• 6615 Citations
  • 49 Scopus h-Index
1984 …2021
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Research Output 1984 2019

  • 6615 Citations
  • 49 Scopus h-Index
  • 119 Article
  • 1 Comment/debate
  • 1 Short survey
  • 1 Review article
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Article
2007

Erratum: Aurothiomalate inhibits transformed growth by targeting the PB1 domain of atypical protein kinase Cι (Journal of Biological Chemistry (2006) 281, (28450-28459))

Erdogan, E., Lamark, T., Stallings-Mann, M., Jamieson, L., Pellecchia, M., Thompson, E. A., Johansen, T. & Fields, A. P., Mar 30 2007, In : Journal of Biological Chemistry. 282, 13, p. 10132 1 p.

Research output: Contribution to journalArticle

Gold Sodium Thiomalate
Protein Kinases
Growth
92 Citations (Scopus)

Protein kinase Cι: Human oncogene, prognostic marker and therapeutic target

Fields, A. P. & Regala, R. P., Jun 2007, In : Pharmacological Research. 55, 6, p. 487-497 11 p.

Research output: Contribution to journalArticle

Oncogenes
Protein Kinase C
Neoplasms
Therapeutics
Gene Amplification
16 Citations (Scopus)

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction

Rudolph, J. L., Shi, G. X., Erdogan, E., Fields, A. P. & Andres, D. A., Dec 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 12, p. 1793-1800 8 p.

Research output: Contribution to journalArticle

Cell Polarity
Mitogen-Activated Protein Kinase Kinases
ral Guanine Nucleotide Exchange Factor
MAP Kinase Signaling System
Extracellular Signal-Regulated MAP Kinases
49 Citations (Scopus)

Targeting the oncogenic protein kinase Cι signalling pathway for the treatment of cancer

Fields, A. P., Frederick, L. A. & Regala, R. P., Nov 2007, In : Biochemical Society Transactions. 35, 5, p. 996-1000 5 p.

Research output: Contribution to journalArticle

Protein Kinase C
Neoplasms
Gold Sodium Thiomalate
Tumors
Isoenzymes
2006
119 Citations (Scopus)

A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells

Stailings-Mann, M., Jamieson, L., Regala, R. P., Weems, C., Murray, N. R. & Fields, A. P., Feb 1 2006, In : Cancer Research. 66, 3, p. 1767-1774 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein Kinase C
Aurothioglucose
Growth
Gold Sodium Thiomalate
71 Citations (Scopus)

Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ci

Erdogan, E., Lamark, T., Stallings-Mann, M., Jamieson, L., Pellechia, M., Thompson, E. A., Johansen, T. & Fields, A. P., Sep 22 2006, In : Journal of Biological Chemistry. 281, 38, p. 28450-28459 10 p.

Research output: Contribution to journalArticle

Gold Sodium Thiomalate
Protein Kinases
Growth
Cells
Protein Kinase C
74 Citations (Scopus)

Evi1 is a survival factor which conveys resistance to both TGFβ- and taxol-mediated cell death via PI3K/AKT

Liu, Y., Chen, L., Ko, T. C., Fields, A. P. & Thompson, E. A., Jun 15 2006, In : Oncogene. 25, 25, p. 3565-3575 11 p.

Research output: Contribution to journalArticle

Virus Integration
1-Phosphatidylinositol 4-Kinase
Paclitaxel
Cell Death
Survival
45 Citations (Scopus)

Peroxisome proliferator-activated receptor γ promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2

Chen, L., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24575-24587 13 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Peroxisome Proliferator-Activated Receptors
Epithelial-Mesenchymal Transition
Chemical activation
Phosphorylation
27 Citations (Scopus)

RS5444, a novel PPARγ agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells

Chen, L., Bush, C. R., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Jun 7 2006, In : Molecular and Cellular Endocrinology. 251, 1-2, p. 17-32 16 p.

Research output: Contribution to journalArticle

PPAR gamma
Epithelial Cells
Phenotype
Rats
rosiglitazone
2005
200 Citations (Scopus)

Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer

Regala, R. P., Weems, C., Jamieson, L., Khoor, A., Edell, E., Lohse, C. M. & Fields, A. P., Oct 1 2005, In : Cancer Research. 65, 19, p. 8905-8911 7 p.

Research output: Contribution to journalArticle

Oncogenes
Non-Small Cell Lung Carcinoma
Protein Kinase C
Neoplasms
Gene Amplification
149 Citations (Scopus)

Atypical protein kinase Cτ plays a critical role in human lung cancer cell growth and tumorigenicity

Regala, R. P., Weems, C., Jamieson, L., Copland, J. A. III., Thompson, E. A. & Fields, A. P., Sep 2 2005, In : Journal of Biological Chemistry. 280, 35, p. 31109-31115 7 p.

