Research output per year
Research output per year
- 1 - 50 out of 79 results
Search results
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2022
TCF-1: a maverick in T cell development and function
Gounari, F. & Khazaie, K., May 2022, In: Nature immunology. 23, 5, p. 671-678 8 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Tcf-1 promotes genomic instability and T cell transformation in response to aberrant β-catenin activation
Arnovitz, S., Mathur, P., Tracy, M., Mohsin, A., Mondal, S., Quandt, J., Hernandez, K. M., Khazaie, K., Dose, M., Emmanuel, A. O. & Gounari, F., Aug 9 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 32, e2201493119.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer
Osman, A., Yan, B., Li, Y., Pavelko, K. D., Quandt, J., Saadalla, A., Singh, M. P., Kazemian, M., Gounari, F. & Khazaie, K., Sep 2021, In: Nature immunology. 22, 9, p. 1152-1162 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression
Quandt, J., Arnovitz, S., Haghi, L., Woehlk, J., Mohsin, A., Okoreeh, M., Mathur, P. S., Emmanuel, A. O., Osman, A., Krishnan, M., Morin, S. B., Pearson, A. T., Sweis, R. F., Pekow, J., Weber, C. R., Khazaie, K. & Gounari, F., Apr 2021, In: Nature immunology. 22, 4, p. 471-484 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2020
CRELD1 controls T cell homeostasis
Gounari, F., Dec 2020, In: Nature immunology. 21, 12, p. 1480-1482 3 p.Research output: Contribution to journal › Article › peer-review
Open Access -
DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells
Kong, D., Wan, Q., Li, J., Zuo, S., Liu, G., Liu, Q., Wang, C., Bai, P., Duan, S. Z., Zhou, B., Gounari, F., Lyu, A., Lazarus, M., Breyer, R. M. & Yu, Y., Feb 25 2020, In: Circulation. 141, 8, p. 655-666 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer
Saadalla, A., Lima, M. M., Tsai, F., Osman, A., Singh, M. P., Linden, D. R., Dennis, K. L., Haeryfar, S. M. M., Gurish, M. F., Gounari, F. & Khazaie, K., Dec 3 2019, In: Frontiers in immunology. 10, 2777.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation
Yoshida, T., Hu, Y., Zhang, Z., Emmanue, A. O., Galani, K., Muhire, B., Snippert, H. J., Williams, C. J., Tolstorukov, M. Y., Gounari, F. & Georgopoulos, K., Jul 2019, In: Genes and Development. 33, 13-14, p. 763-781 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis
Mandal, M., Okoreeh, M. K., Kennedy, D. E., Maienschein-Cline, M., Ai, J., McLean, K. C., Kaverina, N., Veselits, M., Aifantis, I., Gounari, F. & Clark, M. R., Oct 1 2019, In: Nature immunology. 20, 10, p. 1393-1403 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner
Saadalla, A. M., Osman, A., Gurish, M. F., Dennis, K. L., Blatner, N. R., Pezeshki, A., McNagny, K. M., Cheroutre, H., Gounari, F. & Khazaie, K., Feb 13 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1588-1592 5 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4 + CD8 + thymocytes
Emmanuel, A. O., Arnovitz, S., Haghi, L., Mathur, P. S., Mondal, S., Quandt, J., Okoreeh, M. K., Maienschein-Cline, M., Khazaie, K., Dose, M. & Gounari, F., Dec 1 2018, In: Nature immunology. 19, 12, p. 1366-1378 13 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer
Khan, M. W., Saadalla, A., Ewida, A. H., Al-Katranji, K., Al-Saoudi, G., Giaccone, Z. T., Gounari, F., Zhang, M., Frank, D. A. & Khazaie, K., Jan 1 2018, In: Cancer Immunology, Immunotherapy. 67, 1, p. 13-23 11 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
2016
Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia
Hu, Y., Zhang, Z., Kashiwagi, M., Yoshida, T., Joshi, I., Jena, N., Somasundaram, R., Emmanuel, A. O., Sigvardsson, M., Fitamant, J., El-Bardeesy, N., Gounari, F., Van Etten, R. A. & Georgopoulos, K., Sep 1 2016, In: Genes and Development. 30, 17, p. 1971-1990 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Erratum: Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the notch signaling pathway (J. Immunol. (2015) 194 (3191-3200))
