Gastroenterology and Hepatology

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2020

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., Jan 16 2020, In : Nature. 577, 7790, p. 432-436 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Clinical Outcomes of Portosystemic Shunts on the Outcome of Liver Transplantation

Rodriguez, E. A., Perez, R., Zhang, N., Lim, E. S., Miller, C., Schwartz, M. A., McGirr, A. J., Srinivasan, A., Hewitt, W., Silva, A. C., Rakela, J. & Vargas, H. E., May 1 2020, In : Liver Transplantation. 26, 5, p. 693-701 9 p.

Research output: Contribution to journalArticle

EarLy Elimination of Fatty Acids iN hypertriglyceridemia-induced acuTe pancreatitis (ELEFANT trial): Protocol of an open-label, multicenter, adaptive randomized clinical trial

Zádori, N., Gede, N., Antal, J., Szentesi, A., Alizadeh, H., Vincze, Á., Izbéki, F., Papp, M., Czakó, L., Varga, M., de-Madaria, E., Petersen, O. H., Singh, V. P., Mayerle, J., Faluhelyi, N., Miseta, A., Reiber, I. & Hegyi, P., Apr 2020, In : Pancreatology. 20, 3, p. 369-376 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Interobserver Agreement for Classifying Post-liver Transplant Biliary Strictures in Donation After Circulatory Death Donors

Kohli, D. R., Pannala, R., Crowell, M. D., Fukami, N., Faigel, D. O., Aqel, B. A. & Harrison, M. E., Jan 1 2020, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Kinetics of Gallbladder Emptying During Cholecystokinin Cholescintigraphy as an Indicator of In Vivo Hormonal Sensitivity

Miller, L. J., Harikumar, K. G., Desai, A. J., Siddiki, H. & Nguyen, B. D., Mar 1 2020, In : Journal of nuclear medicine technology. 48, 1, p. 40-45 6 p.

Research output: Contribution to journalArticle

Molecular inhibitor of QSOX1 suppresses tumor growth in vivo

Fifield, A. L., Hanavan, P. D., Faigel, D. O., Sergienko, E., Bobkov, A., Meurice, N., Petit, J. L., Polito, A., Caulfield, T. R., Castle, E. P., Copland, J. A., Mukhopadhyay, D., Pal, K., Dutta, S. K., Luo, H., Ho, T. H. & Lake, D. F., Jan 1 2020, In : Molecular cancer therapeutics. 19, 1, p. 112-122 11 p.

Research output: Contribution to journalArticle

Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities

Kammoun, M., Piquereau, J., Nadal-Desbarats, L., Même, S., Beuvin, M., Bonne, G., Veksler, V., Le Fur, Y., Pouletaut, P., Même, W., Szeremeta, F., Constans, J. M., Bruinsma, E. S., Nelson Holte, M. H., Najafova, Z., Johnsen, S. A., Subramaniam, M., Hawse, J. R. & Bensamoun, S. F., Mar 1 2020, In : Acta Physiologica. 228, 3, e13394.

Research output: Contribution to journalArticle

Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation

de Oliveira, C., Khatua, B., Noel, P., Kostenko, S., Bag, A., Balakrishnan, B., Patel, K. S., Guerra, A. A., Martinez, M. N., Trivedi, S., McCullough, A., Lam-Himlin, D. M., Navina, S., Faigel, D. O., Fukami, N., Pannala, R., Phillips, A. E., Papachristou, G. I., Kershaw, E. E., Lowe, M. E. & 1 others, Singh, V. P., Apr 1 2020, In : Journal of Clinical Investigation. 130, 4, p. 1931-1947 17 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Prospective multicenter study to evaluate capsule endoscopy competency using a validated assessment tool

Rajan, E., Martinez, M., Gorospe, E., Al Bawardy, B., Dobashi, A., Mara, K. C., Hansel, S. L., Bruining, D. H., Murray, J. A., Leggett, C. L., Nehra, V., Iyer, P. G., Pasha, S. F., Leighton, J. A., Shiff, A. D., Gurudu, S. R., Raffals, L. E., Lavey, C., Katzka, D. A. & Chen, C. H. H., May 2020, In : Gastrointestinal endoscopy. 91, 5, p. 1140-1145 6 p.

Research output: Contribution to journalArticle

Rational development of a high-affinity secretin receptor antagonist

Dong, M., Harikumar, K. G., Raval, S. R., Milburn, J. E., Clark, C., Alcala-Torano, R., Mobarec, J. C., Reynolds, C. A., Ghirlanda, G., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., Jul 2020, In : Biochemical Pharmacology. 177, 113929.

Research output: Contribution to journalArticle

Risk of Gastrointestinal Bleeding Increases With Combinations of Antithrombotic Agents and Patient Age

Abraham, N. S., Noseworthy, P. A., Inselman, J., Herrin, J., Yao, X., Sangaralingham, L. R., Cornish, G., Ngufor, C. & Shah, N. D., Feb 2020, In : Clinical Gastroenterology and Hepatology. 18, 2, p. 337-346.e19

Research output: Contribution to journalArticle

1 Scopus citations

Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: Randomized crossover trial

Brandler, J., Miller, L. J., Wang, X. J., Burton, D., Busciglio, I., Arndt, K., Harmsen, W. S. & Camilleri, M., Jan 1 2020, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 318, 4, p. G635-G645

Research output: Contribution to journalArticle

Successful Use of Intragastric Balloon Therapy as a Bridge to Heart Transplantation

Patel, N. J., Gómez, V., Steidley, D. E., Roust, L., Leoni Moreno, J. C., Abraham, N. S. & Pannala, R., Jan 1 2020, (Accepted/In press) In : Obesity Surgery.

Research output: Contribution to journalArticle

The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming

Xie, W., Miehe, M., Laufer, S. & Johnsen, S. A., Apr 1 2020, In : Cell Death and Disease. 11, 4, 287.

Research output: Contribution to journalArticle

Open Access

Unique Phenotypic Characteristics and Clinical Course in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis: A Multicenter US Experience

Wang, M. H., Mousa, O. Y., Friton, J. J., Raffals, L. E., Leighton, J. A., Pasha, S. F., Picco, M. F., Cushing, K. C., Monroe, K., Nix, B. D., Newberry, R. D. & Faubion, W. A., Apr 11 2020, In : Inflammatory bowel diseases. 26, 5, p. 774-779 6 p.

Research output: Contribution to journalArticle

2019

Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression

Hasselluhn, M. C., Schmidt, G. E., Ellenrieder, V., Johnsen, S. & Hessmann, E., Jun 1 2019, In : Cell Death and Disease. 10, 6, 446.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Advances in the diagnosis and surveillance of Barrett's esophagus (with videos)

The ASGE Technology Committee, Sep 2019, In : Gastrointestinal endoscopy. 90, 3, p. 325-334 10 p.

Research output: Contribution to journalArticle

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells

Sen, M., Wang, X., Hamdan, F. H., Rapp, J., Eggert, J., Kosinsky, R. L., Wegwitz, F., Kutschat, A. P., Younesi, F. S., Gaedcke, J., Grade, M., Hessmann, E., Papantonis, A., Stróbel, P. & Johnsen, S., Jun 19 2019, In : Clinical Epigenetics. 11, 1, 92.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

ASGE EndoVators Summit: simulators and the future of endoscopic training

Walsh, C. M., Cohen, J., Woods, K. L., Wang, K. K. N., Andersen, D. K., Anderson, M. A., Dunkin, B. J., Edmundowicz, S. A., Faigel, D. O., Law, J. K., Marks, J. M., Sedlack, R. E., Thompson, C. C. & Vargo, J. J., Jul 1 2019, In : Gastrointestinal endoscopy. 90, 1, p. 13-26 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

ASGE guideline for endoscopic full-thickness resection and submucosal tunnel endoscopic resection

ASGE Technology Committee, Aug 2019, In : VideoGIE. 4, 8, p. 343-350 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

ASGE principles of endoscopic training

Chair of 2017-18 ASGE Training Committee, Jul 1 2019, In : Gastrointestinal endoscopy. 90, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Barrett esophagus length, nodularity, and low-grade dysplasia are predictive of progression to esophageal adenocarcinoma

Solanky, D., Krishnamoorthi, R., Crews, N., Johnson, M., Wang, K., Wolfsen, H., Fleischer, D., Ramirez, F. C., Katzka, D., Buttar, N. & Iyer, P. G., May 1 2019, In : Journal of clinical gastroenterology. 53, 5, p. 361-365 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury during Severe Acute Pancreatitis

Khatua, B., Trivedi, R. N., Noel, P., Patel, K., Singh, R. J., de Oliveira, C., Trivedi, S., Mishra, V., Lowe, M. & Singh, V. P., Jun 1 2019, In : American Journal of Pathology. 189, 6, p. 1226-1240 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer

Tüzmen, Ş., Hostetter, G., Watanabe, A., Ekmekçi, C., Carrigan, P. E., Shechter, I., Kallioniemi, O., Miller, L. J. & Mousses, S., Jan 1 2019, In : Personalized Medicine. 16, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Clinical and Molecular Features of Post-Colonoscopy Colorectal Cancers

Samadder, N. J., Neklason, D., Snow, A., Samowitz, W., Cessna, M. H., Rowe, K., Sandhu, I., Boucher, K., Pappas, L., Smith, K. R., Wong, J., Curtin, K., Provenzale, D. & Burt, R. W., Dec 2019, In : Clinical Gastroenterology and Hepatology. 17, 13, p. 2731-2739.e2

Research output: Contribution to journalArticle

2 Scopus citations
Open Access

Competency in esophagogastroduodenoscopy: a validated tool for assessment and generalizable benchmarks for gastroenterology fellows

ACE Research Group, Oct 2019, In : Gastrointestinal endoscopy. 90, 4, p. 613-620.e1

Research output: Contribution to journalArticle

3 Scopus citations

Devices for endoscopic hemostasis of nonvariceal GI bleeding (with videos)

ASGE Technology Committee Chair & ASGE Technology Committee, Jul 2019, In : VideoGIE. 4, 7, p. 285-299 15 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Effervescent agents in acute esophageal food impaction

David, J., Backstedt, D., O’Keefe, K. J., Salehpour, K., Gerkin, R. D. & Ramirez, F. C., Jan 1 2019, In : Diseases of the Esophagus. 32, 4

Research output: Contribution to journalArticle

Open Access

Efficacy of Per-oral Methylene Blue Formulation for Screening Colonoscopy

Repici, A., Wallace, M. B., East, J. E., Sharma, P., Ramirez, F. C., Bruining, D. H., Young, M., Gatof, D., Irene (Mimi) Canto, M., Marcon, N., Cannizzaro, R., Kiesslich, R., Rutter, M., Dekker, E., Siersema, P. D., Spaander, M., Kupcinskas, L., Jonaitis, L., Bisschops, R., Radaelli, F. & 8 others, Bhandari, P., Wilson, A., Early, D., Gupta, N., Vieth, M., Lauwers, G. Y., Rossini, M. & Hassan, C., Jun 1 2019, In : Gastroenterology. 156, 8, p. 2198-2207.e1

Research output: Contribution to journalArticle

13 Scopus citations

Endoscopic simulators

ASGE Technology Committee, Jul 2019, In : Gastrointestinal endoscopy. 90, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Epigenome mapping identifies tumor-specific gene expression in primary rectal cancer

Flebbe, H., Hamdan, F. H., Kari, V., Kitz, J., Gaedcke, J., Ghadimi, B. M., Johnsen, S. & Grade, M., Aug 1 2019, In : Cancers. 11, 8, 1142.

Research output: Contribution to journalArticle

Open Access

Factors Associated With Use of Nonoral Nutrition and Hydration Support in Adult Patients With Postural Tachycardia Syndrome

Tseng, A. S., Traub, N. A., Harris, L. A., Crowell, M. D., Hoffman-Snyder, C. R., Goodman, B. P. & DiBaise, J. D., Jan 1 2019, In : Journal of Parenteral and Enteral Nutrition. 43, 6, p. 734-741 8 p.

Research output: Contribution to journalArticle

Factors That Affect Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Pancreatitis: A Systematic Review, Meta-Analysis, and Meta-Regression

El Kurdi, B., Babar, S., El Iskandarani, M., Bataineh, A., Lerch, M. M., Young, M. & Singh, V. P., Sep 1 2019, In : Clinical and translational gastroenterology. 10, 9, p. e00072

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Familial pancreatic cancer risk: a population-based study in Utah

Kohli, D. R., Smith, K. R., Wong, J., Yu, Z., Boucher, K., Faigel, D. O., Pannala, R., Burt, R. W., Curtin, K. & Samadder, N. J., Dec 1 2019, In : Journal of gastroenterology. 54, 12, p. 1106-1112 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases

Samadder, N. J., Valentine, J. F., Guthery, S., Singh, H., Bernstein, C. N., Leighton, J. A., Wan, Y., Wong, J., Boucher, K., Pappas, L., Rowe, K., Burt, R. W., Curtin, K. & Smith, K. R., Jan 1 2019, In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

6 Scopus citations

Intestinal metaplasia of the gastric cardia: findings in patients with versus without Barrett's esophagus

Siddiki, H. A., Lam-Himlin, D. M., Kahn, A., Bandres, M. V., Burdick, G. E., Crowell, M. D., Pannala, R., Ramirez, F. C., Vela, M. F. & Fleischer, D. E., Jan 1 2019, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Loss of rnf40 decreases nf-κb activity in colorectal cancer cells and reduces colitis burden in mice

Kosinsky, R. L., Chua, R. L., Qui, M., Saul, D., Mehlich, D., Ströbel, P., Schildhaus, H. U., Wegwitz, F., Faubion, W. A. & Johnsen, S. A., Mar 26 2019, In : Journal of Crohn's and Colitis. 13, 3, p. 362-373 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Management of nonvariceal upper gastrointestinal bleeding: Guideline recommendations from the international consensus group

Barkun, A. N., Almadi, M., Kuipers, E. J., Laine, L., Sung, J., Tse, F., Leontiadis, G. I., Abraham, N. S., Calvet, X., Chan, F. K. L., Douketis, J., Enns, R., Gralnek, I. M., Jairath, V., Jensen, D., Lau, J., Lip, G. Y. H., Loffroy, R., Maluf-Filho, F., Meltzer, A. C. & 4 others, Reddy, N., Saltzman, J. R., Marshall, J. K. & Bardou, M., Dec 3 2019, In : Annals of internal medicine. 171, 11, p. 805-822 18 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue

Sternby, H., Mahle, M., Linder, N., Erichson-Kirst, L., Verdonk, R. C., Dimova, A., Ignatavicius, P., Ilzarbe, L., Koiva, P., Penttilä, A., Regnér, S., Bollen, T. L., Brill, R., Stangl, F., Wohlgemuth, W. A., Singh, V., Busse, H., Michl, P., Beer, S. & Rosendahl, J., Dec 1 2019, In : United European Gastroenterology Journal. 7, 10, p. 1312-1320 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mental health disorders are more common in colorectal cancer survivors and associated with decreased overall survival

Lloyd, S., Baraghoshi, D., Tao, R., Garrido-Laguna, I., Gilcrease, G. W., Whisenant, J., Weis, J. R., Scaife, C., Pickron, T. B., Huang, L. C., Monroe, M. M., Abdelaziz, S., Fraser, A. M., Smith, K. R., Deshmukh, V., Newman, M., Rowe, K. G., Snyder, J., Samadder, N. J. & Hashibe, M., Apr 1 2019, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 42, 4, p. 355-362 8 p.

Research output: Contribution to journalArticle

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Desai, A. J., Mechin, I., Nagarajan, K., Valant, C., Wootten, D., Lam, P. C. H., Orry, A., Abagyan, R., Nair, A., Sexton, P. M., Christopoulos, A. & Miller, L. J., Mar 1 2019, In : Molecular Pharmacology. 95, 3, p. 245-259 15 p.

Research output: Contribution to journalArticle

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival

de Oliveira, C., Khatua, B., Bag, A., El-Kurdi, B., Patel, K., Mishra, V., Navina, S. & Singh, V. P., Feb 1 2019, In : Gastroenterology. 156, 3, p. 735-747.e10

Research output: Contribution to journalArticle

2 Scopus citations

Novel Genetic Risk Variants Can Predict Anti-TNF Agent Response in Patients with Inflammatory Bowel Disease

Wang, M. H., Friton, J. J., Raffals, L. E., Leighton, J. A., Pasha, S. F., Picco, M. F., Cushing, K. C., Monroe, K., Nix, B. D., Newberry, R. D. & Faubion, W. A., Aug 14 2019, In : Journal of Crohn's and Colitis. 13, 8, p. 1036-1043 8 p., jjz017.

Research output: Contribution to journalArticle

1 Scopus citations

Organ Failure Due to Systemic Injury in Acute Pancreatitis

Garg, P. K. & Singh, V. P., May 2019, In : Gastroenterology. 156, 7, p. 2008-2023 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Outcomes of endoscopic therapy in donation after cardiac death liver transplant biliary strictures

Kohli, D. R., Harrison, M. E., Mujahed, T., Fukami, N., Faigel, D. O., Pannala, R., Moss, A. & Aqel, B. A., Jan 1 2019, (Accepted/In press) In : HPB.

Research output: Contribution to journalArticle

1 Scopus citations

Perturbing enhancer activity in cancer therapy

Hamdan, F. H. & Johnsen, S., May 1 2019, In : Cancers. 11, 5, 634.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Predictors of Biliary Strictures After Liver Transplantation Among Recipients of DCD (Donation After Cardiac Death) Grafts

Kohli, D. R., Harrison, M. E., Adike, A. O., El Kurdi, B., Fukami, N., Faigel, D. O., Pannala, R., Moss, A. A. & Aqel, B. A., Jan 1 2019, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

3 Scopus citations

Radiopathological correlation of a von Hippel-Lindau syndrome associated pancreatic neuroendocrine tumour with clear cell features

Hopp, A. C., Collins, J. M., Nguyen, C. C. & Yang, M., Feb 1 2019, In : BMJ Case Reports. 12, 2, e227891.

Research output: Contribution to journalArticle

The Clinician's Guide to Suspected Small Bowel Bleeding

Kuo, J. R., Pasha, S. F. & Leighton, J. A., Apr 1 2019, In : The American Journal of Gastroenterology. 114, 4, p. 591-598 8 p.

Research output: Contribution to journalArticle

3 Scopus citations