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Projects 1975 2021

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Synucleins
Parkinson Disease
Pathology
Nuclear Envelope
Brain

Targeting MMP-9 for breast cancer therapy (R21 CA205471 Resubmission)

Radisky, E. S.

National Institutes of Health

7/1/166/30/18

Project: Research projectExploratory/Developmental Grants

Matrix Metalloproteinase 9
Breast Neoplasms
Matrix Metalloproteinase Inhibitors
Therapeutics
Matrix Metalloproteinases
alpha-Synuclein
Adenosine Triphosphate
Parkinson Disease
Brain Injuries
Traumatic Brain Injury

Functions of human and mouse Trem2 in vivo

Fryer, J. D.

National Institutes of Health

4/1/163/31/18

Project: Research projectExploratory/Developmental Grants

Alzheimer Disease
Lipoprotein Receptors
Apolipoprotein E4
tau Proteins
Frontotemporal Dementia

Novel SCD1 inhibitors for treatment of cancer

Copland, J. A. I. & Hazlehurst, L.

National Institutes of Health

3/5/162/28/17

Project: Research projectSmall Business Technology Transfer (STTR) Grants - Phase I

Stearoyl-CoA Desaturase
Neoplasms
Therapeutics
Biological Availability
Survival

Targeting Protein Kinase D in Triple Negative Breast Cancers

Storz, P.

National Institutes of Health

8/21/157/31/17

Project: Research projectExploratory/Developmental Grants

Triple Negative Breast Neoplasms
Breast Neoplasms
Protein Isoforms
Drug Therapy
Neoplasms

Genetic and Functional Analysis of Nested AD Risk Genes CTNNA3 and LRRTM3

Younkin, S. G., Ertekin-Taner, N. & Ertekin-Taner, N.

National Institutes of Health

8/1/155/31/17

Project: Research projectExploratory/Developmental Grants

Genome-Wide Association Study
Genes
Costs and Cost Analysis
Alzheimer Disease
Exome
Clusterin
Alzheimer Disease
Cerebral Amyloid Angiopathy
Apolipoproteins E
Amyloid

Stories of our Men: American Indian/Alaska Native Colorectal Health

Kaur, J. S. & Littleton, D.

National Institutes of Health

5/5/154/30/18

Project: Research projectResources Project Grant (NLM)

American Indian
health
community
movies
physician

Discoidin Domain Receptors: Novel Players in Pancreatitis and Pancreatic Preneoplasia

Crawford, H. H., Fridman, R. A. & Fridman, R. A.

National Institutes of Health

12/10/1411/30/16

Project: Research projectExploratory/Developmental Grants

Metaplasia
Pancreatitis
Acinar Cells
Adenocarcinoma
Collagen
Acute Pain
Paclitaxel
Auranofin
Intractable Pain
Pain

c9RAN proteins as a biomarker for C9ORF72-associated ALS and FTD

Boylan, K. B. & Gendron, T. D.

National Institutes of Health

9/15/148/31/16

Project: Research projectExploratory/Developmental Grants

Biomarkers
Amyotrophic Lateral Sclerosis
Proteins
Frontotemporal Dementia With Motor Neuron Disease
Immunoassay

Building the Foundation of Epigenomics Roadmaps

Li, Z. & Asmann, Y. W.

National Institutes of Health

9/11/148/31/16

Project: Research projectResearch Project

chromatin
sequencing
cancer
markers
genome

Endocrine disruptors effect on inflammatory heart disease

Fairweather, D.

National Institutes of Health

8/1/147/31/16

Project: Research projectExploratory/Developmental Grants

Endocrine Disruptors
Myocarditis
Heart Diseases
Dilated Cardiomyopathy
Estrogen Receptors
Neurodegenerative Diseases
Microglia
Phagocytosis
Ligands
Neurons

ApoE isoform-specific therapy for Alzheimer disease

Bu, G. D.

National Institutes of Health

9/30/136/30/18

Project: Research projectResearch Project

Apolipoprotein E4
Apolipoprotein E3
Apolipoproteins E
Alzheimer Disease
Protein Isoforms

A system approach to targeting innate immunity in AD

Younkin, S. G., Golde, T. E., Price, N., Golde, T. E., Ertekin-Taner, N., Ertekin-Taner, N. & Golde, T. E.

National Institutes of Health

9/20/138/31/18

Project: Research projectResearch Project--Cooperative Agreements

Innate Immunity
Alzheimer Disease
Cognition
Genetic Loci
Gliosis

Extracellular non-coding RNA biomarkers of hepatocellular cancer

Patel, T. C.

National Institutes of Health

8/1/137/31/18

Project: Research projectExploratory/Developmental Cooperative Agreement Phase I, Exploratory/Developmental Cooperative Agreement Phase II

Untranslated RNA
Liver Neoplasms
Biomarkers
Long Noncoding RNA
Exosomes

Defining SPINK1 as a tumor driver and therapeutic target in ovarian cancer

Radisky, E. S.

National Institutes of Health

7/1/136/30/15

Project: Research projectExploratory/Developmental Grants

Ovarian Neoplasms
Epidermal Growth Factor Receptor
Neoplasms
Therapeutics
X Ray Crystallography

RNA foci in C9FTD/ALS

Petrucelli, L.

National Institutes of Health

7/1/136/30/16

Project: Research projectExploratory/Developmental Grants

Amyotrophic Lateral Sclerosis
RNA
RNA-Binding Proteins
Frontotemporal Lobar Degeneration
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Molecular Biology
Proteins
Mutation
Neurodegenerative Diseases
Serine Proteases
Prostatic Neoplasms
Biomarkers
Prostatectomy
Neoplasm Metastasis

Understanding the Mechanisms of TDP-43 Function

Zhang, Y. & Fryer, J. D.

National Institutes of Health

2/15/131/31/16

Project: Research projectExploratory/Developmental Grants

Tyrosine
Phosphorylation
Frontotemporal Dementia
Bacterial Artificial Chromosomes
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Poisons
Alternative Splicing
Mutation
RNA

Comparative Genomics Study of Foxa/ER Targets in Liver Cancer and Breast Cancer

Li, Z.

National Institutes of Health

8/9/1211/30/16

Project: Research projectCareer Transition Award, Research Transition Award

Estrogen Receptor alpha
Liver Neoplasms
Genomics
Breast Neoplasms
Neoplasms

PD iPS Cell Line Consortium

Wszolek, Z. K., Isacson, O. L. E., Studer, L. P., Dawson, T. M., Isacson, O. L. E., Studer, L. P., Dawson, T. M. & Studer, L. P.

National Institutes of Health

7/1/126/30/14

Project: Research projectResource-Related Research Projects--Cooperative Agreements

Mutation
Research Subjects
Parkinson Disease
Consent Forms
Parkinsonian Disorders

Sex Differences in Complement during Myocarditis/DCM

Fairweather, D.

National Institutes of Health

6/15/127/31/17

Project: Research projectResearch Project

Myocarditis
Dilated Cardiomyopathy
Sex Characteristics
Cardiovascular Diseases
Inflammation

Regional, Synpatic, Cellular Modulation of Abeta Metabolism

Bu, G. D., Holtzman, D. M., Cirrito, J., Snider, B. & Holtzman, D. M.

National Institutes of Health

5/15/124/30/17

Project: Research projectResearch Program Projects

Lipoprotein Receptors
Heparan Sulfate Proteoglycans
Amyloid
Amyloid beta-Protein Precursor
Endocytosis

Understanding the role of MAPT in Parkinsonian disorders

Ross, O. A.

National Institutes of Health

4/1/121/31/17

Project: Research projectResearch Project

Progressive Supranuclear Palsy
Parkinsonian Disorders
Parkinson Disease
Haplotypes
Frontotemporal Dementia

MicroRNAs in lobular involution and breast cancer

Thompson, E. A. & Necela, B.

National Institutes of Health

9/26/118/31/13

Project: Research projectExploratory/Developmental Grants

Breast Diseases
MicroRNAs
Breast
Breast Neoplasms
Epithelial Cells

Develop and Characterize a Novel Animal Model of Pancreatic Cancer

Ji, B. D.

National Institutes of Health

9/15/118/31/14

Project: Research projectExploratory/Developmental Grants

Pancreatic Neoplasms
Animal Models
Pancreatic Ducts
Adenocarcinoma
Genetic Models

Health Communication &Health Literacy to Improve Care for Latinos with Diabetes

White, R. O.

National Institutes of Health

9/1/115/31/16

Project: Research projectMentored Patient-Oriented Research Career Development Award

Health Communication
Health Literacy
Hispanic Americans
Research Personnel
Health
Frontotemporal Lobar Degeneration
Exons
RNA
Amyotrophic Lateral Sclerosis
Protein Isoforms
Gold Sodium Thiomalate
Non-Small Cell Lung Carcinoma
Lung
Therapeutics
Neoplasms

Pathologically modified TDP-43 in neurodegenerative diseases

Gendron, T. D.

National Institutes of Health

6/1/115/31/14

Project: Research projectExploratory/Developmental Grants

Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Frontotemporal Dementia
Alzheimer Disease
Pathology

ADAM17 in pancreatic cancer and pancreatitis

Crawford, H. H.

National Institutes of Health

3/4/112/29/16

Project: Research projectResearch Project

Pancreatic Neoplasms
Pancreatitis
Adenocarcinoma
Chronic Pancreatitis
Pharmacology

Cytokine Modulation of AB Associated Pathologies in Mouse Models of AD

Das, P.

National Institutes of Health

3/1/112/28/15

Project: Research projectResearch Project

Alzheimer Disease
Pathology
Cytokines
Amyloid
Neuroglia

Chemopreventive signaling pathways

Thompson, E. A.

National Institutes of Health

2/3/111/31/14

Project: Research projectSmall Research Grants

Peroxisomes
Aberrant Crypt Foci
Calcineurin
Colonic Neoplasms
Azoxymethane

Role of Immunity in Efficacy of Chemotherapy Plus Trastuzumab

Knutson, K. L., Perez, E. A. & Clynes, R.

National Institutes of Health

1/1/1112/31/16

Project: Research projectResearch Project

Immunity
Drug Therapy
Breast Neoplasms
Antibody Formation
Trastuzumab
Metaplasia
Pancreatic Neoplasms
Adenocarcinoma
Carcinogenesis
Mitogen-Activated Protein Kinase Kinases
Knockout Mice
Leucine
Phosphotransferases
Mutation
Parkinson Disease
Parkinsonian Disorders
Synucleins
Parkinson Disease
Research
Molecular Biology

The NINDS International Stroke Genetics Consortium Study

Meschia, J. F., Worrall, B., Rexrode, K., Psaty, B., Daniel, W., Kittner, S., Howard, G., Sacco, R. L., Wassertheil-Smoller, S., Rosand, J. & Sacco, R. L.

National Institutes of Health

7/1/106/30/16

Project: Research projectResearch Project--Cooperative Agreements

National Institute of Neurological Disorders and Stroke
Stroke

Atypical PKC signaling in lung cancer stem cells

Fields, A. P.

National Institutes of Health

7/1/106/30/12

Project: Research projectExploratory/Developmental Grants

Neoplastic Stem Cells
Lung Neoplasms
Alveolar Epithelial Cells
Protein Kinase C
Gold Sodium Thiomalate

Development and Testing of Hsp90 Inhibitors

Petrucelli, L.

National Institutes of Health

7/1/1012/31/15

Project: Research projectResearch Project--Cooperative Agreements

Frontotemporal Lobar Degeneration
Blood-Brain Barrier
Investigational New Drug Application
Progressive Supranuclear Palsy
Therapeutics

Fusion gene mutations as biomarkers of pancreatic cancer lymph node metastases

Wallace, M. B., Murray, N. R. & Thompson, E. A.

National Institutes of Health

7/1/106/30/13

Project: Research projectExploratory/Developmental Grants

Research Project

Patten, C. A., Kaur, J. S., Solomon, T. G. A., Solomon, T. G. A. & Solomon, T. G. A.

National Institutes of Health

7/1/108/31/16

Project: Research projectSpecialized Center--Cooperative Agreements

Eagles
North American Indians
Neoplasms
Community-Institutional Relations
Tobacco Use Cessation

RhoB in cancer pathogenesis and as a target in combinatorial therapy

Copland, J. A. I. & Smallridge, R.

National Institutes of Health

7/1/104/30/16

Project: Research projectResearch Project

Neoplasms
rhoB GTP-Binding Protein
Paclitaxel
Apoptosis
Therapeutics
Renal Cell Carcinoma
Biomarkers
Neoplasms
Therapeutics
Tumor Biomarkers

Tumor Microenvironment/Angiogenesis Training Grant

Mukhopadhyay, D., Mc Niven, M. A. & Mc Niven, M. A.

National Cancer Institute United States, National Institutes of Health

6/1/105/31/16

Project: Research projectInstitutional National Research Service Award

Tumor Microenvironment
Neoplasms
Cell Biology
Education
Extracellular Matrix