, R. J., O'Toole, R. J., White, K. A. M., Ogden, A. R., Painter, M. M., Wootla, B., Papke, L. M., Denic, A., Weimer, J. M., Carey, W. A. & Rodriguez, M., May 28 2015, In : PLoS One. 10, 5, e0128007.

Research output: Contribution to journalArticle

motor development
Motor Neurons
motor neurons
Neurons
hypoxia
19 Citations (Scopus)

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis

Xu, X., Denic, A., Jordan, L. R., Wittenberg, N. J., Warrington, A. E., Wootla, B., Papke, L. M., Zoecklein, L. J., Yoo, D., Shaver, J., Oh, S. H., Pease, L. R. & Rodriguez, M., Aug 1 2015, In : DMM Disease Models and Mechanisms. 8, 8, p. 831-842 12 p.

Research output: Contribution to journalArticle

Gangliosides
Amyotrophic Lateral Sclerosis
Anterior Horn Cells
Neurons
Immunoglobulin M
12 Citations (Scopus)

Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease

Wootla, B., Denic, A., Watzlawik, J. O., Warrington, A. E. & Rodriguez, M., Sep 26 2015, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Oligodendroglia
Demyelinating Diseases
Axons
Spinal Cord
Antibodies
10 Citations (Scopus)
Brain Stem
Multiple Sclerosis
Immunoglobulin M
Axons
Spinal Cord
33 Citations (Scopus)
Anatomy
Kidney
Biopsy
Large-Core Needle Biopsy
Chronic Renal Insufficiency
11 Citations (Scopus)

Naturally occurringmonoclonal antibodies and their therapeutic potential for neurologic diseases

Wootla, B., Watzlawik, J. O., Warrington, A. E., Wittenberg, N. J., Denic, A., Xu, X., Jordan, L. R., Papke, L. M., Zoecklein, L. J., Pierce, M. L., Oh, S. H., Kantarci, O. H. & Rodriguez, M., Nov 1 2015, In : JAMA Neurology. 72, 11, p. 1346-1353 8 p.

Research output: Contribution to journalArticle

Nervous System Diseases
Poisons
Antibodies
Central Nervous System
Oligodendroglia
1 Citation (Scopus)

Pathophysiology of experimental autoimmune encephalomyelitis

Denic, A., Wootla, B., Pirko, I. & Mangalam, A., Jan 1 2015, Multiple Sclerosis: A Mechanistic View. Elsevier Inc., p. 249-280 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Autoimmune Experimental Encephalomyelitis
Multiple Sclerosis
Autoimmune Diseases of the Nervous System
T-Lymphocytes
Genetic Engineering
10 Citations (Scopus)

Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice

Perschbacher, K., Smestad, J. A., Peters, J. P., Standiford, M. M., Denic, A., Wootla, B., Warrington, A. E., Rodriguez, M. & Maher III, L. J., Feb 1 2015, In : Nucleic Acid Therapeutics. 25, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Pharmacokinetics
Tissue
Polymerase Chain Reaction
Neurology
21 Citations (Scopus)

Untargeted plasma metabolomics identifies endogenous metabolite with drug-like properties in chronic animal model of multiple sclerosis

Poisson, L. M., Suhail, H., Singh, J., Datta, I., Denic, A., Labuzek, K., Hoda, N., Shankar, A., Kumar, A., Cerghet, M., Elias, S., Mohney, R. P., Rodriguez, M., Rattan, R., Mangalam, A. K. & Giri, S., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30697-30712 16 p.

Research output: Contribution to journalArticle

Metabolomics
Metabolites
Multiple Sclerosis
Animals
Animal Models
2014
12 Citations (Scopus)

Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases

Wittenberg, N. J., Wootla, B., Jordan, L. R., Denic, A., Warrington, A. E., Oh, S. H. & Rodriguez, M., 2014, In : Expert Review of Neurotherapeutics. 14, 4, p. 449-463 15 p.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Surface Plasmon Resonance
Drug Receptors
Nervous System Diseases
Autoantibodies
8 Citations (Scopus)

Polyclonal and monoclonal antibodies in clinic

Wootla, B., Denic, A. & Rodriguez, M., 2014, Methods in Molecular Biology. Humana Press Inc., Vol. 1060. p. 79-110 32 p. (Methods in Molecular Biology; vol. 1060).

