• 7046 Citations
  • 42 Scopus h-Index
19962019
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Research Output 1996 2019

2019

Assessment of pulsatile insulin secretion derived from peripheral plasma C-peptide concentrations by nonparametric stochastic deconvolution

Laurenti, M. C., Vella, A., Varghese, R. T., Andrews, J. C., Sharma, A., Kittah, N. E., Rizza, R. A., Matveyenko, A. V., De Nicolao, G., Cobelli, C. & Dalla Man, C., May 1 2019, In : American journal of physiology. Endocrinology and metabolism. 316, 5, p. E687-E694

Research output: Contribution to journalArticle

C-Peptide
Insulin
Hepatic Veins
Type 2 Diabetes Mellitus
Liver

Association between allelic variants in the glucagon-like peptide 1 and cholecystokinin receptor genes with gastric emptying and glucose tolerance

Anderson, B., Carlson, P., Laurenti, M., Vella, A., Camilleri, M., Desai, A., Feuerhak, K. & Bharucha, A. E., Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13724.

Research output: Contribution to journalArticle

Cholecystokinin Receptors
Gastric Emptying
T Cell Transcription Factor 1
Glucose
Glucagon-Like Peptide 1
1 Citation (Scopus)

Contribution of endogenous glucagon-like peptide-1 to changes in glucose metabolism and islet function in people with type 2 diabetes four weeks after Roux-en-Y gastric bypass (RYGB)

Shah, M., Laurenti, M. C., Dalla Man, C., Ma, J., Cobelli, C., Rizza, R. A. & Vella, A., Apr 1 2019, In : Metabolism: Clinical and Experimental. 93, p. 10-17 8 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Gastric Bypass
Type 2 Diabetes Mellitus
Glucose
Insulin

Letter to the Editor: "Defects in GLP-1 Response to an Oral Challenge Do Not Play a Significant Role in the Pathogenesis of Prediabetes"

Smushkin, G., Sathananthan, A., Man, C. D., Camilleri, M., Cobelli, C., Rizza, R. A. & Vella, A., Nov 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 11, p. 5106-5107 2 p.

Research output: Contribution to journalArticle

Prediabetic State
Glucagon-Like Peptide 1
Defects
2 Citations (Scopus)

Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator

Vella, A., Freeman, J. L. R., Dunn, I., Keller, K., Buse, J. B. & Valcarce, C., Jan 16 2019, In : Science Translational Medicine. 11, 475, eaau3441.

Research output: Contribution to journalArticle

Glucokinase
Hypoglycemia
Liver
Type 2 Diabetes Mellitus
Placebos
Glucokinase
Type 2 Diabetes Mellitus
Liver
Therapeutics
Safety
1 Citation (Scopus)

What is type 2 diabetes?

Hurtado, M. D. & Vella, A., Jan 1 2019, In : Medicine (United Kingdom). 47, 1, p. 10-15 6 p.

Research output: Contribution to journalReview article

Type 2 Diabetes Mellitus
Hyperglycemia
Glucose
Fasting
Peripheral Nervous System Diseases
2018
3 Citations (Scopus)

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose

Karanth, S., Adams, J. D., Serrano, M. D. L. A., Quittner-Strom, E. B., Simcox, J., Villanueva, C. J., Ozcan, L., Holland, W. L., Yost, H. J., Vella, A. & Schlegel, A., Jul 10 2018, In : Cell Reports. 24, 2, p. 312-319 8 p.

Research output: Contribution to journalArticle

Glucagon
Liver
Hepatocytes
Fasting
Glucose
1 Citation (Scopus)

A novel triple-tracer approach to assess postprandial protein turnover

Moran, A., Toffolo, G., Schiavon, M., Vella, A., Klaus, K., Cobelli, C. & Nair, K. S., Oct 1 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 4, p. E469-E477

Research output: Contribution to journalArticle

Phenylalanine
Proteins
Meals
Blood Proteins
Proteome
2 Citations (Scopus)

Deficient Glucagon Response to Hypoglycemia during a Mixed Meal in Total Pancreatectomy/Islet Autotransplantation Recipients

Bogachus, L. D., Bellin, M. D., Vella, A. & Paul Robertson, R., Apr 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 4, p. 1522-1529 8 p.

