Neuroscience

Projects

Projects per year 1991 2014 2017 2019 2020 2021 2025

• 58 Active
• 73 Finished

Projects per year

Search results

• Finished

  Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's disease

  Murray, M. E., Ghetti, B. B. F. & Grinberg, L. L. T.

  National Institute on Aging

  2/15/22 → 11/30/22

  Project: Research project

• Identification of TDP-43 modifiers through single-cell transcriptional and epigenomic dissection of ALS and FTLD-MND

  Donnelly, C. C. J., Kellis, M. M., Heiman, M. M. & Belzil, V.

  National Institute of Neurological Disorders and Stroke

  9/29/21 → 8/31/22

  Project: Research project

  • Frontotemporal Lobar Degeneration 100%
  • Motor Neuron Disease 51%
  • Neuropathology 46%
  • Epigenomics 46%
  • Dissection 38%

• Frontotemporal dementia and related disorders: transcriptomic profiling, biomarker discovery, and mechanistic insight

  Van Blitterswijk, M. & Gendron, T. D.

  National Institute of Neurological Disorders and Stroke

  4/15/21 → 3/31/22

  Project: Research project

  • Frontotemporal Dementia 100%
  • Frontotemporal Dementia With Motor Neuron Disease 61%
  • Biomarkers 52%
  • DNA-Binding Proteins 44%
  • Blood Specimen Collection 36%

• Impact of coding and non-coding variation in progressive supranuclear palsy

  Geschwind, D. H., Dickson, D. W., Schellenberg, G. D., Steen, J. A. & Wang, L. S.

  National Institute of Neurological Disorders and Stroke

  8/1/20 → 7/31/22

  Project: Research project

  • Progressive Supranuclear Palsy 100%
  • Tauopathies 44%
  • Frontotemporal Lobar Degeneration 25%
  • Induced Pluripotent Stem Cells 21%
  • Epigenomics 18%

• High-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

  Rossoll, W.

  National Institute of Neurological Disorders and Stroke

  5/1/20 → 4/30/22

  Project: Research project

  • Ciliary Neurotrophic Factor Receptor 100%
  • Amyotrophic Lateral Sclerosis 57%
  • Ciliary Neurotrophic Factor 43%
  • Motor Neurons 30%
  • Nerve Growth Factors 26%

• Core C

  Gendron, T. D.

  National Institute of Neurological Disorders and Stroke

  4/1/20 → 3/31/22

  Project: Research project

  • Cerebrospinal Fluid 100%
  • Biomarkers 74%
  • Dipeptides 74%
  • Frontotemporal Dementia 71%
  • Proteins 52%

• ConProject-001

  Ertekin-Taner, N., Golde, T. E. & Price, N. D.

  4/1/20 → 12/31/20

  Project: Research project

  • Brain 100%
  • Transcriptome 75%
  • Population 71%
  • Adenosine Monophosphate 68%
  • Epigenome 25%

• ConProject-001

  Ertekin-Taner, N., Golde, T. E. & Price, N. D.

  3/15/20 → 8/31/20

  Project: Research project

  • Adenosine Monophosphate 100%
  • Ocular Vision 37%
  • Asymptomatic Diseases 28%
  • Gene Expression 26%
  • Systems Biology 26%

• TREM2-mediated microglial dynamic function in Alzheimer disease

  Bu, G. D., Zhao, N., Bu, G. D. & Zhao, N.

  National Institute on Aging

  2/1/20 → 12/31/22

  Project: Research project

  • Alzheimer Disease 100%
  • Dementia 29%
  • Induced Pluripotent Stem Cells 29%
  • Pathology 27%
  • Microglia 26%

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  Boeve, B. F., Boxer, A. L., Kantarci, K. M., Kremers, W. K., Rademakers, R. V., Rosen, H. J. & Seeley, W. W.

