General Internal Medicine

Research Output 1975 2019

2019

Implementing a Palliative Medicine Music Therapy Program: A Quality Improvement Project

Wood, C., Cutshall, S. M., Wiste, R. M., Gentes, R. C., Rian, J. S., Tipton, A. M., Ann-Marie, D., Mahapatra, S., Carey, E. & Strand, J. J., Jul 1 2019, In : American Journal of Hospice and Palliative Medicine. 36, 7, p. 603-607 5 p.

Research output: Contribution to journalArticle

Music Therapy
Quality Improvement
Palliative Care
Anxiety
Palliative Medicine

Implications of the Opioid Epidemic for the Clinical Gastroenterology Practice

Thapa, N., Kappus, M., Hurt, R. T. & Diamond, S., Sep 1 2019, In : Current gastroenterology reports. 21, 9, 44.

Research output: Contribution to journalReview article

Gastroenterology
Opioid Analgesics
prucalopride
Constipation
Oxycodone
2 Citations (Scopus)

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X. Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L., Kirkland, J. L. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Cell Aging
Quercetin
High Fat Diet
Nutrition
Fats
1 Citation (Scopus)

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Young Adult
Estrogens
Bone and Bones

In Reply

DeMartino, E. S., Doyle, C. K. & Mueller, P., Sep 3 2019, In : JAMA - Journal of the American Medical Association. 322, 9, 1 p.

Research output: Contribution to journalLetter

Open Access
19 Citations (Scopus)

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., Proctor, C., Correia-Melo, C., Victorelli, S., Fielder, E., Berlinguer-Palmini, R., Owens, A., Greaves, L. C., Kolsky, K. L., Parini, A., Douin-Echinard, V. & 14 others, LeBrasseur, N. K., Arthur, H. M., Tual-Chalot, S., Schafer, M. J., Roos, C. M., Miller, J. D., Robertson, N., Mann, J., Adams, P. D., Tchkonia, T., Kirkland, J. L., Mialet-Perez, J., Richardson, G. D. & Passos, J., Mar 1 2019, In : EMBO Journal. 38, 5, e100492.

Research output: Contribution to journalArticle

Open Access
Telomere
Cardiac Myocytes
Aging of materials
Telomere Shortening
Phenotype
2 Citations (Scopus)

Long-Term Use of Mixed-Oil Lipid Emulsion in Soybean Oil–Intolerant Home Parenteral Nutrition Patients

Mundi, M. S., Kuchkuntla, A. R., Salonen, B. R., Bonnes, S. & Hurt, R. T., Jan 1 2019, In : Journal of Parenteral and Enteral Nutrition.

Research output: Contribution to journalArticle

Intravenous Fat Emulsions
Home Parenteral Nutrition
Emulsions
Soybeans
Oils

Low-level laser therapy for weight reduction: a randomized pilot study

Croghan, I. T., Hurt, R. T., Schroeder, D. R., Fokken, S. C., Jensen, M. D., Clark, M. M. & Ebbert, J. O., Jan 1 2019, (Accepted/In press) In : Lasers in Medical Science.

Research output: Contribution to journalArticle

Open Access
Weight Loss
Waist Circumference
Adipose Tissue
Body Mass Index
Quality of Life

Management Reasoning: Implications for Health Professions Educators and a Research Agenda

Cook, D. A., Durning, S. J., Sherbino, J. & Gruppen, L. D., Sep 1 2019, In : Academic medicine : journal of the Association of American Medical Colleges. 94, 9, p. 1310-1316 7 p.

Research output: Contribution to journalArticle

profession
educator
diagnostic
health
management
3 Citations (Scopus)

Mixing old and young: Enhancing rejuvenation and accelerating aging

Lau, A., Kennedy, B. K., Kirkland, J. L. & Tullius, S. G., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI123946.

