Research Output

1992

Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor

Estus, S., Golde, T. E., Kunishita, T., Blades, D., Lowery, D., Eisen, M., Usiak, M., Qu, X., Tabira, T., Greenberg, B. D. & Younkin, S. G., 1992, In : Science. 255, 5045, p. 726-728 3 p.

Research output: Contribution to journalArticle

342 Scopus citations

Presence of d-alanine in proteins of normal and Alzheimer human brain

D'Aniello, A., Vetere, A., Fisher, G. H., Cusano, G., Chavez, M. & Petrucelli, L., Oct 2 1992, In : Brain Research. 592, 1-2, p. 44-48 5 p.

Research output: Contribution to journalArticle

60 Scopus citations

Processing of the amyloid protein precursor to potentially amyloidogenic derivatives

Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J. & Younkin, S. G., Jan 1 1992, In : Science. 255, 5045, p. 728-730 3 p.

Research output: Contribution to journalArticle

606 Scopus citations

Production of the Alzheimer amyloid β protein by normal proteolytic processing

Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X. D., McKay, D. M., Tintner, R., Frangione, B. & Younkin, S. G., Jan 1 1992, In : Science. 258, 5079, p. 126-129 4 p.

Research output: Contribution to journalArticle

1272 Scopus citations

Quantitfication of d-aspartate in normal and Alzheimer brains

Fisher, G. H., D'Aniello, A., Vetere, A., Cusano, G. P., Chávez, M. & Petrucelli, L., Aug 31 1992, In : Neuroscience Letters. 143, 1-2, p. 215-218 4 p.

Research output: Contribution to journalArticle

38 Scopus citations

Recurrent encephalopathy and seizures in a US native with HTLV-I-associated myelopathy / tropical spastic paraparesis: A clinicopathologic study

Smith, C. R., Dickson, D. & Samkoff, L., Mar 1992, In : Neurology. 42, 3, p. 658-661 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regional localization of the regulatory subunit (RIIβ) of the type II cAMP-dependent protein kinase in human brain

Licameli, V., A. Mattiace, L., Erlichman, J., Davies, P., Dickson, D. & Shafit-Zagardo, B., Apr 24 1992, In : Brain Research. 578, 1-2, p. 61-68 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Regional synaptic pathology in Alzheimer's disease

Honer, W. G., Dickson, D. W., Gleeson, J. & Davies, P., 1992, In : Neurobiology of aging. 13, 3, p. 375-382 8 p.

Research output: Contribution to journalArticle

147 Scopus citations

Regulation of neurotensin receptor expression and function in a neuronal model system

Richelson, E., 1992, In : Annals of the New York Academy of Sciences. 668, p. 120-128 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

R-ELISA: Repeated use of antigen-coated plates for ELISA and its application for testing of antibodies to HIV and other pathogens

Baunoch, D. A., Das, P., Browning, M. E. & Hari, V., Jan 1 1992, In : BioTechniques. 12, 3, p. 412-417 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Secretory processing of the Alzheimer amyloid β A4 protein precursor is increased by protein phosphorylation

Gillespie, S. L., Golde, T. E. & Younkin, S. G., Sep 30 1992, In : Biochemical and Biophysical Research Communications. 187, 3, p. 1285-1290 6 p.

Research output: Contribution to journalArticle

101 Scopus citations

Simple General Acid-base Catalysis of Physiological Acetylcholinesterase Reactions

Pryor, A. N., Selwood, T., Leu, L. S., Andracki, M., Lee, B. H., Rao, M., Rosenberry, T., Doctor, B. P., Silman, I. & Quinn, D. M., May 1 1992, In : Journal of the American Chemical Society. 114, 10, p. 3896-3900 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

The Rat Neurotensin Receptor Expressed in Chinese Hamster Ovary Cells Mediates the Release of Inositol Phosphates

Watson, M. A., Yamada, M., Yamada, M., Cusack, B., Veverka, K., Bolden‐Watson, C. & Richelson, E., Nov 1992, In : Journal of neurochemistry. 59, 5, p. 1967-1970 4 p.

Research output: Contribution to journalArticle

49 Scopus citations

Ultrastructural identification of neurofibrillary tangles in the spinal cords in Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam

Kato, S., Hirano, A., Llena, J. F., Ito, H. & Yen, S. H., Feb 1992, In : Acta neuropathologica. 83, 3, p. 277-282 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
1993

39-kD protein inhibits tissue-type plasminogen activator clearance in vivo

Warshawsky, I., Bu, G. & Schwartz, A. L., 1993, In : Journal of Clinical Investigation. 92, 2, p. 937-944 8 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

A candidate mammalian glycoinositol phospholipid precursor containing three phosphoethanolamines

Ueda, E., Sevlever, D., Prince, G. M., Rosenberry, T. L., Hirose, S. & Medof, M. E., 1993, In : Journal of Biological Chemistry. 268, 14, p. 9998-10002 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures

Oxenrider, K. A., Bu, G. & Sitz, T. O., Feb 1 1993, In : FEBS Letters. 316, 3, p. 273-277 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

A method for radioligand binding assays using a robotic workstation

Cusack, B. & Richelson, E., 1993, In : Journal of Receptors and Signal Transduction. 13, 1-4, p. 123-134 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics

Stanton, T., Bolden-Watson, C., Cusack, B. & Richelson, E., Jun 9 1993, In : Biochemical Pharmacology. 45, 11, p. 2352-2354 3 p.

