Gastroenterology and Hepatology

Research Output 1978 2020

2017
3 Citations (Scopus)

Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients with Recurrent Clostridium difficile Infection

Patron, R. L., Hartmann, C. A., Allen, S., Griesbach, C. L., Kosiorek, H. E., Dibaise, J. K. & Orenstein, R., Oct 1 2017, In : Clinical Infectious Diseases. 65, 7, p. 1214-1217 4 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Vancomycin
Tertiary Care Centers
Multivariate Analysis
9 Citations (Scopus)

White Paper AGA: Optimal Strategies to Define and Diagnose Gastroesophageal Reflux Disease

Vaezi, M. F., Pandolfino, J. E., Vela, M. F. & Shaheen, N. J., Aug 1 2017, In : Clinical Gastroenterology and Hepatology. 15, 8, p. 1162-1172 11 p.

Research output: Contribution to journalArticle

Gastroesophageal Reflux
21 Citations (Scopus)

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

DeBruine, Z. J., Ke, J., Harikumar, K. G., Gu, X., Borowsky, P., Williams, B. O., Xu, W., Miller, L. J., Xu, H. E. & Melcher, K., 2017, In : Genes and Development. 31, 9, p. 916-926 11 p.

Research output: Contribution to journalArticle

Dimerization
Cysteine
Frizzled Receptors
Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-5
2016

A brief history of the ASGE

Faigel, D. O., Jan 1 2016, In : Gastrointestinal Endoscopy. 83, 1, p. 1 1 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Gastrointestinal Endoscopy
Medical Societies
Anniversaries and Special Events
33 Citations (Scopus)

Accuracy of First- and Second-Generation Colon Capsules in Endoscopic Detection of Colorectal Polyps: A Systematic Review and Meta-analysis

Spada, C., Pasha, S. F., Gross, S. A., Leighton, J. A., Schnoll-Sussman, F., Correale, L., González Suárez, B., Costamagna, G. & Hassan, C., Nov 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 11, p. 1533-1543.e8

Research output: Contribution to journalReview article

Capsule Endoscopy
Polyps
Capsules
Meta-Analysis
Colon
46 Citations (Scopus)

ACG Clinical Guideline: Nutrition Therapy in the Adult Hospitalized Patient

McClave, S. A., DiBaise, J. K., Mullin, G. E. & Martindale, R. G., Mar 8 2016, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

Nutrition Therapy
Enteral Nutrition
Guidelines
Stomach
Nutrition Assessment
16 Citations (Scopus)

Acute liver failure associated with Garcinia cambogia use

Corey, R., Werner, K. T., Singer, A., Moss, A., Smith, M., Noelting, J. & Rakela, J., Jan 1 2016, In : Annals of Hepatology. 15, 1, p. 123-126 4 p.

Research output: Contribution to journalArticle

Garcinia cambogia
Acute Liver Failure
Liver Failure
Dietary Supplements
Liver Transplantation
11 Citations (Scopus)

Advances in primary sclerosing cholangitis

Horsley-Silva, J. L., Carey, E. J. & Lindor, K. D., 2016, In : The Lancet Gastroenterology and Hepatology. 1, 1, p. 68-77 10 p.

Research output: Contribution to journalReview article

Sclerosing Cholangitis
Inflammatory Bowel Diseases
Steatorrhea
Ursodeoxycholic Acid
Cholangiocarcinoma
36 Citations (Scopus)

Age, gender, and women's health and the patient

Houghton, L. A., Heitkemper, M., Crowell, M. D., Emmanuel, A., Halpert, A., McRoberts, J. A. & Toner, B., May 1 2016, In : Gastroenterology. 150, 6, p. 1332-1343e4

Research output: Contribution to journalArticle

Women's Health
Gastrointestinal Diseases
Visceral Pain
Health Personnel
Serotonin 5-HT4 Receptor Agonists
26 Citations (Scopus)

A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: Lessons from class B crystal structuress

Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., Mar 1 2016, In : Molecular Pharmacology. 89, 3, p. 335-347 13 p.

