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1976 …2020
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Research Output 1988 2019

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Article
2019

Anorectal pressures measured with high-resolution manometry in healthy people—Normal values and asymptomatic pelvic floor dysfunction

Oblizajek, N. R., Gandhi, S., Sharma, M., Chakraborty, S., Muthyala, A., Prichard, D., Feuerhak, K. & Bharucha, A. E., Jan 1 2019, In : Neurogastroenterology and Motility. e13597.

Research output: Contribution to journalArticle

Pelvic Floor
Manometry
Pressure
Reference Values
Fecal Incontinence

Association between allelic variants in the glucagon-like peptide 1 and cholecystokinin receptor genes with gastric emptying and glucose tolerance

Anderson, B., Carlson, P., Laurenti, M., Vella, A., Camilleri, M., Desai, A., Feuerhak, K. & Bharucha, A. E., Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13724.

Research output: Contribution to journalArticle

Cholecystokinin Receptors
Gastric Emptying
T Cell Transcription Factor 1
Glucose
Glucagon-Like Peptide 1
1 Citation (Scopus)

Comparison of changes in rectal area and volume during MR evacuation proctography in healthy and constipated adults

Puthanmadhom Narayanan, S., Sharma, M., Fletcher, J. G., Karwoski, R. A., Holmes, D. R. & Bharucha, A. E., Jan 1 2019, In : Neurogastroenterology and Motility. e13608.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Rectocele
Software
Gels
2 Citations (Scopus)

Diabetic Gastroparesis

Bharucha, A. E., Kudva, Y. C. & Prichard, D. O., Oct 1 2019, In : Endocrine reviews. 40, 5, p. 1318-1352 35 p.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
Dyspepsia
Ghrelin Receptor
Gastric Outlet Obstruction
2 Citations (Scopus)
Adrenergic Antagonists
Habits
Placebos
Pressure
Constipation

Effects of psychosensory stimulation on anal pressures: Effects of alfuzosin

Muthyala, A., Feuerhak, K. J., Harmsen, W. S., Chakraborty, S., Bailey, K. R. & Bharucha, A. E., Jan 1 2019, In : Neurogastroenterology and Motility. e13618.

Research output: Contribution to journalArticle

Pressure
Stroop Test
Placebos
alfuzosin
Intelligence Tests
3 Citations (Scopus)

GI Dysfunctions in Diabetic Gastroenteropathy, Their Relationships With Symptoms, and Effects of a GLP-1 Antagonist

Chakraborty, S., Halland, M., Burton, D., Desai, A., Neja, B., Low, P. A., Singer, W., Camilleri, M., Zinsmeister, A. R. & Bharucha, A. E., Jun 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 6, p. 1967-1977 11 p.

Research output: Contribution to journalArticle

Gastric Emptying
Lipids
Peptides
Small Intestine
Medical problems
1 Citation (Scopus)

Relationship between symptoms during a gastric emptying study and intestinal chemosensitivity with daily symptoms

Chakraborty, S., Desai, A., Halland, M., Burton, D., Camilleri, M., Zinsmeister, A. R. & Bharucha, A. E., Jan 1 2019, In : Neurogastroenterology and Motility. e13686.

Research output: Contribution to journalArticle

Gastric Emptying
Dyspepsia
Lipids
Glucagon-Like Peptide 1
Symptom Assessment

The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function

All members of the International Anorectal Physiology Working Group, Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13679.

Research output: Contribution to journalArticle

Open Access
Rectal Diseases
Consensus
Manometry
Gastroenterology
Ataxia

Utility of the plasma pancreatic polypeptide response to modified sham feeding in diabetic gastroenteropathy and non-ulcer dyspepsia

Desai, A., Low, P. A., Camilleri, M., Singer, W., Burton, D., Chakraborty, S. & Bharucha, A. E., Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13744.

Research output: Contribution to journalArticle

Pancreatic Polypeptide
Dyspepsia
Gastric Emptying
Hyperglycemia
2018
4 Citations (Scopus)

Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

Lee, T. H., Setty, P. T., Parthasarathy, G., Bailey, K. R., Wood-Wentz, C. M., Fletcher, J. G., Takahashi, N. M., Khosla, S., Moynagh, M. R., Zinsmeister, A. R. & Bharucha, A. E., Sep 1 2018, In : Mayo Clinic Proceedings. 93, 9, p. 1256-1265 10 p.