Research output: Contribution to journalArticle

Pancreatectomy
Autologous Transplantation
Glucagon
Hypoglycemia
Meals
13 Citations (Scopus)

First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes

Cousminer, D. L., Ahlqvist, E., Mishra, R., Andersen, M. K., Chesi, A., Hawa, M. I., Davis, A., Hodge, K. M., Bradfield, J. P., Zhou, K., Guy, V. C., Akerlund, M., Wod, M., Fritsche, L. G., Vestergaard, H., Snyder, J., Højlund, K., Linneberg, A., Käräjämäki, A., Brandslund, I. & 33 others, Kim, C. E., Witte, D., Sørgjerd, E. P., Brillon, D. J., Pedersen, O., Beck-Nielsen, H., Grarup, N., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Melander, O., Harris, R. I., Varvel, S., Grill, V. E. R., Hakonarson, H., Froguel, P., Lonsdale, J. T., Mauricio, D., Schloot, N. C., Khunti, K., Greenbaum, C. J., Asvold, B. O., Yderstræde, K. B., Pearson, E. R., Schwartz, S., Voight, B. F., Hansen, T., Tuomi, T., Boehm, B. O., Groop, L., David Leslie, R. & Grant, S. F. A., Nov 1 2018, In : Diabetes Care. 41, 11, p. 2396-2403 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Population Control
Latent Autoimmune Diabetes in Adults
16 Citations (Scopus)

Hypoglycemia after gastric bypass surgery: Current concepts and controversies

Salehi, M., Vella, A., McLaughlin, T. & Patti, M. E., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 8, p. 2815-2826 12 p.

Research output: Contribution to journalReview article

Gastric Bypass
Hypoglycemia
Surgery
Accidents
Physicians
6 Citations (Scopus)

Impaired insulin action is associated with increased glucagon concentrations in nondiabetic humans

Sharma, A., Varghese, R. T., Shah, M., Man, C. D., Cobelli, C., Rizza, R. A., Bailey, K. R. & Vella, A., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 1, p. 314-319 6 p.

Research output: Contribution to journalArticle

Glucagon
Insulin
Nonesterified Fatty Acids
Fasting
Heparin
51 Citations (Scopus)

Lifestyle Intervention and Medical Management With vs Without Roux-en-Y Gastric Bypass and Control of Hemoglobin A1c, LDL Cholesterol, and Systolic Blood Pressure at 5 Years in the Diabetes Surgery Study

Ikramuddin, S., Korner, J., Lee, W. J., Thomas, A. J., Connett, J. E., Bantle, J. P., Leslie, D. B., Wang, Q., Inabnet, W. B., Jeffery, R. W., Chong, K., Chuang, L. M., Jensen, M. D., Vella, A., Ahmed, L., Belani, K. & Billington, C. J., Jan 16 2018, In : JAMA. 319, 3, p. 266-278 13 p.

Research output: Contribution to journalComment/debate

Gastric Bypass
LDL Cholesterol
Life Style
Hemoglobins
Blood Pressure
1 Citation (Scopus)

Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function

Ruetten, H., Gebauer, M., Raymond, R. H., Calle, R. A., Cobelli, C., Ghosh, A., Robertson, R. P., Shankar, S. S., Staten, M. A., Stefanovski, D., Vella, A., Wright, K. & Fryburg, D. A., Oct 1 2018, In : Metabolic Syndrome and Related Disorders. 16, 8, p. 406-415 10 p.