Research output: Contribution to journalArticle

Hydrogen
Peptides
Oxyntomodulin
Calcium
Corticotropin-Releasing Hormone Receptors
23 Citations (Scopus)

Alkaline phosphatase normalization is a biomarker of improved survival in primary sclerosing cholangitis

Hilscher, M., Enders, F. T., Carey, E. J., Lindor, K. D. & Tabibian, J. H., Mar 1 2016, In : Annals of Hepatology. 15, 2, p. 246-253 8 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Alkaline Phosphatase
Biomarkers
Survival
Liver Transplantation
9 Citations (Scopus)

Analysis of Biopsies From Duodenal Bulbs of All Endoscopy Patients Increases Detection of Abnormalities but has a Minimal Effect on Diagnosis of Celiac Disease

Stoven, S. A., Choung, R. S., Rubio-Tapia, A., Absah, I., Lam-Himlin, D. M., Harris, L. A., Ngamruengphong, S., Vazquez Roque, M. I., Wu, T. T. & Murray, J. A., Nov 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 11, p. 1582-1588 7 p.

Research output: Contribution to journalArticle

Celiac Disease
Endoscopy
Biopsy
Serology
Duodenitis
62 Citations (Scopus)

ASGE Technology Committee systematic review and meta-analysis assessing the ASGE Preservation and Incorporation of Valuable Endoscopic Innovations thresholds for adopting real-time imaging-assisted endoscopic targeted biopsy during endoscopic surveillance of Barrett's esophagus

Thosani, N., Abu Dayyeh, B. K., Sharma, P., Aslanian, H. R., Enestvedt, B. K., Komanduri, S., Manfredi, M., Navaneethan, U., Maple, J. T., Pannala, R., Parsi, M. A., Smith, Z. L., Sullivan, S. A. & Banerjee, S., Apr 1 2016, In : Gastrointestinal Endoscopy. 83, 4, p. 684-698.e7

Research output: Contribution to journalArticle

Gastrointestinal Endoscopy
Barrett Esophagus
Advisory Committees
Meta-Analysis
Confidence Intervals
8 Citations (Scopus)

A System to Assess the Competency for Interpretation of Esophageal Manometry Identifies Variation in Learning Curves

Yadlapati, R., Keswani, R. N., Ciolino, J. D., Grande, D. P., Listernick, Z. I., Carlson, D. A., Castell, D. O., Dunbar, K. B., Gawron, A. J., Gyawali, C. P., Katz, P. O., Katzka, D. A., Lacy, B. E., Spechler, S. J., Tatum, R., Vela, M. F. & Pandolfino, J. E., 2016, (Accepted/In press) In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Learning Curve
Manometry
Mental Competency
Gastroenterology
Multicenter Studies
6 Citations (Scopus)

Automated endoscope reprocessors

ASGE Technology Committee, Dec 1 2016, In : Gastrointestinal Endoscopy. 84, 6, p. 885-892 8 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Automated polyp detection in colonoscopy videos using shape and context information

Tajbakhsh, N., Gurudu, S. R. & Liang, J., Feb 1 2016, In : IEEE Transactions on Medical Imaging. 35, 2, p. 630-644 15 p., 2487997.

Research output: Contribution to journalArticle

Colonoscopy
Polyps
Feature extraction
Databases
Computer Systems
16 Citations (Scopus)

Baseline impedance measured during high-resolution esophageal impedance manometry reliably discriminates GERD patients

Ravi, K., Geno, D. M., Vela, M. F., Crowell, M. D. & Katzka, D. A., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Manometry
Gastroesophageal Reflux
Electric Impedance
Costs and Cost Analysis
Acids
101 Citations (Scopus)

Biopsychosocial aspects of functional gastrointestinal disorders: How central and environmental processes contribute to the development and expression of functional gastrointestinal disorders

Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B. & Naliboff, B. D., May 1 2016, In : Gastroenterology. 150, 6, p. 1355-1367e2

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Psychology
Biological Factors
Maintenance
Pharmacology
32 Citations (Scopus)

Celecoxib for the prevention of colorectal adenomas: Results of a suspended randomized controlled trial

Thompson, P. A., Ashbeck, E. L., Roe, D. J., Fales, L., Buckmeier, J., Wang, F., Bhattacharyya, A., Hsu, C. H., Chow, S. H. H., Ahnen, D. J., Boland, C. R., Heigh, R. I., Fay, D. E., Hamilton, S. R., Jacobs, E. T., Martinez, E. M., Alberts, D. S. & Lance, P., Dec 1 2016, In : Journal of the National Cancer Institute. 108, 12, djw151.