Research output: Contribution to journalArticle

58 Scopus citations

Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids

D'Aniello, A., D'Onofrio, G., Pischetola, M., D'Aniello, G., Vetere, A., Petrucelli, L. & Fisher, G. H., Dec 1 1993, In : Journal of Biological Chemistry. 268, 36, p. 26941-26949 9 p.

Research output: Contribution to journalArticle

225 Scopus citations

Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes

Bolden-Watson, C. & Richelson, E., 1993, In : Life Sciences. 52, 12, p. 1023-1029 7 p.

Research output: Contribution to journalArticle

396 Scopus citations

Central Nervous System in Pediatric AIDS: Results from Neuropathologic Pediatric AIDS Registry

KOZLOWSKI, P. B., SHER, J. H., RAO, C., ANZIL, P. A., WRZOLEK, M. A., SHARER, L., CHO, E. S., DICKSON, D. W., WEIDENHEIM, K. M., LLENA, J. F., NELSON, S. J. & KANZER, M. D., Oct 1993, In : Annals of the New York Academy of Sciences. 693, 1, p. 295-296 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Central Nervous System Pathology in Pediatric AIDS

DICKSON, DENNIS. W., LLENA, JOSEFINA. F., NELSON, STEPHEN. J. & WEIDENHEIM, KAREN. M., Oct 1993, In : Annals of the New York Academy of Sciences. 693, 1, p. 93-106 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cytokine production by human fetal microglia and astrocytes: Differential induction by lipopolysaccharide and IL-1β

Lee, S. C., Liu, W., Dickson, D. W., Brosnan, C. F. & Berman, J. W., 1993, In : Journal of Immunology. 150, 7, p. 2659-2667 9 p.

Research output: Contribution to journalArticle

710 Scopus citations

Desensitization and down-regulation of neurotensin receptors in murine neuroblastoma clone N1E-115 by [D-Lys8] neurotensin(8- 13)

Di Paola, E. D., Cusack, B., Yamada, M. & Richelson, E., 1993, In : Journal of Pharmacology and Experimental Therapeutics. 264, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Detection of antibodies to the HIV-1 p25/24 and gp120 proteins by sphere- linked immunodiagnostic assay (SLIDA)

Das, P. & Hari, V., Jan 1 1993, In : BioTechniques. 14, 5, p. 775+777+779+781

Research output: Contribution to journalArticle

Facilitation of adaptation and acute tolerance to stressful sensory input by doxepin and scopolamine plus amphetamine

Kohl, R. L., Sandoz, G. R., Reschke, M. F., Calkins, D. S. & Richelson, E., 1993, In : Journal of Clinical Pharmacology. 33, 11, p. 1092-1103 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Further characterization of neurotensin receptor desensitization and down-regulation in clone N1E-115 neuroblastoma cells

Yamada, M., Yamada, M. & Richelson, E., Apr 25 1993, In : Biochemical Pharmacology. 45, 10, p. 2149-2154 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
119 Scopus citations

Haloperidol but Not Clozapine Increases Neurotensin Receptor mRNA Levels in Rat Substantia Nigra

Bolden‐Watson, C., Watson, M. A., Murray, K. D., Isackson, P. J. & Richelson, E., Sep 1993, In : Journal of neurochemistry. 61, 3, p. 1141-1143 3 p.

Research output: Contribution to journalArticle

38 Scopus citations

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular β- amyloid or A4 peptides

Wertkin, A. M., Turner, R. S., Pleasure, S. J., Golde, T. E., Younkin, S. G., Trojanowski, J. Q. & Lee, V. M. Y., 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 20, p. 9513-9517 5 p.

