Pediatric and Adolescent Medicine

Research Output 1991 2019

2019
3 Citations (Scopus)

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

Aguayo-Mazzucato, C., Andle, J., Lee, T. B., Midha, A., Talemal, L., Chipashvili, V., Hollister-Lock, J., Van Deursen, J., Weir, G. & Bonner-Weir, S., Jul 2 2019, In : Cell Metabolism. 30, 1, p. 129-142.e4

Research output: Contribution to journalArticle

Cell Aging
Type 2 Diabetes Mellitus
Insulin Resistance
Metabolome
High Fat Diet
1 Citation (Scopus)
Serology
Practice Guidelines
Abdomen
Celiac Disease
Immunoglobulin A

A Mixed-Methods Exploration of Pediatric Intensivists' Attitudes toward End-of-Life Care in Vietnam

Fadadu, P. P., Liu, J. C., Schiltz, B. M., Xoay, T. D., Phuc, P. H., Kumbamu, A. & Ouellette, Y., Aug 1 2019, In : Journal of Palliative Medicine. 22, 8, p. 885-893 9 p.

Research output: Contribution to journalArticle

Terminal Care
Vietnam
Decision Making
Interviews
Pediatrics
2 Citations (Scopus)

Association Between Antibiotics in the First Year of Life and Celiac Disease

Dydensborg Sander, S., Nybo Andersen, A. M., Murray, J. A., Karlstad, Ø., Husby, S. & Størdal, K., Jun 1 2019, In : Gastroenterology. 156, 8, p. 2217-2229 13 p.

Research output: Contribution to journalArticle

Celiac Disease
Anti-Bacterial Agents
Denmark
Norway
Odds Ratio
10 Citations (Scopus)

Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection

DISCO Consortium & CARDIoGRAMPlusC4D Study Group, Jan 8 2019, In : Journal of the American College of Cardiology. 73, 1, p. 58-66 9 p.

Research output: Contribution to journalArticle

Genetic Loci
Endothelin-1
Fibromuscular Dysplasia
Odds Ratio
Confidence Intervals
1 Citation (Scopus)

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J-P., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, Gores, G. J., Li, H. & Van Deursen, J., Jul 1 2019, In : Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journalArticle

Chromosomal Instability
Cyclins
Liver
Neoplasms
Chromosomes

Cellular identification and quantification of senescence-associated β-galactosidase activity in vivo

Childs, B. G., Bussian, T. J. & Baker, D. J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 31-38 8 p. (Methods in Molecular Biology; vol. 1896).

Research output: Chapter in Book/Report/Conference proceedingChapter

Galactosidases
Staining and Labeling
Biological Phenomena
Cell Cycle Checkpoints
Transmission Electron Microscopy
7 Citations (Scopus)

Coeliac disease

Lindfors, K., Ciacci, C., Kurppa, K., Lundin, K. E. A., Makharia, G. K., Mearin, M. L., Murray, J. A., Verdu, E. F. & Kaukinen, K., Dec 1 2019, In : Nature Reviews Disease Primers. 5, 1, 3.

Research output: Contribution to journalReview article

Celiac Disease
Glutens
Diet
Gluten-Free Diet
Adaptive Immunity
Open Access
Inflammatory Bowel Diseases
Proteomics
Ulcerative Colitis
Crohn Disease
Biomarkers

Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320)

Liebowitz, M., Kaempf, J., Erdeve, O., Bulbul, A., Håkansson, S., Lindqvist, J., Farooqi, A., Katheria, A., Sauberan, J., Singh, J., Nelson, K., Wickremasinghe, A., Dong, L., Hassinger, D. C., Aucott, S. W., Hayashi, M., Heuchan, A. M., Carey, W. A., Derrick, M., Wolf, I. S. & 6 others, Kimball, A., Sankar, M., Leone, T., Perez, J., Serize, A. & Clyman, R. I., May 1 2019, In : Journal of Perinatology. 39, 5, p. 599-607 9 p.