Research output: Chapter in Book/Report/Conference proceedingChapter

Monoclonal Antibodies
Antibodies
Glycosylation
Immune System
Clone Cells
2013
32 Citations (Scopus)

CD8+ T cells in multiple sclerosis

Denic, A., Wootla, B. & Rodriguez, M., Sep 2013, In : Expert Opinion on Therapeutic Targets. 17, 9, p. 1053-1066 14 p.

Research output: Contribution to journalArticle

T-cells
Multiple Sclerosis
T-Lymphocytes
Interleukin-17
T-Lymphocyte Subsets
1 Citation (Scopus)

Measuring binding interactions of neurite-extension promoting antibodies to supported lipid membranes using a multichannel microfluidic plasmonic nanohole array biosensor

Jordan, L., Xu, X., Wittenberg, N. J., Warrington, A. E., Denic, A., Wootla, B., Yoo, D., Watzlawik, J., Rodriguez, M. & Oh, S. H., 2013, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, Vol. 1. p. 215-217 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gangliosides
Membrane Lipids
Microfluidics
Biosensors
Antibodies
9 Citations (Scopus)

Therapeutics to promote CNS repair: A natural human neuron-binding igm regulates membrane-raft dynamics and improves motility in a mouse model of multiple sclerosis

Xu, X., Denic, A., Warrington, A. E., Bieber, A. J. & Rodriguez, M., Jan 2013, In : Journal of Clinical Immunology. 33, SUPPL.1

Research output: Contribution to journalArticle

Multiple Sclerosis
Immunoglobulin M
Neurons
Membranes
Antibodies
10 Citations (Scopus)

The road to remyelination in demyelinating diseases: Current status and prospects for clinical treatment

Wootla, B., Watzlawik, J. O., Denic, A. & Rodriguez, M., Jun 2013, In : Expert Review of Clinical Immunology. 9, 6, p. 535-549 15 p.

Research output: Contribution to journalArticle

Oligodendroglia
Demyelinating Diseases
Myelin Sheath
Multiple Sclerosis
Antibodies
2012
9 Citations (Scopus)

Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis

Denic, A., Pirko, I., Wootla, B., Bieber, A., Macura, S. I. & Rodriguez, M., Sep 2012, In : Brain Pathology. 22, 5, p. 698-708 11 p.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Brain Stem
Multiple Sclerosis
Spinal Cord
Demyelinating Diseases
7 Citations (Scopus)

Need for a paradigm shift in therapeutic approaches to CNS injury

Wootla, B., Denic, A., Warrington, A. E. & Rodriguez, M., Apr 2012, In : Expert Review of Neurotherapeutics. 12, 4, p. 409-420 12 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Regeneration
Therapeutics
Neurons
Antibodies
11 Citations (Scopus)

Preclinical 1H-MRS neurochemical profiling in neurological and psychiatric disorders

Lee, M. R., Denic, A., Hinton, D. J., Mishra, P. K., Choi, D. S., Pirko, I., Rodriguez, M. & Macura, S. I., Jul 2012, In : Bioanalysis. 4, 14, p. 1787-1804 18 p.

Research output: Contribution to journalArticle

Nervous System Diseases
Psychiatry
Animals
Nuclear magnetic resonance
Magnetic Resonance Spectroscopy
2011
18 Citations (Scopus)

A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination

Denic, A., Macura, S. I., Warrington, A. E., Pirko, I., Grossardt, B. R., Pease, L. R. & Rodriguez, M., Oct 12 2011, In : PLoS One. 6, 10, e26001.