Research output: Contribution to journalArticle

Cell growth
Lung Neoplasms
Cells
Non-Small Cell Lung Carcinoma
Growth
2004
37 Citations (Scopus)

Bcr-Abl Regulates Protein Kinase Cι (PKCι) Transcription via an Elk1 Site in the PKCι Promoter

Gustafson, W. C., Ray, S., Jamieson, L., Thompson, E. A., Brasier, A. R. & Fields, A. P., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9400-9408 9 p.

Research output: Contribution to journalArticle

Transcription
Protein Kinase C
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genes
Chemical activation
56 Citations (Scopus)

Genomic mechanisms of p210BCR-ABL signaling: Induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis

Ray, S., Lu, Y., Kaufmann, S. H., Gustafson, W. C., Karp, J. E., Boldogh, I., Fields, A. P. & Brasier, A. R., Aug 20 2004, In : Journal of Biological Chemistry. 279, 34, p. 35604-35615 12 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Response Elements
Paclitaxel
Apoptosis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
116 Citations (Scopus)

Protein kinase c (PKC) βII induces cell invasion through a Ras/Mek-, PKCι/Rac 1-dependent signaling pathway

Zhang, J., Anastasiadis, P. Z., Liu, Y., Thompson, E. A. & Fields, A. P., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22118-22123 6 p.

Research output: Contribution to journalArticle

ras Proteins
Protein Kinases
Protein Kinase C
Rats
Epithelial Cells
44 Citations (Scopus)

Protein kinase C beta;II regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo

Liu, Y., Su, W., Thompson, E. A., Leitges, M., Murray, N. R. & Fields, A. P., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45556-45563 8 p.

Research output: Contribution to journalArticle

Protein Kinase C beta
Protein Kinase C
Rats
Epithelium
Epithelial Cells
109 Citations (Scopus)

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P. Z., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

Protein Kinase C
Colon
Carcinogenesis
Carcinogens
Phosphotransferases
2003
7 Citations (Scopus)
Azoxymethane
Animal Disease Models
Carcinogens
Colonic Neoplasms
Protein Kinase C
7 Citations (Scopus)

Genomic Analysis of Glucocorticoid-regulated Promoters in Murine T-lymphoma Cells

Chen, L., Finnerty, C., Gustafson, W. C., Bush, C. R., Chi, P., Guo, H., Luxon, B., Fields, A. P. & Thompson, E. A., 2003, In : Recent Progress in Hormone Research. 58, p. 155-174 20 p.

Research output: Contribution to journalArticle

T-Cell Lymphoma
Cycloheximide
Glucocorticoids
Dexamethasone
Genes
36 Citations (Scopus)

Protein kinase C in disease: cancer.

Fields, A. P. & Gustafson, W. C., 2003, In : Methods in molecular biology (Clifton, N.J.). 233, p. 519-537 19 p.

Research output: Contribution to journalArticle

Cell Division
Protein Kinase C
Isoenzymes
Signal Transduction
Cell Cycle
50 Citations (Scopus)

Quantification of human intestinal gene expression profiles using exfoliated colonocytes: A pilot study

Davidson, L. A., Lupton, J. R., Miskovsky, E., Fields, A. P. & Chapkin, R. S., Jan 2003, In : Biomarkers. 8, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

Transcriptome
Gene expression
Messenger RNA
Bearings (structural)
Colonic Neoplasms
2 Citations (Scopus)

Rapid backbone 1H, 13C, and 15N assignment of the V1 domain of human PKC iota using the new program IBIS [1]

Roehrl, M. H. A., Hyberts, S. G., Sun, Z. Y. J., Fields, A. P. & Wagner, G., Aug 1 2003, In : Journal of Biomolecular NMR. 26, 4, p. 373-374 2 p.

Research output: Contribution to journalArticle

Biomolecular Nuclear Magnetic Resonance
Protein Conformation
Protein Kinase C
Isoenzymes
protein kinase C lambda
66 Citations (Scopus)

Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis

Yu, W., Murray, N. R., Weems, C., Chen, L., Guo, H., Ethridge, R., Ceci, J. D., Evers, B. M., Thompson, E. A. & Fields, A. P., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11167-11174 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Protein Kinase C
Colon
Carcinogenesis
Celecoxib
2002
60 Citations (Scopus)

Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis

Murray, N. R., Weems, C., Chen, L., Leon, J., Wangsheng, W., Davidson, L. A., Jamieson, L., Chapkin, R. S., Thompson, E. A. & Fields, A. P., Jun 10 2002, In : Journal of Cell Biology. 157, 6, p. 915-920 6 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Transforming Growth Factors
Protein Kinase C
Colon
Carcinogenesis
2001
114 Citations (Scopus)

Cloning of a novel phosphatidylinositol kinase-related kinase. Characterization of the human SMG-1 RNA surveillance protein

Denning, G., Jamieson, L., Maquat, L. E., Thompson, E. A. & Fields, A. P., Jun 22 2001, In : Journal of Biological Chemistry. 276, 25, p. 22709-22714 6 p.

