Mayo Clinic

Projects

Projects per year 1973 2021

• 39 Active
• 1580 Finished
• 2180 Not started

Projects per year

Search results

• Regulation of Vascular BK Channels in Diabetes

  Lee, H. C.

  Project: Research project

  • Large-Conductance Calcium-Activated Potassium Channels 100%
  • Reactive Oxygen Species 13%
  • Oxidation-Reduction 12%
  • Cysteine 11%
  • Endothelium 11%

• Therapeutic Strategy to slow progression of calcific aortic valve stenosis

  Sarano, M. E., Miller, J. D. & Schaff, H. V.

  Project: Research project

  • Calcification of Aortic Valve 100%
  • Aortic Valve Stenosis 75%
  • Aortic Valve 20%
  • Organized Financing 18%
  • Ventricular Dysfunction 6%

• Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease

  Mielke, M. M. & Miller, V. M.

  Project: Research project

  • dementia 100%
  • leadership 47%
  • menopause 31%
  • career 31%
  • work force 28%

• Novel treatment for polycystic kidney disease

  Torres, V.

  Project: Research project

  • Polycystic Kidney Diseases 100%
  • Deamino Arginine Vasopressin 33%
  • Endoplasmic Reticulum 32%
  • TRPP Cation Channels 28%
  • Aquaporin 2 25%

• Unruptured Intracranial Aneurysms: Neurologic Outcome

  Brown, R. D. J.

  Project: Research project

  • Intracranial Aneurysm 100%
  • Natural History 50%
  • Rupture 28%
  • Nervous System 13%
  • Stroke 11%

• Inhibition of TNF in Patients with Alcoholic Hepatitis

  Shah, V.

  Project: Research project

  • Alcoholic Hepatitis 100%
  • Tumor Necrosis Factor-alpha 51%
  • Etanercept 45%
  • Interleukin-6 20%
  • Liver Diseases 15%

• Multi-parameter Nonlinear Elasticity Mapping of Breast Masses

  Alizad, A. & Fatemi, M.

  Project: Research project

  • breast 100%
  • elastic properties 86%
  • anxiety 11%
  • pathology 8%
  • cancer 6%

• Mouse Models of Eosinophil-Associated Lung Dysfunction

  Lee, N. A.

  Project: Research project

  • Eosinophils 100%
  • Lung 66%
  • Pathology 39%
  • Asthma 24%
  • Inflammation 18%

• RNA Decoys for DNA Binding Proteins

  Maher III, J.

  Project: Research project

  • RNA 100%
  • Genetic Selection 93%
  • DNA-Binding Proteins 80%
  • NF-kappa B 76%
  • Yeasts 58%

• Cell-Penetrating Aptamers Targeting Sub-Cellular Compartments

  Maher III, J.

  Project: Research project

  • Nucleic Acid 100%
  • Enzyme Activity 39%
  • Toxic 17%
  • Lipid 16%
  • Cation 13%

• Healthy Immigrant Families: Working Together To Move More and To Eat Well

  Sia, I. G. & Wieland, M. L.

  Project: Research project

  • immigrant 100%
  • nutrition 98%
  • refugee 95%
  • blood pressure 35%
  • adolescent 32%

• GABA reactivates hepatocytes in aged liver (R21 AG52822 Resubmission)

  Nguyen, J. H.

  Project: Research project

  • gamma-Aminobutyric Acid 100%
  • Liver 76%
  • Hepatocytes 62%
  • Tissue Donors 46%
  • Liver Regeneration 36%

• Assessment of metabolic bone disease of prematurity using an acoustic method

  Alizad, A. & Fatemi, M.

  Project: Research project

  • premature birth 100%
  • osteopenia 87%
  • bones 69%
  • acoustics 49%
  • ultrasonography 45%

• Understanding the Mechanisms of TDP-43 Function

  Fryer, J. D. & Zhang, Y.

  Project: Research project

  • Tyrosine 100%
  • Phosphorylation 74%
  • Frontotemporal Dementia 45%
  • Bacterial Artificial Chromosomes 25%
  • Amyotrophic Lateral Sclerosis 19%

• Molecular Mechanisms of Portal Hypertension

  Shah, V.

  Project: Research project

  • Hepatic Stellate Cells 100%
  • Portal Hypertension 57%
  • Pseudopodia 27%
  • Nitric Oxide 23%
  • Cyclic GMP-Dependent Protein Kinases 15%

• Liquid biopsy for alcoholic hepatitis: diagnosis, prognosis and technology development

  Malhi, H. M. & Shah, V.

  Project: Research project

  • Alcoholic Hepatitis 100%
  • Extracellular Vesicles 90%
  • Sphingolipids 41%
  • Hepatocytes 20%
  • Biomarkers 15%

• Noninvasive assessment of alcoholic hepatitis effects in promoting age-related cognitive decline with multiparametric magnetic resonance elastography (MRE) imaging

  Shah, V. & Yin, M.

  Project: Research project

  • Elasticity Imaging Techniques 100%
  • Alcoholic Hepatitis 72%
  • Cognitive Dysfunction 42%
  • Liver 34%
  • Brain 25%

• Metabolic regulation of satellite cell function

  Doles, J.

  Project: Research project

  • Tristetraprolin 100%
  • Messenger RNA 43%
  • Muscle Cells 42%
  • Adult Stem Cells 35%
  • Stem Cells 33%

• AUTOMATIC CORRECTION OF MOTION ARTIFACTS IN MR IMAGES

  Manduca, A.

  Project: Research project

  • Imaging techniques 100%
  • Image quality 60%
  • Image acquisition 50%
  • Magnetic resonance imaging 45%
  • Angiography 28%

• Generalized waveform methods for breast viscoelasticity mapping

  Fatemi, M.

  Project: Research project

  • Viscoelasticity 100%
  • Tissue 89%
  • Radiation 64%
  • Shear waves 63%
  • Imaging techniques 62%

• Automatic Correction of Motion Artifacts in MR Images

  Manduca, A.

  Project: Research project

  • Imaging techniques 100%
  • Magnetic resonance imaging 68%
  • Image quality 40%
  • Angiography 28%
  • Motion tracking 26%

• VIBRO-ACOUSTOGRAPHY SYSTEM WITH CONTACT ARRAY PROBE

  Fatemi, M.

  Project: Research project

  • Tissue 100%
  • Imaging techniques 38%
  • Pathology 38%
  • Dynamic response 28%
  • Ultrasonics 28%

• Mechanisms of sepsis-associated muscle stem cell dysfunction

  Doles, J.

  Project: Research project

  • Sepsis 100%
  • Stem Cells 67%
  • Muscle Cells 23%
  • National Institute of General Medical Sciences (U.S.) 12%
  • Cytokines 12%

• Optimizing stroke prevention for older adults with atrial fibrillation: Towards rigorous evaluation and judicious application of a new device

  Noseworthy, P. & Yao, X.

  Project: Research project

  • Atrial Fibrillation 100%
  • Stroke 64%
  • Machine Learning 42%
  • Warfarin 39%
  • Clinical Trials 36%

• Alpha-1 AD Carriers and Lung Cancer Risk

  Yang, P.

  Project: Research project

  • Lung Neoplasms 100%
  • Smokers 53%
  • Leukocyte Elastase 40%
  • Alleles 30%
  • Siblings 28%

• Spinal muscular atrophy: a novel role of SMN in axonal ribonucleoprotein complexe

  Rossoll, W.

  Project: Research project

  • Motor Neurons 100%
  • Spinal Muscular Atrophy 40%
  • Proteins 28%
  • Ribonucleoproteins 27%
  • Axons 19%

• High-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

  Rossoll, W.

  Project: Research project

  • Ciliary Neurotrophic Factor Receptor 100%
  • Amyotrophic Lateral Sclerosis 49%
  • Ciliary Neurotrophic Factor 40%
  • Motor Neurons 28%
  • Nerve Growth Factors 24%

• High-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

  Rossoll, W.

  Project: Research project

  • Ciliary Neurotrophic Factor Receptor 100%
  • Amyotrophic Lateral Sclerosis 49%
  • Ciliary Neurotrophic Factor 40%
  • Motor Neurons 28%
  • Nerve Growth Factors 24%

• Post-translational Modifications in DNA Damage Response: a Structural Perspective

  Mer, G.

  Project: Research project

  • DNA Damage 100%
  • Ubiquitination 62%
  • DNA 51%
  • Proliferating Cell Nuclear Antigen 37%
  • Post Translational Protein Processing 35%

• Structural basis of RNF168-mediated ubiquitin signaling at chromosomal DNA breaks

  Mer, G.

  Project: Research project

  • Homologous Recombination 100%
  • Ubiquitin-Conjugating Enzymes 85%
  • Histones 83%
  • Chromatin 78%
  • Ubiquitin 59%

• Structural biology of DNA damage response in chromatin

  Mer, G.

  Project: Research project

  • Chromatin 100%
  • DNA Damage 98%
  • Post Translational Protein Processing 69%
  • Nucleosomes 53%
  • Homologous Recombination 50%

• Growth Regulatory Mechanisms of KLF in Barrett's Epithelium

  Buttar, N. S.

  Project: Research project

  • esophagus 100%
  • epithelium 71%
  • neoplasms 45%
  • promoter regions 31%
  • mucosa 28%

• Catheter-Directed Thrombolytic Therapy: Deep Thrombosis

  Ashrani, A. A.

  Project: Research project

  • Thrombolytic Therapy 100%
  • Postthrombotic Syndrome 92%
  • Curriculum 85%
  • Venous Thrombosis 83%
  • Catheters 45%

• Neuropsychology of Dementia with Lewy Bodies

  Ferman, T. J.

  Project: Research project

  • Alzheimer Disease 40%
  • Organized Financing 23%
  • REM Sleep Behavior Disorder 18%
  • Lewy Bodies 17%
  • Dementia 16%

• The Role of Caveolins in Lung Inflammation

  Pabelick, C. M.

  Project: Research project

  • Caveolin 1 100%
  • Smooth Muscle 58%
  • Caveolae 46%
  • Caveolins 28%
  • Inflammation 12%

• IMPACT OF SEX-RELATED HORMONE LEVELS AND GENETIC VARIATION ON ALCOHOL USE DISORDERS AND RELATED PHENOTYPES IN MALES AND FEMALES

  Karpyak, V. M. & Winham, S. J.

  Project: Research project

  • Gonadal Steroid Hormones 100%
  • Alcoholism 91%
  • Sex Characteristics 60%
  • Genetic Variation 35%
  • Craving 21%

• Alzheimer's Clinical Trials Consortium (ACTC)

  Petersen, R. C.

  Project: Research project

  • Clinical Trials 100%
  • Alzheimer Disease 86%
  • Research Personnel 38%
  • Neurodegenerative Diseases 24%
  • Dementia 23%

• The pathophysiological role of the immunoproteasome in atherosclerosis

  Herrmann, J.

  Project: Research project

  • Atherosclerosis 100%
  • Apolipoproteins E 32%
  • High Fat Diet 20%
  • Interferon-gamma 18%
  • Molecular Mechanisms of Pharmacological Action 16%

• Protein Therapeutics to Prevent Heart Failure Post Myocardial Infarction

  Burnett, J. C. J.

  Project: Research project

  • Myocardial Infarction 100%
  • Heart Failure 78%
  • Brain Natriuretic Peptide 67%
  • Safety 35%
  • peptide B 24%

• Molecular Pathogenesis of Hepatocellular Carcinoma

  Roberts, L. R.

  Project: Research project

  • Hepatocellular Carcinoma 100%
  • Heparitin Sulfate 45%
  • Glycosaminoglycans 39%
  • Cell Line 22%
  • Intercellular Signaling Peptides and Proteins 20%

• Extracellular vesicle RNA signaling in liver tumor microenvironment

  Patel, T. C.

  Project: Research project

  • Extracellular Vesicles 100%
  • Liver Neoplasms 67%
  • Neoplasms 65%
  • Stromal Cells 51%
  • RNA 47%

• Cardiovascular Peptides and Myocardial Infarction

  Burnett, J. C. J.

  Project: Research project

  • Natriuretic Peptides 100%
  • Myocardial Infarction 81%
  • Guanylate Cyclase 40%
  • atrial natriuretic factor receptor A 38%
  • Aldosterone 33%

• Novel Peptide Therapeutics for Cardiorenal Protection in Heart Failure

  Burnett, J. C. J.

  Project: Research project

  • Renin-Angiotensin System 100%
  • Heart Failure 90%
  • Kidney 66%
  • Angiotensinogen 35%
  • Angiotensin II 26%

• Senescence and Growth Differentiation Factors as Modifiers of Aging

  LeBrasseur, N. K.

  Project: Research project

  • Growth Differentiation Factors 100%
  • Plasminogen Activator Inhibitor 2 52%
  • activin A 47%
  • Body Composition 33%
  • Proteins 33%

• Pathways linking neuropsychiatric symptoms with Alzheimer's disease neuroimaging biomarkers and the outcome of incident Mild Cognitive Impairment/ Dementia

  Geda, Y. E.

  Project: Research project

  • Alzheimer Disease 100%
  • Neuroimaging 53%
  • Biomarkers 38%
  • Epidemiology 31%
  • Psychiatry 22%

• Molecular Discriminators in Benign Breast Tissue for Future Risk of ER positive a

  Degnim, A. C.

  Project: Research project

  • Breast Neoplasms 100%
  • Breast 71%
  • Mutation 35%
  • Biopsy 28%
  • Neoplasms 25%

• Molecular Mechanisms of Cholestatic Fibrogenesis

  Huebert, R. C.

  Project: Research project

  • Enhancer of Zeste Homolog 2 Protein 100%
  • Hepatic Stellate Cells 69%
  • Fibronectins 47%
  • Acetylation 42%
  • Fibrosis 42%

• Computerized Adaptive Testing to Direct Delivery of Hospital-Based Rehabilitation

  Cheville, A. L.

  Project: Research project

  • Subacute Care 100%
  • Physical Therapists 50%
  • Proxy 47%
  • Rehabilitation 35%
  • Rehabilitation Hospitals 30%

• Senescence-related Proteins and Growth and Differentiation Factors as Modifiers of Aging

  LeBrasseur, N. K.

  Project: Research project

  • Growth Differentiation Factors 100%
  • Plasminogen Activator Inhibitor 2 52%
  • Proteins 37%
  • Walking Speed 26%
  • Physical Functional Performance 25%

• Pairing Observational and Patient-level Clinical Trial Data to Assess Cardiovascular Risk Reduction with Catheter Ablation for Atrial Fibrillation

  Noseworthy, P., Yao, X. & Yao, X.

  Project: Research project

  • Data Warehousing 100%
  • Atrial Fibrillation 75%
  • Randomized Controlled Trials 68%
  • Electronic Health Records 51%
  • Observational Studies 39%