• 6898 Citations
  • 50 Scopus h-Index
1984 …2020

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Article
2004

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

113 Scopus citations
2005

Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer

Regala, R. P., Weems, C., Jamieson, L., Khoor, A., Edell, E. S., Lohse, C. M. & Fields, A. P., Oct 1 2005, In : Cancer research. 65, 19, p. 8905-8911 7 p.

Research output: Contribution to journalArticle

210 Scopus citations

Atypical protein kinase Cτ plays a critical role in human lung cancer cell growth and tumorigenicity

Regala, R. P., Weems, C., Jamieson, L., Copland, J. A., Thompson, E. A. & Fields, A. P., Sep 2 2005, In : Journal of Biological Chemistry. 280, 35, p. 31109-31115 7 p.

Research output: Contribution to journalArticle

154 Scopus citations
2006

A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells

Stailings-Mann, M., Jamieson, L., Regala, R. P., Weems, C., Murray, N. R. & Fields, A. P., Feb 1 2006, In : Cancer research. 66, 3, p. 1767-1774 8 p.

Research output: Contribution to journalArticle

123 Scopus citations

Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ci

Erdogan, E., Lamark, T., Stallings-Mann, M., Jamieson, L., Pellechia, M., Aubrey Thompson, E., Johansen, T. & Fields, A. P., Sep 22 2006, In : Journal of Biological Chemistry. 281, 38, p. 28450-28459 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Evi1 is a survival factor which conveys resistance to both TGFβ- and taxol-mediated cell death via PI3K/AKT

Liu, Y., Chen, L., Ko, T. C., Fields, A. P. & Thompson, E. A., Jun 15 2006, In : Oncogene. 25, 25, p. 3565-3575 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Peroxisome proliferator-activated receptor γ promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2

Chen, L., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24575-24587 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

RS5444, a novel PPARγ agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells

Chen, L., Bush, C. R., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Jun 7 2006, In : Molecular and Cellular Endocrinology. 251, 1-2, p. 17-32 16 p.

Research output: Contribution to journalArticle

28 Scopus citations
2007

Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon

Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P. & Thompson, E. A., Aug 20 2007, In : Physiological Genomics. 30, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction

Rudolph, J. L., Shi, G. X., Erdogan, E., Fields, A. P. & Andres, D. A., Dec 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 12, p. 1793-1800 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeting the oncogenic protein kinase Cι signalling pathway for the treatment of cancer

Fields, A. P., Frederick, L. A. & Regala, R. P., Nov 1 2007, In : Biochemical Society Transactions. 35, 5, p. 996-1000 5 p.

Research output: Contribution to journalArticle

51 Scopus citations
2008

Atypical protein kinase Cι expression and aurothiomalate sensitivity in human lung cancer cells

Regala, R. P., Thompson, E. A. & Fields, A. P., Jul 15 2008, In : Cancer research. 68, 14, p. 5888-5895 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer

Frederick, L. A., Matthews, J. A., Jamieson, L., Justilien, V., Thompson, E. A., Radisky, D. C. & Fields, A. P., Aug 14 2008, In : Oncogene. 27, 35, p. 4841-4853 13 p.

Research output: Contribution to journalArticle

67 Scopus citations

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon

Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In : International Journal of Cancer. 122, 11, p. 2462-2470 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Protein kinase C isozymes as therapeutic targets for treatment of human cancers

Fields, A. P. & Murray, N. R., Sep 15 2008, In : Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
12 Scopus citations
2009

Atypical protein kinase Cι is required for bronchioalveolar stem cell expansion and lung tumorigenesis

Regala, R. P., Davis, R. K., Kunz, A., Khoor, A., Leitges, M. & Fields, A. P., Oct 1 2009, In : Cancer research. 69, 19, p. 7603-7611 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

Ect2 links the PKC-Par6α complex to Rac1 activation and cellular transformation

Justilien, V. & Fields, A. P., Oct 15 2009, In : Oncogene. 28, 41, p. 3597-3607 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Meta-analysis of oncogenic protein kinase Cι signaling in lung adenocarcinoma

Erdogan, E., Klee, E. W., Thompson, E. A. & Fields, A. P., Mar 1 2009, In : Clinical Cancer Research. 15, 5, p. 1527-1533 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression

Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In : Cancer research. 69, 2, p. 656-662 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Protein kinase cβ is an effective target for chemoprevention of colon cancer

Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In : Cancer research. 69, 4, p. 1643-1650 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis

Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In : Cancer research. 70, 5, p. 2064-2074 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Splice variants of SmgGDS control small gtpase prenylation and membrane localization

Berg, T. J., Gastonguay, A. J., Lorimer, E. L., Kuhnmuench, J. R., Li, R., Fields, A. P. & Williams, C. L., Nov 12 2010, In : Journal of Biological Chemistry. 285, 46, p. 35255-35266 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer

Fields, A. P. & Justilien, V., Aug 18 2010, In : Advances in Enzyme Regulation. 50, 1, p. 190-200 11 p.

Research output: Contribution to journalArticle

69 Scopus citations
2011

Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation

Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In : PloS one. 6, 10, e26439.