Research output: Contribution to journalArticle

Patent Ductus Arteriosus
Acetaminophen
Indomethacin
Constriction
Pharmaceutical Preparations

Crystallizing BubR1’s kinase activity

Limzerwala, J. F. & Van Deursen, J., Jan 1 2019, In : Cell Research.

Research output: Contribution to journalComment/debate

Open Access
Phosphotransferases
4 Citations (Scopus)

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

Caminero, A., McCarville, J. L., Galipeau, H. J., Deraison, C., Bernier, S. P., Constante, M., Rolland, C., Meisel, M., Murray, J. A., Yu, X. B., Alaedini, A., Coombes, B. K., Bercik, P., Southward, C. M., Ruf, W., Jabri, B., Chirdo, F. G., Casqueiro, J., Surette, M. G., Vergnolle, N. & 1 others, Verdu, E. F., Dec 1 2019, In : Nature communications. 10, 1, 1198.

Research output: Contribution to journalArticle

Open Access
PAR-2 Receptor
protease
Glutens
antigens
Celiac Disease

Editorial: Pediatric critical care in resource-limited settings

Murthy, S., Chugh, K., Musa, N., Ouellette, Y. & Phan, P. H., Jan 1 2019, In : Frontiers in Pediatrics. 7, MAR, 80.

Research output: Contribution to journalEditorial

Open Access
Health Manpower
Critical Care
Pediatrics
Global Health
Health Equity
Hemophagocytic Lymphohistiocytosis
Pediatrics
Mortality
Coinfection
Cytomegalovirus
3 Citations (Scopus)

Home health care availability and discharge delays in children with medical complexity

Maynard, R., Christensen, E., Cady, R., Jacob, A., Ouellette, Y., Podgorski, H., Schiltz, B., Schwantes, S. & Wheeler, W., Jan 1 2019, In : Pediatrics. 143, 1, e20181951.

Research output: Contribution to journalArticle

Home Nursing
Home Care Services
Delivery of Health Care
Length of Stay
Subacute Care
1 Citation (Scopus)

Hypoplastic leftheart syndrome: An overview for primary care providers

Javed, R., Cetta, F., Said, S. M., Olson, T. M., O'Leary, P. W. & Qureshi, M. Y., Jan 1 2019, In : Pediatrics in Review. 40, 7, p. 344-353 10 p.

Research output: Contribution to journalReview article

Primary Health Care
Hemodynamics
Hypoplastic Left Heart Syndrome
Dehydration
Respiratory Tract Infections
1 Citation (Scopus)

Immunotherapy in pediatric B-cell acute lymphoblastic leukemia

Wyatt, K. D. & Bram, R. J., Jan 1 2019, In : Human Immunology.

Research output: Contribution to journalReview article

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunotherapy
B-Lymphocytes
Pediatrics
Bispecific Antibodies
1 Citation (Scopus)

Increased local failure for patients with intermediate-risk rhabdomyosarcoma on ARST0531: A report from the Children's Oncology Group

Casey, D. L., Chi, Y. Y., Donaldson, S. S., Hawkins, D. S., Tian, J., Arndt, C. A. S., Rodeberg, D. A., Routh, J. C., Lautz, T. B., Gupta, A. A., Yock, T. I. & Wolden, S. L., Jan 1 2019, In : Cancer.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
irinotecan
Vincristine
Alveolar Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma

Inhibition of ‘jumping genes’ promotes healthy ageing

Childs, B. & Van Deursen, J., Feb 7 2019, In : Nature. 566, 7742, p. 46-48 3 p.