Research output: Contribution to journalArticle

Incretins
Meals
Arginine
Glucagon-Like Peptide 1
Glucose

Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function

Foundation for the NIH Biomarkers Consortium Beta Cell Project Team, Jun 1 2018, In : Contemporary Clinical Trials Communications. 10, p. 94-99 6 p.

Research output: Contribution to journalArticle

Meals
Arginine
Inpatients
Outpatients
Budgets
2 Citations (Scopus)

Performance of individually measured vs population-based C-peptide kinetics to assess β-cell function in the presence and absence of acute insulin resistance

Varghese, R. T., Dalla Man, C., Laurenti, M. C., Piccinini, F., Sharma, A., Shah, M., Bailey, K. R., Rizza, R. A., Cobelli, C. & Vella, A., Mar 1 2018, In : Diabetes, Obesity and Metabolism. 20, 3, p. 549-555 7 p.

Research output: Contribution to journalArticle

C-Peptide
Insulin Resistance
Population
Glucose Tolerance Test
Somatostatin

Walking a fine line between -cell secretion and proliferation

Vella, A. & Matveyenko, A. V., Jan 1 2018, In : Journal of Biological Chemistry. 293, 36, p. 14190-14191 2 p.

Research output: Contribution to journalArticle

Medical problems
Type 2 Diabetes Mellitus
Cell Proliferation
Insulin
Phenotype
2 Citations (Scopus)

What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us about the Pathogenesis of Type 2 Diabetes?

Adams, J. D. & Vella, A., Oct 1 2018, In : Metabolic Syndrome and Related Disorders. 16, 8, p. 383-389 7 p.

Research output: Contribution to journalReview article

T Cell Transcription Factor 1
Type 2 Diabetes Mellitus
Hyperglycemia
Insulin Resistance
Insulin
4 Citations (Scopus)
Upper Gastrointestinal Tract
Endocrine System
Bariatric Surgery
Gastrointestinal Tract
Weights and Measures
2017

Anthropometric features are not predictive of 72-hour fast duration in insulinomas

Donegan, D., Jakubikova, I. & Vella, A., Aug 1 2017, In : Endocrine Practice. 23, 8, p. 923-928 6 p.

Research output: Contribution to journalArticle

Insulinoma
C-Peptide
Hypoglycemia
Neoplasms
Proinsulin
3 Citations (Scopus)

Deficient Endogenous Glucose Production During Exercise After Total Pancreatectomy/Islet Autotransplantation

Bogachus, L. D., Oseid, E., Bellin, M., Vella, A. & Robertson, R. P., Sep 1 2017, In : The Journal of clinical endocrinology and metabolism. 102, 9, p. 3288-3295 8 p.

Research output: Contribution to journalArticle

Pancreatectomy
Autologous Transplantation
Exercise
Glucose
Exercise equipment
25 Citations (Scopus)

Effects of liraglutide on weight, satiation, and gastric functions in obesity: a randomised, placebo-controlled pilot trial

Halawi, H., Khemani, D., Eckert, D., O'Neill, J., Kadouh, H., Grothe, K., Clark, M. M., Burton, D. D., Vella, A., Acosta, A., Zinsmeister, A. R. & Camilleri, M., Dec 1 2017, In : The Lancet Gastroenterology and Hepatology. 2, 12, p. 842-843 2 p.

Research output: Contribution to journalArticle

Satiation
Stomach
Obesity
Placebos
Weights and Measures
1 Citation (Scopus)

Exocrine and endocrine interactions in cystic fibrosis: A potential key to understanding insulin secretion in health and disease?

Cobelli, C. & Vella, A., Jan 1 2017, In : Diabetes. 66, 1, p. 20-22 3 p.

