Research Output

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Review article
1986

The nuclear matrix: current concepts and unanswered questions.

Kaufmann, S. H., Fields, A. P. & Shaper, J. H., Jan 1 1986, In : Methods and achievements in experimental pathology. 12, p. 141-171 31 p.

Research output: Contribution to journalReview article

39 Scopus citations
1993

The current status of camptothecin analogues as antitumor agents

Slichenmyer, W. J., Rowinsky, E. K., Donehower, R. C. & Kaufmann, S. H., Feb 17 1993, In : Journal of the National Cancer Institute. 85, 4, p. 271-291 21 p.

Research output: Contribution to journalReview article

620 Scopus citations
1994

Proximal signals and the control of S-phase entry in interleukin-2- stimulated T lymphocytes

Abraham, R. T., Karnitz, L. M., Burns, L. A. & Brunn, G. J., 1994, In : Advances in experimental medicine and biology. 365, p. 197-210 14 p.

Research output: Contribution to journalReview article

5 Scopus citations
1995

Topoisomerase II as a target for anticancer chemotherapy.

Kaufmann, S. H. & Hancock, R., 1995, In : Acta biochimica Polonica. 42, 4, p. 381-393 13 p.

Research output: Contribution to journalReview article

Open Access
1996

Interleukin-2 receptor signaling mechanisms

Karnitz, L. M. & Abraham, R. T., Jan 1 1996, In : Advances in Immunology. 61, p. 147-199 53 p.

Research output: Contribution to journalReview article

46 Scopus citations

The role of proteases during apoptosis

Patel, T., Gores, G. J. & Kaufmann, S. H., Apr 1996, In : FASEB Journal. 10, 5, p. 587-597 11 p.

Research output: Contribution to journalReview article

528 Scopus citations
1997

Caspases and caspase inhibitors

Villa, P., Kaufmann, S. H. & Earnshaw, W. C., Oct 1 1997, In : Trends in biochemical sciences. 22, 10, p. 388-393 6 p.

Research output: Contribution to journalReview article

538 Scopus citations

Topotecan in combination chemotherapy

Rowinsky, E. K. & Kaufmann, S. H., Dec 1 1997, In : Seminars in oncology. 24, 6 SUPPL. 20, p. S2011-S2026

Research output: Contribution to journalReview article

8 Scopus citations

Topotecan in combination chemotherapy.

Rowinsky, E. K. & Kaufmann, S. H., Dec 1997, In : Seminars in oncology. 24, 6 Suppl 20, p. S20-11-S20-1126

Research output: Contribution to journalReview article

13 Scopus citations
1998

Cell death induced by topoisomerase-targeted drugs: More questions than answers

Kaufmann, S. H., Oct 1 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1400, 1-3, p. 195-211 17 p.

Research output: Contribution to journalReview article

285 Scopus citations

Topoisomerase II and the response to antileukemic therapy

Kaufmann, S. H., Gore, S. D., Miller, C. B., Jones, R. J., Zwelling, L. A., Schneider, E., Burke, P. J. & Karp, J. E., Jan 1 1998, In : Leukemia and Lymphoma. 29, 3-4, p. 217-237 21 p.

Research output: Contribution to journalReview article

26 Scopus citations
1999

Mammalian caspases: Structure, activation, substrates, and functions during apoptosis

Earnshaw, W. C., Martins, L. M. & Kaufmann, S. H., Oct 4 1999, In : Annual Review of Biochemistry. 68, p. 383-424 42 p.

Research output: Contribution to journalReview article

2331 Scopus citations
2000

Apoptosis in cancer: Cause and cure

Kaufmann, S. H. & Gores, G. J., Jan 1 2000, In : BioEssays. 22, 11, p. 1007-1017 11 p.

Research output: Contribution to journalReview article

162 Scopus citations

Detection of DNA cleavage in apoptotic cells

Kaufmann, S. H., Mesner, P. W., Samejima, K., Toné, S. & Earnshaw, W. C., 2000, In : Methods in enzymology. 322, p. 3-15 13 p.

Research output: Contribution to journalReview article

46 Scopus citations
2001

Apoptosis and the response to anticancer therapy

Mow, B. M. F., Blajeski, A. L., Chandra, J. & Kaufmann, S. H., Nov 13 2001, In : Current Opinion in Oncology. 13, 6, p. 453-462 10 p.

Research output: Contribution to journalReview article

80 Scopus citations

Current status of clinical trials of farnesyltransferase inhibitors

Karp, J. E., Kaufmann, S. H., Adjei, A. A., Lancet, J. E., Wright, J. J. & End, D. W., Nov 13 2001, In : Current Opinion in Oncology. 13, 6, p. 470-476 7 p.

Research output: Contribution to journalReview article

119 Scopus citations

Is TRAIL hepatotoxic?

Gores, G. J. & Kaufmann, S. H., Jan 1 2001, In : Hepatology. 34, 1, p. 3-6 4 p.

Research output: Contribution to journalReview article

67 Scopus citations

Novel pharmacological agents in clinical development for solid tumours

Dy, G. K., Haluska, P. & Adjei, A. A., Jan 1 2001, In : Expert Opinion on Investigational Drugs. 10, 12, p. 2059-2088 30 p.

Research output: Contribution to journalReview article

14 Scopus citations

Programmed cell death: Alive and well in the new millennium

Kaufmann, S. H. & Hengartner, M. O., Dec 1 2001, In : Trends in Cell Biology. 11, 12, p. 526-534 9 p.

Research output: Contribution to journalReview article

563 Scopus citations

Receptor tyrosine kinase inhibitors

Haluska, P. & Adjei, A. A., Mar 14 2001, In : Current Opinion in Investigational Drugs. 2, 2, p. 280-286 7 p.

Research output: Contribution to journalReview article

30 Scopus citations

TGFβ-mediated signaling and transcriptional regulation in pancreatic development and cancer

Ellenrieder, V., Fernandez Zapico, M. E. & Urrutia, R., 2001, In : Current Opinion in Gastroenterology. 17, 5, p. 434-440 7 p.

Research output: Contribution to journalReview article

12 Scopus citations
2002
9 Scopus citations

ITAMs versus ITIMs: Striking a balance during cell regulation

Billadeau, D. D. & Leibson, P. J., 2002, In : Journal of Clinical Investigation. 109, 2, p. 161-168 8 p.

Research output: Contribution to journalReview article

Open Access
141 Scopus citations

Pancreatic cancer research: Challenges, opportunities, and recent developments

Fernandez-Zapico, M. E., Kaczynski, J. A. & Urrutia, R., Sep 1 2002, In : Current Opinion in Gastroenterology. 18, 5, p. 563-567 5 p.

Research output: Contribution to journalReview article

6 Scopus citations

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

Turner, M. & Billadeau, D. D., Jul 1 2002, In : Nature Reviews Immunology. 2, 7, p. 476-486 11 p.

Research output: Contribution to journalReview article

244 Scopus citations
2003

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

Kaufmann, S. H. & Vaux, D. L., Oct 20 2003, In : Oncogene. 22, 47 REV. ISS. 6, p. 7414-7430 17 p.

Research output: Contribution to journalReview article

243 Scopus citations

BRCA proteins and DNA damage checkpoints

Lou, Z. & Chen, J., Jan 1 2003, In : Frontiers in Bioscience. 8, SUPPL., p. s718-s721

Research output: Contribution to journalReview article

9 Scopus citations

Expression profiling in pancreatic cancer research: The initial steps and the road ahead

Fernandez-Zapico, M. E., Callahan, G., Delgado, S. & Urrutia, R., Sep 1 2003, In : Current Opinion in Gastroenterology. 19, 5, p. 467-472 6 p.

Research output: Contribution to journalReview article

Treatment of Brain Metastases from Melanoma

McWilliams, R. R., Brown, P. D., Buckner, J. C., Link, M. J. & Markovic, S. N., Dec 2003, In : Mayo Clinic proceedings. 78, 12, p. 1529-1536 8 p.

Research output: Contribution to journalReview article

Open Access
42 Scopus citations
2004

Dial 9-1-1 for DNA damage: The Rad9-Hus1-Rad1 (9-1-1) clamp complex

Parrilla-Castellar, E. R., Arlander, S. J. H. & Karnitz, L., Aug 1 2004, In : DNA Repair. 3, 8-9, p. 1009-1014 6 p.

Research output: Contribution to journalReview article

218 Scopus citations

Molecular pathways of pancreatic carcinogenesis

Fernandez-Zapico, M. E. & Urrutia, R., Nov 2004, In : Drug Discovery Today: Disease Mechanisms. 1, 2, p. 247-252 6 p.

Research output: Contribution to journalReview article

6 Scopus citations
2005

'Good mentorship is invaluable' - An interview with Dr. Eugene P. DiMagno

Fernandez-Zapico, M. E., Jan 1 2005, In : Pancreatology. 5, 1, p. 5-7 3 p.