Research output: Contribution to journalArticle

Celecoxib
Adenoma
Randomized Controlled Trials
Placebos
Selenium
4 Citations (Scopus)

Characterization and predictive value of near infrared 2-deoxyglucose optical imaging in severe acute pancreatitis

De Oliveira, C., Patel, K., Mishra, V., Trivedi, R. N., Noel, P., Singh, A., Yaron, J. R. & Singh, V. P., Feb 1 2016, In : PLoS One. 11, 2, e0149073.

Research output: Contribution to journalArticle

2-deoxyglucose
pancreatitis
Optical Imaging
Deoxyglucose
Pancreatitis
16 Citations (Scopus)

Cholangiopancreatoscopy

Komanduri, S., Thosani, N., Abu Dayyeh, B. K., Aslanian, H. R., Enestvedt, B. K., Manfredi, M., Maple, J. T., Navaneethan, U., Pannala, R., Parsi, M. A., Smith, Z. L., Sullivan, S. A. & Banerjee, S., 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Endoscopes
Endoscopic Retrograde Cholangiopancreatography
Pancreatic Ducts
Bile Ducts
Endoscopy
33 Citations (Scopus)

Clinical Features and Outcomes of Complementary and Alternative Medicine Induced Acute Liver Failure and Injury

Hillman, L., Gottfried, M., Whitsett, M., Rakela, J., Schilsky, M., Lee, W. M. & Ganger, D., Apr 5 2016, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

Acute Liver Failure
Complementary Therapies
Wounds and Injuries
Chemical and Drug Induced Liver Injury
Prescriptions
661 Citations (Scopus)

Convolutional Neural Networks for Medical Image Analysis: Full Training or Fine Tuning?

Tajbakhsh, N., Shin, J. Y., Gurudu, S. R., Hurst, R. T., Kendall, C. B., Gotway, M. & Liang, J., May 1 2016, In : IEEE Transactions on Medical Imaging. 35, 5, p. 1299-1312 14 p., 7426826.

Research output: Contribution to journalArticle

Gastroenterology
Diagnostic Imaging
Cardiology
Radiology
Image analysis
3 Citations (Scopus)

Dabigatran Versus Warfarin in Relation to Renal Function in Patients with Atrial Fibrillation

Munoz, F. D. C., Yao, X., Abraham, N. S., Bellolio, F., Rabinstein, A., Asirvatham, S. J., McBane, R. D., Gersh, B. J., Shah, N. D. & Noseworthy, P., Jul 5 2016, In : Journal of the American College of Cardiology. 68, 1, p. 129-131 3 p.

Research output: Contribution to journalLetter

Warfarin
Atrial Fibrillation
Kidney
Dabigatran
36 Citations (Scopus)

Design of treatment trials for functional gastrointestinal disorders

Irvine, E. J., Tack, J., Crowell, M. D., Gwee, K. A., Ke, M., Schmulson, M. J., Whitehead, W. E. & Spiegel, B., May 1 2016, In : Gastroenterology. 150, 6, p. 1469-1480e1

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Nocebo Effect
Therapeutics
Placebos
Placebo Effect
4 Citations (Scopus)

Detection of suspected small bowel bleeding: challenges and controversies

Pasha, S. F. & Leighton, J. A., Nov 1 2016, In : Expert Review of Gastroenterology and Hepatology. 10, 11, p. 1235-1244 10 p.

Research output: Contribution to journalReview article

Hemorrhage
Iron-Deficiency Anemias
PubMed
Endoscopy
Databases
92 Citations (Scopus)

Development and validation of the Rome IV diagnostic questionnaire for adults

Palsson, O. S., Whitehead, W. E., Van Tilburg, M. A. L., Chang, L., Chey, W., Crowell, M. D., Keefer, L., Lembo, A. J., Parkman, H. P., Rao, S. S. C., Sperber, A., Spiegel, B., Tack, J., Vanner, S., Walker, L. S., Whorwell, P. & Yang, Y., May 1 2016, In : Gastroenterology. 150, 6, p. 1481-1491 11 p.