Research output: Contribution to journalComment/debate

Cystic Fibrosis
Insulin
Health
10 Citations (Scopus)

Glucose metabolism during rotational shift-work in healthcare workers

Sharma, A., Laurenti, M. C., Dalla Man, C., Varghese, R. T., Cobelli, C., Rizza, R. A., Matveyenko, A. V. & Vella, A., Aug 1 2017, In : Diabetologia. 60, 8, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

Delivery of Health Care
Glucose
Cross-Over Studies
Meals
Insulin
3 Citations (Scopus)

Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146

Lu, J., Varghese, R. T., Zhou, L., Vella, A. & Jensen, M. D., Mar 1 2017, In : Metabolism: Clinical and Experimental. 68, p. 55-63 9 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Glucose Tolerance Test
Glucose
Fasting
Monounsaturated Fatty Acids
2 Citations (Scopus)

Obstacles to translating genotype-phenotype correlates in metabolic disease

Sharma, A. & Vella, A., Jan 1 2017, In : Physiology. 32, 1, p. 42-50 9 p.

Research output: Contribution to journalReview article

Metabolic Diseases
Type 2 Diabetes Mellitus
Genotype
Phenotype
Therapeutics
8 Citations (Scopus)

Pathogenesis and management of hypoglycemia

Kittah, N. E. & Vella, A., Jul 1 2017, In : European Journal of Endocrinology. 177, 1, p. R37-R47

Research output: Contribution to journalReview article

Hypoglycemia
Insulinoma
Glucose
Meals
Insulin
Insulinoma
Hypoglycemia
Calcium
Liver
Neoplasm Metastasis

The Currency of Science

Vella, A., Oct 1 2017, In : Metabolic Syndrome and Related Disorders. 15, 8, p. 385-386 2 p.

Research output: Contribution to journalEditorial

8 Citations (Scopus)

The Gastrointestinal Tract as an Integrator of Mechanical and Hormonal Response to Nutrient Ingestion

Vella, A. & Camilleri, M., Nov 1 2017, In : Diabetes. 66, 11, p. 2729-2737 9 p.

Research output: Contribution to journalReview article

Gastrointestinal Tract
Eating
Glucose
Food
Meals
17 Citations (Scopus)

Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults

Newhouse, L. P., Joyner, M. J., Curry, T. B., Laurenti, M. C., Man, C. D., Cobelli, C., Vella, A. & Limberg, J. K., Jan 1 2017, In : Physiological Reports. 5, 1, e13106.

Research output: Contribution to journalArticle

Glucose
Sleep Apnea Syndromes
Insulin Resistance
Glucose Tolerance Test
Hypoxia
2016
7 Citations (Scopus)

A Model for the Estimation of Hepatic Insulin Extraction after a Meal

Piccinini, F., Dalla Man, C., Vella, A. & Cobelli, C., Sep 1 2016, In : IEEE Transactions on Biomedical Engineering. 63, 9, p. 1925-1932 8 p., 7347364.

Research output: Contribution to journalArticle

Insulin
Glucose
Kinetics
Peptides
Plasmas
11 Citations (Scopus)

Diabetes-associated variation in TCF7L2 is not associated with hepatic or extrahepatic insulin resistance

Varghese, R. T., Viegas, I., Barosa, C., Marques, C., Shah, M., Rizza, R. A., Jones, J. G. & Vella, A., Apr 1 2016, In : Diabetes. 65, 4, p. 887-892 6 p.

Research output: Contribution to journalArticle

Insulin Resistance
Glucose
Liver
Insulin
Gluconeogenesis
35 Citations (Scopus)

Durability of addition of Roux-en-Y Gastric Bypass to lifestyle intervention and medical management in achieving primary treatment goals for uncontrolled type 2 diabetes in mild to moderate obesity: A randomized control trial

Ikramuddin, S., Korner, J., Lee, W. J., Bantle, J. P., Thomas, A. J., Connett, J. E., Leslie, D. B., Inabnet, W. B., Wang, Q., Jeffery, R. W., Chong, K., Chuang, L. M., Jensen, M. D., Vella, A., Ahmed, L., Belani, K., Olofson, A. E., Bainbridge, H. A. & Billington, C. J., Sep 1 2016, In : Diabetes Care. 39, 9, p. 1510-1518 9 p.

