Research Output

2012

Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: Results from the consortium of investigators of modifiers of BRCA1/2 (CIMBA)

Mavaddat, N., Barrowdale, D., Andrulis, I. L., Domchek, S. M., Eccles, D., Nevanlinna, H., Ramus, S. J., Spurdle, A., Robson, M., Sherman, M., Mulligan, A. M., Couch, F. J., Engel, C., McGuffog, L., Healey, S., Sinilnikova, O. M., Southey, M. C., Terry, M. B., Goldgar, D., O'Malley, F. & 113 others, John, E. M., Janavicius, R., Tihomirova, L., Hansen, T. V. O., Nielsen, F. C., Osorio, A., Stavropoulou, A., Benítez, J., Manoukian, S., Peissel, B., Barile, M., Volorio, S., Pasini, B., Dolcetti, R., Putignano, A. L., Ottini, L., Radice, P., Hamann, U., Rashid, M. U., Hogervorst, F. B., Kriege, M., Van Der Luijt, R. B., Peock, S., Frost, D., Evans, D. G., Brewer, C., Walker, L., Rogers, M. T., Side, L. E., Houghton, C., Weaver, J. E., Godwin, A. K., Schmutzler, R. K., Wappenschmidt, B., Meindl, A., Kast, K., Arnold, N., Niederacher, D., Sutter, C., Deissler, H., Gadzicki, D., Preisler-Adams, S., Varon-Mateeva, R., Schönbuchner, I., Gevensleben, H., Stoppa-Lyonnet, D., Belotti, M., Barjhoux, L., Isaacs, C., Peshkin, B. N., Caldes, T., De Al Hoya, M., Cañadas, C., Heikkinen, T., Heikkilä, P., Aittomäki, K., Blanco, I., Lazaro, C., Brunet, J., Agnarsson, B. A., Arason, A., Barkardottir, R. B., Dumont, M., Simard, J., Montagna, M., Agata, S., D'Andrea, E., Yan, M., Fox, S., Rebbeck, T. R., Rubinstein, W., Tung, N., Garber, J. E., Wang, X., Fredericksen, Z., Pankratz, V. S., Lindor, N. M., Szabo, C., Offit, K., Sakr, R., Gaudet, M. M., Singer, C. F., Tea, M. K., Rappaport, C., Mai, P. L., Greene, M. H., Sokolenko, A., Imyanitov, E., Toland, A. E., Senter, L., Sweet, K., Thomassen, M., Gerdes, A. M., Kruse, T., Caligo, M., Aretini, P., Rantala, J., Von Wachenfeld, A., Henriksson, K., Steele, L., Neuhausen, S. L., Nussbaum, R., Beattie, M., Odunsi, K., Sucheston, L., Gayther, S. A., Nathanson, K., Gross, J., Walsh, C., Karlan, B., Chenevix-Trench, G., Easton, D. F. & Antoniou, A. C., Jan 2012, In : Cancer Epidemiology Biomarkers and Prevention. 21, 1, p. 134-147 14 p.

Research output: Contribution to journalArticle

278 Scopus citations

Performance of PREMM 1,2,6, MMRpredict, and MMRpro in detecting Lynch syndrome among endometrial cancer cases

Mercado, R. C., Hampel, H., Kastrinos, F., Steyerberg, E., Balmana, J., Stoffel, E., Cohn, D. E., Backes, F. J., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Casey, G., Haile, R., Madhavan, S., De La Chapelle, A. & Syngal, S., Jul 1 2012, In : Genetics in Medicine. 14, 7, p. 670-680 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Post-systolic shortening: A functional window into ischemic memory?

Belohlavek, M., Jan 2012, In : JACC: Cardiovascular Imaging. 5, 1, p. 12-14 3 p.

Research output: Contribution to journalEditorial

3 Scopus citations

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

De, S., Kumari, J., Mudgal, R., Modi, P., Gupta, S., Futami, K., Goto, H., Lindor, N. M., Furuichi, Y., Mohanty, D. & Sengupta, S., Aug 14 2012, In : Journal of cell science. 125, 10, p. 2509-2522 14 p.

Research output: Contribution to journalArticle

66 Scopus citations

Return of individual research results from genome-wide association studies: Experience of the Electronic Medical Records and Genomics (eMERGE) Network

Fullerton, S. M., Wolf, W. A., Brothers, K. B., Clayton, E. W., Crawford, D. C., Denny, J. C., Greenland, P., Koenig, B. A., Leppig, K. A., Lindor, N. M., McCarty, C. A., McGuire, A. L., McPeek Hinz, E. R., Mirel, D. B., Ramos, E. M., Ritchie, M. D., Smith, M. E., Waudby, C. J., Burke, W. & Jarvik, G. P., Apr 1 2012, In : Genetics in Medicine. 14, 4, p. 424-431 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome

Win, A. K., Lindor, N. M., Young, J. P., MacRae, F. A., Young, G. P., Williamson, E., Parry, S., Goldblatt, J., Lipton, L., Winship, I., Leggett, B., Tucker, K. M., Giles, G. G., Buchanan, D. D., Clendenning, M., Rosty, C., Arnold, J., Joan Levine, A., Haile, R. W., Gallinger, S. & 4 others, Marchand, L. L., Newcomb, P. A., Hopper, J. L. & Jenkins, M. A., Sep 19 2012, In : Journal of the National Cancer Institute. 104, 18, p. 1363-1372 10 p.

Research output: Contribution to journalArticle

134 Scopus citations

Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism

Tajbakhsh, N., Xue, W., Wu, H., Liang, J., McMahon, E. M. & Belohlavek, M., May 14 2012, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging. 83170G. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8317).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The germline MLH1 K618A variant and susceptibility to lynch syndrome-associated tumors

Medeiros, F., Lindor, N. M., Couch, F. J. & Highsmith, W. E., May 1 2012, In : Journal of Molecular Diagnostics. 14, 3, p. 264-273 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

The small GTPase RhoG mediates glioblastoma cell invasion

Kwiatkowska, A., Didier, S., Fortin, S., Chuang, Y., White, T., Berens, M. E., Rushing, E., Eschbacher, J., Tran, N. L., Chan, A. & Symons, M., Sep 11 2012, In : Molecular cancer. 11, 65.

Research output: Contribution to journalArticle

43 Scopus citations
19 Scopus citations

Weighted least-squares finite element method for cardiac blood flow simulation with echocardiographic data

Wei, F., Westerdale, J., McMahon, E. M., Belohlavek, M. & Heys, J. J., 2012, In : Computational and Mathematical Methods in Medicine. 2012, 371315.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain

Wu, H. J., Wu, W., Sun, H. Y., Qin, G. W., Wang, H. B., Wang, P., Yalamanchili, H. K., Wang, J., Tse, H. F., Lau, C. P., Vanhoutte, P. M. & Li, G. R., Dec 1 2011, In : Journal of Molecular and Cellular Cardiology. 51, 6, p. 966-973 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese

Zhang, G., Chen, X., Chan, L., Zhang, M., Zhu, B., Wang, L., Zhu, X., Zhang, J., Zhou, B. & Wang, J., Dec 1 2011, In : Scientific reports. 1, 20.

Research output: Contribution to journalArticle

30 Scopus citations

A smartphone client-server teleradiology system for primary diagnosis of acute stroke

Mitchell, J. R., Sharma, P., Modi, J., Simpson, M., Thomas, M., Hill, M. D. & Goyal, M., Apr 1 2011, In : Journal of medical Internet research. 13, 2, p. e31

Research output: Contribution to journalArticle

50 Scopus citations

B cells inflamed within and without

Chesi, M., Feb 17 2011, In : Blood. 117, 7, p. 2079-2080 2 p.

Research output: Contribution to journalComment/debate

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., Chesi, M., Schinzel, A. C., McKeown, M. R., Heffernan, T. P., Vakoc, C. R., Bergsagel, P. L., Ghobrial, I. M., Richardson, P. G., Young, R. A., Hahn, W. C. & 4 others, Anderson, K. C., Kung, A. L., Bradner, J. E. & Mitsiades, C. S., Sep 16 2011, In : Cell. 146, 6, p. 904-917 14 p.

Research output: Contribution to journalArticle

1612 Scopus citations

ChIP-Array: Combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor

Qin, J., Li, M. J., Wang, P., Zhang, M. Q. & Wang, J., Jul 1 2011, In : Nucleic acids research. 39, SUPPL. 2, p. W430-W436

Research output: Contribution to journalArticle

45 Scopus citations

Clinical and biological implications of MYC activation: A common difference between MGUS and newly diagnosed multiple myeloma

Chng, W. J., Huang, G. F., Chung, T. H., Ng, S. B., Gonzalez-Paz, N., Troska-Price, T., Mulligan, G., Chesi, M., Bergsagel, P. L. & Fonseca, R., Jun 2011, In : Leukemia. 25, 6, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

159 Scopus citations

Correlated evolution of transcription factors and their binding sites

Yang, S., Yalamanchili, H. K., Li, X., Yao, K. M., Sham, P. C., Zhang, M. Q. & Wang, J., Nov 1 2011, In : Bioinformatics. 27, 21, p. 2972-2978 7 p., btr503.

Research output: Contribution to journalArticle

17 Scopus citations

Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese society of echocardiography

Mor-Avi, V., Lang, R. M., Badano, L. P., Belohlavek, M., Cardim, N. M., Derumeaux, G., Galderisi, M., Marwick, T., Nagueh, S. F., Sengupta, P. P., Sicari, R., Smiseth, O. A., Smulevitz, B., Takeuchi, M., Thomas, J. D., Vannan, M., Voigt, J. U. & Zamorano, J. L., Mar 2011, In : European Journal of Echocardiography. 12, 3, p. 167-205 39 p.

Research output: Contribution to journalArticle

565 Scopus citations

Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications: Endorsed by the Japanese Society of Echocardiography

Mor-Avi, V., Lang, R. M., Badano, L. P., Belohlavek, M., Cardim, N. M., Derumeaux, G., Galderisi, M., Marwick, T., Nagueh, S. F., Sengupta, P. P., Sicari, R., Smiseth, O. A., Smulevitz, B., Takeuchi, M., Thomas, J. D., Vannan, M., Voigt, J. U. & Zamorano, J. L., Mar 1 2011, In : Journal of the American Society of Echocardiography. 24, 3, p. 277-313 37 p.

Research output: Contribution to journalReview article

707 Scopus citations

EpiRegNet: Constructing epigenetic regulatory network from high throughput gene expression data for humans

Wang, L. Y., Wang, P., Li, M. J., Qin, J., Wang, X., Zhang, M. Q. & Wang, J., Jan 1 2011, In : Epigenetics. 6, 12, p. 1505-1512 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Flow velocity vector fields by ultrasound particle imaging velocimetry :In vitro comparison with optical flow velocimetry

Westerdale, J., Belohlavek, M., McMahon, E. M., Jiamsripong, P., Heys, J. J. & Milano, M., Feb 1 2011, In : Journal of Ultrasound in Medicine. 30, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia

Roher, A. E., Tyas, S. L., Maarouf, C. L., Daugs, I. D., Kokjohn, T. A., Emmerling, M. R., Garami, Z., Belohlavek, M., Sabbagh, M. N., Sue, L. I. & Beach, T. G., Jul 1 2011, In : Alzheimer's and Dementia. 7, 4, p. 436-444 9 p.

Research output: Contribution to journalArticle

68 Scopus citations
Open Access
40 Scopus citations

MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration

Arora, S., Ranade, A. R., Tran, N. L., Nasser, S., Sridhar, S., Korn, R. L., Ross, J. T. D., Dhruv, H., Foss, K. M., Sibenaller, Z., Ryken, T., Gotway, M. B., Kim, S. & Weiss, G. J., Dec 1 2011, In : International Journal of Cancer. 129, 11, p. 2621-2631 11 p.