Krishnamoorthy, V., Carr, T., De Pooter, R. F., Emanuelle, A. O., Gounari, F. & Kee, B. L., Jun 15 2015, In: Journal of Immunology. 194, 12, p. 6191 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer
Phillips, J. D., Knab, L. M., Blatner, N. R., Haghi, L., DeCamp, M. M., Meyerson, S. L., Heiferman, M. J., Heiferman, J. R., Gounari, F., Bentrem, D. J. & Khazaie, K., Sep 21 2015, In: Cancer Immunology, Immunotherapy. 64, 9, p. 1185-1191 7 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway
Krishnamoorthy, V., Carr, T., De Pooter, R. F., Akinola, E. O., Gounari, F. & Kee, B. L., Apr 1 2015, In: Journal of Immunology. 194, 7, p. 3191-3200 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
T-cell expression of IL10 is essential for tumor immune surveillance in the small intestine
Dennis, K. L., Saadalla, A., Blatner, N. R., Wang, S., Venkateswaran, V., Gounari, F., Cheroutre, H., Weaver, C. T., Roers, A., Egilmez, N. K. & Khazaie, K., Jul 2015, In: Cancer Immunology Research. 3, 7, p. 806-814 9 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2014
Robin Holliday 1932-2014.
Jeggo, P. & Gounari, F., Jun 2014, In: Nature structural & molecular biology. 21, 6, p. 501-502 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
β-Catenin induces T-cell transformation by promoting genomic instability
Dose, M., Emmanuel, A. O., Chaumeil, J., Zhang, J., Sun, T., Germar, K., Aghajani, K., Davis, E. M., Keerthivasan, S., Bredemeyer, A. L., Sleckman, B. P., Rosen, S. T., Skok, J. A., Le Beau, M. M., Georgopoulos, K. & Gounari, F., Jan 7 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 1, p. 391-396 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
β-catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells
Keerthivasan, S., Aghajani, K., Dose, M., Molinero, L., Khan, M. W., Venkateswaran, V., Weber, C., Emmanuel, A. O., Sun, T., Bentrem, D. J., Mulcahy, M., Keshavarzian, A., Ramos, E. M., Blatner, N., Khazaie, K. & Gounari, F., Feb 26 2014, In: Science translational medicine. 6, 225, 225ra28.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
2013
A far downstream enhancer for murine Bcl11b controls its T-cell specific expression
Li, L., Zhang, J. A., Dose, M., Kueh, H. Y., Mosadeghi, R., Gounari, F. & Rothenberg, E. V., Aug 8 2013, In: Blood. 122, 6, p. 902-911 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Current status of interleukin-10 and regulatory T-cells in cancer
Dennis, K. L., Blatner, N. R., Gounari, F. & Khazaie, K., Nov 2013, In: Current Opinion in Oncology. 25, 6, p. 637-645 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access139 Scopus citations -
Fingerprinting ikaros
Gounari, F. & Kee, B. L., 2013, In: Nature immunology. 14, 10, p. 1034-1035 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The two faces of regulatory t cells in cancer
Blatner, N. R., Gounari, F. & Khazaie, K., May 2013, In: OncoImmunology. 2, 5, e23852.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Transcriptional regulation of the Ikzf1 locus
Yoshida, T., Landhuis, E., Dose, M., Hazan, I., Zhang, J., Naito, T., Jackson, A. F., Wu, J., Perotti, E. A., Kaufmann, C., Gounari, F., Morgan, B. A. & Georgopoulos, K., 2013, In: Blood. 122, 18, p. 3149-3159 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2012
Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid
Khazaie, K., Zadeh, M., Khan, M. W., Bere, P., Gounari, F., Dennis, K., Blatner, N. R., Owen, J. L., Klaenhammer, T. R. & Mohamadzadeh, M., Jun 26 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. 10462-10467 6 p.Research output: Contribution to journal › Article › peer-review
Open Access94 Scopus citations -
Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.
Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., Halverson, A. L., Stryker, S. J., Boller, A. M., Singal, A., Sneed, R. K., Sarraj, B., Ansari, M. J., Oft, M., Iwakura, Y., Zhou, L., & 4 others, Dec 12 2012, In: Science translational medicine. 4, 164Research output: Contribution to journal › Article › peer-review
127 Scopus citations -
Generation of CD4CreERT2 transgenic mice to study development of peripheral CD4-T-cells
Aghajani, K., Keerthivasan, S., Yu, Y. & Gounari, F., Dec 2012, In: Genesis. 50, 12, p. 908-913 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis
Zhang, J., Jackson, A. F., Naito, T., Dose, M., Seavitt, J., Liu, F., Heller, E. J., Kashiwagi, M., Yoshida, T., Gounari, F., Petrie, H. T. & Georgopoulos, K., Jan 2012, In: Nature immunology. 13, 1, p. 86-94 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2011
CDK6 kinase activity is required for thymocyte development
Hu, M. G., Deshpande, A., Schlichting, N., Hinds, E. A., Mao, C., Dose, M., Hu, G. F., Van Etten, R. A., Gounari, F. & Hinds, P. W., Jun 9 2011, In: Blood. 117, 23, p. 6120-6131 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Sleeping beauty: Does ETP-ALL awaken later?
Dose, M. & Gounari, F., Oct 27 2011, In: Blood. 118, 17, p. 4500-4501 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Germar, K., Dose, M., Konstantinou, T., Zhang, J., Wang, H., Lobry, C., Arnett, K. L., Blacklow, S. C., Aifantis, I., Aster, J. C. & Gounari, F., Dec 13 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 50, p. 20060-20065 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The significant role of mast cells in cancer
Khazaie, K., Blatner, N. R., Khan, M. W., Gounari, F., Gounaris, E., Dennis, K., Bonertz, A., Tsai, F. N., Strouch, M. J., Cheon, E., Phillips, J. D., Beckhove, P. & Bentrem, D. J., Mar 2011, In: Cancer and Metastasis Reviews. 30, 1, p. 45-60 16 p.Research output: Contribution to journal › Article › peer-review
138 Scopus citations -
β-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation
Driessens, G., Zheng, Y., Locke, F., Cannon, J. L., Gounari, F. & Gajewski, T. F., Jan 15 2011, In: Journal of Immunology. 186, 2, p. 784-790 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2010
The TLX1 oncogene drives aneuploidy in T cell transformation
De Keersmaecker, K., Real, P. J., Gatta, G. D., Palomero, T., Sulis, M. L., Tosello, V., Van Vlierberghe, P., Barnes, K., Castillo, M., Sole, X., Hadler, M., Lenz, J., Aplan, P. D., Kelliher, M., Kee, B. L., Pandolfi, P. P., Kappes, D., Gounari, F., Petrie, H., Van Der Meulen, J., & 14 others, Nov 2010, In: Nature Medicine. 16, 11, p. 1321-1327 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2009
A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis
Hu, M. G., Deshpande, A., Enos, M., Mao, D., Hinds, E. A., Hu, G. F., Chang, R., Guo, Z., Dose, M., Mao, C., Tsichlis, P. N., Gounari, F. & Hinds, P. W., Feb 1 2009, In: Cancer research. 69, 3, p. 810-818 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Intrathymic proliferation wave essential for Vα14+ natural killer T cell development depends on c-Myc
Dose, M., Sleckman, B. P., Han, J., Bredemeyer, A. L., Bendelac, A. & Gounari, F., May 26 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 21, p. 8641-8646 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity
Kreslavsky, T., Savage, A. K., Hobbs, R., Gounari, F., Bronson, R., Pereira, P., Pandolfi, P. P., Bendelac, A. & Von Boehmer, H., Jul 28 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 30, p. 12453-12458 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The My(c)stery of iNKT cell ontogeny
Dose, M. & Gounari, F., Oct 1 2009, In: Cell Cycle. 8, 19, p. 3082-3085 4 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis
Gounaris, E., Blatner, N. R., Dennis, K., Magnusson, F., Gurish, M. F., Strom, T. B., Beckhove, P., Gounari, F. & Khazaie, K., Jul 1 2009, In: Cancer research. 69, 13, p. 5490-5497 8 p.Research output: Contribution to journal › Article › peer-review
Open Access136 Scopus citations -
β-catenin/Tcf determines the outcome of thymic selection in response to αβTCR signaling
Kovalovsky, D., Yu, Y., Dose, M., Emmanouilidou, A., Konstantinou, T., Germar, K., Aghajani, K., Guo, Z., Mandal, M. & Gounari, F., Sep 15 2009, In: Journal of Immunology. 183, 6, p. 3873-3884 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2008
Fifty ways to Notch T-ALL
Dose, M. & Gounari, F., Aug 1 2008, In: Blood. 112, 3, p. 457-458 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
Li, X., Gounari, F., Protopopov, A., Khazaie, K. & Von Boehmer, H., Nov 12 2008, In: Journal of Experimental Medicine. 205, 12, p. 2851-2861 11 p.Research output: Contribution to journal › Article › peer-review
Open Access70 Scopus citations -
2007
Lef-1: NOTCHed up in T-cell lymphomas
Gounari, F. & Dose, M., Oct 1 2007, In: Blood. 110, 7, p. 2227 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Mast cells are an essential hematopoietic component for polyp development
Gounaris, E., Erdman, S. E., Restaino, C., Gurish, M. F., Friend, D. S., Gounari, F., Lee, D. M., Zhang, G., Glickman, J. N., Shin, K., Rao, V. P., Poutahidis, T., Weissleder, R., McNagny, K. M. & Khazaie, K., Dec 11 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 50, p. 19977-19982 6 p.Research output: Contribution to journal › Article › peer-review
Open Access196 Scopus citations -
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition
Mao, C., Till, E. G., Dose, M., Haks, M. C., Bear, S. E., Maroulakou, I., Horie, K., Gaitanaris, G. A., Fidanza, V., Ludwig, T., Wiest, D. L., Gounari, F. & Tsichlis, P. N., May 1 2007, In: Journal of Immunology. 178, 9, p. 5443-5453 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
β-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
Guo, Z., Dose, M., Kovalovsky, D., Chang, R., O'Neil, J., Look, A. T., Von Boehmer, H., Khazaie, K. & Gounari, F., Jun 15 2007, In: Blood. 109, 12, p. 5463-5472 10 p.Research output: Contribution to journal › Article › peer-review
Open Access94 Scopus citations -
2006
c-Myc mediates pre-TCR-induced proliferation but not developmental progression
Dose, M., Khan, I., Guo, Z., Kovalovsky, D., Krueger, A., Von Boehmer, H., Khazaie, K. & Gounari, F., Oct 15 2006, In: Blood. 108, 8, p. 2669-2677 9 p.Research output: Contribution to journal › Article › peer-review
Open Access74 Scopus citations -
Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate
Garbe, A. I., Krueger, A., Gounari, F., Zúñiga-Pflücker, J. C. & Von Boehmer, H., Jun 12 2006, In: Journal of Experimental Medicine. 203, 6, p. 1579-1590 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2005
Loss of adenomatous polyposis coli gene function disrupts thymic development
Gounari, F., Chang, R., Cowan, J., Guo, Z., Dose, M., Gounaris, E. & Khazaie, K., Aug 2005, In: Nature immunology. 6, 8, p. 800-809 10 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations