Research Output

2017

Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control

Pawlyn, C., Bright, M. D., Buros, A. F., Stein, C. K., Walters, Z., Aronson, L. I., Mirabella, F., Jones, J. R., Kaiser, M. F., Walker, B. A., Jackson, G. H., Clarke, P. A., Bergsagel, P. L., Workman, P., Chesi, M., Morgan, G. J. & Davies, F. E., Jan 1 2017, In : Blood Cancer Journal. 7, 3, e549.

Research output: Contribution to journalArticle

33 Scopus citations

Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair

López-Iglesias, A. A., Herrero, A. B., Chesi, M., San-Segundo, L., González-Méndez, L., Hernández-García, S., Misiewicz-Krzeminska, I., Quwaider, D., Martín-Sánchez, M., Primo, D., Paíno, T., Bergsagel, P. L., Mehrling, T., González-Díaz, M., San-Miguel, J. F., Mateos, M. V., Gutiérrez, N. C., Garayoa, M. & Ocio, E. M., Jun 20 2017, In : Journal of Hematology and Oncology. 10, 1, 127.

Research output: Contribution to journalArticle

12 Scopus citations

Prevalence and penetrance of major genes and polygenes for colorectal cancer

Win, A. K., Jenkins, M. A., Dowty, J. G., Antoniou, A. C., Lee, A., Giles, G. G., Buchanan, D. D., Clendenning, M., Rosty, C., Ahnen, D. J., Thibodeau, S. N., Casey, G., Gallinger, S., Le Marchand, L., Haile, R. W., Potter, J. D., Zheng, Y., Lindor, N. M., Newcomb, P. A., Hopper, J. L. & 1 others, MacInnis, R. J., Mar 1 2017, In : Cancer Epidemiology Biomarkers and Prevention. 26, 3, p. 404-412 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

May-Wilson, S., Sud, A., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hänninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A. P., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S., Palotie, A. & 34 others, Renkonen-Sinisalo, L., Lepistö, A., Böhm, J., Mecklin, J. P., Al-Tassan, N. A., Palles, C., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Fisher, D., Kerr, R., Kerr, D., Passarelli, M. N., Figueiredo, J. C., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Aaltonen, L. A., Cheadle, J. P., Tomlinson, I. P., Dunlop, M. G. & Houlston, R. S., Oct 2017, In : European Journal of Cancer. 84, p. 228-238 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Baxter, L. C., Gaw, N., Ranjbar, S., Plasencia, J., Dueck, A., Peng, S., Smith, K. A., Nakaji, P., Karis, J. P., Quarles, C. C., Wu, T., Loftus, J. C., Jenkins, R. B., Sicotte, H., Kollmeyer, T. M., O'Neill, B. P., Elmquist, W. & 7 others, Hoxworth, J. M., Frakes, D., Sarkaria, J. N., Swanson, K., Tran, N., Li, J. & Mitchell, J. R., 2017, In : Neuro-Oncology. 19, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Retrospective validation of a computer-assisted quantification model of intracerebral hemorrhage volume on accuracy, precision, and acquisition time, compared with standard ABC/2 manual volume calculation

Xue, W., Vegunta, S., Zwart, C. M., Aguilar, M. I., Patel, A. C., Hoxworth, J. M., Demaerschalk, B. M. & Mitchell, J. R., Aug 1 2017, In : American Journal of Neuroradiology. 38, 8, p. 1536-1542 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples

Nazarov, P. V., Muller, A., Kaoma, T., Nicot, N., Maximo, C., Birembaut, P., Tran, N. L., Dittmar, G. & Vallar, L., Jun 6 2017, In : BMC genomics. 18, 1, 443.

Research output: Contribution to journalArticle

30 Scopus citations

Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework

Li, M., Li, J., Li, M. J., Pan, Z., Hsu, J. S., Liu, D. J., Zhan, X., Junwen, W., Youqiang, S. & Sham, P. C., May 19 2017, In : Nucleic acids research. 45, 9, e75.

Research output: Contribution to journalArticle

13 Scopus citations

Tacrolimus dose requirement based on the CYP3A5 genotype in renal transplant patients

Qu, L., Lu, Y., Ying, M., Li, B., Weng, C., Xie, Z., Liang, L., Lin, C., Yang, X., Feng, S., Wang, Y., Shen, X., Zhou, Q., Chen, Y., Chen, Z., Wu, J., Lin, W., Shen, Y., Qin, J., Xu, H. & 5 others, Xu, F., Wang, J., Chen, J., Jiang, H. & Huang, H., 2017, In : Oncotarget. 8, 46, p. 81285-81294 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes

DeRycke, M. S., Gunawardena, S., Balcom, J. R., Pickart, A. M., Waltman, L. A., French, A. J., McDonnell, S., Riska, S. M., Fogarty, Z. C., Larson, M. C., Middha, S., Eckloff, B. W., Asmann, Y. W., Ferber, M. J., Haile, R. W., Gallinger, S., Clendenning, M., Rosty, C., Win, A. K., Buchanan, D. D. & 6 others, Hopper, J. L., Newcomb, P. A., Le Marchand, L., Goode, E. L., Lindor, N. M. & Thibodeau, S. N., Jan 1 2017, In : Molecular Genetics and Genomic Medicine. 5, 5, p. 553-569 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort

Colon Cancer Family Registry (CCFR), Nov 1 2017, In : Oncotarget. 8, 55, p. 93450-93463 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma

Le Moigne, R., Aftab, B. T., Djakovic, S., Dhimolea, E., Valle, E., Murnane, M., King, E. M., Soriano, F., Menon, M. K., Wu, Z. Y., Wong, S. T., Lee, G. J., Yao, B., Wiita, A. P., Lam, C., Rice, J., Wang, J., Chesi, M., Bergsagel, P. L., Kraus, M. & 11 others, Driessen, C., Von Soly, S. K., Yakes, F. M., Wustrow, D., Shawver, L., Zhou, H. J., Martin, T. G., Wolf, J. L., Mitsiades, C. S., Anderson, D. J. & Rolfe, M., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Timing of aspirin and other nonsteroidal anti-inflammatory drug use among patients with colorectal cancer in relation to tumor markers and survival

Hua, X., Phipps, A. I., Burnett-Hartman, A. N., Adams, S. V., Hardikar, S., Cohen, S. A., Kocarnik, J. M., Ahnen, D. J., Lindor, N. M., Baron, J. A. & Newcomb, P. A., Aug 20 2017, In : Journal of Clinical Oncology. 35, 24, p. 2806-2813 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

UClncR: Ultrafast and comprehensive long non-coding RNA detection from RNA-seq

Sun, Z. D., Nair, A., Chen, X., Prodduturi, N., Wang, J. & Kocher, J-P., Dec 1 2017, In : Scientific Reports. 7, 1, 14196.

Research output: Contribution to journalArticle

11 Scopus citations
4 Scopus citations

Whole-genome analysis of an extensive drug-resistant acinetobacter baumannii ST195 isolate from a recipient after DCD renal transplantation in China

Jiang, H., Cao, L., Shen, Q., Qu, L., Jiang, Y., Qu, T., Zhang, J., Lu, Y., Li, B., Zhu, C., Liu, G., Wang, R., Chen, M., Wang, Y., Wang, Y., Feng, S., Wang, J., Yu, Y., Wu, J. & Chen, J., Jan 1 2017, In : Kidney and Blood Pressure Research. 42, 6, p. 1247-1257 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Whole-Genome Sequencing in Healthy People

Lindor, N. M., Thibodeau, S. N. & Burke, W., Jan 1 2017, In : Mayo Clinic Proceedings. 92, 1, p. 159-172 14 p.

Research output: Contribution to journalReview article

21 Scopus citations
2016

Acoustically Active Catheter for Intracardiac Navigation by Color Doppler Ultrasonography

Katayama, M., Zarbatany, D., Cha, S. S., Fatemi, M. & Belohlavek, M., Nov 17 2016, (Accepted/In press) In : Ultrasound in Medicine and Biology.

Research output: Contribution to journalArticle

3 Scopus citations

Applications of integrative OMICs approaches to gene regulation studies

Qin, J., Yan, B., Hu, Y., Wang, P. & Wang, J., Dec 1 2016, In : Quantitative Biology. 4, 4, p. 283-301 19 p.

Research output: Contribution to journalReview article

3 Scopus citations

Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)

Xicola, R. M., Bontu, S., Doyle, B. J., Rawson, J., Garre, P., Lee, E., De la Hoya, M., Bessa, X., Clofent, J., Bujanda, L., Balaguer, F., Castellví-Bel, S., Alenda, C., Jover, R., Ruiz-Ponte, C., Syngal, S., Andreu, M., Carracedo, A., Castells, A., Newcomb, P. A. & 6 others, Lindor, N., Potter, J. D., Baron, J. A., Ellis, N. A., Caldes, T. & Lor, X. L., Aug 1 2016, In : Carcinogenesis. 37, 8, p. 751-758 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Automated three-dimensional reconstruction of the left ventricle from multiple-axis echocardiography

Rajan, N. K., Song, Z., Hoffmann, K. R., Belohlavek, M., McMahon, E. M. & Borazjani, I., Jan 1 2016, In : Journal of Biomechanical Engineering. 138, 1, 11003.