Research output: Contribution to journalArticle

Constipation
Irritable Bowel Syndrome
Dyspepsia
Gastrointestinal Diseases
Gastroenterology
13 Citations (Scopus)

Devices and techniques for ERCP in the surgically altered GI tract

Enestvedt, B. K., Kothari, S., Pannala, R., Yang, J., Fujii-Lau, L. L., Hwang, J. H., Konda, V., Manfredi, M., Maple, J. T., Murad, F. M., Woods, K. L. & Banerjee, S., Mar 4 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

Dutch Pancreatitis Study Group, Dutch Pancreatitis Study Group & Sarr, M., 2016, In : HPB. 18, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Pancreatitis
Necrosis
Fine Needle Biopsy
Drainage
Catheters
97 Citations (Scopus)

Direct Comparison of Dabigatran, Rivaroxaban, and Apixaban for Effectiveness and Safety in Nonvalvular Atrial Fibrillation

Noseworthy, P., Yao, X., Abraham, N. S., Sangaralingham, L. R., McBane, R. D. & Shah, N. D., Dec 1 2016, In : Chest. 150, 6, p. 1302-1312 11 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Safety
Hemorrhage
Anticoagulants
Propensity Score
201 Citations (Scopus)
Warfarin
Atrial Fibrillation
Safety
Stroke
Hemorrhage
170 Citations (Scopus)

Effect of Adherence to Oral Anticoagulants on Risk of Stroke and Major Bleeding Among Patients With Atrial Fibrillation

Yao, X., Abraham, N. S., Caleb Alexander, G., Crown, W., Montori, V. M., Sangaralingham, L. R., Gersh, B. J., Shah, N. D. & Noseworthy, P., 2016, In : Journal of the American Heart Association. 5, 2, p. 1-12 12 p.

Research output: Contribution to journalArticle

Anticoagulants
Atrial Fibrillation
Stroke
Hemorrhage
Warfarin
11 Citations (Scopus)

Emerging drugs for the treatment of Primary Biliary Cholangitis

Ali, A. H., Tabibian, J. H., Carey, E. J. & Lindor, K. D., Jan 2 2016, In : Expert Opinion on Emerging Drugs. 21, 1, p. 39-56 18 p.

Research output: Contribution to journalArticle

Cholangitis
Pharmaceutical Preparations
Ursodeoxycholic Acid
Therapeutics
HLA Antigens
5 Citations (Scopus)

Endoscopic electronic medical record systems Prepared by

ASGE Technology Committee, Jan 1 2016, In : Gastrointestinal Endoscopy. 83, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

Electronic Health Records
Technology
Gastrointestinal Endoscopy
Endoscopy
Publications
9 Citations (Scopus)

Endoscopic ultrasound-guided fine needle aspiration cytology of metastatic renal cell carcinoma to the pancreas: A multi-center experience

Pannala, R., Hallberg-Wallace, K., Smith, A., Nassar, A., Zhang, J., Zarka, M., Reynolds, J. & Chen, L., Jan 1 2016, In : CytoJournal. 13, 1, 24.

Research output: Contribution to journalArticle

Endoscopic Ultrasound-Guided Fine Needle Aspiration
Renal Cell Carcinoma
Cell Biology
Pancreas
Neoplasm Metastasis
1 Citation (Scopus)
Clostridium difficile
Proton Pump Inhibitors
Microbiota
Gene Library
Publications

Esophageal leukoplakia: a rare cause of white patches in esophagus with malignant potential

Ratuapli, S. K., Thind, K., Fleischer, D. E., Shiff, A. D., Foxx-Orenstein, A. E. & Lam-Himlin, D. M., Oct 1 2016, In : Diseases of the Esophagus. 29, 7, p. 885 1 p.

Research output: Contribution to journalArticle

Leukoplakia
Esophagus
4 Citations (Scopus)

Esophageal stents: When and how

Kachaamy, T. & Pannala, R., Jun 1 2016, In : Minerva Gastroenterologica e Dietologica. 62, 2, p. 155-166 12 p.

Research output: Contribution to journalReview article

Stents
Pathologic Constriction
Deglutition Disorders
Surgical Instruments
Metals

EUS for pancreaticobiliary duct access and drainage

Fukami, N., Apr 22 2016, Advanced Pancreaticobiliary Endoscopy. Springer International Publishing, p. 183-191 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drainage
9 Citations (Scopus)

EUS-guided portal injection chemotherapy for treatment of hepatic metastases: Feasibility in the acute porcine model

Faigel, D. O., Lake, D. F., Landreth, T. L., Kelman, C. C. & Marler, R. J., Feb 1 2016, In : Gastrointestinal Endoscopy. 83, 2, p. 444-446 3 p.

