• 7413 Citations
  • 43 Scopus h-Index
19962020

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2020

Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

Eckhardt, B. A., Rowsey, J. L., Thicke, B. S., Fraser, D. G., O'Grady, K. L., Bondar, O. P., Hines, J. M., Singh, R. J., Thoreson, A. R., Rakshit, K., Lagnado, A. B., Passos, J. F., Vella, A., Matveyenko, A. V., Khosla, S., Monroe, D. G. & Farr, J. N., May 7 2020, In : JCI Insight. 5, 9

Research output: Contribution to journalArticle

Open Access

Association between allelic variants in the glucagon-like peptide 1 and cholecystokinin receptor genes with gastric emptying and glucose tolerance

Anderson, B., Carlson, P., Laurenti, M., Vella, A., Camilleri, M., Desai, A., Feuerhak, K. & Bharucha, A. E., Jan 1 2020, In : Neurogastroenterology and Motility. 32, 1, e13724.

Research output: Contribution to journalArticle

1 Scopus citations

Fasting glucagon concentrations are associated with longitudinal decline of β-cell function in non-diabetic humans

Adams, J. D., Dalla Man, C., Laurenti, M. C., Andrade, M. D. H., Cobelli, C., Rizza, R. A., Bailey, K. R. & Vella, A., Apr 2020, In : Metabolism: Clinical and Experimental. 105, 154175.

Research output: Contribution to journalArticle

1 Scopus citations

Glucose metabolism in Cushing's syndrome

Sharma, A. & Vella, A., Jun 1 2020, In : Current opinion in endocrinology, diabetes, and obesity. 27, 3, p. 140-145 6 p.

Research output: Contribution to journalArticle

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., McCready, L. K., Rizza, R. A., Matveyenko, A., Kassem, M., Andersen, T. L., Vella, A., Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., Dec 1 2020, In : Nature communications. 11, 1, 87.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes

Calderon, G., McRae, A., Rievaj, J., Davis, J., Zandvakili, I., Linker-Nord, S., Burton, D., Roberts, G., Reimann, F., Gedulin, B., Vella, A., LaRusso, N. F., Camilleri, M., Gribble, F. M. & Acosta, A., May 2020, In : EBioMedicine. 55, 102759.

Research output: Contribution to journalArticle

Open Access

Malignant Insulinoma: A Rare Form of Neuroendocrine Tumor

Sada, A., Glasgow, A. E., Vella, A., Thompson, G. B., McKenzie, T. J. & Habermann, E. B., Jan 1 2020, (Accepted/In press) In : World Journal of Surgery.

Research output: Contribution to journalArticle

2019

Assessment of pulsatile insulin secretion derived from peripheral plasma c-peptide concentrations by nonparametric stochastic deconvolution

Laurenti, M. C., Vella, A., Varghese, R. T., Andrews, J. C., Sharma, A., Kittah, N. E., Rizza, R. A., Matveyenko, A., De Nicolao, G., Cobelli, C. & Dalla Man, C., May 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 5, p. E687-E694

Research output: Contribution to journalArticle

Contribution of endogenous glucagon-like peptide-1 to changes in glucose metabolism and islet function in people with type 2 diabetes four weeks after Roux-en-Y gastric bypass (RYGB)

Shah, M., Laurenti, M. C., Dalla Man, C., Ma, J., Cobelli, C., Rizza, R. A. & Vella, A., Apr 2019, In : Metabolism: Clinical and Experimental. 93, p. 10-17 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Letter to the Editor: "Defects in GLP-1 Response to an Oral Challenge Do Not Play a Significant Role in the Pathogenesis of Prediabetes"

Smushkin, G., Sathananthan, A., Man, C. D., Camilleri, M., Cobelli, C., Rizza, R. A. & Vella, A., Nov 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 11, p. 5106-5107 2 p.

Research output: Contribution to journalArticle

Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator

Vella, A., Freeman, J. L. R., Dunn, I., Keller, K., Buse, J. B. & Valcarce, C., Jan 16 2019, In : Science Translational Medicine. 11, 475, eaau3441.

Research output: Contribution to journalArticle

6 Scopus citations
1 Scopus citations
2018

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose

Karanth, S., Adams, J. D., Serrano, M. D. L. A., Quittner-Strom, E. B., Simcox, J., Villanueva, C. J., Ozcan, L., Holland, W. L., Yost, H. J., Vella, A. & Schlegel, A., Jul 10 2018, In : Cell Reports. 24, 2, p. 312-319 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

A novel triple-tracer approach to assess postprandial protein turnover

Moran, A., Toffolo, G., Schiavon, M., Vella, A., Klaus, K., Cobelli, C. & Nair, K. S., Oct 1 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 4, p. E469-E477

Research output: Contribution to journalArticle

2 Scopus citations

Deficient Glucagon Response to Hypoglycemia during a Mixed Meal in Total Pancreatectomy/Islet Autotransplantation Recipients

Bogachus, L. D., Bellin, M. D., Vella, A. & Paul Robertson, R., Apr 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 4, p. 1522-1529 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes

Cousminer, D. L., Ahlqvist, E., Mishra, R., Andersen, M. K., Chesi, A., Hawa, M. I., Davis, A., Hodge, K. M., Bradfield, J. P., Zhou, K., Guy, V. C., Akerlund, M., Wod, M., Fritsche, L. G., Vestergaard, H., Snyder, J., Højlund, K., Linneberg, A., Käräjämäki, A., Brandslund, I. & 33 others, Kim, C. E., Witte, D., Sørgjerd, E. P., Brillon, D. J., Pedersen, O., Beck-Nielsen, H., Grarup, N., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Melander, O., Harris, R. I., Varvel, S., Grill, V. E. R., Hakonarson, H., Froguel, P., Lonsdale, J. T., Mauricio, D., Schloot, N. C., Khunti, K., Greenbaum, C. J., Asvold, B. O., Yderstræde, K. B., Pearson, E. R., Schwartz, S., Voight, B. F., Hansen, T., Tuomi, T., Boehm, B. O., Groop, L., David Leslie, R. & Grant, S. F. A., Nov 1 2018, In : Diabetes care. 41, 11, p. 2396-2403 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Impaired insulin action is associated with increased glucagon concentrations in nondiabetic humans

Sharma, A., Varghese, R. T., Shah, M., Man, C. D., Cobelli, C., Rizza, R. A., Bailey, K. R. & Vella, A., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 1, p. 314-319 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function

Ruetten, H., Gebauer, M., Raymond, R. H., Calle, R. A., Cobelli, C., Ghosh, A., Robertson, R. P., Shankar, S. S., Staten, M. A., Stefanovski, D., Vella, A., Wright, K. & Fryburg, D. A., Oct 1 2018, In : Metabolic Syndrome and Related Disorders. 16, 8, p. 406-415 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function

Foundation for the NIH Biomarkers Consortium Beta Cell Project Team, Jun 2018, In : Contemporary Clinical Trials Communications. 10, p. 94-99 6 p.

Research output: Contribution to journalArticle

Performance of individually measured vs population-based C-peptide kinetics to assess β-cell function in the presence and absence of acute insulin resistance

Varghese, R. T., Dalla Man, C., Laurenti, M. C., Piccinini, F., Sharma, A., Shah, M., Bailey, K. R., Rizza, R. A., Cobelli, C. & Vella, A., Mar 1 2018, In : Diabetes, Obesity and Metabolism. 20, 3, p. 549-555 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Walking a fine line between -cell secretion and proliferation

Vella, A. & Matveyenko, A. V., Jan 1 2018, In : Journal of Biological Chemistry. 293, 36, p. 14190-14191 2 p.

Research output: Contribution to journalArticle

2017

Anthropometric features are not predictive of 72-hour fast duration in insulinomas

Donegan, D., Jakubikova, I. & Vella, A., Aug 1 2017, In : Endocrine Practice. 23, 8, p. 923-928 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Deficient Endogenous Glucose Production During Exercise After Total Pancreatectomy/Islet Autotransplantation

Bogachus, L. D., Oseid, E., Bellin, M., Vella, A. & Robertson, R. P., Sep 1 2017, In : The Journal of clinical endocrinology and metabolism. 102, 9, p. 3288-3295 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of liraglutide on weight, satiation, and gastric functions in obesity: a randomised, placebo-controlled pilot trial

Halawi, H., Khemani, D., Eckert, D., O'Neill, J., Kadouh, H., Grothe, K., Clark, M. M., Burton, D. D., Vella, A., Acosta, A., Zinsmeister, A. R. & Camilleri, M., Dec 1 2017, In : The Lancet Gastroenterology and Hepatology. 2, 12, p. 842-843 2 p.

Research output: Contribution to journalArticle

36 Scopus citations

Glucose metabolism during rotational shift-work in healthcare workers

Sharma, A., Laurenti, M. C., Dalla Man, C., Varghese, R. T., Cobelli, C., Rizza, R. A., Matveyenko, A. V. & Vella, A., Aug 1 2017, In : Diabetologia. 60, 8, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146

Lu, J., Varghese, R. T., Zhou, L., Vella, A. & Jensen, M. D., Mar 1 2017, In : Metabolism: Clinical and Experimental. 68, p. 55-63 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Selective arterial calcium stimulation with hepatic venous sampling in immune-mediated hypoglycemia

Thompson, S. M., Vella, A., Service, F. J. & Andrews, J. C., Jan 1 2017, In : Journal of the Endocrine Society. 1, 6, p. 671-675 5 p.