Research output: Contribution to journalArticle

1 Scopus citations

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

Dunning, A. M., Michailidou, K., Kuchenbaecker, K. B., Thompson, D., French, J. D., Beesley, J., Healey, C. S., Kar, S., Pooley, K. A., Lopez-Knowles, E., Dicks, E., Barrowdale, D., Sinnott-Armstrong, N. A., Sallari, R. C., Hillman, K. M., Kaufmann, S., Sivakumaran, H., Marjaneh, M. M., Lee, J. S., Hills, M. & 228 others, Jarosz, M., Drury, S., Canisius, S., KBolla, M., Dennis, J., Wang, Q., LHopper, J., Southey, M. C., Broeks, A., Schmidt, M. K., Lophatananon, A., Muir, K., Beckmann, M. W., Fasching, P. A., Dos-Santos-Silva, I., Peto, J., Sawyer, E. J., Tomlinson, I., Burwinkel, B., Marme, F., Guénel, P., Truong, T., Bojesen, S. E., Flyger, H., Gonzlez-Neira, A., Perez, J. I. A., Anton-Culver, H., Eunjung, L., Arndt, V., Brenner, H., Meindl, A., Schmutzler, R. K., Brauch, H., Hamann, U., Aittomki, K., Blomqvist, C., Ito, H., Matsuo, K., Bogdanova, N., Dörk, T., Lindblom, A., Margolin, S., Kosma, V. M., Mannermaa, A., Tseng, C. C., Wu, A. H., Lambrechts, D., Wildiers, H., Chang-Claude, J., Rudolph, A., Peterlongo, P., Radice, P., EOlson, J., GGiles, G., Milne, R. L., Haiman, C. A., Henderson, B. E., Goldberg, M. S., Teo, S. H., Yip, C. H., Nord, S., Borresen-Dale, A. L., Kristensen, V., Long, J., Zheng, W., Pylks, K., Winqvist, R., Andrulis, I. L., Knight, J. A., Devilee, P., Seynaeve, C., Figueroa, J., Sherman, M. E., Czene, K., Darabi, H., Hollestelle, A., Van Den Ouweland, A. M. W., Humphreys, K., Gao, Y. T., Shu, X. O., Cox, A., Cross, S. S., Blot, W., Cai, Q., Ghoussaini, M., Perkins, B. J., Shah, M., Choi, J. Y., Kang, D., Lee, S. C., Hartman, M., Kabisch, M., Torres, D., Jakubowska, A., Lubinski, J., Brennan, P., Sangrajrang, S., Ambrosone, C. B., Toland, A. E., Shen, C. Y., Wu, P. E., Orr, N., Swerdlow, A., McGuffog, L., Healey, S., Lee, A., Kapuscinski, M., John, E. M., Terry, M. B., Daly, M. B., Goldgar, D. E., Buys, S. S., Janavicius, R., Tihomirova, L., Tung, N., Dorfling, C. M., Van Rensburg, E. J., Neuhausen, S. L., Ejlertsen, B., OHansen, T. V., Osorio, A., Benitez, J., Rando, R., Weitzel, J. N., Bonanni, B., Peissel, B., Manoukian, S., Papi, L., Ottini, L., Konstantopoulou, I., Apostolou, P., Garber, J., Rashid, M. U., Frost, D., Izatt, L., Ellis, S., Godwin, A. K., Arnold, N., Niederacher, D., Rhiem, K., Bogdanova-Markov, N., Sagne, C., Stoppa-Lyonnet, D., Damiola, F., Sinilnikova, O. M., Mazoyer, S., Isaacs, C., MClaes, K. B., De Leeneer, K., De La Hoya, M., Caldes, T., Nevanlinna, H., Khan, S., Mensenkamp, A. R., Hooning, M. J., Rookus, M. A., Kwong, A., Olah, E., Diez, O., Brunet, J., Pujana, M. A., Gronwald, J., Huzarski, T., Barkardottir, R. B., Laframboise, R., Soucy, P., Montagna, M., Agata, S., Teixeira, M. R., Kyung Park, S., Lindor, N., Couch, F. J., Tischkowitz, M., Foretova, L., Vijai, J., Offit, K., Singer, C. F., Rappaport, C., MPhelan, C., Greene, M. H., Mai, P. L., Rennert, G., Imyanitov, E. N., Hulick, P. J., Phillips, K. A., Piedmonte, M., Mulligan, A. M., Glendon, G., Bojesen, A., Thomassen, M., Caligo, M. A., Yoon, S. Y., Friedman, E., Laitman, Y., Borg, A., Von Wachenfeldt, A., Ehrencrona, H., Rantala, J., Olopade, O. I., Ganz, P. A., Nussbaum, R. L., Gayther, S. A., LNathanson, K., Domchek, S. M., Arun, B. K., Mitchell, G., Karlan, B. Y., Lester, J., Maskarinec, G., Woolcott, C., Scott, C., Stone, J., Apicella, C., Tamimi, R., Luben, R., Khaw, K. T., Helland, S., Haakensen, V., Dowsett, M., Pharoah, P. D. P., Simard, J., Hall, P., Garca-Closas, M., Vachon, C., Chenevix-Trench, G., Antoniou, A. C., Easton, D. F. & Edwards, S. L., Mar 29 2016, In : Nature Genetics. 48, 4, p. 374-386 13 p.

Research output: Contribution to journalArticle

56 Scopus citations

Carfilzomib and the cardiorenal system in myeloma: An endothelial effect?

Rosenthal, A., Luthi, J., Belohlavek, M., Kortüm, K. M., Mookadam, F., Mayo, A., Fonseca, R., Bergsagel, P. L., Reeder, C. B., Mikhael, J. R. & Stewart, A. K., 2016, In : Blood Cancer Journal. 6, 1, e384.

Research output: Contribution to journalArticle

43 Scopus citations

Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

Shang, J., Reece, J. C., Buchanan, D. D., Giles, G. G., Figueiredo, J. C., Casey, G., Gallinger, S., Thibodeau, S. N., Lindor, N. M., Newcomb, P. A., Potter, J. D., Baron, J. A., Hopper, J. L., Jenkins, M. A. & Win, A. K., Aug 1 2016, In : International Journal of Colorectal Disease. 31, 8, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chromogranin a is preferentially cleaved into proangiogenic peptides in the bone marrow of multiple myeloma patients

Bianco, M., Gasparri, A. M., Colombo, B., Curnis, F., Girlanda, S., Ponzoni, M., Bertilaccio, M. T. S., Calcinotto, A., Sacchi, A., Ferrero, E., Ferrarini, M., Chesi, M., Bergsagel, P. L., Bellone, M., Tonon, G., Ciceri, F., Marcatti, M., Caligaris-Cappio, F. & Corti, A., Apr 1 2016, In : Cancer research. 76, 7, p. 1781-1791 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Clinicopathologic risk factor distributions for MLH1 promoter region methylation in CIMP-positive tumors

Levine, A. J., Phipps, A. I., Baron, J. A., Buchanan, D. D., Ahnen, D. J., Cohen, S. A., Lindor, N. M., Newcomb, P. A., Rosty, C., Haile, R. W., Laird, P. W. & Weisenberger, D. J., Jan 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Combining existing numerical models with data assimilation using weighted least-squares finite element methods

Rajaraman, P. K., Manteuffel, T. A., Belohlavek, M. & Heys, J. J., 2016, (Accepted/In press) In : International Journal for Numerical Methods in Biomedical Engineering.

Research output: Contribution to journalArticle

Comparison of Prediction Models for Lynch Syndrome among Individuals with Colorectal Cancer

Lynch Syndrome prediction model validation study group, Feb 1 2016, In : Journal of the National Cancer Institute. 108, 2, djv308.

Research output: Contribution to journalArticle

20 Scopus citations

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations

Colorectal Transdisciplinary (CORECT) Study, Ovarian Cancer Association Consortium (OCAC), The PRACTICAL Consortium, Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), African American Breast Cancer Consortium (AABC) & African Ancestry Prostate Cancer Consortium (AAPC), Sep 1 2016, In : Cancer research. 76, 17, p. 5103-5114 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk

Garcia-Albeniz, X., Rudolph, A., Hutter, C., White, E., Lin, Y., Rosse, S. A., Figueiredo, J. C., Harrison, T. A., Jiao, S., Brenner, H., Casey, G., Hudson, T. J., Thornquist, M., Le Marchand, L., Potter, J., Slattery, M. L., Zanke, B., Baron, J. A., Caan, B. J., Chanock, S. J. & 36 others, Berndt, S. I., Stelling, D., Fuchs, C. S., Hoffmeister, M., Butterbach, K., Du, M., James Gauderman, W., Gunter, M. J., Lemire, M., Ogino, S., Lin, J., Hayes, R. B., Haile, R. W., Schoen, R. E., Warnick, G. S., Jenkins, M. A., Thibodeau, S. N., Schumacher, F. R., Lindor, N. M., Kolonel, L. N., Hopper, J. L., Gong, J., Seminara, D., Pflugeisen, B. M., Ulrich, C. M., Qu, C., Duggan, D., Cotterchio, M., Campbell, P. T., Carlson, C. S., Newcomb, P. A., Giovannucci, E., Hsu, L., Chan, A. T., Peters, U. & Chang-Claude, J., Jan 19 2016, In : British journal of cancer. 114, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dataset of TWIST1-regulated genes in the cranial mesoderm and a transcriptome comparison of cranial mesoderm and cranial neural crest

Bildsoe, H., Fan, X., Wilkie, E. E., Ashoti, A., Jones, V. J., Power, M., Qin, J., Wang, J., Tam, P. P. L. & Loebel, D. A. F., Dec 2016, In : Data in Brief. 9, p. 372-375 4 p.

Research output: Contribution to journalArticle

Determining the familial risk distribution of colorectal cancer: a data mining approach

Chau, R., Jenkins, M. A., Buchanan, D. D., Ait Ouakrim, D., Giles, G. G., Casey, G., Gallinger, S., Haile, R. W., Le Marchand, L., Newcomb, P. A., Lindor, N. M., Hopper, J. L. & Win, A. K., Apr 1 2016, In : Familial Cancer. 15, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes

Lindor, N. M., Hopper, J. & Dowty, J., Mar 9 2016, (Accepted/In press) In : Familial Cancer. p. 1-4 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Vigorito, E., Kuchenbaecker, K. B., Beesley, J., Adlard, J., Agnarsson, B. A., Andrulis, I. L., Arun, B. K., Barjhoux, L., Belotti, M., Benitez, J., Berger, A., Bojesen, A., Bonanni, B., Brewer, C., Caldes, T., Caligo, M. A., Campbell, I., Chan, S. B., Claes, K. B. M., Cohn, D. E. & 126 others, Cook, J., Daly, M. B., Damiola, F., Davidson, R., Pauw, A. D., Delnatte, C., Diez, O., Domchek, S. M., Dumont, M., Durda, K., Dworniczak, B., Easton, D. F., Eccles, D., Edwinsdotter Ardnor, C., Eeles, R., Ejlertsen, B., Ellis, S., Evans, D. G., Feliubadalo, L., Fostira, F., Foulkes, W. D., Friedman, E., Frost, D., Gaddam, P., Ganz, P. A., Garber, J., Garcia-Barberan, V., Gauthier-Villars, M., Gehrig, A., Gerdes, A. M., Giraud, S., Godwin, A. K., Goldgar, D. E., Hake, C. R., Hansen, T. V. O., Healey, S., Hodgson, S., Hogervorst, F. B. L., Houdayer, C., Hulick, P. J., Imyanitov, E. N., Isaacs, C., Izatt, L., Izquierdo, A., Jacobs, L., Jakubowska, A., Janavicius, R., Jaworska-Bieniek, K., Jensen, U. B., John, E. M., Vijai, J., Karlan, B. Y., Kast, K., Investigators, KC. F., Khan, S., Kwong, A., Laitman, Y., Lester, J., Lesueur, F., Liljegren, A., Lubinski, J., Mai, P. L., Manoukian, S., Mazoyer, S., Meindl, A., Mensenkamp, A. R., Montagna, M., Nathanson, K. L., Neuhausen, S. L., Nevanlinna, H., Niederacher, D., Olah, E., Olopade, O. I., Ong, K. R., Osorio, A., Park, S. K., Paulsson-Karlsson, Y., Pedersen, I. S., Peissel, B., Peterlongo, P., Pfeiler, G., Phelan, C. M., Piedmonte, M., Poppe, B., Pujana, M. A., Radice, P., Rennert, G., Rodriguez, G. C., Rookus, M. A., Ross, E. A., Schmutzler, R. K., Simard, J., Singer, C. F., Slavin, T. P., Soucy, P., Southey, M., Steinemann, D., Stoppa-Lyonnet, D., Sukiennicki, G., Sutter, C., Szabo, C. I., Tea, M. K., Teixeira, M. R., Teo, S. H., Terry, M. B., Thomassen, M., Tibiletti, M. G., Tihomirova, L., Tognazzo, S., van Rensburg, E. J., Varesco, L., Varon-Mateeva, R., Vratimos, A., Weitzel, J. N., McGuffog, L., Kirk, J., Toland, A. E., Hamann, U., Lindor, N., Ramus, S. J., Greene, M. H., Couch, F. J., Offit, K., Pharoah, P. D. P., Chenevix-Trench, G. & Antoniou, A. C., 2016, In : PloS one. 11, 7, p. e0158801

Research output: Contribution to journalArticle

5 Scopus citations

Five endometrial cancer risk loci identified through genome-wide association analysis

Cheng, T. H. T., Thompson, D. J., O'Mara, T. A., Painter, J. N., Glubb, D. M., Flach, S., Lewis, A., French, J. D., Freeman-Mills, L., Church, D., Gorman, M., Martin, L., Hodgson, S., MWebb, P., Attia, J., Holliday, E. G., McEvoy, M., Scott, R. J., KHenders, A., Martin, N. G. & 67 others, Montgomery, G. W., Nyholt, D. R., Ahmed, S., Healey, C. S., Shah, M., Dennis, J., Fasching, P. A., Beckmann, M. W., Hein, A., Ekici, A. B., Hall, P., Czene, K., Darabi, H., Li, J., Dörk, T., Dürst, M., Hillemanns, P., Runnebaum, I., Amant, F., Schrauwen, S., Zhao, H., Lambrechts, D., Depreeuw, J., Dowdy, S. C., Goode, E. L., Fridley, B. L., Winham, S. J., NjØlstad, T. S., Salvesen, H. B., Trovik, J., Werner, H. M. J., Ashton, K., Otton, G., Proietto, T., Liu, T., Mints, M., Tham, E., Li, M. J., Yip, S. H., Wang, J., KBolla, M., Michailidou, K., Wang, Q., Tyrer, J. P., Dunlop, M., Houlston, R., Palles, C., Hopper, J. L., Peto, J., Swerdlow, A. J., Burwinkel, B., Brenner, H., Meindl, A., Brauch, H., Lindblom, A., Chang-Claude, J., Couch, F. J., Giles, G. G., Kristensen, V. N., Cox, A., MCunningham, J., Pharoah, P. D. P., Dunning, A. M., Edwards, S. L., Easton, D. F., Tomlinson, I. & Spurdle, A. B., Jun 1 2016, In : Nature Genetics. 48, 6, p. 667-674 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Functional networks of aging markers in the glomeruli of IgA nephropathy: A new therapeutic opportunity

Jiang, H., Liang, L., Qin, J., Lu, Y., Li, B., Wang, Y., Lin, C., Zhou, Q., Feng, S., Yip, S. H., Xu, F., Lai, E. Y., Wang, J. & Chen, J., Jun 7 2016, In : Oncotarget. 7, 23, p. 33616-33626 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer

CCFR and GECCO, Oct 2016, In : PLoS genetics. 12, 10, e1006296.

Research output: Contribution to journalArticle

16 Scopus citations

Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the colon cancer family registry cohort

Rosty, C., Clendenning, M., Walsh, M. D., Eriksen, S. V., Southey, M. C., Winship, I. M., Macrae, F. A., Boussioutas, A., Poplawski, N. K., Parry, S., Arnold, J., Young, J. P., Casey, G., Haile, R. W., Gallinger, S., Le Marchand, L., Newcomb, P. A., Potter, J. D., Derycke, M., Lindor, N. M. & 6 others, Thibodeau, S. N., Baron, J. A., Win, A. K., Hopper, J. L., Jenkins, M. A. & Buchanan, D. D., Jan 1 2016, In : BMJ open. 6, 2, e010293.

