• 6897 Citations
  • 50 Scopus h-Index
1984 …2020

Research output per year

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Research Output

2014

A Mixed-Methods Feasibility Trial of Protein Kinase C Iota Inhibition with Auranofin in Asymptomatic Ovarian Cancer Patients

Jatoi, A., Radecki Breitkopf, C., Foster, N. R., Block, M. S., Grudem, M., Wahner Hendrickson, A. E., Carlson, R. E., Barrette, B., Karlin, N. & Fields, A. P., Dec 6 2014, (Accepted/In press) In : Oncology (Switzerland). p. 208-213 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Atypical Protein Kinase Cι as a human oncogene and therapeutic target

Parker, P. J., Justilien, V., Riou, P., Linch, M. & Fields, A. P., Mar 1 2014, In : Biochemical Pharmacology. 88, 1, p. 1-11 11 p.

Research output: Contribution to journalComment/debate

57 Scopus citations

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer cell. 25, 2, p. 139-151 13 p.

Research output: Contribution to journalArticle

171 Scopus citations
2015

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In : Oncotarget. 6, 17, p. 15297-15310 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
74 Scopus citations

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature communications. 6, 6200.

Research output: Contribution to journalArticle

36 Scopus citations
2016

A proof-of-concept trial of protein kinase C iota inhibition with auranofin for the paclitaxel-induced acute pain syndrome

Jatoi, A., Grudem, M. E., Dockter, T. J., Block, M. S., Villasboas Bisneto, J. J. C. ., Tan, A., Deering, E., Kasi, P. M., Mansfield, A., Botero, J. P., Okuno, S. H., Smith, D. R. & Fields, A. P., Nov 12 2016, (Accepted/In press) In : Supportive Care in Cancer. p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oncogenic PKCι decides tumor-initiating cell fate

Fields, A. P., Ali, S. A. & Murray, N. R., Sep 16 2016, In : Cell Cycle. 15, 18, p. 2383-2384 2 p.

Research output: Contribution to journalComment/debate

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

20 Scopus citations

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse

Murray, N. R., Justilien, V. & Fields, A. P., Oct 10 2016, In : Cancer Cell. 30, 4, p. 505-507 3 p.

Research output: Contribution to journalShort survey

6 Scopus citations

Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model

Riabov, V., Yin, S., Song, B., Avdic, A., Schledzewski, K., Ovsiy, I., Gratchev, A., Verdiell, M. L., Sticht, C., Schmuttermaier, C., Schönhaber, H., Weiss, C., Fields, A. P., Simon-Keller, K., Pfister, F., Berlit, S., Marx, A., Arnold, B., Goerdt, S. & Kzhyshkowska, J., May 24 2016, In : Oncotarget. 7, 21, p. 31097-31110 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

The chromosome 3q26 OncCassette: A multigenic driver of human cancer

Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In : Advances in Biological Regulation. 60, p. 47-63 17 p.

Research output: Contribution to journalArticle

27 Scopus citations
2017

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma

Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In : Cancer Cell. 31, 2, p. 256-269 14 p.

Research output: Contribution to journalArticle

45 Scopus citations
2018

Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma

Wen, H. J., Walsh, M. P., Yan, I. K., Takahashi, K., Fields, A. & Patel, T., Apr 27 2018, In : iScience. 2, p. 210-220 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Protein kinase Cι: A versatile oncogene in the lung

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.

Research output: Contribution to journalArticle

2019
Open Access

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC

Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Sep 3 2019, In : Small GTPases. 10, 5, p. 388-394 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167.e7

Research output: Contribution to journalArticle

3 Scopus citations
2020

Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma

Liu, Y., Yin, N., Wang, X., Khoor, A., Sambandam, V., Ghosh, A. B., Fields, Z. A., Murray, N. R., Justilien, V. & Fields, A. P., Jan 21 2020, In : Cell reports. 30, 3, p. 771-782.e6

Research output: Contribution to journalArticle

Open Access
1 Scopus citations