Research output: Contribution to journalArticle

24 Scopus citations

Oncogenic activity of Ect2 is regulated through protein kinase Cι-mediated phosphorylation

Justilien, V., Jameison, L., Der, C. J., Rossman, K. L. & Fields, A. P., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8149-8157 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis

Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 1 2011, In : Inflammatory bowel diseases. 17, 8, p. 1685-1697 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)

O'Neill, A. K., Gallegos, L. L., Justilien, V., Garcia, E. L., Leitges, M., Fields, A. P., Hall, R. A. & Newton, A. C., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43559-43568 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
2012

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι

Sajan, M. P., Nimal, S., Mastorides, S., Acevedo-Duncan, M., Kahn, C. R., Fields, A. P., Braun, U., Leitges, M. & Farese, R. V., Apr 1 2012, In : Metabolism: Clinical and Experimental. 61, 4, p. 459-469 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Deep sequence analysis of non-small cell lung cancer: Integrated analysis of gene expression, alternative splicing, and single nucleotide variations in lung adenocarcinomas with and without oncogenic KRAS mutations

Kalari, K. R., Rossell, D., Necela, B. M., Asmann, Y. W., Nair, A., Baheti, S., Kachergus, J. M., Younkin, C. S., Baker, T., Carr, J. M., Tang, X., Walsh, M. P., Chai, H. S., Sun, Z., Hart, S. N., Leontovich, A. A., Hossain, A., Kocher, J. P., Perez, E. A., Reisman, D. N. & 2 others, Fields, A. P. & Thompson, E. A., Dec 1 2012, In : Frontiers in Oncology. 2, FEB, 00012.

Research output: Contribution to journalArticle

32 Scopus citations
42 Scopus citations

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PloS one. 7, 4, e35040.

Research output: Contribution to journalArticle

59 Scopus citations

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

Stallings-Mann, M. L., Waldmann, J., Zhang, Y., Miller, E., Gauthier, M. L., Visscher, D. W., Downey, G. P., Radisky, E. S., Fields, A. P. & Radisky, D. C., Jul 11 2012, In : Science translational medicine. 4, 142, 142ra95.

Research output: Contribution to journalArticle

65 Scopus citations

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia

Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In : PloS one. 7, 2, e30509.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Atypical protein kinase Ci is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled 2

Greer, Y. E., Fields, A. P., Brown, A. M. C. & Rubin, J. S., Mar 29 2013, In : Journal of Biological Chemistry. 288, 13, p. 9438-9446 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer

Deng, X., Cao, Y., Liu, Y., Li, F., Sambandam, K., Rajaraman, S., Perkins, A. S., Fields, A. P., Hellmich, M. R., Townsend, C. M., Thompson, E. A. & Ko, T. C., Apr 1 2013, In : Molecular Carcinogenesis. 52, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
34 Scopus citations

PKCi maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis

Wang, Y., Hill, K. S. & Fields, A. P., Dec 1 2013, In : Molecular Cancer Research. 11, 12, p. 1624-1635 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma

Kikuchi, K., Soundararajan, A., Zarzabal, L. A., Weems, C. R., Nelon, L. D., Hampton, S. T., Michalek, J. E., Rubin, B. P., Fields, A. P. & Keller, C., Jan 17 2013, In : Oncogene. 32, 3, p. 286-295 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism

Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In : PloS one. 8, 8, e72061.

Research output: Contribution to journalArticle

24 Scopus citations
7 Scopus citations
2014

A Mixed-Methods Feasibility Trial of Protein Kinase C Iota Inhibition with Auranofin in Asymptomatic Ovarian Cancer Patients

Jatoi, A., Radecki Breitkopf, C., Foster, N. R., Block, M. S., Grudem, M., Wahner Hendrickson, A. E., Carlson, R. E., Barrette, B., Karlin, N. & Fields, A. P., Dec 6 2014, (Accepted/In press) In : Oncology (Switzerland). p. 208-213 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer cell. 25, 2, p. 139-151 13 p.

Research output: Contribution to journalArticle

171 Scopus citations
2015

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In : Oncotarget. 6, 17, p. 15297-15310 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature communications. 6, 6200.

Research output: Contribution to journalArticle

36 Scopus citations
2016

A proof-of-concept trial of protein kinase C iota inhibition with auranofin for the paclitaxel-induced acute pain syndrome

Jatoi, A., Grudem, M. E., Dockter, T. J., Block, M. S., Villasboas Bisneto, J. J. C. ., Tan, A., Deering, E., Kasi, P. M., Mansfield, A., Botero, J. P., Okuno, S. H., Smith, D. R. & Fields, A. P., Nov 12 2016, (Accepted/In press) In : Supportive Care in Cancer. p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

20 Scopus citations

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model

Riabov, V., Yin, S., Song, B., Avdic, A., Schledzewski, K., Ovsiy, I., Gratchev, A., Verdiell, M. L., Sticht, C., Schmuttermaier, C., Schönhaber, H., Weiss, C., Fields, A. P., Simon-Keller, K., Pfister, F., Berlit, S., Marx, A., Arnold, B., Goerdt, S. & Kzhyshkowska, J., May 24 2016, In : Oncotarget. 7, 21, p. 31097-31110 14 p.

Research output: Contribution to journalArticle

21 Scopus citations