• 7324 Citations
  • 43 Scopus h-Index
19962020

Research output per year

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Research Output

2020

Fasting glucagon concentrations are associated with longitudinal decline of β-cell function in non-diabetic humans

Adams, J. D., Dalla Man, C., Laurenti, M. C., Andrade, M. D. H., Cobelli, C., Rizza, R. A., Bailey, K. R. & Vella, A., Apr 2020, In : Metabolism: Clinical and Experimental. 105, 154175.

Research output: Contribution to journalArticle

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., McCready, L. K., Rizza, R. A., Matveyenko, A., Kassem, M., Andersen, T. L., Vella, A., Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., Dec 1 2020, In : Nature communications. 11, 1, 87.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Assessment of pulsatile insulin secretion derived from peripheral plasma C-peptide concentrations by nonparametric stochastic deconvolution

Laurenti, M. C., Vella, A., Varghese, R. T., Andrews, J. C., Sharma, A., Kittah, N. E., Rizza, R. A., Matveyenko, A. V., De Nicolao, G., Cobelli, C. & Dalla Man, C., May 1 2019, In : American journal of physiology. Endocrinology and metabolism. 316, 5, p. E687-E694

Research output: Contribution to journalArticle

Association between allelic variants in the glucagon-like peptide 1 and cholecystokinin receptor genes with gastric emptying and glucose tolerance

Anderson, B., Carlson, P., Laurenti, M., Vella, A., Camilleri, M., Desai, A., Feuerhak, K. & Bharucha, A. E., Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13724.

Research output: Contribution to journalArticle

1 Scopus citations

Contribution of endogenous glucagon-like peptide-1 to changes in glucose metabolism and islet function in people with type 2 diabetes four weeks after Roux-en-Y gastric bypass (RYGB)

Shah, M., Laurenti, M. C., Dalla Man, C., Ma, J., Cobelli, C., Rizza, R. A. & Vella, A., Apr 1 2019, In : Metabolism: Clinical and Experimental. 93, p. 10-17 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Letter to the Editor: "Defects in GLP-1 Response to an Oral Challenge Do Not Play a Significant Role in the Pathogenesis of Prediabetes"

Smushkin, G., Sathananthan, A., Man, C. D., Camilleri, M., Cobelli, C., Rizza, R. A. & Vella, A., Nov 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 11, p. 5106-5107 2 p.

Research output: Contribution to journalArticle

Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator

Vella, A., Freeman, J. L. R., Dunn, I., Keller, K., Buse, J. B. & Valcarce, C., Jan 16 2019, In : Science Translational Medicine. 11, 475, eaau3441.

Research output: Contribution to journalArticle

5 Scopus citations
1 Scopus citations

What is type 2 diabetes?

Hurtado, M. D. & Vella, A., Jan 1 2019, In : Medicine (United Kingdom). 47, 1, p. 10-15 6 p.

Research output: Contribution to journalReview article

1 Scopus citations
2018

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose

Karanth, S., Adams, J. D., Serrano, M. D. L. A., Quittner-Strom, E. B., Simcox, J., Villanueva, C. J., Ozcan, L., Holland, W. L., Yost, H. J., Vella, A. & Schlegel, A., Jul 10 2018, In : Cell Reports. 24, 2, p. 312-319 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

A novel triple-tracer approach to assess postprandial protein turnover

Moran, A., Toffolo, G., Schiavon, M., Vella, A., Klaus, K., Cobelli, C. & Nair, K. S., Oct 1 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 4, p. E469-E477

Research output: Contribution to journalArticle

2 Scopus citations

Deficient Glucagon Response to Hypoglycemia during a Mixed Meal in Total Pancreatectomy/Islet Autotransplantation Recipients

Bogachus, L. D., Bellin, M. D., Vella, A. & Paul Robertson, R., Apr 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 4, p. 1522-1529 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes

Cousminer, D. L., Ahlqvist, E., Mishra, R., Andersen, M. K., Chesi, A., Hawa, M. I., Davis, A., Hodge, K. M., Bradfield, J. P., Zhou, K., Guy, V. C., Akerlund, M., Wod, M., Fritsche, L. G., Vestergaard, H., Snyder, J., Højlund, K., Linneberg, A., Käräjämäki, A., Brandslund, I. & 33 others, Kim, C. E., Witte, D., Sørgjerd, E. P., Brillon, D. J., Pedersen, O., Beck-Nielsen, H., Grarup, N., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Melander, O., Harris, R. I., Varvel, S., Grill, V. E. R., Hakonarson, H., Froguel, P., Lonsdale, J. T., Mauricio, D., Schloot, N. C., Khunti, K., Greenbaum, C. J., Asvold, B. O., Yderstræde, K. B., Pearson, E. R., Schwartz, S., Voight, B. F., Hansen, T., Tuomi, T., Boehm, B. O., Groop, L., David Leslie, R. & Grant, S. F. A., Nov 1 2018, In : Diabetes care. 41, 11, p. 2396-2403 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hypoglycemia after gastric bypass surgery: Current concepts and controversies

Salehi, M., Vella, A., McLaughlin, T. & Patti, M. E., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 8, p. 2815-2826 12 p.

Research output: Contribution to journalReview article

24 Scopus citations

Impaired insulin action is associated with increased glucagon concentrations in nondiabetic humans

Sharma, A., Varghese, R. T., Shah, M., Man, C. D., Cobelli, C., Rizza, R. A., Bailey, K. R. & Vella, A., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 1, p. 314-319 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Lifestyle Intervention and Medical Management With vs Without Roux-en-Y Gastric Bypass and Control of Hemoglobin A1c, LDL Cholesterol, and Systolic Blood Pressure at 5 Years in the Diabetes Surgery Study

Ikramuddin, S., Korner, J., Lee, W. J., Thomas, A. J., Connett, J. E., Bantle, J. P., Leslie, D. B., Wang, Q., Inabnet, W. B., Jeffery, R. W., Chong, K., Chuang, L. M., Jensen, M. D., Vella, A., Ahmed, L., Belani, K. & Billington, C. J., Jan 16 2018, In : JAMA. 319, 3, p. 266-278 13 p.

Research output: Contribution to journalComment/debate

61 Scopus citations

Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function

Ruetten, H., Gebauer, M., Raymond, R. H., Calle, R. A., Cobelli, C., Ghosh, A., Robertson, R. P., Shankar, S. S., Staten, M. A., Stefanovski, D., Vella, A., Wright, K. & Fryburg, D. A., Oct 1 2018, In : Metabolic Syndrome and Related Disorders. 16, 8, p. 406-415 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function

Foundation for the NIH Biomarkers Consortium Beta Cell Project Team, Jun 1 2018, In : Contemporary Clinical Trials Communications. 10, p. 94-99 6 p.

Research output: Contribution to journalArticle

Performance of individually measured vs population-based C-peptide kinetics to assess β-cell function in the presence and absence of acute insulin resistance

Varghese, R. T., Dalla Man, C., Laurenti, M. C., Piccinini, F., Sharma, A., Shah, M., Bailey, K. R., Rizza, R. A., Cobelli, C. & Vella, A., Mar 1 2018, In : Diabetes, Obesity and Metabolism. 20, 3, p. 549-555 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Walking a fine line between -cell secretion and proliferation

Vella, A. & Matveyenko, A. V., Jan 1 2018, In : Journal of Biological Chemistry. 293, 36, p. 14190-14191 2 p.

Research output: Contribution to journalArticle

What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us about the Pathogenesis of Type 2 Diabetes?

Adams, J. D. & Vella, A., Oct 1 2018, In : Metabolic Syndrome and Related Disorders. 16, 8, p. 383-389 7 p.

Research output: Contribution to journalReview article

3 Scopus citations
6 Scopus citations
2017

Anthropometric features are not predictive of 72-hour fast duration in insulinomas

Donegan, D., Jakubikova, I. & Vella, A., Aug 1 2017, In : Endocrine Practice. 23, 8, p. 923-928 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Deficient Endogenous Glucose Production During Exercise After Total Pancreatectomy/Islet Autotransplantation

Bogachus, L. D., Oseid, E., Bellin, M., Vella, A. & Robertson, R. P., Sep 1 2017, In : The Journal of clinical endocrinology and metabolism. 102, 9, p. 3288-3295 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of liraglutide on weight, satiation, and gastric functions in obesity: a randomised, placebo-controlled pilot trial

Halawi, H., Khemani, D., Eckert, D., O'Neill, J., Kadouh, H., Grothe, K., Clark, M. M., Burton, D. D., Vella, A., Acosta, A., Zinsmeister, A. R. & Camilleri, M., Dec 1 2017, In : The Lancet Gastroenterology and Hepatology. 2, 12, p. 842-843 2 p.

