Molecular Neuroscience

Research output

Research output per year 2010 2018 2021 2022 2023

• 18 Article
• 7 Review article
• 2 Comment/debate
• 1 Chapter
• 2 More
  • 1 Editorial
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2023

  Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease

  Rego, S., Sanchez, G. & Da Mesquita, S., Dec 2023, In: Molecular neurodegeneration. 18, 1, 55.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Immunity 100%
  • Alzheimer Disease 95%
  • Brain 60%
  • Meninges 52%
  • Microglia 27%
• 2022

  Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation

  Goldman, D. H., Dykstra, T., Smirnov, I., Blackburn, S. M., Da Mesquita, S., Kipnis, J. & Herz, J., Aug 2022, In: Nature Aging. 2, 8, p. 704-713 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia 100%
  • Inflammation 57%
  • Consummatory Behavior 39%
  • Brain 36%
  • Illness Behavior 33%

• Charting the meningeal lymphatic network

  Da Mesquita, S., Aug 1 2022, In: Journal of Experimental Medicine. 219, 8, e20220891.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Meninges 100%
  • Cerebrospinal Fluid Leak 96%
  • Lymphatic Vessels 93%
  • Optical Imaging 85%
  • Spinal Cord 63%

• Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration

  Silvin, A., Uderhardt, S., Piot, C., Da Mesquita, S., Yang, K., Geirsdottir, L., Mulder, K., Eyal, D., Liu, Z., Bridlance, C., Thion, M. S., Zhang, X. M., Kong, W. T., Deloger, M., Fontes, V., Weiner, A., Ee, R., Dress, R., Hang, J. W., Balachander, A., & 10 othersChakarov, S., Malleret, B., Dunsmore, G., Cexus, O., Chen, J., Garel, S., Dutertre, C. A., Amit, I., Kipnis, J. & Ginhoux, F., Aug 9 2022, In: Immunity. 55, 8, p. 1448-1465.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia 100%
  • Macrophages 68%
  • Brain 48%
  • Myeloid Cells 43%
  • Population 27%

• Editorial: Multifaceted Interactions Between Immunity and the Diseased Brain

  Funk, K. E., Montagne, A., Falcao, A. M. & Da Mesquita, S., Jun 8 2022, In: Frontiers in Cellular Neuroscience. 16, 941590.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Lymphatic drainage at the meningeal-brain interface in aging and Alzheimer’s disease

  Da Mesquita, S., Dec 2022, In: Alzheimer's and Dementia. 18, S4, e060350.

  Research output: Contribution to journal › Comment/debate › peer-review

  • dementia 100%
  • Drainage 84%
  • brain 83%
  • Alzheimer Disease 77%
  • Brain 48%

• Shaping social behavior in an enriched environment

  Amorim, L., Dá Mesquita, S., Jacinto, L., Castelhano-Carlos, M. J., Santos, N. C., Leite-Almeida, H. & Sousa, N., Oct 13 2022, In: Frontiers in Behavioral Neuroscience. 16, 999325.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Social Behavior 100%
  • Interpersonal Relations 45%
  • Food 45%
  • Impulsive Behavior 24%
  • Animals 21%
• 2021

  Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology

  Mesquita, S. D., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W. & Kipnis, J., May 2021, In: Science Advances. 7, 21, eabe4601.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • C Chemokines 100%
  • Chemokine Receptors 72%
  • Amyloid 61%
  • Cognition 51%
  • Pathology 40%

• CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges

  das Neves, S. P., Delivanoglou, N. & Da Mesquita, S., Apr 28 2021, In: Frontiers in Pharmacology. 12, 655052.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Lymphatic System 100%
  • Central Nervous System 86%
  • Drainage 65%
  • Neuroimmunomodulation 56%
  • Meninges 50%

• Functional characterization of the dural sinuses as a neuroimmune interface

  Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., Erdmann-Gilmore, P., & 4 othersSmirnov, I., Lopes, M. B., Herz, J. & Kipnis, J., Feb 18 2021, In: Cell. 184, 4, p. 1000-1016.e27

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Central Nervous System 88%
  • Antigens 75%
  • Cerebrospinal Fluid 52%
  • Immune Privilege 44%
  • Neuroimmunomodulation 43%

• Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

  Dominantly Inherited Alzheimer Network, May 13 2021, In: Nature. 593, 7858, p. 255-260 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia 100%
  • Immunotherapy 86%
  • Alzheimer Disease 76%
  • Passive Immunization 39%
  • Amyloid 31%

• SERPINA3 in glioblastoma and Alz h eimer's dis e as e

  Norton, E. S., Da Mesquita, S. & Guerrero-Cazares, H., 2021, In: Aging. 13, 18, p. 21812-21813 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioblastoma 100%
  • Brain 49%
  • Alzheimer Disease 39%
  • Amyloid 32%
  • Apolipoprotein E2 25%
• 2020

  Bioorthogonal labeling reveals different expression of glycans in mouse hippocampal neuron cultures during their development

  Soares da Costa, D., Sousa, J. C., Mesquita, S. D., Petkova-Yankova, N. I., Marques, F., Reis, R. L., Sousa, N. & Pashkuleva, I., Feb 12 2020, In: Molecules. 25, 4, 795.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • mice 100%
  • marking 97%
  • neurons 95%
  • Polysaccharides 89%
  • Neurons 58%

• Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

  Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., Lopes, M. B., Cao, W. S., Xie, X. S., Herz, J. & Kipnis, J., Nov 1 2020, In: Nature immunology. 21, 11, p. 1421-1429 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-17 100%
  • Anxiety 67%
  • T-Lymphocytes 58%
  • Neurons 58%
  • Vertebrates 28%
• 2018

  CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

  Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., Da Mesquita, S., Frost, E. L., Gaultier, A., Harris, T. H., Cao, R., Hu, S., Lukens, J. R., Smirnov, I., Overall, C. C., Oliver, G., & 1 othersKipnis, J., Oct 1 2018, In: Nature Neuroscience. 21, 10, p. 1380-1391 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drainage 100%
  • T-Lymphocytes 72%
  • Multiple Sclerosis 69%
  • Meninges 50%
  • Cerebrospinal Fluid Leak 48%

• Erratum to: Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease (Nature, (2018), 560, 7717, (185-191), 10.1038/s41586-018-0368-8)

  Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., & 3 othersOverall, C. C., Acton, S. T. & Kipnis, J., Dec 6 2018, In: Nature. 564, 7734, p. E7

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Alzheimer Disease 100%
  • History 96%

• Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

  Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., & 3 othersOverall, C. C., Acton, S. T. & Kipnis, J., Aug 9 2018, In: Nature. 560, 7717, p. 185-191 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glymphatic System 100%
  • Alzheimer Disease 49%
  • Extracellular Fluid 47%
  • Central Nervous System 46%
  • mouse vascular endothelial growth factor C 44%

• Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours

  Ferreira, A. C., Santos, T., Sampaio-Marques, B., Novais, A., Mesquita, S. D., Ludovico, P., Bernardino, L., Correia-Neves, M., Sousa, N., Palha, J. A., Sousa, J. C. & Marques, F., Apr 1 2018, In: Molecular Psychiatry. 23, 4, p. 1031-1039 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipocalin-2 100%
  • Neural Stem Cells 84%
  • Neurogenesis 79%
  • Fear 26%
  • Iron 24%

• Morphological and functional analysis of CNS-associated lymphatics

  Herz, J., Louveau, A., Da Mesquita, S. & Kipnis, J., 2018, Methods in Molecular Biology. Humana Press Inc., p. 141-151 11 p. (Methods in Molecular Biology; vol. 1846).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glymphatic System 100%
  • Meninges 81%
  • Central Nervous System 46%
  • Brain 31%
  • Cerebrospinal Fluid 27%

• The Meningeal Lymphatic System: A New Player in Neurophysiology

  Da Mesquita, S., Fu, Z. & Kipnis, J., Oct 24 2018, In: Neuron. 100, 2, p. 375-388 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Lymphatic System 100%
  • Neurophysiology 98%
  • Glymphatic System 61%
  • Brain 38%
  • Cerebrospinal Fluid 33%
• 2017

  DAMed in (Trem) 2 Steps

  Da Mesquita, S. & Kipnis, J., Jun 15 2017, In: Cell. 169, 7, p. 1172-1174 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  Open Access

  • Microglia 100%
  • Neurodegenerative Diseases 42%
  • Alzheimer Disease 38%
  • Population 19%
• 2016

  Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

  Dá Mesquita, S., Ferreira, A. C., Sousa, J. C., Correia-Neves, M., Sousa, N. & Marques, F., Sep 1 2016, In: Neuroscience and Biobehavioral Reviews. 68, p. 547-562 16 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Amyloid 100%
  • Immune System 83%
  • Alzheimer Disease 81%
  • Pathology 66%
  • Brain 51%

• Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer's Disease?