Research output: Contribution to journalArticle

20 Scopus citations

GWASdb v2: An update database for human genetic variants identified by genome-wide association studies

Li, M. J., Liu, Z., Wang, P., Wong, M. P., Nelson, M. R., Kocher, J. P. A., Yeager, M., Sham, P. C., Chanock, S. J., Xia, Z. & Wang, J., 2016, In : Nucleic acids research. 44, D1, p. D869-D876

Research output: Contribution to journalArticle

77 Scopus citations

IAP antagonists induce anti-tumor immunity in multiple myeloma

Chesi, M., Mirza, N. N., Garbitt, V. M., Sharik, M. E., Dueck, A., Asmann, Y., Akhmetzyanova, I., Kosiorek, H. E., Calcinotto, A., Riggs, D. L., Keane, N., Ahmann, G. J., Morrison, K. M., Fonseca, R., Lacy, M., Dingli, D. M., Kumar, S. K., Ailawadhi, S., Dispenzieri, A., Buadi, F. & 7 others, Gertz, M., Reeder, C. B., Lin, Y., Chanan Khan, A. A., Stewart, A. K., Fooksman, D. & Bergsagel, P. L., Dec 1 2016, In : Nature Medicine. 22, 12, p. 1411-1420 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Couch, F. J., Kuchenbaecker, K. B., Michailidou, K., Mendoza-Fandino, G. A., Nord, S., Lilyquist, J., Olswold, C., Hallberg, E., Agata, S., Ahsan, H., Aittomäki, K., Ambrosone, C., Andrulis, I. L., Anton-Culver, H., Arndt, V., Arun, B. K., Arver, B., Barile, M., Barkardottir, R. B., Barrowdale, D. & 229 others, Beckmann, L., Beckmann, M. W., Benitez, J., Blank, S. V., Blomqvist, C., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Bonanni, B., Brauch, H., Brenner, H., Burwinkel, B., Buys, S. S., Caldes, T., Caligo, M. A., Canzian, F., Carpenter, J., Chang-Claude, J., Chanock, S. J., Chung, W. K., Claes, K. B. M., Cox, A., Cross, S. S., Cunningham, J. M., Czene, K., Daly, M. B., Damiola, F., Darabi, H., De La Hoya, M., Devilee, P., Diez, O., Ding, Y. C., Dolcetti, R., Domchek, S. M., Dorfling, C. M., Dos-Santos-Silva, I., Dumont, M., Dunning, A. M., Eccles, D. M., Ehrencrona, H., Ekici, A. B., Eliassen, H., Ellis, S., Fasching, P. A., Figueroa, J., Flesch-Janys, D., Försti, A., Fostira, F., Foulkes, W. D., Friebel, T., Friedman, E., Frost, D., Gabrielson, M., Gammon, M. D., Ganz, P. A., Gapstur, S. M., Garber, J., Gaudet, M. M., Gayther, S. A., Gerdes, A. M., Ghoussaini, M., Giles, G. G., Glendon, G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., González-Neira, A., Greene, M. H., Gronwald, J., Guénel, P., Gunter, M., Haeberle, L., Haiman, C. A., Hamann, U., Hansen, T. V. O., Hart, S., Healey, S., Heikkinen, T., Henderson, B. E., Herzog, J., Hogervorst, F. B. L., Hollestelle, A., Hooning, M. J., Hoover, R. N., Hopper, J. L., Humphreys, K., Hunter, D. J., Huzarski, T., Imyanitov, E. N., Isaacs, C., Jakubowska, A., James, P., Janavicius, R., Jensen, U. B., John, E. M., Jones, M., Kabisch, M., Kar, S., Karlan, B. Y., Khan, S., Khaw, K. T., Kibriya, M. G., Knight, J. A., Ko, Y. D., Konstantopoulou, I., Kosma, V. M., Kristensen, V., Kwong, A., Laitman, Y., Lambrechts, D., Lazaro, C., Lee, E., Le Marchand, L., Lester, J., Lindblom, A., Lindor, N., Lindstrom, S., Liu, J., Long, J., Lubinski, J., Mai, P. L., Makalic, E., Malone, K. E., Mannermaa, A., Manoukian, S., Margolin, S., Marme, F., Martens, J. W. M., Mcguffog, L., Meindl, A., Miller, A., Milne, R. L., Miron, P., Montagna, M., Mazoyer, S., Mulligan, A. M., Muranen, T. A., Nathanson, K. L., Neuhausen, S. L., Nevanlinna, H., Nordestgaard, B. G., Nussbaum, R. L., Offit, K., Olah, E., Olopade, O. I., Olson, J. E., Osorio, A., Park, S. K., Peeters, P. H., Peissel, B., Peterlongo, P., Peto, J., Phelan, C. M., Pilarski, R., Poppe, B., Pylkäs, K., Radice, P., Rahman, N., Rantala, J., Rappaport, C., Rennert, G., Richardson, A., Robson, M., Romieu, I., Rudolph, A., Rutgers, E. J., Sanchez, M. J., Santella, R. M., Sawyer, E. J., Schmidt, D. F., Schmidt, M. K., Schmutzler, R. K., Schumacher, F., Scott, R., Senter, L., Sharma, P., Simard, J., Singer, C. F., Sinilnikova, O. M., Soucy, P., Southey, M., Steinemann, D., Stenmark-Askmalm, M., Stoppa-Lyonnet, D., Swerdlow, A., Szabo, C. I., Tamimi, R., Tapper, W., Teixeira, M. R., Teo, S. H., Terry, M. B., Thomassen, M., Thompson, D., Tihomirova, L., Toland, A. E., Tollenaar, R. A. E. M., Tomlinson, I., Truong, T., Tsimiklis, H., Teulé, A., Tumino, R., Tung, N., Turnbull, C., Ursin, G., Van Deurzen, C. H. M., Van Rensburg, E. J., Varon-Mateeva, R., Wang, Z., Wang-Gohrke, S., Weiderpass, E., Weitzel, J. N., Whittemore, A., Wildiers, H., Winqvist, R., Yang, X. R., Yannoukakos, D., Yao, S., Zamora, M. P., Zheng, W., Hall, P., Kraft, P., Vachon, C., Slager, S., Chenevix-Trench, G., Pharoah, P. D. P., Monteiro, A. A. N., García-Closas, M., Easton, D. F. & Antoniou, A. C., Apr 27 2016, In : Nature communications. 7, 11375.

Research output: Contribution to journalArticle

43 Scopus citations

Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk

Zeng, C., Matsuda, K., Jia, W. H., Chang, J., Kweon, S. S., Xiang, Y. B., Shin, A., Jee, S. H., Kim, D. H., Zhang, B., Cai, Q., Guo, X., Long, J., Wang, N., Courtney, R., Pan, Z. Z., Wu, C., Takahashi, A., Shin, M. H., Matsuo, K. & 87 others, Matsuda, F., Gao, Y. T., Oh, J. H., Kim, S., Jung, K. J., Ahn, Y. O., Ren, Z., Li, H. L., Wu, J., Shi, J., Wen, W., Yang, G., Li, B., Ji, B. T., Gruber, S. B., Schumacher, F. R., Stenzel, S. L., Casey, G., Hopper, J. L., Jenkins, M. A., Kim, H. R., Jeong, J. Y., Park, J. W., Tajima, K., Cho, S. H., Kubo, M., Shu, X. O., Lin, D., Zeng, Y. X., Zheng, W., Brenner, H., Schoen, R. E., Küry, S., Baron, J. A., Berndt, S. I., Bezieau, S., Caan, B. J., Carlson, C. S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Conti, D. V., Curtis, K., Duggan, D., Fuchs, C. S., Gallinger, S., Giovannucci, E. L., Haile, R. W., Harrison, T. A., Hayes, R. B., Hoffmeister, M., Hsu, L., Hudson, T. J., Hunter, D. J., Hutter, C. M., Jackson, R. D., Jiao, S., Le Marchand, L., Lemire, M., Lindor, N. M., Ma, J., Newcomb, P. A., Peters, U., Potter, J. D., Qu, C., Seminara, D., Slattery, M. L., Thibodeau, S. N., White, E., Zanke, B. W., Blalock, K., Campbell, P. T., Edlund, C. K., Figueiredo, J., Gauderman, W. J., Gong, J., Green, R. C., Harju, J. F., Jacobs, E. J., Li, L., Lin, Y., Manion, F. J., Moreno, V., Mukherjee, B., Raskin, L., Severi, G. & Thomas, D. C., Jun 1 2016, In : Gastroenterology. 150, 7, p. 1633-1645 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Induction of iron excess restricts malignant plasma cells expansion and potentiates bortezomib effect in models of multiple myeloma

Bordini, J., Galvan, S., Ponzoni, M., Bertilaccio, M. T. S., Chesi, M., Bergsagel, P. L., Camaschella, C. & Campanella, A., Dec 13 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

4 Scopus citations

Knowledge and Uptake of Genetic Counseling and Colonoscopic Screening Among Individuals at Increased Risk for Lynch Syndrome and their Endoscopists from the Family Health Promotion Project

Patel, S. G., Ahnen, D. J., Kinney, A. Y., Horick, N., Finkelstein, D. M., Hill, D. A., Lindor, N. M., MaCrae, F. & Lowery, J. T., Feb 9 2016, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

17 Scopus citations

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

Jarvis, D., Mitchell, J. S., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hänninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A. P., Kaprio, J., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S. & 37 others, Palotie, A., Järvinen, H., Renkonen-Sinisalo, L., Lepistö, A., Böhm, J., Meklin, J. P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Taipale, J., Aaltonen, L. A., Cheadle, J. P., Dunlop, M. G., Tomlinson, I. P. & Houlston, R. S., Jul 12 2016, In : British journal of cancer. 115, 2, p. 266-272 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Wang, Z., Seow, W. J., Shiraishi, K., Hsiung, C. A., Matsuo, K., Liu, J., Chen, K., Yamji, T., Yang, Y., Chang, I. S., Wu, C., Hong, Y. C., Burdett, L., Wyatt, K., Chung, C. C., Li, S. A., Yeager, M., Hutchinson, A., Hu, W., Caporaso, N. & 130 others, Landi, M. T., Chatterjee, N., Song, M., Fraumeni, J. F., Kohno, T., Yokota, J., Kunitoh, H., Ashikawa, K., Momozawa, Y., Daigo, Y., Mitsudomi, T., Yatabe, Y., Hida, T., Hu, Z., Dai, J., Ma, H., Jin, G., Song, B., Wang, Z., Cheng, S., Yin, Z., Li, X., Ren, Y., Guan, P., Chang, J., Tan, W., Chen, C. J., Chang, G. C., Tsai, Y. H., Su, W. C., Chen, K. Y., Huang, M. S., Chen, Y. M., Zheng, H., Li, H., Cui, P., Guo, H., Xu, P., Liu, L., Iwasaki, M., Shimazu, T., Tsugane, S., Zhu, J., Jiang, G., Fei, K., Park, J. Y., Kim, Y. H., Sung, J. S., Park, K. H., Kim, Y. T., Jung, Y. J., Kang, C. H., Park, I. K., Kim, H. N., Jeon, H. S., Choi, J. E., Choi, Y. Y., Kim, J. H., Oh, I. J., Kim, Y. C., Sung, S. W., Kim, J. S., Yoon, H. I., Kweon, S. S., Shin, M. H., Seow, A., Chen, Y., Lim, W. Y., Liu, J., Wong, M. P., Lee, V. H. F., Bassig, B. A., Tucker, M., Berndt, S. I., Chow, W. H., Ji, B. T., Wang, J., Xu, J., Sihoe, A. D. L., Ho, J. C. M., Chan, J. K. C., Wang, J. C., Lu, D., Zhao, X., Zhao, Z., Wu, J., Chen, H., Jin, L., Wei, F., Wu, G., An, S. J., Zhang, X. C., Su, J., Wu, Y. L., Gao, Y. T., Xiang, Y. B., He, X., Li, J., Zheng, W., Shu, X. O., Cai, Q., Klein, R., Pao, W., Lawrence, C., Hosgood, H. D., Hsiao, C. F., Chien, L. H., Chen, Y. H., Chen, C. H., Wang, W. C., Chen, C. Y., Wang, C. L., Yu, C. J., Chen, H. L., Su, Y. C., Tsai, F. Y., Chen, Y. S., Li, Y. J., Yang, T. Y., Lin, C. C., Yang, P. C., Wu, T., Lin, D., Zhou, B., Yu, J., Shen, H., Kubo, M., Chanock, S. J., Rothman, N. & Lan, Q., Feb 1 2016, In : Human molecular genetics. 25, 3, p. 620-629 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Multivitamin, calcium and folic acid supplements and the risk of colorectal cancer in Lynch syndrome

Chau, R., Dashti, S. G., Ouakrim, D. A., Buchanan, D. D., Clendenning, M., Rosty, C., MWinship, I., Young, J. P., Giles, G. G., Macrae, F. A., Boussioutas, A., Parry, S., Figueiredo, J. C., Levine, A. J., Ahnen, D. J., Casey, G., Haile, R. W., Gallinger, S., Marchand, L. L., Thibodeau, S. N. & 7 others, Lindor, N. M., Newcomb, P. A., Potter, J. D., Baron, J. A., Hopper, J. L., Jenkins, M. A. & Win, A. K., Jan 1 2016, In : International journal of epidemiology. 45, 3, p. 940-953 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

KConFab investigators, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Consortium of Modifiers of BRCA1 and BRCA2, Australian Ovarian Cancer Study Group, Australian Ovarian Cancer Study Group, Australian Ovarian Cancer Study Group & GEMO Study Collaborators, May 1 2016, In : Gynecologic oncology. 141, 2, p. 386-401 16 p.

Research output: Contribution to journalReview article

8 Scopus citations

Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience

Lazaridis, K. N., Schahl, K. A., Cousin, M. A., Babovic-Vuksanovic, D., Riegert-Johnson, D. L., Gavrilova, R. H., McAllister, T. M., Lindor, N. M., Abraham, R. S., Ackerman, M. J., Pichurin, P. N., Deyle, D. R., Gavrilov, D. K., Hand, J. L., Klee, E. W., Stephens, M. C., Wick, M. J., Atkinson, E. J., Linden, D. R., Ferber, M. J. & 19 others, Wieben, E. D., Farrugia, G., Baudhuin, L. M., Beck, S. A., Beek, G. J., Go, R. S., Guthrie, K. J., Hovan, M. J., Hunt, K. S., Kemppainen, J. L., Kruisselbrink, T. M., McCormick, J. B., McLaughlin, B. M., Murphree, M. I., Niewold, T. B., Oglesbee, D., Reed, A., Thibodeau, S. N. & Thorland, E. C., Mar 1 2016, In : Mayo Clinic Proceedings. 91, 3, p. 297-307 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma

Markowitz, D., Powell, C., Tran, N. L., Berens, M. E., Ryken, T. C., Vanan, M., Rosen, L., He, M., Sun, S., Symons, M., Al-Abed, Y. & Ruggieri, R., Aug 2016, In : Molecular cancer therapeutics. 15, 8, p. 1799-1808 10 p.

Research output: Contribution to journalArticle

4 Scopus citations