Research Output

Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro

Richelson, E. & Nelson, A., Aug 17 1984, In : European Journal of Pharmacology. 103, 3-4, p. 197-204 8 p.

Research output: Contribution to journalArticle

195 Scopus citations

Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics

Stanton, T., Bolden-Watson, C., Cusack, B. & Richelson, E., Jun 9 1993, In : Biochemical Pharmacology. 45, 11, p. 2352-2354 3 p.

Research output: Contribution to journalArticle

58 Scopus citations

Antemortem diagnosis of diffuse Lewy body disease

Crystal, H. A., Dickson, D. W., Lizardi, J. E., Davies, P. & Wolfson, L. I., Oct 1990, In : Neurology. 40, 10, p. 1523-1528 6 p.

Research output: Contribution to journalArticle

146 Scopus citations

Antemortem diagnosis of frontotemporal lobar degeneration

Knopman, D. S., Boeve, B. F., Parisi, J. E., Dickson, D. W., Smith, G. E., Ivnik, R. J., Josephs, K. A. & Petersen, R. C., Apr 1 2005, In : Annals of neurology. 57, 4, p. 480-488 9 p.

Research output: Contribution to journalArticle

160 Scopus citations

Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND

Vemuri, P., Simon, G., Kantarci, K., Whitwell, J. L., Senjem, M. L., Przybelski, S. A., Gunter, J. L., Josephs, K. A., Knopman, D. S., Boeve, B. F., Ferman, T. J., Dickson, D. W., Parisi, J. E., Petersen, R. C. & Jack, C. R., Mar 15 2011, In : NeuroImage. 55, 2, p. 522-531 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Antemortem memory impairment screen performance is correlated with postmortem Alzheimer pathology [4]

Verghese, J., Buschke, H., Kuslansky, G., J Katz, M., Weidenheim, K., B Lipton, R. & Dickson, D. W., Jul 1 2003, In : Journal of the American Geriatrics Society. 51, 7, p. 1043-1045 3 p.

Research output: Contribution to journalLetter

7 Scopus citations
118 Scopus citations

Antemortem MRI findings associated with microinfarcts at autopsy

Raman, M. R., Preboske, G. M., Przybelski, S. A., Gunter, J. L., Senjem, M. L., Vemuri, P., Murphy, M. C., Murray, M. E., Boeve, B. F., Knopman, D. S., Petersen, R. C., Parisi, J. E., Dickson, D. W., Jack, C. R. & Kantarci, K., Jun 3 2014, In : Neurology. 82, 22, p. 1951-1958 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

Jack, C. R., Dickson, D. W., Parisi, J. E., Xu, Y. C., Cha, R. H., O'Brien, P. C., Edland, S. D., Smith, G. E., Boeve, B. F., Tangalos, E. G., Kokmen, E. & Petersen, R. C., Mar 12 2002, In : Neurology. 58, 5, p. 750-757 8 p.

Research output: Contribution to journalArticle

444 Scopus citations

Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Bejanin, A., Murray, M. E., Martin, P., Botha, H., Tosakulwong, N., Schwarz, C. G., Senjem, M. L., Chételat, G., Kantarci, K., Jack, C. R., Boeve, B. F., Knopman, D. S., Petersen, R. C., Giannini, C., Parisi, J. E., Dickson, D. W., Whitwell, J. L. & Josephs, K. A., Nov 1 2019, In : Brain. 142, 11, p. 3621-3635 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers

Jacova, C., Hsiung, G. Y. R., Tawankanjanachot, I., Dinelle, K., McCormick, S., Gonzalez, M., Lee, H., Sengdy, P., Bouchard-Kerr, P., Baker, M., Rademakers, R., Sossi, V., Stoessl, A. J., Feldman, H. H. & Mackenzie, I. R., Oct 8 2013, In : Neurology. 81, 15, p. 1322-1331 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis

Liao, F., Hori, Y., Hudry, E., Bauer, A. Q., Jiang, H., Mahan, T. E., Lefton, K. B., Zhang, T. J., Dearborn, J. T., Kim, J., Culver, J. P., Betensky, R., Wozniak, D. F., Hyman, B. T. & Holtzman, D. M., 2014, In : Journal of Neuroscience. 34, 21, p. 7281-7292 12 p.

Research output: Contribution to journalArticle

72 Scopus citations

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

Kim, J., Eltorai, A. E. M., Jiang, H., Liao, F., Verghese, P. B., Kim, J., Stewart, F. R., Basak, J. M. & Holtzman, D. M., Nov 2012, In : Journal of Experimental Medicine. 209, 12, p. 2149-2156 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Anti-Aβ42- and anti-Aβ40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

Levites, Y., Das, P., Price, R. W., Rochette, M. J., Kostura, L. A., McGowan, E. M., Murphy, M. P. & Golde, T. E., Jan 2006, In : Journal of Clinical Investigation. 116, 1, p. 193-201 9 p.

Research output: Contribution to journalArticle

158 Scopus citations

Antibodies to neurofilament, glial filament, and fibroblast intermediate filament proteins bind to different cell types of the nervous system

Yen, S. H. & Fields, K. L., 1981, In : Journal of Cell Biology. 88, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

Open Access
321 Scopus citations

Anticholinergic activity of imipramine and some analogs at muscarinic receptors of cultured mouse neuroblastoma cells

Petersen, R. C. & Richelson, E., Jan 1 1982, In : Psychopharmacology. 76, 1, p. 26-28 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Anticipation in a family with primary familial brain calcification caused by an SLC20A2 variant

Konno, T., Blackburn, P. R., Rozen, T., Van Gerpen, J. A., Ross, O. A., Atwal, P. S. & Wszolek, Z. K., Jan 1 2018, (Accepted/In press) In : Neurologia i Neurochirurgia Polska.

Research output: Contribution to journalArticle

3 Scopus citations

Antidepressant drugs block muscarinic acetylcholine receptor mediated formation of cyclic GMP in cultured mouse neuroblastoma cells

Divinetz-Romero, S. & Richelson, E., 1977, In : Federation Proceedings. 36, 3

Research output: Contribution to journalArticle

Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050

Shaw, A. M., Boules, M., Zhang, Y., Williams, K., Robinson, J., Carlier, P. R. & Richelson, E., Jan 19 2007, In : European Journal of Pharmacology. 555, 1, p. 30-36 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(Methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)

Liang, Y., Shaw, A. M., Boules, M., Briody, S., Robinson, J., Oliveros, A., Blazar, E., Williams, K., Zhang, Y., Carlier, P. R. & Richelson, E., Nov 2008, In : Journal of Pharmacology and Experimental Therapeutics. 327, 2, p. 573-583 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Antidepressants: A clinical update for medical practitioners

Richardson, J. W. & Richelson, E., 1984, In : Mayo Clinic Proceedings. 59, 5, p. 330-337 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Antidepressants and Brain Neurochemistry

RICHELSON, ELLIOTT., 1990, In : Mayo Clinic proceedings. 65, 9, p. 1227-1236 10 p.

Research output: Contribution to journalReview article

Open Access
61 Scopus citations

Antidepressants are weak competitive antagonists of histamine H2 receptors in dissociated brain tissue

Kanba, S. & Richelson, E., Oct 28 1983, In : European Journal of Pharmacology. 94, 3-4, p. 313-318 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function

Fryer, J. D. & Lukas, R. J., Feb 24 1999, In : Journal of neurochemistry. 72, 3, p. 1117-1124 8 p.

Research output: Contribution to journalArticle

115 Scopus citations

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Maianti, J. P., McFedries, A., Foda, Z. H., Kleiner, R. E., Du, X. Q., Leissring, M. A., Tang, W. J., Charron, M. J., Seeliger, M. A., Saghatelian, A. & Liu, D. R., 2014, In : Nature. 511, 7507, p. 94-98 5 p.

Research output: Contribution to journalArticle

118 Scopus citations

Antimuscarinic and other receptor-blocking properties of antidepressants

Richelson, E., 1983, In : Mayo Clinic proceedings. 58, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Antimuscarinic effects of lithium

Kanba, S. & Richelson, E., 1984, In : New England Journal of Medicine. 310, 15, p. 989-990 2 p.

Research output: Contribution to journalArticle

19 Scopus citations

Antinociceptive, hypothermic, hypotensive, and reinforcing effects of a novel neurotensin receptor agonist, NT69L, in rhesus monkeys

Fantegrossi, W. E., Ko, M. C. H., Woods, J. H. & Richelson, E., Feb 1 2005, In : Pharmacology Biochemistry and Behavior. 80, 2, p. 341-349 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Antiparallel β-sheet structure within the C-terminal region of 42-residue Alzheimer's amyloid-β peptides when they form 150-kDa oligomers

Huang, D., Zimmerman, M. I., Martin, P. K., Nix, A. J., Rosenberry, T. L. & Paravastu, A. K., Jul 3 2015, In : Journal of Molecular Biology. 427, 13, p. 2319-2328 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Antiparkinson-like effects of a novel neurotensin analog in unilaterally 6-hydroxydopamine lesioned rats

Boules, M., Warrington, L., Fauq, A., McCormick, D. & Richelson, E., Oct 5 2001, In : European Journal of Pharmacology. 428, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Antipsychotic agents: A clinical update

Black, J. L., Richelson, E. & Richardson, J. W., 1985, In : Mayo Clinic Proceedings. 60, 11, p. 777-789 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Antipsychotic drugs: Prediction of side-effect profiles based on neuroreceptor data derived from human brain tissue

Black, J. L. & Richelson, E., 1987, In : Mayo Clinic Proceedings. 62, 5, p. 369-372 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Antipsychotics block muscarinic acetylcholine receptor-mediated cyclic GMP formation in cultured mouse neuroblastoma cells

Richelson, E., 1977, In : Nature. 266, 5600, p. 371-373 3 p.

Research output: Contribution to journalArticle

20 Scopus citations

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid β42 in transfected cells

Refolo, L. M., Eckman, C., Prada, C. M., Yager, D., Sambamurti, K., Mehta, N., Hardy, J. & Younkin, S. G., Nov 29 1999, In : Journal of neurochemistry. 73, 6, p. 2383-2388 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

Gendron, T. F., Bieniek, K. F., Zhang, Y. J., Jansen-West, K., Ash, P. E. A., Caulfield, T., Daughrity, L., Dunmore, J. H., Castanedes-Casey, M., Chew, J., Cosio, D. M., Van Blitterswijk, M., Lee, W. C., Rademakers, R., Boylan, K. B., Dickson, D. W. & Petrucelli, L., 2013, In : Acta neuropathologica. 126, 6, p. 829-844 16 p.

Research output: Contribution to journalArticle

270 Scopus citations

Antisera to an amino-terminal peptide detect the amyloid protein precursor of alzheimer's disease and recognize senile plaques

Palmert, M. R., Podlisny, M. B., Witker, D. S., Oltersdorf, T., Younkin, L. H., Selkoe, D. J. & Younkin, S. G., Oct 14 1988, In : Biochemical and Biophysical Research Communications. 156, 1, p. 432-437 6 p.

Research output: Contribution to journalArticle

64 Scopus citations

Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic later sclerosis

Van Blitterswijk, M., Gulati, S., Smoot, E., Jaffa, M., Maher, N., Hyman, B. T., Ivinson, A. J., Scherzer, C. R., Schoenfeld, D. A., Cudkowicz, M. E., Brown, R. H. & Bosco, D. A., Nov 2011, In : Amyotrophic Lateral Sclerosis. 12, 6, p. 430-438 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

A partial loss of function allele of Methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

Samaco, R. C., Fryer, J. D., Ren, J., Fyffe, S., Chao, H. T., Sun, Y., Greer, J. J., Zoghbi, H. Y. & Neul, J. L., Jun 15 2008, In : Human molecular genetics. 17, 12, p. 1718-1727 10 p.

Research output: Contribution to journalArticle

139 Scopus citations

A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Leissring, M. A., Murphy, M. P., Mead, T. R., Akbari, Y., Sugarman, M. C., Jannatipour, M., Anliker, B., Müller, U., Saftig, P., De Strooper, B., Wolfe, M. S., Golde, T. E. & LaFerla, F. M., Apr 2 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4697-4702 6 p.

Research output: Contribution to journalArticle

233 Scopus citations

ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-β pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis

Fagan, A. M., Christopher, E., Taylor, J. W., Parsadanian, M., Spinner, M., Watson, M., Fryer, J. D., Wahrle, S., Bales, K. R., Paul, S. M. & Holtzman, D. M., Oct 2004, In : American Journal of Pathology. 165, 4, p. 1413-1422 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

APOE «4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

Dickson, D. W., Heckman, M. G., Murray, M. E., Soto, A. I., Walton, R. L., Diehl, N. N., Van Gerpen, J. A., Uitti, R. J., Wszolek, Z. K., Ertekin-Taner, N., Knopman, D. S., Petersen, R. C., Graff-Radford, N. R., Boeve, B. F., Bu, G., Ferman, T. J. & Ross, O. A., Sep 18 2018, In : Neurology. 91, 12, p. E1182-E1195

Research output: Contribution to journalArticle

28 Scopus citations
1 Scopus citations

ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles

dos Santos Rodrigues, B., Kanekiyo, T. & Singh, J., Nov 1 2019, In : Pharmaceutical research. 36, 11, 161.

Research output: Contribution to journalArticle

4 Scopus citations

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G., May 1 2016, In : Annals of neurology. 79, 5, p. 758-774 17 p.

Research output: Contribution to journalArticle

37 Scopus citations

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Liu, C. C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W. & Bu, G., Dec 6 2017, In : Neuron. 96, 5, p. 1024-1032.e3

Research output: Contribution to journalArticle

76 Scopus citations

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Zhao, N., Attrebi, O. N., Ren, Y., Qiao, W., Sonustun, B., Martens, Y. A., Meneses, A. D., Li, F., Shue, F., Zheng, J., van Ingelgom, A. J., Davis, M. D., Kurti, A., Knight, J. A., Linares, C., Chen, Y., Delenclos, M., Liu, C. C., Fryer, J. D., Asmann, Y. W. & 4 others, McLean, P. J., Dickson, D. W., Ross, O. A. & Bu, G., Feb 5 2020, In : Science translational medicine. 12, 529, eaay1809.

Research output: Contribution to journalArticle

9 Scopus citations

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M. L., Liu, C. C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. & Kanekiyo, T., Mar 2019, In : Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease

Youmans, K. L., Tai, L. M., Nwabuisi-Heath, E., Jungbauer, L., Kanekiyo, T., Gan, M., Kim, J., Eimer, W. A., Estus, S., Rebeck, G. W., Weeber, E. J., Bu, G., Yu, C. & LaDu, M. J., Dec 7 2012, In : Journal of Biological Chemistry. 287, 50, p. 41774-41786 13 p.

Research output: Contribution to journalArticle

126 Scopus citations

ApoE and Aβ in Alzheimer's disease: Accidental encounters or partners?

Kanekiyo, T., Xu, H. & Bu, G., Feb 19 2014, In : Neuron. 81, 4, p. 740-754 15 p.

Research output: Contribution to journalReview article

264 Scopus citations