Research output: Contribution to journalArticle

Open Access
Interspersed Repetitive Sequences
Retroelements
Genome
Health

Lack of Equipoise in the PDA-TOLERATE Trial: A Comparison of Eligible Infants Enrolled in the Trial and Those Treated Outside the Trial

Liebowitz, M., Katheria, A., Sauberan, J., Singh, J., Nelson, K., Hassinger, D. C., Aucott, S. W., Kaempf, J., Kimball, A., Fernandez, E., Carey, W. A., Perez, J., Serize, A., Wickremasinghe, A., Dong, L., Derrick, M., Wolf, I. S., Heuchan, A. M., Sankar, M., Bulbul, A. & 1 others, Clyman, R. I., Jan 1 2019, (Accepted/In press) In : Journal of Pediatrics.

Research output: Contribution to journalArticle

Bronchopulmonary Dysplasia
Patent Ductus Arteriosus
Premature Birth
Physicians
Infant Mortality
1 Citation (Scopus)

Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis

Mangalam, A. K. & Murray, J. A., Jan 2 2019, In : Expert Review of Neurotherapeutics. 19, 1, p. 45-53 9 p.

Research output: Contribution to journalReview article

Prevotella
Multiple Sclerosis
Dysbiosis
Bacteria
Autoimmune Experimental Encephalomyelitis

Micronutrient Deficiencies Are Common in Contemporary Celiac Disease Despite Lack of Overt Malabsorption Symptoms

Bledsoe, A. C., King, K. S., Larson, J. J., Snyder, M., Absah, I., Choung, R. S. & Murray, J. A., Jul 1 2019, In : Mayo Clinic proceedings. 94, 7, p. 1253-1260 8 p.

Research output: Contribution to journalArticle

Open Access
Micronutrients
Celiac Disease
Ferritins
Nutrition Surveys
Vitamin B 12

On the First Usage of the Term “Rhabdomyosarcoma”

Raney, R. B., Arndt, C. A. S. & Parham, D. M., Jan 1 2019, In : Pediatric and Developmental Pathology. 22, 1, 1 p.

Research output: Contribution to journalLetter

Rhabdomyosarcoma

Outcomes of outborn extremely preterm neonates admitted to an NICU with respiratory distress

Fang, J., Mara, K. C., Weaver, A., Clark, R. H. & Carey, W. A., Jan 1 2019, (Accepted/In press) In : Archives of Disease in Childhood: Fetal and Neonatal Edition.

Research output: Contribution to journalArticle

Neonatal Intensive Care Units
Necrotizing Enterocolitis
Newborn Infant
Periventricular Leukomalacia
Propensity Score

Pak2 kinase promotes cellular senescence and organismal aging

Lee, J. S., Mo, Y., Gan, H., Burgess, R. J., Baker, D. J., Van Deursen, J. & Zhang, Z., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13311-13319 9 p.

Research output: Contribution to journalArticle

Open Access
Cell Aging
Phosphotransferases
Heterochromatin
Nucleosomes
Fibroblasts

Patient-oriented education and visual-aid intervention are inadequate to identify patients with potential capsule retention: a prospective randomized study

Al-Bawardy, B., Kamboj, A. K., Desai, S., Gorospe, E., Bruining, D. H., Gostout, C. J., Hansel, S. L., Larson, M. V., Murray, J. A., Nehra, V., Leggett, C., Szarka, L., Watson, R. E. & Rajan, E., Jan 1 2019, In : Scandinavian Journal of Gastroenterology.

Research output: Contribution to journalArticle

Audiovisual Aids
Patient Education
Capsules
Prospective Studies
Wrist
1 Citation (Scopus)

Patterns of amiodarone-induced thyroid dysfunction in infants and children

Creo, A., Anderson, H., Cannon, B., Lteif, A., Kumar, S., Tebben, P., Iqbal, A. M., Ramakrishna, A. & Pittock, S., Sep 1 2019, In : Heart rhythm. 16, 9, p. 1436-1442 7 p.

