Neuroscience

4/1/16 → 3/31/18

Project: Research project

alpha-Synuclein

Adenosine Triphosphate

Parkinson Disease

Brain Injuries

Traumatic Brain Injury

Functions of human and mouse Trem2 in vivo

Fryer, J. D.

4/1/16 → 3/31/18

Project: Research project

Alzheimer Disease

Lipoprotein Receptors

Apolipoprotein E4

tau Proteins

Frontotemporal Dementia

Genetic and Functional Analysis of Nested AD Risk Genes CTNNA3 and LRRTM3

Younkin, S. G., Ertekin-Taner, N. & Ertekin-Taner, N.

8/1/15 → 5/31/17

Project: Research project

Genome-Wide Association Study

Genes

Costs and Cost Analysis

Alzheimer Disease

Exome

Development and characterization of a novel Clusterin mouse model

Fryer, J. D.

5/15/15 → 4/30/17

Project: Research project

Clusterin

Alzheimer Disease

Cerebral Amyloid Angiopathy

Apolipoproteins E

tau Proteins

Pathobiology of Neurodegeneration in C9ORF72 Repeat Expansion

Boylan, K. B., Petrucelli, L. & Dickson, D. W.

9/30/14 → 6/30/19

Project: Research project

Amyotrophic Lateral Sclerosis

Frontotemporal Lobar Degeneration

Methylation

RNA-Binding Proteins

Histones

c9RAN proteins as a biomarker for C9ORF72-associated ALS and FTD

Gendron, T. D. & Boylan, K. B.

9/15/14 → 8/31/16

Project: Research project

Biomarkers

Amyotrophic Lateral Sclerosis

Proteins

Frontotemporal Dementia With Motor Neuron Disease

Immunoassay

The role of acetylation in regulating pathophysiology of tau

Petrucelli, L. & Wolozin, B.

9/1/14 → 8/31/19

Project: Research project

Histone Deacetylases

Acetylation

Tauopathies

Antisense Oligonucleotides

Pathology

Molecular mechanisms of Parkin-directed mitochondrial quality control

Springer, W.

8/1/14 → 7/31/19

Project: Research project

Quality Control

Unfolded Protein Response

Ubiquitin

Energy Metabolism

Parkinson Disease

Role of soluble TREM2 and its R47H and D87N variants in neurodegenerative disease

Younkin, S. G.

7/1/14 → 6/30/16

Project: Research project

Neurodegenerative Diseases

Microglia

Phagocytosis

Ligands

Neurons

ApoE isoform-specific therapy for Alzheimer disease

9/30/13 → 6/30/18

Project: Research project

Apolipoprotein E4

Apolipoprotein E3

Apolipoproteins E

Alzheimer Disease

Protein Isoforms

A system approach to targeting innate immunity in AD

Golde, T. E., Price, N., Golde, T. E., Ertekin-Taner, N., Ertekin-Taner, N., Golde, T. E. & Younkin, S. G.

9/20/13 → 8/31/18

Project: Research project

Innate Immunity

Alzheimer Disease

Cognition

Genetic Loci

Gliosis

RNA foci in C9FTD/ALS

7/1/13 → 6/30/16

Project: Research project

Amyotrophic Lateral Sclerosis

RNA

RNA-Binding Proteins

Frontotemporal Lobar Degeneration

Neurodegenerative Diseases

Molecular genetic studies of progranulin regulators in FTLD and ALS

Rademakers, R. V.

4/15/13 → 3/31/18

Project: Research project

Frontotemporal Lobar Degeneration

Molecular Biology

Proteins

Mutation

Neurodegenerative Diseases

Understanding the Mechanisms of TDP-43 Function

Zhang, Y. & Fryer, J. D.

2/15/13 → 1/31/16

Project: Research project

Tyrosine

Phosphorylation

Frontotemporal Dementia

Bacterial Artificial Chromosomes

Amyotrophic Lateral Sclerosis

GGGGCC hexanucleotide repeat expansions in neurodegenerative disease

Rademakers, R. V.

9/30/12 → 6/30/17

Project: Research project

Neurodegenerative Diseases

Poisons

Alternative Splicing

Mutation

RNA

Regional, Synpatic, Cellular Modulation of Abeta Metabolism

Bu, G. D., Holtzman, D. M., Cirrito, J., Snider, B. & Holtzman, D. M.

5/15/12 → 4/30/17

Project: Research project

Lipoprotein Receptors

Heparan Sulfate Proteoglycans

Amyloid

Amyloid beta-Protein Precursor

Endocytosis

Understanding the role of MAPT in Parkinsonian disorders

Ross, O. A.

4/1/12 → 1/31/17

Project: Research project

Progressive Supranuclear Palsy

Parkinsonian Disorders

Parkinson Disease

Haplotypes

Frontotemporal Dementia

Misregulation of the TDP-43 RNA target, Sortilin, in neurodegeneration

8/15/11 → 4/30/16

Project: Research project

Frontotemporal Lobar Degeneration

Exons

RNA

Amyotrophic Lateral Sclerosis

Protein Isoforms

Pathologically modified TDP-43 in neurodegenerative diseases

Gendron, T. D.

6/1/11 → 5/31/14

Project: Research project

Amyotrophic Lateral Sclerosis

Neurodegenerative Diseases

Frontotemporal Dementia

Alzheimer Disease

Pathology

Cytokine Modulation of AB Associated Pathologies in Mouse Models of AD

Das, P.

3/1/11 → 2/28/15

Project: Research project

Alzheimer Disease

Pathology

Cytokines

Amyloid

Neuroglia

Functional Characterization of LRRK2 Knock-out and Knock-in Mouse Models

Melrose, H. L.

9/1/10 → 8/31/14

Project: Research project

Knockout Mice

Leucine

Phosphotransferases

Mutation

Parkinson Disease

Identification of genetic risk factors that predict disease onset, susceptibility

Ross, O. A., Wszolek, Z. K., Rademakers, R. V., Dickson, D. W. & Farrer, M.

9/1/10 → 6/30/17

Project: Research project

Parkinsonian Disorders

Synucleins

Parkinson Disease

Research

Molecular Biology

Development and Testing of Hsp90 Inhibitors

7/1/10 → 12/31/15

Project: Research project

Frontotemporal Lobar Degeneration

Blood-Brain Barrier

Investigational New Drug Application

Progressive Supranuclear Palsy

Therapeutics

ApoE Receptor Biology and Neurodegeneration

Bu, G. D., Weeber, E. J., Rebeck, G. W., Ladu, M., Estus, S., Rebeck, G. W. & Rebeck, G. W.

8/15/09 → 6/30/15

Project: Research project

Low Density Lipoprotein Receptor-Related Protein-1

Lipoprotein Receptors

Cell Biology

Molecular Biology

Apolipoproteins E

Role of oligomeric alpha-synuclein in synucleinopathies

McLean, P. J.

7/15/09 → 3/31/14

Project: Research project

alpha-Synuclein

Parkinson Disease

Lewy Bodies

Lewy Body Disease

Molecular Chaperones

Progranulin: Mutation and Regulation in Neurodegenerative disease

Rademakers, R. V.

6/1/09 → 5/31/14

Project: Research project

Frontotemporal Lobar Degeneration

Neurodegenerative Diseases

Mutation

DNA-Binding Proteins

Alzheimer Disease

High-throughput compound screening for modulators of insulin-degrading enzyme.

Leissring, M. A.

5/15/08 → 4/30/11

Project: Research project

Insulysin

Peptide Hydrolases

Enzyme Activators

Alzheimer Disease

Biological Phenomena

LRP AND APP PROCESSING IN NEURODEGENERATION

4/1/08 → 3/31/13

Project: Research project

Lipoprotein Receptors

Amyloid beta-Protein Precursor

Alzheimer Disease

Apolipoproteins E

Proteins

Preclinical Evaluation of a Novel Hsp90 inhibitor in Mutant Tau Mice

2/1/08 → 1/31/11

Project: Research project

tanespimycin

HSP90 Heat-Shock Proteins

Alzheimer Disease

tau Proteins

Neurodegenerative Diseases

HTS for Modulators of Beta-Amyloid Catabolism by Insulin-Degrading Enzyme

Leissring, M. A.

9/1/07 → 8/31/09

Project: Research project

Insulysin

Amyloid

Peptide Hydrolases

Alzheimer Disease

Small Molecule Libraries

The genetics of chromosome 17q21-linked tau-negative FTD

Petrucelli, L., Hutton, M. L. & Hutton, M. L.

9/1/06 → 3/31/15

Project: Research project

DNA-Binding Proteins

Cell Death

Frontotemporal Dementia

Mutation

Amyotrophic Lateral Sclerosis

CHIP: A Link between Parkin and Cell Death

7/15/06 → 6/30/09

Project: Research project

HSC70 Heat-Shock Proteins

Staphylococcal Protein A

Cell Death

Parkinsonian Disorders

Proteasome Endopeptidase Complex

The role of capicua in spinocerebellar ataxia type 1

Fryer, J. D.

6/1/06 → 5/31/09

Project: Research project

Spinocerebellar Ataxias

Ataxin-1

Purkinje Cells

Microarray Analysis

Neurodegenerative Diseases

NT69L: a potential, novel antischizophrenic drug

Richelson, E.