Research output: Contribution to journalArticle

Diverticulitis
Obesity
Incidence
Body Mass Index
Population
1 Citation (Scopus)

A pharmacological challenge predicts reversible rectal sensorimotor dysfunctions in women with fecal incontinence

Sharma, M., Feuerhak, K., Zinsmeister, A. R. & Bharucha, A. E., Oct 1 2018, In : Neurogastroenterology and Motility. 30, 10, e13383.

Research output: Contribution to journalArticle

Fecal Incontinence
Clonidine
Atropine
Pharmacology
Compliance
11 Citations (Scopus)

Normal values for assessment of anal sphincter morphology, anorectal motion, and pelvic organ prolapse with MRI in healthy women

Tirumanisetty, P., Prichard, D., Fletcher, J. G., Chakraborty, S., Zinsmeister, A. R. & Bharucha, A. E., Jan 1 2018, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Pelvic Organ Prolapse
Anal Canal
Parity
Reference Values
Defecation
2 Citations (Scopus)

Painful and Painless Constipation: All Roads Lead to (A Change in) Rome

Bharucha, A. E. & Sharma, M., Mar 21 2018, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-4 4 p.

Research output: Contribution to journalArticle

Constipation
1 Citation (Scopus)

Relationship between symptoms and quality of life in fecal incontinence

Bedard, K., Heymen, S., Palsson, O. S., Bharucha, A. E. & Whitehead, W. E., Mar 1 2018, In : Neurogastroenterology and Motility. 30, 3, e13241.

Research output: Contribution to journalArticle

Fecal Incontinence
Quality of Life
Confidence Intervals
Linear Models
Gases
6 Citations (Scopus)

Reproducibility of gastric emptying assessed with scintigraphy in patients with upper GI symptoms

Desai, A., O'Connor, M., Neja, B., Delaney, K., Camilleri, M., Zinsmeister, A. R. & Bharucha, A. E., Jan 1 2018, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Gastric Emptying
Radionuclide Imaging
Gastroparesis
Meals
Stomach
1 Citation (Scopus)

Transforming the Activation of Clinical Trials

Watters, J. T., Pitzen, J. H., Sanders, L. J., Bruce, V. N. M., Cornell, A. R., Cseko, G. C., Grace, J. S., Kwon, P. S., Kukla, A. K., Lee, M. S., Monosmith, M. D., Myren, J. D., Kottschade, R. S., Shaft, M. N., Weis, J. J. A., Welter, J. C. & Bharucha, A. E., Jan 1 2018, In : Clinical Pharmacology and Therapeutics. 103, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Clinical Trials
United States Food and Drug Administration
Therapeutics
2017
5 Citations (Scopus)

Assessing the colonic microbiome, hydrogenogenic and hydrogenotrophic genes, transit and breath methane in constipation

Wolf, P. G., Parthasarathy, G., Chen, J., O'Connor, H. M., Chia, N. D., Bharucha, A. E. & Rex Gaskins, H., 2017, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Microbiota
Methane
Constipation
Hydrogensulfite Reductase
Genes
21 Citations (Scopus)

Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying

Hayashi, Y., Toyomasu, Y., Saravanaperumal, S. A., Bardsley, M. R., Smestad, J. A., Lorincz, A., Eisenman, S. T., Cipriani, G., Nelson Holte, M. H., Al Khazal, F. J., Syed, S. A., Gajdos, G. B., Choi, K. M., Stoltz, G. J., Miller, K. E., Kendrick, M. L., Rubin, B. P., Gibbons, S. J., Bharucha, A. E., Linden, D. R. & 3 others, Maher III, L. J., Farrugia, G. & Ordog, T., Aug 1 2017, In : Gastroenterology. 153, 2, p. 521-535.e20

Research output: Contribution to journalArticle

Interstitial Cells of Cajal
Gastric Emptying
Mitogen-Activated Protein Kinase 1
Hyperglycemia
Cell Lineage
21 Citations (Scopus)

Methods of anorectal manometry vary widely in clinical practice: Results from an international survey

The International Anorectal Physiology Working Party Group (IAPWG), Aug 1 2017, In : Neurogastroenterology and Motility. 29, 8, e13016.