Research output: Contribution to journalArticle

Cloning
Phosphatidylinositols
Organism Cloning
Phosphotransferases
RNA
167 Citations (Scopus)

Elevated protein kinase C βII is an early promotive event in colon carcinogenesis

Gökmen-Polar, Y., Murray, N. R., Velasco, M. A., Gatalica, Z. & Fields, A. P., Feb 15 2001, In : Cancer Research. 61, 4, p. 1375-1381 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
Colon
Carcinogenesis
Aberrant Crypt Foci
Azoxymethane

Erratum: Presence and activation of nuclear phosphoinositide 3-kinase C2β during compensatory liver growth (Journal Biological Chemistry (2001) 276 (17754-17761))

Sindić, A., Aleksandrova, A., Fields, A. P., Volinia, S. & Banfić, H., Aug 31 2001, In : Journal of Biological Chemistry. 276, 35, p. 33291 1 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Liver
Phosphotransferases
Chemical activation
59 Citations (Scopus)

NF-κB/RelA transactivation is required for atypical protein kinase Cl-mediated cell survival

Lu, Y., Jamieson, L., Brasier, A. R. & Fields, A. P., Aug 9 2001, In : Oncogene. 20, 35, p. 4777-4792 16 p.

Research output: Contribution to journalArticle

Paclitaxel
Protein Kinases
Transcriptional Activation
Cell Survival
Apoptosis
41 Citations (Scopus)

Presence and Activation of Nuclear Phosphoinositide 3-Kinase C2β during Compensatory Liver Growth

Sindić, A., Aleksandrova, A., Fields, A. P., Volinia, S. & Banfić, H., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 17754-17761 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Liver
Phosphotransferases
Chemical activation
2000
22 Citations (Scopus)

Activation of transcription factor SAF involves its phosphorylation by protein kinase C

Ray, A., Fields, A. P. & Ray, B. K., Dec 15 2000, In : Journal of Biological Chemistry. 275, 50, p. 39727-39733 7 p.

Research output: Contribution to journalArticle

Activating Transcription Factors
Phosphorylation
Protein Kinase C
Transcription Factors
Chemical activation
657 Citations (Scopus)

Protein kinase C isozymes and the regulation of diverse cell responses

Dempsey, E. C., Newton, A. C., Mochly-Rosen, D., Fields, A. P., Reyland, M. E., Insel, P. A. & Messing, R. O., 2000, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 279, 3 23-3

Research output: Contribution to journalArticle

Protein Kinase C
Isoenzymes
3-Phosphoinositide-Dependent Protein Kinases
Phosphorylation
Apoptosis
1999
65 Citations (Scopus)
Interleukin-1
Protein Kinase C
Hepatocytes
Feedback
Tumor Necrosis Factor-alpha
144 Citations (Scopus)

Overexpression of protein kinase C β(II) induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

Murray, N. R., Davidson, L. A., Chapkin, R. S., Gustafson, W. C., Schattenberg, D. G. & Fields, A. P., May 17 1999, In : Journal of Cell Biology. 145, 4, p. 699-711 13 p.

Research output: Contribution to journalArticle

Protein Kinase C
Colon
Carcinogenesis
Catenins
Adenomatous Polyposis Coli
65 Citations (Scopus)

Protein kinase Cα regulates human monocyte O2̇ production and low density lipoprotein lipid oxidation

Li, Q., Subbulakshmi, V., Fields, A. P., Murray, N. R. & Cathcart, M. K., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3764-3771 8 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
Protein Kinase C
Monocytes
Lipids
Oxidation
96 Citations (Scopus)

Protein kinase Cι activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

Jamieson, L., Carpenter, L., Biden, T. J. & Fields, A. P., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 3927-3930 4 p.

Research output: Contribution to journalArticle

Paclitaxel
Drug Resistance
Protein Kinase C
K562 Cells
Apoptosis
1998
38 Citations (Scopus)

Mapping of a molecular determinant for protein kinase C β(II) isozyme function

Gökmen-Polar, Y. & Fields, A. P., Aug 7 1998, In : Journal of Biological Chemistry. 273, 32, p. 20261-20266 6 p.

Research output: Contribution to journalArticle

Protein Kinase C
Isoenzymes
Phosphatidylglycerols
Lamin Type B
Catalytic Domain
59 Citations (Scopus)

Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C

Murray, N. R. & Fields, A. P., May 8 1998, In : Journal of Biological Chemistry. 273, 19, p. 11514-11520 7 p.