5/15/06 → 3/31/10

Project: Research project

Clozapine

Antipsychotic Agents

Pharmaceutical Preparations

Injections

Neurotensin Receptors

ApoE Receptor Pathways to Intraneuronal Abeta

5/1/06 → 5/31/17

Project: Research project

Low Density Lipoprotein Receptor-Related Protein-1

Apolipoproteins E

Alzheimer Disease

Proteins

Endocytosis

ADMINISTRATIVE CORE

Dickson, D. W., Mortimer, J. A., Pfeiffer, E., Loewenstein, D., Mortimer, J. A., Yougui, W., Arendash, G. & Potter, H.

4/1/05 → 3/31/12

Project: Research project

Alzheimer Disease

Research

Brain

Blood Vessels

Biostatistics

Peripheral Degradation of Amyloid Beta-Protein

Leissring, M. A.

2/15/05 → 10/5/07

Project: Research project

Amyloid beta-Peptides

Peptide Hydrolases

Amyloid Precursor Protein Secretases

Proteolysis

Alzheimer Disease

Modeling Neurofibrillary Degeneration

Yen, S. C.

9/15/04 → 5/31/10

Project: Research project

Neurofibrillary Tangles

Tauopathies

Peptide Hydrolases

Phosphotransferases

Pick Disease of the Brain

Molecular Pathobiology of LRP1B Tumor Suppressor

7/1/04 → 6/30/09

Project: Research project

Urokinase Plasminogen Activator Receptors

Cell Movement

Endocytosis

Neoplasms

LDL Receptors

Trafficking of LRP and Megalin in Polarized Cells

4/1/04 → 3/31/07

Project: Research project

Low Density Lipoprotein Receptor-Related Protein-2

Low Density Lipoprotein Receptor-Related Protein-1

Endocytosis

Epithelial Cells

Transcytosis

Parkin, Ubiquitination and Cell Death

7/15/01 → 6/30/06

Project: Research project

Ubiquitination

Cell Death

Proteins

Parkinson Disease

Poisons

BIOGENESIS OF LIPOPROTEINS RECEPTORS

12/1/00 → 11/30/04

Project: Research project

CELLULAR PATHOGENESIS OF PEDIATRIC LIVER DISEASE

Bu, G. D., Perlmutter, D., Strauss, A., Gitlin, J. D. & Simon, T.

6/1/00 → 11/30/04

Project: Research project

Lipoprotein Receptors

LDL Receptors

electron microscopy

organelles

microscopes

PLASMA A BETA AS A SURROGATE GENETIC MARKER FOR LOAD

Younkin, S. G.

4/1/00 → 5/31/15

Project: Research project

Genetic Markers

Genetic Load

Biomarkers

Alzheimer Disease

Genes

MORRIS K. UDALL PARKINSONS DISEASE RESEARCH CENTER OF EX

Wszolek, Z. K., Dickson, D. W., Hardy, J. A., Farrer, M., Yen, S. C., Hardy, J. A., Duff, K. & Gasser, T.

9/30/99 → 8/31/10

Project: Research project

Parkinsonian Disorders

alpha-Synuclein

Parkinson Disease

Molecular Biology

Lewy Body Disease

TAU AND NEURODEGENERATION

Yen, S. C., Dickson, D. W., Hardy, J. A., Hutton, M. L., Hardy, J. A., Duff, K., Farrer, M., Hutton, M. L. & Hutton, M. L.

9/1/99 → 5/31/12

Project: Research project

Tauopathies

Neurodegenerative Diseases

Progressive Supranuclear Palsy

Frontotemporal Dementia

Mutation

BRAIN AS TARGET FOR ANTISENSE PEPTIDE NUCLEIC ACID DRUGS

Richelson, E.

8/1/99 → 7/31/02

Project: Research project

Peptide Nucleic Acids

Brain

Pharmaceutical Preparations

Serotonin Plasma Membrane Transport Proteins

Pharmacokinetics

THE BIOLOGY OF ALZHEIMERS DISEASE IN TRANSGENIC MICE

Younkin, S. G., Carlson, G. A., Carlson, G. A., Chapman, P., Hyman, B. & Ashe, K.

6/15/99 → 11/30/04

Project: Research project

Amyloid

Mutation

Flavin-Adenine Dinucleotide

Transgenes

Transgenic Mice

MAYO ALZHEIMERS DISEASE RESEARCH CENTER

Petrucelli, L., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Boeve, B. F., Younkin, S. G., Kantarci, K. M., Smith, G. E., Rademakers, R. V., Petersen, R. C., Pankratz, V. S., Yen, S. C., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Vemuri, P. D., Lucas, J. A., Knopman, D. S., Hutton, M. L., Bu, G. D., Edland, S. D., Hutton, M. L., Clifford, J., Kokman, E., Ertekin-Taner, N., Hutton, M. L. & Ertekin-Taner, N.