Research output: Contribution to journalArticle

Manometry
Guidelines
Technology
Surveys and Questionnaires
Pressure
5 Citations (Scopus)

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

Zhong, J., Ye, Z., Lenz, S. W., Clark, C. R., Bharucha, A. E., Farrugia, G., Robertson, K. D., Zhang, Z., Ordog, T. & Lee, J. H., Dec 21 2017, In : BMC Genomics. 18, 1, 985.

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
DNA
Gene Library
Libraries
Buffers
15 Citations (Scopus)
Gastric Emptying
Medical problems
Type 1 Diabetes Mellitus
Glucose
Erythromycin
5 Citations (Scopus)

Reproducibility of assessing fecal microbiota in chronic constipation

Parthasarathy, G., Chen, J., Chia, N. D., O'Connor, H. M., Gaskins, H. R. & Bharucha, A. E., 2017, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Microbiota
Constipation
Healthy Volunteers
Laxatives
Energy Intake
8 Citations (Scopus)

Surgical Interventions and the Use of Device-Aided Therapy for the Treatment of Fecal Incontinence and Defecatory Disorders

Bharucha, A. E., Rao, S. S. C. & Shin, A. S., Dec 1 2017, In : Clinical Gastroenterology and Hepatology. 15, 12, p. 1844-1854 11 p.

Research output: Contribution to journalArticle

Fecal Incontinence
Practice Guidelines
Equipment and Supplies
Therapeutics
Colostomy
2016
88 Citations (Scopus)

Anorectal disorders

Rao, S. S. C., Bharucha, A. E., Chiarioni, G., Felt-Bersma, R., Knowles, C., Malcolm, A. & Wald, A., May 1 2016, In : Gastroenterology. 150, 6, p. 1430-1442e4

Research output: Contribution to journalArticle

Rectal Diseases
Fecal Incontinence
Defecation
Pain
Pelvic Floor
4 Citations (Scopus)

Determinants and clinical impact of pressure drift in manoscan anorectal high resolution manometry system

Parthasarathy, G., McMaster, J., Feuerhak, K., Zinsmeister, A. R. & Bharucha, A. E., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Manometry
Pressure
Catheters
Hot Temperature
Body Temperature
60 Citations (Scopus)

Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic defecation

Grossi, U., Carrington, E. V., Bharucha, A. E., Horrocks, E. J., Scott, S. M. & Knowles, C. H., Mar 1 2016, In : Gut. 65, 3, p. 447-455 9 p.

Research output: Contribution to journalArticle

Defecation
Manometry
Constipation
Healthy Volunteers
Ataxia
25 Citations (Scopus)

Diagnostic disagreement between tests of evacuatory function: a prospective study of 100 constipated patients

Palit, S., Thin, N., Knowles, C. H., Lunniss, P. J., Bharucha, A. E. & Scott, S. M., Oct 1 2016, In : Neurogastroenterology and Motility. 28, 10, p. 1589-1598 10 p.

Research output: Contribution to journalArticle

Manometry
Prospective Studies
Constipation
Therapeutics
23 Citations (Scopus)

Diaphragmatic breathing for rumination syndrome: Efficacy and mechanisms of action

Halland, M., Parthasarathy, G., Bharucha, A. E. & Katzka, D. A., Mar 1 2016, In : Neurogastroenterology and Motility. 28, 3, p. 384-391 8 p.

Research output: Contribution to journalArticle

Respiration
Esophagogastric Junction
Pressure
Upper Esophageal Sphincter
Manometry
15 Citations (Scopus)

Effect of pramlintide on postprandial glucose fluxes in type 1 diabetes

Hinshaw, L., Schiavon, M., Dadlani, V., Mallad, A., Dalla Man, C., Bharucha, A. E., Basu, R., Geske, J. R., Carter, R. E., Cobelli, C., Basu, A. & Kudva, Y. C., May 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 5, p. 1954-1962 9 p.