Research output: Contribution to journalArticle

Open Access

Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults

Newhouse, L. P., Joyner, M. J., Curry, T. B., Laurenti, M. C., Man, C. D., Cobelli, C., Vella, A. & Limberg, J. K., Jan 1 2017, In : Physiological Reports. 5, 1, e13106.

Research output: Contribution to journalArticle

18 Scopus citations
2016

A Model for the Estimation of Hepatic Insulin Extraction after a Meal

Piccinini, F., Dalla Man, C., Vella, A. & Cobelli, C., Sep 1 2016, In : IEEE Transactions on Biomedical Engineering. 63, 9, p. 1925-1932 8 p., 7347364.

Research output: Contribution to journalArticle

9 Scopus citations

Diabetes-associated variation in TCF7L2 is not associated with hepatic or extrahepatic insulin resistance

Varghese, R. T., Viegas, I., Barosa, C., Marques, C., Shah, M., Rizza, R. A., Jones, J. G. & Vella, A., Apr 1 2016, In : Diabetes. 65, 4, p. 887-892 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Durability of addition of Roux-en-Y Gastric Bypass to lifestyle intervention and medical management in achieving primary treatment goals for uncontrolled type 2 diabetes in mild to moderate obesity: A randomized control trial

Ikramuddin, S., Korner, J., Lee, W. J., Bantle, J. P., Thomas, A. J., Connett, J. E., Leslie, D. B., Inabnet, W. B., Wang, Q., Jeffery, R. W., Chong, K., Chuang, L. M., Jensen, M. D., Vella, A., Ahmed, L., Belani, K., Olofson, A. E., Bainbridge, H. A. & Billington, C. J., Sep 1 2016, In : Diabetes Care. 39, 9, p. 1510-1518 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Mechanisms underlying the pathogenesis of isolated impaired glucose tolerance in humans

Varghese, R. T., Man, C. D., Sharma, A., Viegas, I., Barosa, C., Marques, C., Shah, M., Miles, J. M., Rizza, R. A., Jones, J. G., Cobelli, C. & Vella, A., Dec 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4816-4824 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Model-Based Quantification of Glucagon-Like Peptide-1-Induced Potentiation of Insulin Secretion in Response to a Mixed Meal Challenge

Dalla Man, C., Micheletto, F., Sathananthan, M., Vella, A. & Cobelli, C., Jan 1 2016, In : Diabetes Technology and Therapeutics. 18, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

National Differences in Remission of Type 2 Diabetes Mellitus After Roux-en-Y Gastric Bypass Surgery-Subgroup Analysis of 2-Year Results of the Diabetes Surgery Study Comparing Taiwanese with Americans with Mild Obesity (BMI 30–35 kg/m2)

Chong, K., Ikramuddin, S., Lee, W. J., Billington, C. J., Bantle, J. P., Wang, Q., Thomas, A. J., Connett, J. E., Leslie, D. B., Inabnet, W. B., Jeffery, R. W., Sarr, M. G., Jensen, M. D., Vella, A., Ahmed, L., Belani, K., Schone, J. L., Olofson, A. E., Bainbridge, H. A., Laqua, P. S. & 2 others, Korner, J. & Chuang, L. M., Oct 25 2016, (Accepted/In press) In : Obesity Surgery. p. 1-7 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Standardized mixed-meal tolerance and arginine stimulation tests provide reproducible and complementary measures of β-cell function: Results from the foundation for the national institutes of health biomarkers consortium investigative series

Shankar, S. S., Vella, A., Raymond, R. H., Staten, M. A., Calle, R. A., Bergman, R. N., Cao, C., Chen, D., Cobelli, C., Man, C. D., Deeg, M., Dong, J. Q., Lee, D. S., Polidori, D., Robertson, R. P., Ruetten, H., Stefanovski, D., Vassileva, M. T., Weir, G. C. & Fryburg, D. A., Sep 1 2016, In : Diabetes care. 39, 9, p. 1602-1613 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

TCF7L2 genotype and α-cell function in humans without diabetes

Shah, M., Varghese, R. T., Miles, J. M., Piccinini, F., Dalla Man, C., Cobelli, C., Bailey, K. R., Rizza, R. A. & Vella, A., Feb 1 2016, In : Diabetes. 65, 2, p. 371-380 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents

Javed, A., Balagopal, P. B., Vella, A., Fischer, P. R., Piccinini, F., Dalla Man, C., Cobelli, C., Giesler, P. D., Laugen, J. M. & Kumar, S., May 1 2015, In : Thyroid. 25, 5, p. 478-484 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Association of UCP-3 rs1626521 with obesity and stomach functions in humans

Acosta, A., Camilleri, M., Shin, A., Vazquez-Roque, M. I., Iturrino, J., Lanza, I. R., Nair, K. S., Burton, D., O'Neill, J., Eckert, D., Carlson, P., Vella, A. & Zinsmeister, A. R., Apr 1 2015, In : Obesity. 23, 4, p. 898-906 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: A prospective double-blind randomized trial

Javed, A., Vella, A., Babu Balagopal, P., Fischer, P. R., Weaver, A. L., Piccinini, F., Man, C. D., Cobelli, C., Giesler, P. D., Laugen, J. M. & Kumar, S., 2015, In : Journal of Nutrition. 145, 2, p. 284-290 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Defective Glucagon-Like Peptide 1 Secretion in Prediabetes and Type 2 Diabetes Is Influenced by Weight and Sex. Chicken, Egg, or None of the Above?

Vella, A. & Cobelli, C., Jul 1 2015, In : Diabetes. 64, 7, p. 2324-2325 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Impact of variant pancreatic arterial anatomy and overlap in regional perfusion on the interpretation of selective arterial calcium stimulation with hepatic venous sampling for preoperative localization of occult insulinoma

Thompson, S. M., Vella, A., Service, F. J., Grant, C. S., Thompson, G. B. & Andrews, J. C., 2015, In : Surgery (United States). 158, 1, p. 162-172 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Preserved insulin secretory capacity and weight loss are the predominant predictors of glycemic control in patients with type 2 diabetes randomized to roux-en-y gastric bypass

Nguyen, K. T., Billington, C. J., Vella, A., Wang, Q., Ahmed, L., Bantle, J. P., Bessler, M., Connett, J. E., Inabnet, W. B., Thomas, A., Ikramuddin, S. & Korner, J., Sep 1 2015, In : Diabetes. 64, 9, p. 3104-3110 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Regenerative medicine in diabetes

Matveyenko, A. V. & Vella, A., Apr 1 2015, In : Mayo Clinic Proceedings. 90, 4, p. 546-554 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Relationship between glycemic control and gastric emptying in poorly controlled type 2 diabetes

Bharucha, A. E., Kudva, Y., Basu, A., Camilleri, M., Low, P. A., Vella, A. & Zinsmeister, A. R., Mar 1 2015, In : Clinical Gastroenterology and Hepatology. 13, 3, p. 466-476.e1

Research output: Contribution to journalArticle

38 Scopus citations

Roux-en-Y gastric bypass for diabetes (the Diabetes Surgery Study): 2-year outcomes of a 5-year, randomised, controlled trial

Ikramuddin, S., Billington, C. J., Lee, W. J., Bantle, J. P., Thomas, A. J., Connett, J. E., Leslie, D. B., Inabnet, W. B., Jeffery, R. W., Chong, K., Chuang, L. M., Sarr, M. G., Jensen, M. D., Vella, A., Ahmed, L., Belani, K., Schone, J. L., Olofson, A. E., Bainbridge, H. A., Laqua, P. S. & 2 others, Wang, Q. & Korner, J., Jun 1 2015, In : The Lancet Diabetes and Endocrinology. 3, 6, p. 413-422 10 p.

Research output: Contribution to journalArticle

107 Scopus citations

Selective arterial calcium stimulation with hepatic venous sampling differentiates insulinoma from nesidioblastosis

Thompson, S. M., Vella, A., Thompson, G. B., Rumilla, K. M., Service, F. J., Grant, C. S. & Andrews, J. C., Nov 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 11, p. 4189-4197 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Six and 12 weeks of caloric restriction increases β cell function and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes

Sathananthan, M., Shah, M., Edens, K. L., Grothe, K., Piccinini, F., Farrugia, L. P., Micheletto, F., Man, C. D., Cobelli, C., Rizza, R. A., Camilleri, M. & Vella, A., 2015, In : Journal of Nutrition. 145, 9, p. 2046-2051 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Contribution of endogenous glucagon-like peptide 1 to glucose metabolism after roux-en-y gastric bypass

Shah, M., Law, J. H., Micheletto, F., Sathananthan, M., Dalla Man, C., Cobelli, C., Rizza, R. A., Camilleri, M., Zinsmeister, A. R. & Vella, A., Feb 1 2014, In : Diabetes. 63, 2, p. 483-493 11 p.

Research output: Contribution to journalArticle

79 Scopus citations