Research output: Contribution to journalReview article

Rejuvenation
Transplantation
Transplants
Age Factors
Hematopoietic Stem Cell Transplantation
5 Citations (Scopus)

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

Hurria, A., Carpenter, C. R., McFarland, F., Lundebjerg, N. E., de Cabo, R., Ferrucci, L., Studenski, S. A., Barzilai, N., Briggs, J. P., Ix, J. H., Kitzman, D. W., Kuchel, G. A., Musi, N., Newman, J. C., Rando, T. A., Smith, A. K., Walston, J. D., Kirkland, J. L. & Yung, R., Jan 1 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Organized Financing
Research
Geriatrics
National Institute on Aging (U.S.)
Chronic Disease

Multi-level model to predict antibody response to influenza vaccine using gene expression interaction network feature selection

Parvandeh, S., Poland, G. A., Kennedy, R. B. & McKinney, B. A., Mar 2019, In : Microorganisms. 7, 3, 79.

Research output: Contribution to journalArticle

Open Access
Influenza Vaccines
Antibody Formation
Vaccination
Gene Expression
Human Influenza

Myths and social structure: The unbearable necessity of mythology in medical education

Martimianakis, M. A., Tilburt, J. C., Michalec, B. & Hafferty, F. W., Jan 1 2019, (Accepted/In press) In : Medical education.

Research output: Contribution to journalArticle

mythology
social structure
myth
education
sociology of science

Nonsurgical integrative inpatient treatments for symptomatic lumbar spinal stenosis: A multi-arm randomized controlled pilot trial

Kim, K., Shin, K. M., Hunt, C. L., Wang, Z., Bauer, B. A., Kwon, O., Lee, J. H., Seo, B. N., Jung, S. Y., Youn, Y., Lee, S. H., Choi, J. C., Jung, J. E., Kim, J., Qu, W., Kim, T. H. & Eldrige, J. S., Jan 1 2019, In : Journal of Pain Research. 12, p. 1103-1113 11 p.

Research output: Contribution to journalArticle

Open Access
Spinal Stenosis
Inpatients
Arm
Randomized Controlled Trials
Therapeutics
4 Citations (Scopus)

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., Burns, T. C. & 4 others, Passos, J., von Zglinicki, T., Kirkland, J. L. & Jurk, D., Jan 1 2019, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Manuscripts
Cell Aging
Neurogenesis
Publications
Anxiety
18 Citations (Scopus)

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., Burns, T. C. & 4 others, Passos, J., von Zglinicki, T., Kirkland, J. L. & Jurk, D., May 7 2019, In : Cell Metabolism. 29, 5, p. 1061-1077.e8

Research output: Contribution to journalArticle

Open Access
Cell Aging
Neurogenesis
Anxiety
Obesity
Obese Mice

Patient-centered surgical prehabilitation

Bingener, J., Cutshall, S. M., Skaran, P. E. & Bauer, B. A., Sep 1 2019, In : American journal of surgery. 218, 3, 1 p.

Research output: Contribution to journalLetter

Percutaneous “biopsy” of biopsy clips: A commentary on our initial experience

Samreen, N., Lee, C., Sandhu, N. & Ghosh, K., Jan 1 2019, In : Breast Journal.

Research output: Contribution to journalComment/debate

Surgical Instruments
Biopsy

Perspectives on the use of aromatherapy from clinicians attending an integrative medicine continuing education event

Pearson, A. C. S., Cutshall, S. M., Hooten, W. M., Rodgers, N. J., Bauer, B. A. & Bhagra, A., Jul 12 2019, In : BMC Complementary and Alternative Medicine. 19, 1, 174.

Research output: Contribution to journalArticle

Open Access
Aromatherapy
Integrative Medicine
Continuing Education
Volatile Oils
Aptitude
2 Citations (Scopus)

Pharmacogenomic clinical decision support design and multi-site process outcomes analysis in the eMERGE Network

Herr, T. M., Peterson, J. F., Rasmussen, L. V., Caraballo, P., Peissig, P. L. & Starren, J. B., Feb 1 2019, In : Journal of the American Medical Informatics Association : JAMIA. 26, 2, p. 143-148 6 p.