  National Institute on Aging

  9/15/19 → 6/30/22

  Project: Research project

  • Frontotemporal Lobar Degeneration 100%
  • Alzheimer Disease 12%
  • Dementia 10%
  • Microtubule-Associated Proteins 9%
  • Information Dissemination 9%

• Selective autophagy in Alzheimer's disease and related dementias

  Springer, W. & Fryer, J. D.

  National Institute on Aging

  8/1/19 → 7/31/21

  Project: Research project

  • Autophagy 100%
  • Alzheimer Disease 57%
  • Dementia 54%
  • Secretory Pathway 10%
  • Animal Models 6%

• Development of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for ALS Therapy

  Rossoll, W.

  U.S. Army

  7/15/19 → 7/15/19

  Project: Research project

  • Ciliary Neurotrophic Factor Receptor 100%
  • Amyotrophic Lateral Sclerosis 86%
  • Ciliary Neurotrophic Factor 84%
  • Axons 31%
  • Neurons 22%

• DEVELOPMENT OF CILIARY NEUROTROPHIC FACTOR (CNTF) RECEPTOR AGONISTS FOR ALS THERAPY

  Rossoll, W.

  Congressionally Directed Medical Research Programs

  7/15/19 → 7/14/21

  Project: Research project

  • Ciliary Neurotrophic Factor Receptor 100%
  • Amyotrophic Lateral Sclerosis 54%
  • Ciliary Neurotrophic Factor 32%
  • Motor Neurons 31%
  • Nerve Growth Factors 24%

• High-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

  Rossoll, W.

  National Institute of Neurological Disorders and Stroke

  5/1/19 → 4/30/20

  Project: Research project

  • Ciliary Neurotrophic Factor Receptor 100%
  • Amyotrophic Lateral Sclerosis 55%
  • Ciliary Neurotrophic Factor 42%
  • Motor Neurons 29%
  • Nerve Growth Factors 26%

• Identify mediators of neuronal susceptibility in amyotrophic lateral sclerosis

  Belzil, V.

  ALS Association

  11/1/18 → 5/31/20

  Project: Research project

  • Amyotrophic Lateral Sclerosis 100%
  • Motor Neurons 60%
  • Informatics 19%
  • Nerve Degeneration 19%
  • Motor Cortex 15%

• Pathogenic effects of plasma ApoE on CNS function and Alzheimer's disease

  Liu, C.

  National Institute on Aging

  1/1/18 → 12/31/19

  Project: Research project

  • Apolipoproteins E 100%
  • Alzheimer Disease 60%
  • Apolipoprotein E4 53%
  • Brain 34%
  • Amyloid 29%

• Impact of coding and non-coding variation in progressive supranuclear palsy

  Geschwind, D. H., Coppola, G., Dickson, D. W., Schellenberg, G. D., Steen, J. A. & Wang, L. S.

  9/25/17 → 7/31/20

  Project: Research project

  • Progressive Supranuclear Palsy 100%
  • Tauopathies 43%
  • Frontotemporal Lobar Degeneration 30%
  • Whole Genome Sequencing 12%
  • Genetic Variation 10%

• Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease

  Rissman, R. A., Hook, V. Y. H. & Ikezu, T.

  National Institute on Aging

  9/15/17 → 8/31/19

  Project: Research project

  • Exosomes 100%
  • Alzheimer Disease 47%
  • Endosomal Sorting Complexes Required for Transport 24%
  • Induced Pluripotent Stem Cells 18%
  • Alzheimer disease, familial, type 3 13%

• Clinicopathologic and Neuroimaging Differences in Alzheimer's Disease Variants

  Murray, M. E.

  National Institute on Aging

  9/1/17 → 5/31/18

  Project: Research project

  • Alzheimer Disease 100%
  • Neuroimaging 99%
  • Neuropathology 13%
  • Autopsy 10%
  • Disease Progression 9%

• EARLY-ONSET PARKINSON'S DISEASE IS A MITOCHONDRIAL DISEASE: A NIGRAL MITOCHONDRIAL CYTOPATHY

  Springer, W.