Research output: Contribution to journalArticle

Open Access
185 Scopus citations

Identification of a Polymorphism in the Human Neurotensin Receptor Gene

WATSON, MICHAEL., ISACKSON, PAUL. J., MAKKER, MANISHA., YAMADA, MITSUHIKO. S., YAMADA, MISA., CUSACK, BERNADETTE. & RICHELSON, ELLIOTT., 1993, In : Mayo Clinic proceedings. 68, 11, p. 1043-1048 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein

Warshawsky, I., Bu, G. & Schwartz, A. L., Jan 1 1993, In : Journal of Biological Chemistry. 268, 29, p. 22046-22054 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Immunohistochemical Studies on Cerebellar Purkinje Cells of Patients with Menkes' Kinky Hair Disease

Kato, S., Ito, M., Ohama, E., Mikoshiba, K., Maeda, N., Yen, SH. H., Hirano, A., Herz, F. & Shintaku, M., Jun 1993, In : Neuropathology. 13, 2, p. 159-166 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Improved method for hydrolyzing proteins and peptides without inducing racemization and for determining their true D-amino acid content

D′Aniello, A., Petrucelli, L., Gardner, C. & Fisher, G., Sep 1993, In : Analytical Biochemistry. 213, 2, p. 290-295 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Inositol glycan phosphate derived from human erythrocyte acetylcholinesterase glycolipid anchor and inositol cyclic 1,2-phosphate antagonize glucagon activation of glycogen phosphorylase

Deeg, M. A., Brass, E. P. & Rosenberry, T. L., Sep 1993, In : Diabetes. 42, 9, p. 1318-1323 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells

Iadonato, S. P., Bu, G., Maksymovitch, E. A. & Schwartz, A. L., 1993, In : Biochemical Journal. 296, 3, p. 867-875 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Macrophage colony-stimulating factor in human fetal astrocytes and microglia: Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia

Lee, S. C., Liu, W., Roth, P., Dickson, D. W., Berman, J. W. & Brosnan, C. F., 1993, In : Journal of Immunology. 150, 2, p. 594-604 11 p.

Research output: Contribution to journalArticle

156 Scopus citations

Mannosamine inhibits the synthesis of putative glycoinositol phospholipid anchor precursors in mammalian cells without incorporating into an accumulated intermediate

Sevlever, D. & Rosenberry, T. L., Jan 1 1993, In : Journal of Biological Chemistry. 268, 15, p. 10938-10945 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

Dickson, D. W., Lee, S. C., Mattiace, L. A., Yen, SH. C. & Brosnan, C., Jan 1993, In : Glia. 7, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

763 Scopus citations

Molecular biology of Alzheimer's disease.

Whitehouse, P. J., Landreth, G. & Younkin, S., 1993, In : Molecular genetic medicine. 3, p. 95-137 43 p.

Research output: Contribution to journalReview article

2 Scopus citations

Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations

Wu, E., Dickson, D. W., Jacobson, S. & Raine, C. S., Aug 1993, In : Acta neuropathologica. 86, 3, p. 224-235 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Neurotensin stimulates cyclic AMP formation in CHO-rNTR-10 cells expressing the cloned rat neurotensin receptor

Yamada, M., Yamada, M., Watson, M. A. & Richelson, E., Jan 4 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 244, 1, p. 99-101 3 p.

Research output: Contribution to journalArticle

45 Scopus citations

Pharmacological studies on novel neurotensin mimetics: Discovery of a pharmacologically unique agent exhibiting concentration-dependent dual effects as antagonist and agonist

Cusack, B., Richelson, E., Pang, Y. P., Zaidi, J. & Kozikowski, A. P., 1993, In : Molecular pharmacology. 44, 5, p. 1036-1040 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Production of Amyloid β Protein from Normal Amyloid β‐Protein Precursor (βAPP) and the Mutated βAPPS Linked to Familial Alzheimer's Disease

GOLDE, TODD. E., CAI, XIAODAN. D., SHOJI, MIKIO. & YOUNKIN, STEVEN. G., Sep 1993, In : Annals of the New York Academy of Sciences. 695, 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Productive infection of human fetal microglia by HIV-1

Lee, S. C., Hatch, W. C., Liu, W., Kress, Y., Lyman, W. D. & Dickson, D. W., 1993, In : American Journal of Pathology. 143, 4, p. 1032-1039 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Productive Infection of Human Fetal Microglia in Vitro by HIV‐1

LEE, SUNHEE. C., HATCH, WILLIAM. C., LIU, WEI., BROSNAN, CELIA. F. & DICKSON, DENNIS. W., Oct 1993, In : Annals of the New York Academy of Sciences. 693, 1, p. 314-316 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells

Bu, G., Maksymovitch, E. A. & Schwartz, A. L., Jan 1 1993, In : Journal of Biological Chemistry. 268, 17, p. 13002-13009 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Release of excess amyloid β protein from a mutant amyloid β protein precursor

Cai, X. D., Golde, T. E. & Younkin, S. G., Jan 1 1993, In : Science. 259, 5094, p. 514-516 3 p.

Research output: Contribution to journalArticle

790 Scopus citations

Reversible heat stress-related loss of phosphorylated Alzheimer-type epitopes in tau proteins of human neuroblastoma cells

Chiang, M. F., Liu, W. K. & Yen, S. H., 1993, In : Journal of Neuroscience. 13, 11, p. 4854-4860 7 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations