Projects 1975 2021

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Synucleins
Parkinson Disease
Pathology
Nuclear Envelope
Brain
alpha-Synuclein
Adenosine Triphosphate
Parkinson Disease
Brain Injuries
Traumatic Brain Injury
Alzheimer Disease
Lipoprotein Receptors
Apolipoprotein E4
tau Proteins
Frontotemporal Dementia

Genetic and Functional Analysis of Nested AD Risk Genes CTNNA3 and LRRTM3

Younkin, S. G., Ertekin-Taner, N. & Ertekin-Taner, N.

National Institutes of Health

8/1/155/31/17

Project: Research project

Genome-Wide Association Study
Genes
Costs and Cost Analysis
Alzheimer Disease
Exome
Clusterin
Alzheimer Disease
Cerebral Amyloid Angiopathy
Apolipoproteins E
tau Proteins
Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Methylation
RNA-Binding Proteins
Histones
Biomarkers
Amyotrophic Lateral Sclerosis
Proteins
Frontotemporal Dementia With Motor Neuron Disease
Immunoassay
Histone Deacetylases
Acetylation
Tauopathies
Antisense Oligonucleotides
Pathology
Quality Control
Unfolded Protein Response
Ubiquitin
Energy Metabolism
Parkinson Disease
Neurodegenerative Diseases
Microglia
Phagocytosis
Ligands
Neurons
Apolipoprotein E4
Apolipoprotein E3
Apolipoproteins E
Alzheimer Disease
Protein Isoforms

A system approach to targeting innate immunity in AD

Golde, T. E., Price, N., Golde, T. E., Ertekin-Taner, N., Ertekin-Taner, N., Golde, T. E. & Younkin, S. G.

National Institutes of Health

9/20/138/31/18

Project: Research project

Innate Immunity
Alzheimer Disease
Cognition
Genetic Loci
Gliosis

RNA foci in C9FTD/ALS

Petrucelli, L.

National Institutes of Health

7/1/136/30/16

Project: Research project

Amyotrophic Lateral Sclerosis
RNA
RNA-Binding Proteins
Frontotemporal Lobar Degeneration
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Molecular Biology
Proteins
Mutation
Neurodegenerative Diseases
Tyrosine
Phosphorylation
Frontotemporal Dementia
Bacterial Artificial Chromosomes
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Poisons
Alternative Splicing
Mutation
RNA

Regional, Synpatic, Cellular Modulation of Abeta Metabolism

Bu, G. D., Holtzman, D. M., Cirrito, J., Snider, B. & Holtzman, D. M.

National Institutes of Health

5/15/124/30/17

Project: Research project

Lipoprotein Receptors
Heparan Sulfate Proteoglycans
Amyloid
Amyloid beta-Protein Precursor
Endocytosis
Progressive Supranuclear Palsy
Parkinsonian Disorders
Parkinson Disease
Haplotypes
Frontotemporal Dementia
Frontotemporal Lobar Degeneration
Exons
RNA
Amyotrophic Lateral Sclerosis
Protein Isoforms
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Frontotemporal Dementia
Alzheimer Disease
Pathology
Alzheimer Disease
Pathology
Cytokines
Amyloid
Neuroglia
Knockout Mice
Leucine
Phosphotransferases
Mutation
Parkinson Disease
Parkinsonian Disorders
Synucleins
Parkinson Disease
Research
Molecular Biology
Frontotemporal Lobar Degeneration
Blood-Brain Barrier
Investigational New Drug Application
Progressive Supranuclear Palsy
Therapeutics

ApoE Receptor Biology and Neurodegeneration

Bu, G. D., Weeber, E. J., Rebeck, G. W., Ladu, M., Estus, S., Rebeck, G. W. & Rebeck, G. W.

National Institutes of Health

8/15/096/30/15

Project: Research project

Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Cell Biology
Molecular Biology
Apolipoproteins E
alpha-Synuclein
Parkinson Disease
Lewy Bodies
Lewy Body Disease
Molecular Chaperones
Frontotemporal Lobar Degeneration
Neurodegenerative Diseases
Mutation
DNA-Binding Proteins
Alzheimer Disease
Insulysin
Peptide Hydrolases
Enzyme Activators
Alzheimer Disease
Biological Phenomena
Lipoprotein Receptors
Amyloid beta-Protein Precursor
Alzheimer Disease
Apolipoproteins E
Proteins
tanespimycin
HSP90 Heat-Shock Proteins
Alzheimer Disease
tau Proteins
Neurodegenerative Diseases
Insulysin
Amyloid
Peptide Hydrolases
Alzheimer Disease
Small Molecule Libraries

The genetics of chromosome 17q21-linked tau-negative FTD

Petrucelli, L., Hutton, M. L. & Hutton, M. L.

National Institutes of Health

9/1/063/31/15

Project: Research project

DNA-Binding Proteins
Cell Death
Frontotemporal Dementia
Mutation
Amyotrophic Lateral Sclerosis
HSC70 Heat-Shock Proteins
Staphylococcal Protein A
Cell Death
Parkinsonian Disorders
Proteasome Endopeptidase Complex
Spinocerebellar Ataxias
Ataxin-1
Purkinje Cells
Microarray Analysis
Neurodegenerative Diseases

NT69L: a potential, novel antischizophrenic drug

Richelson, E.

National Institutes of Health

5/15/063/31/10

Project: Research project

Clozapine
Antipsychotic Agents
Pharmaceutical Preparations
Injections
Neurotensin Receptors
Low Density Lipoprotein Receptor-Related Protein-1
Apolipoproteins E
Alzheimer Disease
Proteins
Endocytosis

ADMINISTRATIVE CORE

Dickson, D. W., Mortimer, J. A., Pfeiffer, E., Loewenstein, D., Mortimer, J. A., Yougui, W., Arendash, G. & Potter, H.

National Institutes of Health

4/1/053/31/12

Project: Research project

Alzheimer Disease
Research
Brain
Blood Vessels
Biostatistics

Peripheral Degradation of Amyloid Beta-Protein

Leissring, M. A.

National Institutes of Health

2/15/0510/5/07

Project: Research project

Amyloid beta-Peptides
Peptide Hydrolases
Amyloid Precursor Protein Secretases
Proteolysis
Alzheimer Disease

Modeling Neurofibrillary Degeneration

Yen, S. C.

National Institutes of Health

9/15/045/31/10

Project: Research project

Neurofibrillary Tangles
Tauopathies
Peptide Hydrolases
Phosphotransferases
Pick Disease of the Brain
Urokinase Plasminogen Activator Receptors
Cell Movement
Endocytosis
Neoplasms
LDL Receptors
Low Density Lipoprotein Receptor-Related Protein-2
Low Density Lipoprotein Receptor-Related Protein-1
Endocytosis
Epithelial Cells
Transcytosis
Ubiquitination
Cell Death
Proteins
Parkinson Disease
Poisons

CELLULAR PATHOGENESIS OF PEDIATRIC LIVER DISEASE

Bu, G. D., Perlmutter, D., Strauss, A., Gitlin, J. D. & Simon, T.

National Institutes of Health

6/1/0011/30/04

Project: Research project

Lipoprotein Receptors
LDL Receptors
electron microscopy
organelles
microscopes
Genetic Markers
Genetic Load
Biomarkers
Alzheimer Disease
Genes

MORRIS K. UDALL PARKINSONS DISEASE RESEARCH CENTER OF EX

Wszolek, Z. K., Dickson, D. W., Hardy, J. A., Farrer, M., Yen, S. C., Hardy, J. A., Duff, K. & Gasser, T.

National Institutes of Health

9/30/998/31/10

Project: Research project

Parkinsonian Disorders
alpha-Synuclein
Parkinson Disease
Molecular Biology
Lewy Body Disease

TAU AND NEURODEGENERATION

Yen, S. C., Dickson, D. W., Hardy, J. A., Hutton, M. L., Hardy, J. A., Duff, K., Farrer, M., Hutton, M. L. & Hutton, M. L.

National Institutes of Health

9/1/995/31/12

Project: Research project

Tauopathies
Neurodegenerative Diseases
Progressive Supranuclear Palsy
Frontotemporal Dementia
Mutation
Peptide Nucleic Acids
Brain
Pharmaceutical Preparations
Serotonin Plasma Membrane Transport Proteins
Pharmacokinetics

THE BIOLOGY OF ALZHEIMERS DISEASE IN TRANSGENIC MICE

Younkin, S. G., Carlson, G. A., Carlson, G. A., Chapman, P., Hyman, B. & Ashe, K.

National Institutes of Health

6/15/9911/30/04

Project: Research project

Amyloid
Mutation
Flavin-Adenine Dinucleotide
Transgenes
Transgenic Mice

MAYO ALZHEIMERS DISEASE RESEARCH CENTER

Petrucelli, L., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Boeve, B. F., Younkin, S. G., Kantarci, K. M., Smith, G. E., Rademakers, R. V., Petersen, R. C., Pankratz, V. S., Yen, S. C., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Vemuri, P. D., Lucas, J. A., Knopman, D. S., Hutton, M. L., Bu, G. D., Edland, S. D., Hutton, M. L., Clifford, J., Kokman, E., Ertekin-Taner, N., Hutton, M. L. & Ertekin-Taner, N.

National Institutes of Health

5/1/994/30/19

Project: Research project

Alzheimer Disease
Research
Dementia
Lewy Body Disease
Brain