  Congressionally Directed Medical Research Programs

  8/15/17 → 8/14/20

  Project: Research project

  • Mitochondrial cytopathy 100%
  • Quality Control 82%
  • Mitochondrial Diseases 74%
  • Substantia Nigra 63%
  • MicroRNAs 57%

• Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s disease

  Butovsky, O. & Ikezu, T.

  National Institute on Aging

  8/15/17 → 4/30/22

  Project: Research project

  • Microglia 100%
  • Apolipoproteins E 98%
  • Alzheimer Disease 79%
  • c-Mer Tyrosine Kinase 49%
  • Phenotype 22%

• Military medical research and development

  Ross, O. A.

  U.S. Army

  8/15/17 → 8/14/20

  Project: Research project

  • Mitochondrial cytopathy 100%
  • Mitochondrial Diseases 74%
  • Substantia Nigra 63%
  • Biomedical Research 29%
  • Quality Control 19%

• Pathogenic mechanisms of ABCA7 in Alzheimer's disease

  Kanekiyo, T.

  National Institute on Aging

  4/1/17 → 3/31/20

  Project: Research project

  • ATP-Binding Cassette Transporters 100%
  • Alzheimer Disease 52%
  • Microglia 27%
  • Neurons 16%
  • Induced Pluripotent Stem Cells 10%

• Molecular pathobiology of soluble TREM2 in Alzheimer's disease.

  Huang, T. Y. & Bu, G. D.

  4/1/17 → 3/31/22

  Project: Research project

  • Myeloid Cells 100%
  • Genome-Wide Association Study 34%
  • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 30%
  • Cerebrospinal Fluid 28%
  • Alzheimer disease type 2 24%

• In silico identification of population-specific disease pathways

  Carrasquillo, M. M.

  National Institute on Aging

  4/1/17 → 6/30/18

  Project: Research project

  • Alzheimer Disease 100%
  • African Americans 75%
  • Computer Simulation 68%
  • Population 31%
  • Datasets 25%

• Validation of r(G4C2)exp-binding small molecules in vivo and c9FTD/ALS biomarker development

  Petrucelli, L.

  National Institute of Neurological Disorders and Stroke

  12/1/16 → 4/30/22

  Project: Research project

  • Amyotrophic Lateral Sclerosis 100%
  • Biomarkers 46%
  • Cell Nucleus Active Transport 17%
  • poly(glycyl-alanyl) 15%
  • Nucleocytoplasmic Transport Proteins 14%

• Identifying genes and Pathways that impact Tau Toxicity in FTD

  Petrucelli, L., Dickson, D. W. & Schellenberg, G. D.

  9/30/16 → 6/30/21

  Project: Research project

  • Tauopathies 100%
  • Collaborative Cross Mice 34%
  • Primary Spontaneous Pneumothorax 26%
  • Proteostasis 24%
  • Biomarkers 23%

• Apoptotic neuronal cells serve as sources for spreading of human a-synuclein pathology in the brain

  Jiang, P. & Dickson, D. W.

  9/30/16 → 8/31/19

  Project: Research project

  • Nuclear Envelope 67%
  • Synucleins 60%
  • Pathology 50%
  • Ganciclovir 49%
  • Thymidine Kinase 48%

• Core C: Human Biology Validation

  Dickson, D. W.

  National Institute of Neurological Disorders and Stroke

  9/30/16 → 6/30/21

  Project: Research project

  • Tauopathies 100%
  • Progressive Supranuclear Palsy 49%
  • Parkinsonian Disorders 40%
  • Dementia 30%

• Reverse apoE4 effects by apoE2 expression in Alzheimer's disease

  Kanekiyo, T.

  National Institute on Aging

  9/1/16 → 5/31/19

  Project: Research project

  • Apolipoprotein E2 100%
  • Apolipoprotein E4 89%
  • Alzheimer Disease 53%
  • Amyloid 46%
  • Apolipoproteins E 26%

• Brain Neurotropic Growth Factor Delivery to Prevent and Treat Alzheimer's Disease

  Singh, J. & Kanekiyo, T.