  Louveau, A., Da Mesquita, S. & Kipnis, J., Sep 7 2016, In: Neuron. 91, 5, p. 957-973 17 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Nervous System Diseases 100%
  • Multiple Sclerosis 94%
  • Glymphatic System 84%
  • Alzheimer Disease 82%
  • Waste Products 78%
• 2015

  From the periphery to the brain: Lipocalin-2, a friend or foe?

  Ferreira, A. C., Dá Mesquita, S., Sousa, J. C., Correia-Neves, M., Sousa, N., Palha, J. A. & Marques, F., Aug 1 2015, In: Progress in Neurobiology. 131, p. 120-136 17 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Lipocalin-2 100%
  • Brain 36%
  • Iron 35%
  • Siderophores 29%
  • Cell Proliferation 14%

• The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease

  Mesquita, S. D., Ferreira, A. C., Gao, F., Coppola, G., Geschwind, D. H., Sousa, J. C., Correia-Neves, M., Sousa, N., Palha, J. A. & Marques, F., Oct 1 2015, In: Brain, Behavior, and Immunity. 49, p. 280-292 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Choroid Plexus 100%
  • Interferon Type I 96%
  • Transcriptome 74%
  • Interferon-gamma 72%
  • Alzheimer Disease 62%
• 2014

  Lipocalin 2 modulates the cellular response to amyloid beta

  Mesquita, S. D., Ferreira, A. C., Falcao, A. M., Sousa, J. C., Oliveira, T. G., Correia-Neves, M., Sousa, N., Marques, F. & Palha, J. A., Oct 1 2014, In: Cell Death and Differentiation. 21, 10, p. 1588-1599 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipocalin-2 100%
  • Amyloid 71%
  • Astrocytes 69%
  • Iron 46%
  • Alzheimer Disease 29%
• 2013

  Lipocalin-2 is involved in emotional behaviors and cognitive function

  Ferreira, A. C., Pinto, V., Dá Mesquita, S., Novais, A., Sousa, J. C., Correia-Neves, M., Sousa, N., Palha, J. A. & Marques, F., Jul 11 2013, In: Frontiers in Cellular Neuroscience. JUL

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipocalin-2 100%
  • Cognition 59%
  • Hippocampus 35%
  • Spatial Learning 18%
  • Long-Term Potentiation 17%
• 2012

  Lipocalin 2 is present in the EAE brain and is modulated by natalizumab

  Marques, F., Mesquita, S. D., Sousa, J. C., Coppola, G., Gao, F., Geschwind, D. H., Columba-Cabezas, S., Aloisi, F., Degn, M., Cerqueira, J. J., Sousa, N., Correia-Neves, M. & Palha, J. A., Aug 9 2012, In: Frontiers in Cellular Neuroscience. 6, AUG, 33.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Natalizumab 100%
  • Lipocalin-2 92%
  • Autoimmune Experimental Encephalomyelitis 81%
  • Multiple Sclerosis 52%
  • Cerebrospinal Fluid 43%

• Modulation of iron metabolism in aging and in Alzheimer's disease: Relevance of the choroid plexus

  Mesquita, S. D., Ferreira, A. C., Sousa, J. C., Santos, N. C., Correia-Neves, M., Sousa, N., Palha, J. A. & Marques, F., May 22 2012, In: Frontiers in Cellular Neuroscience. MAY 2012

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Choroid Plexus 100%
  • Iron 67%
  • Alzheimer Disease 62%
  • Cerebrospinal Fluid 26%
  • Epithelial Cells 21%
• 2010

  Plasmacytoid and conventional dendritic cells are early producers of IL-12 in Neospora caninum-infected mice

  Teixeira, L., Botelho, A. S., Mesquita, S. D., Correia, A., Cerca, F., Costa, R., Sampaio, P., Castro, A. G. & Vilanova, M., Jan 2010, In: Immunology and Cell Biology. 88, 1, p. 79-86 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Neospora 100%
  • Interleukin-12 67%
  • Dendritic Cells 58%
  • Infections 19%
  • Host Specificity 10%