Research output: Contribution to journalReview article

3 Scopus citations

Novel therapeutics in colorectal cancer

McWilliams, R. R. & Erlichman, C., Aug 1 2005, In : Diseases of the colon and rectum. 48, 8, p. 1632-1650 19 p.

Research output: Contribution to journalReview article

20 Scopus citations

Right place, right time, and only once: Replication initiation in metazoans

Machida, Y. J., Hamlin, J. L. & Dutta, A., Oct 7 2005, In : Cell. 123, 1, p. 13-24 12 p.

Research output: Contribution to journalReview article

227 Scopus citations

Treatment options for brain metastases from melanoma

McWilliams, R. R., Rao, R. D., Brown, P. D., Link, M. J. & Buckner, J. C., Oct 1 2005, In : Expert review of anticancer therapy. 5, 5, p. 809-820 12 p.

Research output: Contribution to journalReview article

11 Scopus citations

When developmental signaling pathways go wrong and their impact on pancreatic cancer development

Lomberk, G., Fernandez-Zapico, M. E. & Urrutia, R., Sep 1 2005, In : Current Opinion in Gastroenterology. 21, 5, p. 555-560 6 p.

Research output: Contribution to journalReview article

6 Scopus citations
2006

Apoptosis in the treatment of cancer: a promise kept?

Meng, X. W., Lee, S. H. & Kaufmann, S. H., Dec 1 2006, In : Current Opinion in Cell Biology. 18, 6, p. 668-676 9 p.

Research output: Contribution to journalReview article

60 Scopus citations

Cellular senescence and DNA repair

Lou, Z. & Chen, J., Aug 15 2006, In : Experimental Cell Research. 312, 14, p. 2641-2646 6 p.

Research output: Contribution to journalReview article

54 Scopus citations

Genetic analysis of apoptotic execution.

Ruchand, S., Samejima, K., Hudson, D., Kaufmann, S. H. & Earnshaw, W. C., 2006, In : Sub-cellular biochemistry. 40, p. 75-90 16 p.

Research output: Contribution to journalReview article

1 Scopus citations
83 Scopus citations

Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias

Buttar, N. S., Fernandez-Zapico, M. E. & Urrutia, R., Sep 2006, In : Current Opinion in Gastroenterology. 22, 5, p. 505-511 7 p.

Research output: Contribution to journalReview article

11 Scopus citations

Regulation of cytoskeletal dynamics at the immune synapse: New stars join the actin troupe

Billadeau, D. D. & Burkhardt, J. K., Nov 2006, In : Traffic. 7, 11, p. 1451-1460 10 p.

Research output: Contribution to journalReview article

55 Scopus citations

Targeting GSK-3: A promising approach for cancer therapy?

Ougolkov, A. V. & Billadeau, D. D., Feb 1 2006, In : Future Oncology. 2, 1, p. 91-100 10 p.

Research output: Contribution to journalReview article

94 Scopus citations

To understand what happens to the foods that you and i eat: An interview with Dr. Vay Liang Go

Fernandez-Zapico, M. E., Aug 2006, In : Pancreatology. 6, 4, p. 263-265 3 p.

Research output: Contribution to journalReview article

2007

Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.

Karnitz, L. M. & Felts, S. J., May 26 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 385, p. pe22

Research output: Contribution to journalReview article

34 Scopus citations

'Do research with seriousness and perseverance': An interview with Prof. Lucio Gullo

Fernandez-Zapico, M. E., Sep 2007, In : Pancreatology. 7, 4, p. 311-313 3 p.

Research output: Contribution to journalReview article

'Look for the right mentor': An interview with Prof. Manfred V. Singer

Fernandez-Zapico, M. E., May 2007, In : Pancreatology. 7, 1, p. 3-6 4 p.

Research output: Contribution to journalReview article

1 Scopus citations

Regulation of T-cell activation by the cytoskeleton

Billadeau, D. D., Nolz, J. C. & Gomez, T. S., Feb 1 2007, In : Nature Reviews Immunology. 7, 2, p. 131-143 13 p.

Research output: Contribution to journalReview article

244 Scopus citations

'The success of the mentee is the mentor's ultimate reward': An interview with Dr. Michael L. Steer

Fernandez-Zapico, M. E., Mar 2007, In : Pancreatology. 6, 6, p. 507-509 3 p.

Research output: Contribution to journalReview article

'You're heading in the right direction': An interview with Dr. Fred Gorelick

Fernandez-Zapico, M. E., Jul 2007, In : Pancreatology. 7, 2-3, p. 93-95 3 p.

Research output: Contribution to journalReview article