  National Institute on Aging

  9/1/16 → 5/31/21

  Project: Research project

  • Liposomes 100%
  • Cell-Penetrating Peptides 97%
  • Transferrin 75%
  • Intercellular Signaling Peptides and Proteins 50%
  • Genetic Therapy 43%

• Integrative translational discovery of vascular risk factors in aging and dementia

  Ertekin-Taner, N., Bu, G. D. & Mangravite, L. M.

  National Institute on Aging

  9/30/15 → 5/31/20

  Project: Research project

  • vascular factor 100%
  • Dementia 70%
  • Cerebral Amyloid Angiopathy 70%
  • Alzheimer Disease 44%
  • Apolipoproteins E 15%

• Manipulating tau's posttranslational modifications to block disease progression in vivo

  Cook, C.

  National Institute of Neurological Disorders and Stroke

  9/30/15 → 8/31/16

  Project: Research project

  • Tauopathies 100%
  • Post Translational Protein Processing 55%
  • Acetylation 54%
  • Disease Progression 43%
  • Histone Deacetylase 6 35%

• Genetic and Functional Analysis of Nested AD Risk Genes CTNNA3 and LRRTM3

  Younkin, S. G. & Ertekin-Taner, N.

  National Institute on Aging

  8/1/15 → 5/31/16

  Project: Research project

  • High-Throughput Nucleotide Sequencing 100%
  • Genome-Wide Association Study 87%
  • Genes 69%
  • Costs and Cost Analysis 38%
  • Alzheimer Disease 32%

• RNA Processing Defects in SMA and Their Contribution to the Disease Phenotype

  Rossoll, W.

  National Institute of Neurological Disorders and Stroke

  7/1/15 → 4/30/20

  Project: Research project

  • Spinal Muscular Atrophy 100%
  • Motor Neurons 76%
  • RNA 48%
  • Phenotype 42%
  • Axons 26%

• Pathobiology of Neurodegeneration in C9ORF72 repeat expansion

  Petrucelli, L., Boylan, K. B., Dickson, D. W., Fryer, J. D., Gendron, T. D. & Oskarsson, B.

  National Institute of Neurological Disorders and Stroke

  9/30/14 → 3/31/22

  Project: Research project

  • Amyotrophic Lateral Sclerosis 100%
  • Frontotemporal Dementia 72%
  • Biomarkers 53%
  • Neurology 36%
  • Brain 34%

• Administrative Core

  Petrucelli, L.

  National Institute of Neurological Disorders and Stroke

  9/30/14 → 6/30/19

  Project: Research project

  • Organized Financing 100%
  • Regenerative Medicine 93%
  • Amyotrophic Lateral Sclerosis 91%
  • Research Subjects 85%
  • Research Design 67%

• Project 2: RAN translation and RNA-binding protein sequestration in c9FTD/ALS

  Petrucelli, L.

  National Institute of Neurological Disorders and Stroke

  9/30/14 → 6/30/19

  Project: Research project

  • Amyotrophic Lateral Sclerosis 100%
  • RNA-Binding Proteins 83%
  • Peptides 35%
  • Frontotemporal Dementia With Motor Neuron Disease 33%
  • RNA 22%

• c9RAN proteins as a biomarker for C9ORF72-associated ALS and FTD

  Gendron, T. D. & Boylan, K. B.

  National Institute of Neurological Disorders and Stroke

  9/15/14 → 8/31/17

  Project: Research project

  • Frontotemporal Dementia With Motor Neuron Disease 100%
  • Amyotrophic Lateral Sclerosis 53%
  • Biomarkers 44%
  • Proteins 32%
  • Immunoassay 12%

• Molecular mechanisms of Parkin-directed mitochondrial quality control

  Springer, W.

  National Institute of Neurological Disorders and Stroke

  8/1/14 → 8/30/19

  Project: Research project

  • Quality Control 100%
  • Unfolded Protein Response 64%
  • Ubiquitin 51%
  • Energy Metabolism 46%
  • Parkinson disease 3 43%

• Role of soluble TREM2 and its R47H and D87N variants in neurodegenerative disease

  Younkin, S. G.

  7/1/14 → 6/30/17

  Project: Research project

  • Microglia 100%
  • Phagocytosis 96%
  • Neurodegenerative Diseases 85%
  • Ligands 69%
  • Neurons 60%

• Project 3

  Bu, G. D.

  National Institute on Aging

  5/1/14 → 4/30/19

  Project: Research project

  • Cerebral Amyloid Angiopathy 100%
  • Apolipoproteins E 66%
  • Apolipoprotein E4 53%
  • Amyloid Plaques 51%
  • Astrocytes 36%

• Project 2

  Petrucelli, L.

  National Institute on Aging

  5/1/14 → 4/30/19

  Project: Research project

  • Histone Deacetylase 6 100%
  • Tauopathies 22%
  • Psychological Inhibition 18%
  • Frontotemporal Dementia 14%
  • Neurofibrillary Tangles 13%

• The effect of maternal obesity and inflammation on neuronal and microglial functi

  Kang, S.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  4/15/14 → 3/31/16

  Project: Research project

  • Maternal Obesity 100%
  • Mothers 51%
  • Inflammation 43%
  • Autism Spectrum Disorder 33%
  • Microglia 33%

• Gene discovery in PSP by transcriptome, neuropathology and sequence analysis

  Ertekin-Taner, N.

  National Institute of Neurological Disorders and Stroke

  7/15/13 → 9/30/18

  Project: Research project

  • Progressive Supranuclear Palsy 100%
  • Neuropathology 64%
  • Genetic Association Studies 54%
  • Gene Expression Profiling 53%
  • Sequence Analysis 47%

• Understanding the Mechanisms of TDP-43 Function

  Zhang, Y. & Fryer, J. D.

  National Institute of Neurological Disorders and Stroke

  2/15/13 → 1/31/16

  Project: Research project

  • Tyrosine 100%
  • Phosphorylation 74%
  • Frontotemporal Dementia 45%
  • Bacterial Artificial Chromosomes 25%
  • Amyotrophic Lateral Sclerosis 19%

• Genetic determinants of a synuclein and tau

  Dickson, D. W.

  National Institute of Neurological Disorders and Stroke

  9/24/12 → 6/30/17

  Project: Research project

  • Progressive Supranuclear Palsy 100%
  • Synucleins 81%
  • Single Nucleotide Polymorphism 41%
  • Phenotype 30%
  • Caudate Nucleus 28%

• Neuropathology Core

  Dickson, D. W.

  National Institute of Neurological Disorders and Stroke

  9/24/12 → 6/30/17

  Project: Research project

  • Neuropathology 100%
  • Synucleins 77%
  • Neurofibrillary Tangles 61%
  • human MAPT protein 44%
  • Electrons 40%

• Regional, Synaptic, Cellular Modulation of Abeta Metabolism

  Holtzman, D. M., Bu, G. D., Cirrito, J. R. & Snider, B. J.

  5/15/12 → 4/30/15

  Project: Research project

  • Heparan Sulfate Proteoglycans 100%
  • Sleep 90%
  • Brain 47%
  • Apolipoproteins E 41%
  • Dementia 32%

• Lipoprotein Receptor And Synaptic Regulation Of A^ Metabolism

  Bu, G. D.

  National Institute of Neurological Disorders and Stroke

  5/15/12 → 4/30/17

  Project: Research project

  • Lipoprotein Receptors 100%
  • Heparan Sulfate Proteoglycans 90%
  • Amyloid 79%
  • Amyloid beta-Protein Precursor 48%
  • Endocytosis 42%