Research output: Contribution to journalArticle

33 Scopus citations

Exocrine and endocrine interactions in cystic fibrosis: A potential key to understanding insulin secretion in health and disease?

Cobelli, C. & Vella, A., Jan 1 2017, In : Diabetes. 66, 1, p. 20-22 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Glucose metabolism during rotational shift-work in healthcare workers

Sharma, A., Laurenti, M. C., Dalla Man, C., Varghese, R. T., Cobelli, C., Rizza, R. A., Matveyenko, A. V. & Vella, A., Aug 1 2017, In : Diabetologia. 60, 8, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146

Lu, J., Varghese, R. T., Zhou, L., Vella, A. & Jensen, M. D., Mar 1 2017, In : Metabolism: Clinical and Experimental. 68, p. 55-63 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Obstacles to translating genotype-phenotype correlates in metabolic disease

Sharma, A. & Vella, A., Jan 1 2017, In : Physiology. 32, 1, p. 42-50 9 p.

Research output: Contribution to journalReview article

3 Scopus citations

Pathogenesis and management of hypoglycemia

Kittah, N. E. & Vella, A., Jul 1 2017, In : European Journal of Endocrinology. 177, 1, p. R37-R47

Research output: Contribution to journalReview article

11 Scopus citations

Selective arterial calcium stimulation with hepatic venous sampling in immune-mediated hypoglycemia

Thompson, S. M., Vella, A., Service, F. J. & Andrews, J. C., Jan 1 2017, In : Journal of the Endocrine Society. 1, 6, p. 671-675 5 p.

Research output: Contribution to journalArticle

Open Access

The Currency of Science

Vella, A., Oct 1 2017, In : Metabolic Syndrome and Related Disorders. 15, 8, p. 385-386 2 p.

Research output: Contribution to journalEditorial

The Gastrointestinal Tract as an Integrator of Mechanical and Hormonal Response to Nutrient Ingestion

Vella, A. & Camilleri, M., Nov 1 2017, In : Diabetes. 66, 11, p. 2729-2737 9 p.

Research output: Contribution to journalReview article

10 Scopus citations

Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults

Newhouse, L. P., Joyner, M. J., Curry, T. B., Laurenti, M. C., Man, C. D., Cobelli, C., Vella, A. & Limberg, J. K., Jan 1 2017, In : Physiological Reports. 5, 1, e13106.

Research output: Contribution to journalArticle

18 Scopus citations
2016

A Model for the Estimation of Hepatic Insulin Extraction after a Meal

Piccinini, F., Dalla Man, C., Vella, A. & Cobelli, C., Sep 1 2016, In : IEEE Transactions on Biomedical Engineering. 63, 9, p. 1925-1932 8 p., 7347364.

Research output: Contribution to journalArticle

9 Scopus citations

Diabetes-associated variation in TCF7L2 is not associated with hepatic or extrahepatic insulin resistance

Varghese, R. T., Viegas, I., Barosa, C., Marques, C., Shah, M., Rizza, R. A., Jones, J. G. & Vella, A., Apr 1 2016, In : Diabetes. 65, 4, p. 887-892 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Durability of addition of Roux-en-Y Gastric Bypass to lifestyle intervention and medical management in achieving primary treatment goals for uncontrolled type 2 diabetes in mild to moderate obesity: A randomized control trial

Ikramuddin, S., Korner, J., Lee, W. J., Bantle, J. P., Thomas, A. J., Connett, J. E., Leslie, D. B., Inabnet, W. B., Wang, Q., Jeffery, R. W., Chong, K., Chuang, L. M., Jensen, M. D., Vella, A., Ahmed, L., Belani, K., Olofson, A. E., Bainbridge, H. A. & Billington, C. J., Sep 1 2016, In : Diabetes Care. 39, 9, p. 1510-1518 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Eulogy for the metabolic clinical investigator?

Vella, A., Jensen, M. D. & Nair, K. S., Oct 1 2016, In : Diabetes. 65, 10, p. 2821-2823 3 p.