Research output: Contribution to journalArticle

Phosphatidylglycerols
Nuclear Proteins
Protein Kinase C
Nuclear Envelope
Chemical activation
3 Citations (Scopus)

Pituitary expression of protein kinase C isotypes during early development

Korytko, A. I., Fields, A. P., Allshouse, L. A. & Cuttler, L., Aug 1998, In : Journal of Neuroendocrinology. 10, 8, p. 569-576 8 p.

Research output: Contribution to journalArticle

Protein Kinase C
Gonadotrophs
Somatotrophs
Immunohistochemistry
Age Groups
1997
104 Citations (Scopus)

A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition

Sun, B., Murray, N. R. & Fields, A. P., Oct 17 1997, In : Journal of Biological Chemistry. 272, 42, p. 26313-26317 5 p.

Research output: Contribution to journalArticle

Phosphoinositide Phospholipase C
G2 Phase
Diglycerides
Phase Transition
Cell Division
151 Citations (Scopus)

Atypical protein kinase C ι protects human leukemia cells against drug- induced apoptosis

Murray, N. R. & Fields, A. P., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27521-27524 4 p.

Research output: Contribution to journalArticle

Protein Kinase C
Leukemia
Apoptosis
K562 Cells
Pharmaceutical Preparations
61 Citations (Scopus)

Identification of protein phosphatase 1 as a mitotic lamin phosphatase

Thompson, L. J., Bollen, M. & Fields, A. P., Nov 21 1997, In : Journal of Biological Chemistry. 272, 47, p. 29693-29697 5 p.

Research output: Contribution to journalArticle

Lamins
Protein Phosphatase 1
Phosphoric Monoester Hydrolases
Nuclear Lamina
Mitosis

Nuclear phosphatidylinositol-specific hhospholipase c is involved in the g2/m phase transition

Fields, A. P. & Sun, B., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

G2 Phase
Phase Transition
phosphatidylinositols
protein kinase C
phase transition

Phosphatidylglycerol is a novel activator of nuclear protein kinase

Murray, C. N. R. & Fields, A. P., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Phosphatidylglycerols
nuclear proteins
phosphatidylglycerols
protein kinase C
Nuclear Proteins
53 Citations (Scopus)

Protein kinase C-mediated interphase lamin B phosphorylation and solubilization

Collas, P., Thompson, L., Fields, A. P., Poccia, D. L. & Courvalin, J. C., Aug 22 1997, In : Journal of Biological Chemistry. 272, 34, p. 21274-21280 7 p.

Research output: Contribution to journalArticle

Lamin Type B
Phosphorylation
Interphase
Protein Kinase C
Spermatozoa
1996
chimerism
Cell proliferation
leukemia
active sites
cell differentiation
127 Citations (Scopus)

βIIprotein kinase C is required for the G2/M phase transition of cell cycle

Thompson, L. J. & Fields, A. P., 1996, In : Journal of Biological Chemistry. 271, 25, p. 15045-15053 9 p.

Research output: Contribution to journalArticle

G2 Phase
Phase Transition
Cell Division
Protein Kinase C
Cell Cycle

βII Protein kinase c is required for the G2/M phase transition of cell cycle

Thompson, L. J. & Fields, A. P., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

G2 Phase
Phase Transition
phase transition
interphase
protein kinases
1995
25 Citations (Scopus)

Human Parainfluenza Virus Type 3 Phosphoprotein: Identification of Serine 333 as the Major Site for PKC ζ Phosphorylation

Huntley, C. C., De, B. P., Murray, N. R., Fields, A. P. & Banerjee, A. K., Aug 20 1995, In : Virology. 211, 2, p. 561-567 7 p.

Research output: Contribution to journalArticle

Human parainfluenza virus 3
Phosphoproteins
Serine
Protein Kinase C
Phosphorylation
31 Citations (Scopus)

Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of βII protein kinase C

Ritke, M. K., Murray, N. R., Allan, W. P., Fields, A. P. & Yalowich, J. C., Nov 1995, In : Molecular Pharmacology. 48, 5, p. 798-805 8 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
K562 Cells
Etoposide
Protein Kinase C
Leukemia
37 Citations (Scopus)
Protein Kinase C
Catalytic Domain
Lamin Type B
Leukemia, Erythroblastic, Acute
Nuclear Envelope
7 Citations (Scopus)

Protein kinase C β from Friend erythroleukemia cells is associated with chromatin and DNA

Mallia, C. M., Jeter, J. R., Fields, A. P., Wilson, R. B. & Beckman, B. S., Oct 1995, In : Molecular and Cellular Biochemistry. 151, 2, p. 107-111 5 p.

Research output: Contribution to journalArticle

Leukemia, Erythroblastic, Acute
Protein Kinase C
Chromatin
DNA
Protein Isoforms