Research output: Contribution to journalArticle

Clinical Decision Support Systems
Pharmacogenetics
Electronic Health Records
4 Citations (Scopus)

Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of Pancreatic Ductal Adenocarcinoma

Sah, R. P., Sharma, A., Nagpal, S., Patlolla, S. H., Sharma, A., Kandlakunta, H., Anani, V., Angom, R. S., Kamboj, A. K., Ahmed, N., Mohapatra, S., Vivekanandhan, S., Philbrick, K. A., Weston, A., Takahashi, N. M., Kirkland, J. L., Javeed, N., Matveyenko, A. V., Levy, M. J., Mukhopadhyay, D. & 1 others, Chari, S. T., May 1 2019, In : Gastroenterology. 156, 6, p. 1742-1752 11 p.

Research output: Contribution to journalArticle

Subcutaneous Fat
Adenocarcinoma
Intra-Abdominal Fat
Hyperglycemia
Abdominal Subcutaneous Fat

Pilot study of a condensed communication skills workshop for gynecologic oncology fellows

Urban, R. R., Fay, E. E., Podgurski, L., Bevis, K., Carey, E., Lefkowits, C. & Amory, J., Nov 1 2019, In : Gynecologic Oncology Reports. 30, 100492.

Research output: Contribution to journalArticle

Open Access
Communication
Education
Curriculum
Learning

Potential Unintended Consequences Of Recent Shared Decision Making Policy Initiatives

Blumenthal-Barby, J., Opel, D. J., Dickert, N. W., Kramer, D. B., Tucker Edmonds, B., Ladin, K., Peek, M. E., Peppercorn, J. & Tilburt, J., Nov 1 2019, In : Health affairs (Project Hope). 38, 11, p. 1876-1881 6 p.

Research output: Contribution to journalArticle

Decision Making
Administrative Personnel

Preserving Civility in Vaccine Policy Discourse: A Way Forward

Poland, G. A., Tilburt, J. C. & Marcuse, E. K., Jan 1 2019, In : JAMA - Journal of the American Medical Association.

Research output: Contribution to journalShort survey

Vaccines
1 Citation (Scopus)

Recommendations of Active Surveillance for Intermediate-risk Prostate Cancer: Results from a National Survey of Radiation Oncologists and Urologists

Kim, S. P., Shah, N. D., Meropol, N. J., Tilburt, J. C., Nguyen, P. L., Yu, J. B., Abouassaly, R., Kim, A. & Gross, C. P., Mar 1 2019, In : European urology oncology. 2, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Radiation Oncologists
Urologists
Surveys and Questionnaires
Odds Ratio

Regulating Decisions for Incapacitated Pregnant Women-Reply

DeMartino, E. S., Doyle, C. K. & Mueller, P., Sep 3 2019, In : JAMA. 322, 9, 1 p.

Research output: Contribution to journalLetter

Pregnant Women

Repair of Central Venous Catheter in a Single-Center Adult Home Parenteral Nutrition Cohort

Velapati, S. R., Schroeder, S., Kuchkuntla, A. R., Salonen, B. R., Bonnes, S. L., Hurt, R. T. & Mundi, M. S., Jan 1 2019, In : Journal of Parenteral and Enteral Nutrition.

Research output: Contribution to journalArticle

Home Parenteral Nutrition
Central Venous Catheters
Catheters
Infection
Venous Thrombosis

Resurgence of Eating Disorders with Olanzapine

Wu, K. L., Lorenz, A. K., Christensen, K. J., Feely, M. A., Carey, E. & Strand, J. J., Feb 1 2019, In : Journal of Palliative Medicine. 22, 2, p. 231-233 3 p.

Research output: Contribution to journalReview article

olanzapine
Bulimia Nervosa
Palliative Care
Nausea
Appetite

RITAN: Rapid integration of term annotation and network resources

Zimmermann, M. T., Kabat, B., Grill, D. E., Kennedy, R. B. & Poland, G. A., Jan 1 2019, In : PeerJ. 2019, 7, 6994.

Research output: Contribution to journalArticle

Open Access
Genes
genes
Computational Biology
Bioinformatics
bioinformatics
26 Citations (Scopus)

Sarcopenia: Aging-related loss of muscle mass and function

Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L. & Sandri, M., Jan 1 2019, In : Physiological Reviews. 99, 1, p. 427-511 85 p.

Research output: Contribution to journalArticle

Sarcopenia
Muscles
Motor Neurons
Muscle Proteins
Cost Savings

Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial

Loprinzi, C., Le-Rademacher, J. G., Majithia, N., McMurray, R. P., O’Neill, C. R., Bendel, M. A., Beutler, A., Lachance, D. H., Cheville, A., Strick, D. M., Black, D. F., Tilburt, J. C. & Smith, T. J., Jan 1 2019, In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

Drug Therapy
Peripheral Nervous System Diseases
Transcutaneous Electric Nerve Stimulation
Therapeutics
Pain
2 Citations (Scopus)

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T. & Kirkland, J. L., Jan 1 2019, In : Seminars in immunology.

Research output: Contribution to journalReview article

Immune System
Therapeutics
Phenotype
Immunologic Factors
Adaptive Immunity

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
Quercetin
Diabetic Nephropathies
Clinical Trials
Macrophages
Tissue
53 Citations (Scopus)

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N. & Kirkland, J. L., Jan 1 2019, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Quercetin
Labels
Cell Aging
Phenotype
1 Citation (Scopus)

Seroprevalence and durability of rubella virus antibodies in a highly immunized population

Crooke, S. N., Haralambieva, I. H., Grill, D. E., Ovsyannikova, I. G., Kennedy, R. B. & Poland, G. A., Jan 1 2019, In : Vaccine.

Research output: Contribution to journalArticle

Rubella virus
Rubella
Seroepidemiologic Studies
durability
seroprevalence
3 Citations (Scopus)

Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A., Nelson, T. J., Hall-Flavin, D., Fredlender, C., Heard, K. J., Deng, Y., Le, A. T., Dave, S., Fung, L., Li, X., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Serotonin
Neurons
Synaptic Transmission

Sex Difference in Celiac Disease in Undiagnosed Populations: A Systematic Review and Meta-analysis

Jansson-Knodell, C. L., Hujoel, I. A., West, C. P., Taneja, V. D., Prokop, L. J., Rubio-Tapia, A. & Murray, J. A., Sep 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 10, p. 1954-1968.e13

Research output: Contribution to journalArticle

Celiac Disease
Sex Characteristics
Meta-Analysis
Population
Blood Donors
4 Citations (Scopus)

Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination

Voigt, E. A., Ovsyannikova, I. G., Kennedy, R. B., Grill, D. E., Goergen, K. M., Schaid, D. J. & Poland, G. A., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Enzyme-Linked Immunospot Assay
Sex Characteristics
Human Influenza
Vaccination
Influenza Vaccines
Open Access
RNA Sequence Analysis
Induced Pluripotent Stem Cells
Electrophysiology
Cardiac Myocytes
Phenotype

Speed and quality goals in procedural skills learning: A randomized experiment

Cook, D. A., Gas, B. L., Pankratz, V. S., Farley, D. R. & Pusic, M. V., Jan 1 2019, (Accepted/In press) In : Medical Teacher.

Research output: Contribution to journalArticle

experiment
confidence
learning
Group
learning process

Statin therapy: Does sex matter?

Faubion, S. S., Kapoor, E., Moyer, A., Hodis, H. N. & Miller, V. M., Jan 1 2019, (Accepted/In press) In : Menopause.

Research output: Contribution to journalReview article

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Therapeutics
Muscle Neoplasms
Cholesterol
Hydroxymethylglutaryl CoA Reductases
Happiness
Quality of Life
Students
Anxiety
Education

Studying treatment resistance in depression using patient derived neurons in vitro

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A., Nelson, T. J., Hall-Flavin, D., Fredlender, C., Heard, K. J., Deng, Y., Le, A. T., Dave, S., Fung, L., Li, X., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jun 1 2019, In : Molecular Psychiatry. 24, 6, 1 p.

Research output: Contribution to journalComment/debate

Neurons
Therapeutics
In Vitro Techniques

Tai Chi for patients with mild cognitive impairment: A protocol for a systematic review and meta-analysis of randomized controlled trials

Yang, J., Chon, T. Y., Li, G., Mallory, M. J., Bublitz, S. E., Do, A., Xiao, L., Xiong, D. & Bauer, B. A., Oct 1 2019, In : Medicine (United States). 98, 40, e17118.

Research output: Contribution to journalReview article

Open Access
Tai Ji
Meta-Analysis
Randomized Controlled Trials
Safety
PubMed

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F., Milic, N. M., Grande, J. P., Xu, M., Tchkonia, T., Kirkland, J. L., Lerman, L. O. & Garovic, V. D., Sep 14 2019, In : Biology of Sex Differences. 10, 1, 49.

Research output: Contribution to journalArticle

Open Access
Pre-Eclampsia
Mesenchymal Stromal Cells
pregnancy
proliferation
migration
12 Citations (Scopus)

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang-Verzosa, G., Johnson, K. O., Cubro, H., Doornebal, E. J., Ogrodnik, M., Jurk, D., Jensen, M. D., Chini, E. N., Miller, J. D., Matveyenko, A. V., Stout, M. B. & 13 others, Schafer, M. J., White, T. A., Hickson, L., Demaria, M., Garovic, V. D., Grande, J. P., Arriaga, E. A., Kuipers, F., von Zglinicki, T., LeBrasseur, N. K., Campisi, J., Tchkonia, T. & Kirkland, J. L., Jun 1 2019, In : Aging Cell. 18, 3, e12950.

Research output: Contribution to journalArticle

Open Access
Obesity
Adipose Tissue
Obese Mice
Insulin Resistance
p16 Genes
2 Citations (Scopus)

The association of resistance training with mortality: A systematic review and meta-analysis

Saeidifard, F., Medina-Inojosa, J. R., West, C. P., Olson, T. P., Somers, V., Bonikowske, A. R., Prokop, L. J., Vinciguerra, M. & Lopez-Jimenez, F., Jan 1 2019, In : European Journal of Preventive Cardiology.

Research output: Contribution to journalArticle

Resistance Training
Meta-Analysis
Mortality
Confidence Intervals
Exercise
Open Access
Acupuncture
Constipation
Randomized Controlled Trials
Electroacupuncture
Confidence Intervals

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

Colon, G., Saccon, T., Schneider, A., Cavalcante, M. B., Huffman, D. M., Berryman, D., List, E., Ikeno, Y., Musi, N., Bartke, A., Kopchick, J., Kirkland, J. L., Tchkonia, T. & Masternak, M. M., Jan 1 2019, (Accepted/In press) In : GeroScience.

Research output: Contribution to journalReview article

Cognition
Growth Hormone
Anterior Pituitary Gland
Disease Resistance
Adiposity

The Feasibility and Effects of Acupuncture on Muscle Soreness and Sense of Well-being in an Adolescent Football Population

Luetmer, M. T., Do, A., Canzanello, N. C., Bauer, B. A. & Laskowski, E. R., Nov 1 2019, In : American journal of physical medicine & rehabilitation. 98, 11, p. 964-970 7 p.

Research output: Contribution to journalArticle

Football
Myalgia
Acupuncture
Child Welfare
Population