Research output: Contribution to journalArticle

Theilovirus
Demyelinating Diseases
Viruses
Neurons
Immunoglobulin M
Encephalitis Viruses
Receptors, Tumor Necrosis Factor, Type II
Receptors, Tumor Necrosis Factor, Type I
Hippocampus
Tumor Necrosis Factor-alpha
14 Citations (Scopus)

Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis

Wootla, B., Denic, A., Keegan, B. M., Winters, J. L., Astapenko, D., Warrington, A. E., Bieber, A. J. & Rodriguez, M., 2011, In : Neurology Research International. 2011, 780712.

Research output: Contribution to journalArticle

Multiple Sclerosis
Immunoglobulins
B-Lymphocytes
Relapsing-Remitting Multiple Sclerosis
Phase II Clinical Trials
41 Citations (Scopus)

MRI in Rodent Models of Brain Disorders

Denic, A., Macura, S. I., Mishra, P., Gamez, J. D., Rodriguez, M. & Pirko, I., Jan 2011, In : Neurotherapeutics. 8, 1, p. 3-18 16 p.

Research output: Contribution to journalArticle

Brain Diseases
Rodentia
Magnetic Resonance Imaging
Central Nervous System Diseases
Nervous System Diseases
158 Citations (Scopus)

The relevance of animal models in multiple sclerosis research

Denic, A., Johnson, A. J., Bieber, A. J., Warrington, A. E., Rodriguez, M. & Pirko, I., Feb 2011, In : Pathophysiology. 18, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Demyelinating Diseases
Multiple Sclerosis
Animal Models
Autoimmune Experimental Encephalomyelitis
Theilovirus
8 Citations (Scopus)

Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis

Denic, A., Zoecklein, L., Kerkvliet, J., Papke, L., Edukulla, R., Warrington, A., Bieber, A., Pease, L. R., David, C. S. & Rodriguez, M., Sep 2011, In : Brain Pathology. 21, 5, p. 501-515 15 p.

Research output: Contribution to journalArticle

Capsid Proteins
Demyelinating Diseases
Viral Proteins
Multiple Sclerosis
Theilovirus
2009
47 Citations (Scopus)

Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection

Buenz, E. J., Sauer, B. M., LaFrance-Corey, R. G., Deb, C., Denic, A., German, C. L. & Howe, C. L., Aug 2009, In : American Journal of Pathology. 175, 2, p. 668-684 17 p.

Research output: Contribution to journalArticle

Picornaviridae Infections
Pyramidal Cells
Apoptosis
Viruses
Picornaviridae
16 Citations (Scopus)

Brainstem 1H Nuclear Magnetic Resonance (NMR) spectroscopy: Marker of demyelination and repair in spinal cord

Denic, A., Bieber, A., Warrington, A., Mishra, P. K., Macura, S. I. & Rodriguez, M., 2009, In : Annals of Neurology. 66, 4, p. 559-564 6 p.

Research output: Contribution to journalArticle

Spinal Cord Regeneration
Demyelinating Diseases
Friend murine leukemia virus
Brain Stem
Magnetic Resonance Spectroscopy
12 Citations (Scopus)

Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination

Kerkvliet, J., Zoecklein, L., Papke, L., Denic, A., Bieber, A. J., Pease, L. R., David, C. S. & Rodriguez, M., Dec 2009, In : Journal of Virology. 83, 23, p. 12279-12289 11 p.

Research output: Contribution to journalArticle

Theilovirus
Demyelinating Diseases
Virus Diseases
gene expression
viruses
18 Citations (Scopus)

Tumor necrosis factor α is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis

Rodriguez, M., Zoecklein, L., Papke, L., Gamez, J., Denic, A., Macura, S. I. & Howe, C. L., Jan 2009, In : Brain Pathology. 19, 1, p. 12-26 15 p.

Research output: Contribution to journalArticle

Encephalitis Viruses
Receptors, Tumor Necrosis Factor, Type II
Receptors, Tumor Necrosis Factor, Type I
Hippocampus
Tumor Necrosis Factor-alpha
2004
1 Citation (Scopus)

Basics of cancer pharmacogenomics

Denic, A. & Radulović, S., Jul 1 2004, In : Journal of B.U.ON.. 9, 3, p. 233-241 9 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Neoplasms