Research output: Contribution to journalArticle

123 Scopus citations

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Pei, H., Zhang, L., Luo, K., Qin, Y., Chesi, M., Fei, F., Bergsagel, P. L., Wang, L., You, Z. & Lou, Z., Feb 3 2011, In : Nature. 470, 7332, p. 124-129 6 p.

Research output: Contribution to journalArticle

282 Scopus citations

Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions

Wang, W., Wei, Z., Lam, T. W. & Wang, J., Dec 1 2011, In : Scientific reports. 1, 55.

Research output: Contribution to journalReview article

58 Scopus citations

NRProF: Neural response based protein function prediction algorithm

Yalamanchili, H. K., Wang, J. & Xiao, Q. W., Oct 28 2011, 2011 IEEE International Conference on Systems Biology, ISB 2011. p. 33-40 8 p. (2011 IEEE International Conference on Systems Biology, ISB 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Potential role of Reynolds number in resolving Doppler- and catheter-based transvalvular gradient discrepancies in aortic stenosis

Adams, J. C., Jiamsripong, P., Belohlavek, M., McMahon, E. M., Marupakula, V., Heys, J. & Chaliki, H. P., Mar 1 2011, In : Journal of Heart Valve Disease. 20, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of Pirh2 in mediating the regulation of p53 and c-Myc

Hakem, A., Bohgaki, M., Lemmers, B., Tai, E., Salmena, L., Matysiak-Zablocki, E., Jung, Y. S., Karaskova, J., Kaustov, L., Duan, S., Madore, J., Boutros, P., Sheng, Y., Chesi, M., Bergsagel, P. L., Perez-Ordonez, B., Mes-Masson, A. M., Penn, L., Squire, J., Chen, X. & 5 others, Jurisica, I., Arrowsmith, C., Sanchez, O., Benchimol, S. & Hakem, R., Nov 2011, In : PLoS genetics. 7, 11, e1002360.

Research output: Contribution to journalArticle

41 Scopus citations

The left ventricle responds to acute graded elevation of right ventricular afterload by augmentation of twist magnitude and untwist rate

Cho, E. J., Jiamsripong, P., Calleja, A. M., Alharthi, M. S., McMahon, E. M., Chandrasekaran, K., Cha, S., Bukatina, A. E., Khandheria, B. K. & Belohlavek, M., Aug 1 2011, In : Journal of the American Society of Echocardiography. 24, 8, p. 922-929 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transcranial Doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's disease

Roher, A. E., Garami, Z., Tyas, S. L., Maarouf, C. L., Kokjohn, T. A., Belohlavek, M., Vedders, L. J., Connor, D., Sabbagh, M. N., Beach, T. G. & Emmerling, M. R., Jul 1 2011, In : Alzheimer's and Dementia. 7, 4, p. 445-455 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Ultrasound-guided placement of a renal artery stent using an intracardiac probe for transvascular imaging

Belohlavek, M., Jiamsripong, P., Mcmahon, E. M., Lombari, T. R. & Lerman, L. O., 2011, In : Open Cardiovascular Medicine Journal. 5, 1, p. 215-217 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2010

3 T deep gray matter T2 hypointensity correlates with disability over time in stable relapsing-remitting multiple sclerosis: A 3-year pilot study

Zhang, Y., Metz, L. M., Yong, V. W. & Mitchell, J. R., Oct 15 2010, In : Journal of the neurological sciences. 297, 1-2, p. 76-81 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

AnalyzeNNLS: Magnetic resonance multiexponential decay image analysis

Bjarnason, T. A. & Mitchell, J. R., Oct 1 2010, In : Journal of Magnetic Resonance. 206, 2, p. 200-204 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging

Drabycz, S., Roldán, G., de Robles, P., Adler, D., McIntyre, J. B., Magliocco, A. M., Cairncross, J. G. & Mitchell, J. R., Jan 15 2010, In : NeuroImage. 49, 2, p. 1398-1405 8 p.