Research output: Contribution to journalArticle

Medical problems
Type 1 Diabetes Mellitus
Fluxes
Glucose
Area Under Curve
13 Citations (Scopus)

Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis

Bharucha, A. E., Daley, S. L., Low, P. A., Gibbons, S. J., Choi, K. M., Camilleri, M., Saw, J. J., Farrugia, G. & Zinsmeister, A. R., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Gastroparesis
Hemin
Heme Oxygenase-1
Gastric Emptying
Placebos
3 Citations (Scopus)

Evaluating the safety and the effects on colonic compliance of neostigmine during motility testing in patients with chronic constipation

Mouchli, M. A., Camilleri, M., Lee, T., Parthasarathy, G., Vijayvargiya, P., Halland, M., Acosta, A. & Bharucha, A. E., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Neostigmine
Constipation
Compliance
Safety
Vital Signs
22 Citations (Scopus)

High-resolution Anorectal Manometry for Identifying Defecatory Disorders and Rectal Structural Abnormalities in Women

Prichard, D. O., Lee, T., Parthasarathy, G., Fletcher, J. G., Zinsmeister, A. R. & Bharucha, A. E., 2016, (Accepted/In press) In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Rectal Diseases
Manometry
Rectal Prolapse
Prolapse
Pressure
36 Citations (Scopus)

How to perform and interpret a high-Resolution anorectal manometry test

Lee, T. H. & Bharucha, A. E., 2016, In : Journal of Neurogastroenterology and Motility. 22, 1, p. 46-59 14 p.

Research output: Contribution to journalArticle

Manometry
Catheters
2 Citations (Scopus)

Influence of reflux and central obesity on intercellular space diameter of esophageal squamous epithelium

Blevins, C. H., Sharma, A. N., Johnson, M. L., Geno, D., Gupta, M., Bharucha, A. E., Katzka, D. A. & Iyer, P. G., 2016, In : United European Gastroenterology Journal. 4, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Abdominal Obesity
Extracellular Space
Epithelium
Ambulatory Monitoring
Gastroesophageal Reflux
12 Citations (Scopus)

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P. J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ordog, T., Camp, J. J., Ge, X., Bharucha, A. E., Linden, D. R., Szurszewski, J. H., Kashyap, P. C. & Farrugia, G., Jul 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 4, p. 454-467 14 p.

Research output: Contribution to journalArticle

Interstitial Cells of Cajal
Gastric Emptying
Interleukin-10
Heme Oxygenase-1
Stomach
14 Citations (Scopus)

Management of opioid-induced constipation

Prichard, D., Norton, C. & Bharucha, A. E., 2016, In : British Journal of Nursing. 25, 10, p. S4-S11

Research output: Contribution to journalArticle

Constipation
Opioid Analgesics
Laxatives
Narcotic Antagonists
Life Style
77 Citations (Scopus)

Relationship between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients with Chronic Constipation

Parthasarathy, G., Chen, J., Chen, X., Chia, N. D., O'Connor, H. M., Wolf, P. G., Gaskins, H. R. & Bharucha, A. E., Feb 1 2016, In : Gastroenterology. 150, 2, p. 367-379e1

Research output: Contribution to journalArticle

Microbiota
Methane
Constipation
Feces
Mucous Membrane
5 Citations (Scopus)

Reproducibility of high-definition (3D) manometry and its agreement with high-resolution (2D) manometry in women with fecal incontinence

Chakraborty, S., Feuerhak, K. J., Zinsmeister, A. R. & Bharucha, A. E., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Fecal Incontinence
Manometry
Pressure
Confidence Intervals
Random Allocation
13 Citations (Scopus)

The incidence rate and characteristics of clinically diagnosed defecatory disorders in the community

Noelting, J., Eaton, J. E., Choung, R. S., Zinsmeister, A. R., Locke, G. R. & Bharucha, A. E., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Incidence
Irritable Bowel Syndrome
Constipation
Mental Disorders
Defecography
7 Citations (Scopus)

Validating endpoints for therapeutic trials in fecal incontinence

Noelting, J., Zinsmeister, A. R. & Bharucha, A. E., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Fecal Incontinence
Therapeutics
2015
57 Citations (Scopus)

ANMS-ESNM position paper and consensus guidelines on biofeedback therapy for anorectal disorders

Rao, S. S. C., Benninga, M. A., Bharucha, A. E., Chiarioni, G., Di Lorenzo, C. & Whitehead, W. E., May 1 2015, In : Neurogastroenterology and Motility. 27, 5, p. 594-609 16 p.

Research output: Contribution to journalArticle

Rectal Diseases
Consensus
Guidelines
Defecation
Therapeutics
5 Citations (Scopus)

A novel technique for bedside anorectal manometry in humans

Bharucha, A. E., Stroetz, R., Feuerhak, K., Szarka, L. & Zinsmeister, A. R., Oct 1 2015, In : Neurogastroenterology and Motility. 27, 10, p. 1504-1508 5 p.

Research output: Contribution to journalArticle

Manometry
Pressure
Fecal Incontinence
Equipment and Supplies
Sensory Thresholds
15 Citations (Scopus)

Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults

O’Dwyer, R. H., Acosta, A., Camilleri, M., Burton, D., Busciglio, I. & Bharucha, A. E., Aug 23 2015, In : Digestive Diseases and Sciences. 60, 8, p. 2398-2407 10 p.

Research output: Contribution to journalArticle

Megacolon
Compliance
Colectomy
Pressure
Pelvic Floor
43 Citations (Scopus)

Delayed gastric emptying is associated with early and long-term hyperglycemia in type 1 diabetes mellitus

Bharucha, A. E., Batey-Schaefer, B., Cleary, P. A., Murray, J. A., Cowie, C., Lorenzi, G., Driscoll, M., Harth, J., Larkin, M., Christofi, M., Bayless, M., Wimmergren, N., Herman, W., Whitehouse, F., Jones, K., Kruger, D., Martin, C., Ziegler, G., Zinsmeister, A. R. & Nathan, D. M., Aug 1 2015, In : Gastroenterology. 149, 2, p. 330-339 10 p.

Research output: Contribution to journalArticle

Gastric Emptying
Diabetes Complications
Type 1 Diabetes Mellitus
Hyperglycemia
Epidemiology
23 Citations (Scopus)

Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome

Loavenbruck, A., Iturrino, J., Singer, W., Sletten, D. M., Low, P. A., Zinsmeister, A. R. & Bharucha, A. E., Jan 1 2015, In : Neurogastroenterology and Motility. 27, 1, p. 92-98 7 p.

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Gastrointestinal Transit
Gastric Emptying
Adrenergic Agents
Vomiting
15 Citations (Scopus)

Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motility disorders

Parthasarathy, G., Ravi, K., Camilleri, M., Andrews, C., Szarka, L., Low, P. A., Zinsmeister, A. R. & Bharucha, A. E., Dec 1 2015, In : Neurogastroenterology and Motility. 27, 12, p. 1736-1746 11 p.

Research output: Contribution to journalArticle

Neostigmine
Gastrointestinal Motility
Gastroparesis
Motor Activity
Cholinesterase Inhibitors
100 Citations (Scopus)

Epidemiology, pathophysiology, and classification of fecal incontinence: State of the Science Summary for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) workshop

Bharucha, A. E., Dunivan, G., Goode, P. S., Lukacz, E. S., Markland, A. D., Matthews, C. A., Mott, L., Rogers, R. G., Zinsmeister, A. R., Whitehead, W. E., Rao, S. S. C. & Hamilton, F. A., Jan 10 2015, In : American Journal of Gastroenterology. 110, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Fecal Incontinence
Epidemiology
Education
Pelvic Floor
25 Citations (Scopus)

Epidemiology and natural history of gastroparesis

Bharucha, A. E., Mar 1 2015, In : Gastroenterology Clinics of North America. 44, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

Gastroparesis
Epidemiology
Gastric Emptying
Gastric Outlet Obstruction
Incidence
9 Citations (Scopus)

Management of opioid-induced constipation for people in palliative care

Prichard, D. & Bharucha, A. E., 2015, In : International Journal of Palliative Nursing. 21, 6, p. 272-280 9 p.

Research output: Contribution to journalArticle

Constipation
Palliative Care
Opioid Analgesics
Laxatives
Narcotic Antagonists