Research output: Contribution to journalArticle

Amiodarone
Thyrotropin
Thyroid Gland
Pediatrics
Thyroid Function Tests
5 Citations (Scopus)

PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age

PDA-TOLERATE (PDA: TO LEave it alone or Respond And Treat Early) Trial Investigators A list of additional PDA-TOLERATE Investigators is available at www.jpeds.com (Appendix), NCRC Nurses, Umea University Hospital & Kaiser Permanente Santa Clara Medical Center, Feb 1 2019, In : Journal of Pediatrics. 205, p. 41-48.e6

Research output: Contribution to journalArticle

Patent Ductus Arteriosus
Randomized Controlled Trials
Therapeutics
Bronchopulmonary Dysplasia
Ligation
1 Citation (Scopus)

Penetration of the Esophageal Epithelium by Dust Mite Antigen in Patients With Eosinophilic Esophagitis

Ravi, A., Marietta, E. V., Geno, D. M., Alexander, J. A., Murray, J. A. & Katzka, D. A., Jul 1 2019, In : Gastroenterology. 157, 1, p. 255-256 2 p.

Research output: Contribution to journalArticle

Eosinophilic Esophagitis
Esophagitis
Mites
Eosinophilia
Dust

Prevotella histicola, A Human Gut Commensal, Is as Potent as COPAXONE® in an Animal Model of Multiple Sclerosis

Shahi, S. K., Freedman, S. N., Murra, A. C., Zarei, K., Sompallae, R., Gibson-Corley, K. N., Karandikar, N. J., Murray, J. A. & Mangalam, A. K., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Prevotella
Multiple Sclerosis
Animal Models
Therapeutics
Bacteria

Rare Missense Variants in TLN1 Are Associated With Familial and Sporadic Spontaneous Coronary Artery Dissection

Turley, T. N., Theis, J. L., Sundsbak, R. S., Evans, J. M., O'Byrne, M. M., Gulati, R., Tweet, M., Hayes, S. N. & Olson, T. M., Apr 1 2019, In : Circulation. Genomic and precision medicine. 12, 4, p. e002437

Research output: Contribution to journalArticle

Talin
Integrins
Coronary Vessels
Staining and Labeling
Genes
1 Citation (Scopus)

Rickets severity predicts clinical outcomes in children with X-linked hypophosphatemia: Utility of the radiographic Rickets Severity Score

Thacher, T. D., Pettifor, J. M., Tebben, P., Creo, A. L., Skrinar, A., Mao, M., Chen, C. Y., Chang, T., San Martin, J. & Carpenter, T. O., May 1 2019, In : Bone. 122, p. 76-81 6 p.

Research output: Contribution to journalArticle

Open Access
Familial Hypophosphatemic Rickets
Rickets
Alkaline Phosphatase
Serum
Pediatrics

Senescent cells in the development of cardiometabolic disease

Postmus, A. C., Sturmlechner, I., Jonker, J. W., Van Deursen, J., van de Sluis, B. & Kruit, J. K., Jun 1 2019, In : Current opinion in lipidology. 30, 3, p. 177-185 9 p.

Research output: Contribution to journalArticle

Cell Aging
Dyslipidemias
Insulin Resistance
Adipose Tissue
Cell Count
2 Citations (Scopus)

Senolytic therapies for healthy longevity

Van Deursen, J., May 17 2019, In : Science. 364, 6441, p. 636-637 2 p.

Research output: Contribution to journalReview article

disease treatment
health status
medicine
rodent
cancer

Sex Difference in Celiac Disease in Undiagnosed Populations: A Systematic Review and Meta-analysis

Jansson-Knodell, C. L., Hujoel, I. A., West, C. P., Taneja, V. D., Prokop, L. J., Rubio-Tapia, A. & Murray, J. A., Sep 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 10, p. 1954-1968.e13

Research output: Contribution to journalArticle

Celiac Disease
Sex Characteristics
Meta-Analysis
Epidemiology
Biopsy
1 Citation (Scopus)

sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice

Cho, C. H., Yoo, K. H., Oliveros, A., Paulson, S., Hussaini, S. M. Q., Van Deursen, J. & Jang, M-H. D., Jan 1 2019, (Accepted/In press) In : Aging Cell. e12899.

Research output: Contribution to journalArticle

Brain
Parahippocampal Gyrus
Corpus Callosum
Neurogenesis
Dentate Gyrus
8 Citations (Scopus)

Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort

Smeland, S., Bielack, S. S., Whelan, J., Bernstein, M., Hogendoorn, P., Krailo, M. D., Gorlick, R., Janeway, K. A., Ingleby, F. C., Anninga, J., Antal, I., Arndt, C. A. S., Brown, K. L. B., Butterfass-Bahloul, T., Calaminus, G., Capra, M., Dhooge, C., Eriksson, M., Flanagan, A. M., Friedel, G. & 32 others, Gebhardt, M. C., Gelderblom, H., Goldsby, R., Grier, H. E., Grimer, R., Hawkins, D. S., Hecker-Nolting, S., Sundby Hall, K., Isakoff, M. S., Jovic, G., Kühne, T., Kager, L., von Kalle, T., Kabickova, E., Lang, S., Lau, C. C., Leavey, P. J., Lessnick, S. L., Mascarenhas, L., Mayer-Steinacker, R., Meyers, P. A., Nagarajan, R., Randall, R. L., Reichardt, P., Renard, M., Rechnitzer, C., Schwartz, C. L., Strauss, S., Teot, L., Timmermann, B., Sydes, M. R. & Marina, N., Mar 1 2019, In : European Journal of Cancer. 109, p. 36-50 15 p.

Research output: Contribution to journalArticle

Osteosarcoma
Cohort Studies
Confidence Intervals
Survival
Neoplasm Metastasis
1 Citation (Scopus)

Synthetic Neoepitopes of the Transglutaminase–Deamidated Gliadin Complex as Biomarkers for Diagnosing and Monitoring Celiac Disease

Choung, R. S., Khaleghi Rostamkolaei, S., Ju, J. M., Marietta, E. V., Van Dyke, C. T., Rajasekaran, J. J., Jayaraman, V., Wang, T., Bei, K., Rajasekaran, K. E., Krishna, K., Krishnamurthy, H. K. & Murray, J. A., Feb 1 2019, In : Gastroenterology. 156, 3, p. 582-591.e1

Research output: Contribution to journalArticle

Gliadin
Celiac Disease
Biomarkers
Peptides
Epitopes
Open Access
Food Hypersensitivity
Irritable Bowel Syndrome
Antigens
Food

The Utility of DXA Assessment at the Forearm, Proximal Femur, and Lateral Distal Femur, and Vertebral Fracture Assessment in the Pediatric Population: The 2019 Official Pediatric Positions of the ISCD

Weber, D. R., Boyce, A., Gordon, C., Hogler, W., Kecskemethy, H. H., Misra, M., Swolin-Eide, D., Tebben, P., Ward, L. M., Wasserman, H., Shuhart, C. & Zemel, B. S., Jan 1 2019, (Accepted/In press) In : Journal of Clinical Densitometry.

Research output: Contribution to journalReview article

Photon Absorptiometry
Forearm
Femur
Pediatrics
Bone and Bones

Updated guidelines by the European Society for the Study of Coeliac Disease

Rubio-Tapia, A. & Murray, J. A., Jun 1 2019, In : United European Gastroenterology Journal. 7, 5, p. 581-582 2 p.

Research output: Contribution to journalEditorial

Open Access
Celiac Disease
Guidelines
2018

Adaptive Designs for Clinical Trials: Application to Healthcare Epidemiology Research

Huskins, W. C., Fowler, V. G. & Evans, S., Mar 19 2018, In : Clinical Infectious Diseases. 66, 7, p. 1140-1146 7 p.

Research output: Contribution to journalArticle

Health Services Research
Epidemiology
Clinical Trials
Random Allocation
Cross Infection
11 Citations (Scopus)

Addition of vincristine and irinotecan to vincristine, dactinomycin, and cyclophosphamide does not improve outcome for intermediate-risk rhabdomyosarcoma: A report from the children’s oncology group

Hawkins, D. S., Chi, Y. Y., Anderson, J. R., Tian, J., Arndt, C. A. S., Bomgaars, L., Donaldson, S. S., Hayes-Jordan, A., Mascarenhas, L., Mccarville, M. B., Mccune, J. S., Mccowage, G., Million, L., Morris, C. D., Parham, D. M., Rodeberg, D. A., Rudzinski, E. R., Shnorhavorian, M., Spunt, S. L., Skapek, S. X. & 4 others, Teot, L. A., Wolden, S., Yock, T. I. & Meyer, W. H., Sep 20 2018, In : Journal of Clinical Oncology. 36, 27, p. 2770-2777 8 p.

Research output: Contribution to journalArticle

irinotecan
Rhabdomyosarcoma
Dactinomycin
Vincristine
Cyclophosphamide
2 Citations (Scopus)

Arrhythmia after cone repair for Ebstein anomaly: The Mayo Clinic experience in 143 young patients

Wackel, P., Cannon, B., Dearani, J., Sessions, K., Holst, K., Johnson, J. & Cetta, F., Jan 1 2018, In : Congenital Heart Disease. 13, 1, p. 26-30 5 p.

Research output: Contribution to journalArticle

Ebstein Anomaly
Cardiac Arrhythmias
Electrophysiology
Telephone
5 Citations (Scopus)

Association of early inhaled nitric oxide with the survival of preterm neonates with pulmonary hypoplasia

Ellsworth, K. R., Ellsworth, M. A., Weaver, A. L., Mara, K. C., Clark, R. H. & Carey, W. A., Jul 1 2018, In : JAMA Pediatrics. 172, 7, e180761.

Research output: Contribution to journalArticle

Nitric Oxide
Lung
Pulmonary Hypertension
Mortality
Periventricular Leukomalacia
3 Citations (Scopus)

Autoimmune and Allergic Disorders are More Common in People with Celiac Disease or on a Gluten-free Diet in the United States

Kim, H. S., Unalp-Arida, A., Ruhl, C. E., Choung, R. S. & Murray, J. A., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Gastroenterology.

Research output: Contribution to journalArticle

Gluten-Free Diet
Celiac Disease
Glutens
Thyroid Diseases
Organic Food
5 Citations (Scopus)

Cardiac imaging in Ebstein anomaly

Qureshi, M. Y., O'Leary, P. W. & Connolly, H. M., Jan 1 2018, (Accepted/In press) In : Trends in Cardiovascular Medicine.

Research output: Contribution to journalArticle

Ebstein Anomaly
Magnetic Resonance Imaging
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Tricuspid Valve
Echocardiography
2 Citations (Scopus)

Celiac Disease

Murray, J. A., Frey, M. R. & Oliva-Hemker, M., Jun 1 2018, In : Gastroenterology. 154, 8, p. 2005-2008 4 p.

Research output: Contribution to journalArticle

Celiac Disease

Celiac disease is uncommon in irritable bowel syndrome in the USA

Almazar, A. E., Talley, N. J., Larson, J. J., Atkinson, E. J., Murray, J. A. & Saito Loftus, Y. A., Jan 1 2018, In : European Journal of Gastroenterology and Hepatology. 30, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Celiac Disease
Antibodies
Genetic Testing
Indirect Fluorescent Antibody Technique
16 Citations (Scopus)

Cellular senescence in brain aging and neurodegenerative diseases: Evidence and perspectives

Baker, D. J. & Petersen, R. C., Apr 2 2018, In : Journal of Clinical Investigation. 128, 4, p. 1208-1216 9 p.

Research output: Contribution to journalReview article

Cell Aging
Brain Diseases
Neurodegenerative Diseases
Cell Cycle Checkpoints
Parkinson Disease