Research output: Contribution to journalArticle

118 Scopus citations

A work-efficient GPU algorithm for level set segmentation

Roberts, M., Sousa, M. C. & Mitchell, J. R., Sep 7 2010, ACM SIGGRAPH 2010 Posters, SIGGRAPH '10. 53. (ACM SIGGRAPH 2010 Posters, SIGGRAPH '10).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Corpus callosum volume and interhemispheric transfer in multiple sclerosis

Brown, L. N., Zhang, Y., Mitchell, J. R., Zabad, R. & Metz, L. M., Sep 1 2010, In : Canadian Journal of Neurological Sciences. 37, 5, p. 615-619 5 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Epigenetics and MicroRNAs combine to modulate the MDM2/p53 axis in myeloma

Chesi, M. & Bergsagel, P. L., Oct 19 2010, In : Cancer cell. 18, 4, p. 299-300 2 p.

Research output: Contribution to journalShort survey

10 Scopus citations

FastPval: A fast and memory efficient program to calculate very low P-values from empirical distribution

Li, M. J., Sham, P. C. & Wang, J., Nov 2010, In : Bioinformatics. 26, 22, p. 2897-2899 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Glycogene expression alterations associated with pancreatic cancer Epithelial-mesenchymal transition in complementary model systems

Maupin, K. A., Sinha, A., Eugster, E., Miller, J., Ross, J., Paulino, V., Keshamouni, V. G., Tran, N., Berens, M., Webb, C. & Haab, B. B., 2010, In : PloS one. 5, 9, e13002.

Research output: Contribution to journalArticle

69 Scopus citations

Impact of pericardial adhesions on diastolic function as assessed by vortex formation time, a parameter of transmitral flow efficiency

Jiamsripong, P., Alharthi, M. S., Calleja, A. M., McMahon, E. M., Katayama, M., Westerdale, J., Milano, M., Heys, J. J., Mookadam, F. & Belohlavek, M., Sep 24 2010, In : Cardiovascular ultrasound. 8, 1, 42.

Research output: Contribution to journalArticle

14 Scopus citations

IPhone-based teleradiology for the diagnosis of acute cervico-dorsal spine trauma

Modi, J., Sharma, P., Earl, A., Simpson, M., Mitchell, J. R. & Goyal, M., Nov 1 2010, In : Canadian Journal of Neurological Sciences. 37, 6, p. 849-854 6 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Nonlinear ultrasound scattering by a cloud of microbubbles

Silva, G. T., Belohlavek, M., McMahon, E. M. & Fatemi, M., Jan 1 2010, In : Physics Procedia. 3, 1, p. 919-926 8 p.

Research output: Contribution to journalConference article

Open Access
1 Scopus citations

Quantitative T2 analysis: The effects of noise, regularization, and multivoxel approaches

Bjarnason, T. A., McCreary, C. R., Dunn, J. F. & Mitchell, J. R., Jan 1 2010, In : Magnetic Resonance in Medicine. 63, 1, p. 212-217 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Revisiting the simplified Bernoulli equation

Heys, J. J., Holyoak, N., Calleja, A. M., Belohlavek, M. & Chaliki, H. P., Nov 19 2010, In : Open Biomedical Engineering Journal. 4, p. 123-128 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

Teo, H., Ghosh, S., Luesch, H., Ghosh, A., Wong, E. T., Malik, N., Orth, A., De Jesus, P., Perry, A. S., Oliver, J. D., Tran, N. L., Speiser, L. J., Wong, M., Saez, E., Schultz, P., Chanda, S. K., Verma, I. M. & Tergaonkar, V., Aug 1 2010, In : Nature Cell Biology. 12, 8, p. 758-767 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling

Paulino, V. M., Yang, Z., Kloss, J., Ennis, M. J., Armstrong, B. A., Loftus, J. C. & Tran, N. L., Nov 2010, In : Molecular Cancer Research. 8, 11, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Weighted least-squares finite elements based on particle imaging velocimetry data

Heys, J. J., Manteuffel, T. A., McCormick, S. F., Milano, M., Westerdale, J. & Belohlavek, M., Jan 1 2010, In : Journal of Computational Physics. 229, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

20 Scopus citations