Research output: Contribution to journalEditorial

4 Scopus citations

Mechanisms underlying the pathogenesis of isolated impaired glucose tolerance in humans

Varghese, R. T., Man, C. D., Sharma, A., Viegas, I., Barosa, C., Marques, C., Shah, M., Miles, J. M., Rizza, R. A., Jones, J. G., Cobelli, C. & Vella, A., Dec 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4816-4824 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Model-Based Quantification of Glucagon-Like Peptide-1-Induced Potentiation of Insulin Secretion in Response to a Mixed Meal Challenge

Dalla Man, C., Micheletto, F., Sathananthan, M., Vella, A. & Cobelli, C., Jan 1 2016, In : Diabetes Technology and Therapeutics. 18, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

National Differences in Remission of Type 2 Diabetes Mellitus After Roux-en-Y Gastric Bypass Surgery-Subgroup Analysis of 2-Year Results of the Diabetes Surgery Study Comparing Taiwanese with Americans with Mild Obesity (BMI 30–35 kg/m2)

Chong, K., Ikramuddin, S., Lee, W. J., Billington, C. J., Bantle, J. P., Wang, Q., Thomas, A. J., Connett, J. E., Leslie, D. B., Inabnet, W. B., Jeffery, R. W., Sarr, M. G., Jensen, M. D., Vella, A., Ahmed, L., Belani, K., Schone, J. L., Olofson, A. E., Bainbridge, H. A., Laqua, P. S. & 2 others, Korner, J. & Chuang, L. M., Oct 25 2016, (Accepted/In press) In : Obesity Surgery. p. 1-7 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Standardized mixed-meal tolerance and arginine stimulation tests provide reproducible and complementary measures of β-cell function: Results from the foundation for the national institutes of health biomarkers consortium investigative series

Shankar, S. S., Vella, A., Raymond, R. H., Staten, M. A., Calle, R. A., Bergman, R. N., Cao, C., Chen, D., Cobelli, C., Man, C. D., Deeg, M., Dong, J. Q., Lee, D. S., Polidori, D., Robertson, R. P., Ruetten, H., Stefanovski, D., Vassileva, M. T., Weir, G. C. & Fryburg, D. A., Sep 1 2016, In : Diabetes Care. 39, 9, p. 1602-1613 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

TCF7L2 genotype and α-cell function in humans without diabetes

Shah, M., Varghese, R. T., Miles, J. M., Piccinini, F., Dalla Man, C., Cobelli, C., Bailey, K. R., Rizza, R. A. & Vella, A., Feb 1 2016, In : Diabetes. 65, 2, p. 371-380 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Understanding diabetes mellitus: Pathophysiology

Shah, M. & Vella, A., Jan 1 2016, Metabolic Syndrome and Diabetes: Medical and Surgical Management. Springer New York, p. 33-45 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2015

Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents

Javed, A., Balagopal, P. B., Vella, A., Fischer, P. R., Piccinini, F., Dalla Man, C., Cobelli, C., Giesler, P. D., Laugen, J. M. & Kumar, S., May 1 2015, In : Thyroid. 25, 5, p. 478-484 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Association of UCP-3 rs1626521 with obesity and stomach functions in humans

Acosta, A., Camilleri, M., Shin, A., Vazquez-Roque, M. I., Iturrino, J., Lanza, I. R., Nair, K. S., Burton, D., O'Neill, J., Eckert, D., Carlson, P., Vella, A. & Zinsmeister, A. R., Apr 1 2015, In : Obesity. 23, 4, p. 898-906 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Bariatric Surgery and Diabetes

Ikramuddin, S., Korner, J., Lee, W. J., Connett, J. E., Inabnet, W. B., Billington, C. J., Thomas, A. J., Leslie, D. B., Chong, K., Jeffery, R. W., Ahmed, L., Vella, A., Chuang, L. M., Bessler, M., Sarr, M. G., Swain, J. M., Laqua, P., Jensen, M. D. & Bantle, J. P., Feb 1 2015, In : Diabetes Technology and Therapeutics. 17, p. S76-S79

Research output: Contribution to journalComment/debate

1 Scopus citations

Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: A prospective double-blind randomized trial

Javed, A., Vella, A., Babu Balagopal, P., Fischer, P. R., Weaver, A. L., Piccinini, F., Man, C. D., Cobelli, C., Giesler, P. D., Laugen, J. M. & Kumar, S., 2015, In : Journal of Nutrition. 145, 2, p. 284-290 7 p.

Research output: Contribution to journalArticle

22 Scopus citations