Research output: Contribution to journalArticle

Gastric Bypass
Type 2 Diabetes Mellitus
Life Style
Obesity
Therapeutics
3 Citations (Scopus)

Eulogy for the metabolic clinical investigator?

Vella, A., Jensen, M. D. & Nair, K. S., Oct 1 2016, In : Diabetes. 65, 10, p. 2821-2823 3 p.

Research output: Contribution to journalEditorial

3 Citations (Scopus)

Mechanisms underlying the pathogenesis of isolated impaired glucose tolerance in humans

Varghese, R. T., Man, C. D., Sharma, A., Viegas, I., Barosa, C., Marques, C., Shah, M., Miles, J. M., Rizza, R. A., Jones, J. G., Cobelli, C. & Vella, A., Dec 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4816-4824 9 p.

Research output: Contribution to journalArticle

Glucose Intolerance
Glucose
Fasting
Clamping devices
Glucose Clamp Technique
5 Citations (Scopus)

Model-Based Quantification of Glucagon-Like Peptide-1-Induced Potentiation of Insulin Secretion in Response to a Mixed Meal Challenge

Dalla Man, C., Micheletto, F., Sathananthan, M., Vella, A. & Cobelli, C., Jan 1 2016, In : Diabetes Technology and Therapeutics. 18, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Meals
Insulin
Glucose
Eating
3 Citations (Scopus)

National Differences in Remission of Type 2 Diabetes Mellitus After Roux-en-Y Gastric Bypass Surgery-Subgroup Analysis of 2-Year Results of the Diabetes Surgery Study Comparing Taiwanese with Americans with Mild Obesity (BMI 30–35 kg/m2)

Chong, K., Ikramuddin, S., Lee, W. J., Billington, C. J., Bantle, J. P., Wang, Q., Thomas, A. J., Connett, J. E., Leslie, D. B., Inabnet, W. B., Jeffery, R. W., Sarr, M. G., Jensen, M. D., Vella, A., Ahmed, L., Belani, K., Schone, J. L., Olofson, A. E., Bainbridge, H. A., Laqua, P. S. & 2 others, Korner, J. & Chuang, L. M., Oct 25 2016, (Accepted/In press) In : Obesity Surgery. p. 1-7 7 p.

Research output: Contribution to journalArticle

Gastric Bypass
Type 2 Diabetes Mellitus
Obesity
C-Peptide
Taiwan
13 Citations (Scopus)

Standardized mixed-meal tolerance and arginine stimulation tests provide reproducible and complementary measures of β-cell function: Results from the foundation for the national institutes of health biomarkers consortium investigative series

Shankar, S. S., Vella, A., Raymond, R. H., Staten, M. A., Calle, R. A., Bergman, R. N., Cao, C., Chen, D., Cobelli, C., Man, C. D., Deeg, M., Dong, J. Q., Lee, D. S., Polidori, D., Robertson, R. P., Ruetten, H., Stefanovski, D., Vassileva, M. T., Weir, G. C. & Fryburg, D. A., Sep 1 2016, In : Diabetes Care. 39, 9, p. 1602-1613 12 p.

Research output: Contribution to journalArticle

National Institutes of Health (U.S.)
Meals
Arginine
Biomarkers
Insulin
21 Citations (Scopus)

TCF7L2 genotype and α-cell function in humans without diabetes

Shah, M., Varghese, R. T., Miles, J. M., Piccinini, F., Dalla Man, C., Cobelli, C., Bailey, K. R., Rizza, R. A. & Vella, A., Feb 1 2016, In : Diabetes. 65, 2, p. 371-380 10 p.

Research output: Contribution to journalArticle

Alleles
Genotype
Insulin
Glucagon
Nonesterified Fatty Acids
3 Citations (Scopus)

Understanding diabetes mellitus: Pathophysiology

Shah, M. & Vella, A., Jan 1 2016, Metabolic Syndrome and Diabetes: Medical and Surgical Management. Springer New York, p. 33-45 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Diabetes Mellitus
2015
9 Citations (Scopus)

Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents

Javed, A., Balagopal, P. B., Vella, A., Fischer, P. R., Piccinini, F., Dalla Man, C., Cobelli, C., Giesler, P. D., Laugen, J. M. & Kumar, S., May 1 2015, In : Thyroid. 25, 5, p. 478-484 7 p.

Research output: Contribution to journalArticle

Thyrotropin
Insulin Resistance
Body Mass Index
Interleukin-6
Thyroid Gland
4 Citations (Scopus)

Association of UCP-3 rs1626521 with obesity and stomach functions in humans

Acosta, A., Camilleri, M., Shin, A., Vazquez Roque, M. I., Iturrino, J., Lanza, I. R., Nair, K. S., Burton, D., O'Neill, J., Eckert, D., Carlson, P., Vella, A. & Zinsmeister, A. R., Apr 1 2015, In : Obesity. 23, 4, p. 898-906 9 p.

Research output: Contribution to journalArticle

Stomach
Obesity
Body Weight
Genes
Meals
21 Citations (Scopus)

Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: A prospective double-blind randomized trial

Javed, A., Vella, A., Babu Balagopal, P., Fischer, P. R., Weaver, A. L., Piccinini, F., Man, C. D., Cobelli, C., Giesler, P. D., Laugen, J. M. & Kumar, S., 2015, In : Journal of Nutrition. 145, 2, p. 284-290 7 p.

Research output: Contribution to journalArticle

Cholecalciferol
Insulin
Vitamin D
Glucose
Vitamin D Deficiency

C-Terminal fragment of adiponectin receptor clinical correlations

Vella, A., Jan 1 2015, Inflammatory Pathways in Diabetes: Biomarkers and Clinical Correlates. Springer International Publishing, p. 111-126 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Adiponectin Receptors
Glucose
Medical problems
Immunosuppressive Agents
Glucose Tolerance Test
5 Citations (Scopus)

Defective Glucagon-Like Peptide 1 Secretion in Prediabetes and Type 2 Diabetes Is Influenced by Weight and Sex. Chicken, Egg, or None of the Above?

Vella, A. & Cobelli, C., Jul 1 2015, In : Diabetes. 64, 7, p. 2324-2325 2 p.

Research output: Contribution to journalArticle

Prediabetic State
Glucagon-Like Peptide 1
Type 2 Diabetes Mellitus
Ovum
Chickens
8 Citations (Scopus)

Impact of variant pancreatic arterial anatomy and overlap in regional perfusion on the interpretation of selective arterial calcium stimulation with hepatic venous sampling for preoperative localization of occult insulinoma

Thompson, S. M., Vella, A., Service, F. J., Grant, C. S., Thompson, G. B. & Andrews, J. C., 2015, In : Surgery (United States). 158, 1, p. 162-172 11 p.

Research output: Contribution to journalArticle

Insulinoma
Anatomy
Perfusion
Calcium
Liver
26 Citations (Scopus)

Preserved insulin secretory capacity and weight loss are the predominant predictors of glycemic control in patients with type 2 diabetes randomized to roux-en-y gastric bypass

Nguyen, K. T., Billington, C. J., Vella, A., Wang, Q., Ahmed, L., Bantle, J. P., Bessler, M., Connett, J. E., Inabnet, W. B., Thomas, A., Ikramuddin, S. & Korner, J., Sep 1 2015, In : Diabetes. 64, 9, p. 3104-3110 7 p.

Research output: Contribution to journalArticle

Gastric Bypass
Type 2 Diabetes Mellitus
Weight Loss
Insulin
Life Style