Research output: Contribution to journalArticle

irinotecan
Swine
Neoplasm Metastasis
Drug Therapy
Injections
8 Citations (Scopus)

Fatty acid ethyl esters are less toxic than their parent fatty acids generated during acute pancreatitis

Patel, K., Durgampudi, C., Noel, P., Trivedi, R. N., De Oliveira, C. & Singh, V. P., Apr 1 2016, In : American Journal of Pathology. 186, 4, p. 874-884 11 p.

Research output: Contribution to journalArticle

Poisons
Pancreatitis
Esters
Fatty Acids
Oleic Acid
1 Citation (Scopus)

Gastric lap-band infection due to Mycobacterium abscessus presenting as new-onset ascites in a cirrhotic patient

Kahn, A., Agrwal, N., Carey, E. J., Madura, J. A., Hewitt, W. R., Lambert, K. L., Grys, T. & Vikram, H. R., 2016, In : Infectious Diseases. 48, 8, p. 632-635 4 p.

Research output: Contribution to journalArticle

Nontuberculous Mycobacterium Infections
Abdominal Abscess
Nontuberculous Mycobacteria
Peritoneal Dialysis
Mycobacterium
7 Citations (Scopus)

Gastrointestinal bleeding secondary to the new anticoagulants

Abraham, N. S. & Horsley-Silva, J. L., Sep 14 2016, (Accepted/In press) In : Current Opinion in Gastroenterology.

Research output: Contribution to journalArticle

Anticoagulants
Hemorrhage
Risk Management
Knowledge Management
Warfarin
23 Citations (Scopus)

Gastroparesis: Quality of Life and Health Care Utilization

Lacy, B. E., Crowell, M. D., Mathis, C., Bauer, D. & Heinberg, L. J., Oct 21 2016, (Accepted/In press) In : Journal of Clinical Gastroenterology.

Research output: Contribution to journalArticle

Patient Acceptance of Health Care
Gastroparesis
Quality of Health Care
Quality of Life
Pain
62 Citations (Scopus)

Glucagon-like peptide-1 and its class B G protein-coupled receptors: A long march to therapeutic successes

de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J. M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M. W., Oct 1 2016, In : Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
G-Protein-Coupled Receptors
Ligands
Enteroendocrine Cells
Pharmacology
3 Citations (Scopus)

Hepatitis E virus serum antibodies and RNA prevalence in patients evaluated for heart and kidney transplantation

Unzueta, A., Valdez, R., Chang, Y. H. H., Desmarteau, Y. M., Heilman, R. L., Scott, R. L., Douglas, D. D. & Rakela, J., Jan 1 2016, In : Annals of Hepatology. 15, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Hepatitis E virus
Heart Transplantation
Kidney Transplantation
RNA
Antibodies
3 Citations (Scopus)

Hepatoid Carcinoma of the Pancreas: Case Report, Next-Generation Tumor Profiling, and Literature Review

Chang, J. M., Katariya, N. N., Lam-Himlin, D. M., Haakinson, D. J., Ramanathan, R. K., Halfdanarson, T. R., Borad, M. J., Pannala, R., Faigel, D. O., Moss, A. A. & Mathur, A., Oct 18 2016, (Accepted/In press) In : Case Reports in Gastroenterology. p. 605-612 8 p.

Research output: Contribution to journalArticle

Pancreas
Carcinoma
Acinar Cell Carcinoma
Neoplasms
Neuroendocrine Cells
15 Citations (Scopus)

Identification of Quality Measures for Performance of and Interpretation of Data From Esophageal Manometry

Yadlapati, R., Gawron, A. J., Keswani, R. N., Bilimoria, K., Castell, D. O., Dunbar, K. B., Gyawali, C. P., Jobe, B. A., Katz, P. O., Katzka, D. A., Lacy, B. E., Massey, B. T., Richter, J. E., Schnoll-Sussman, F., Spechler, S. J., Tatum, R., Vela, M. F. & Pandolfino, J. E., Apr 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 4, p. 526-534.e1

Research output: Contribution to journalArticle

Manometry
Esophageal Motility Disorders
Unnecessary Procedures
Benchmarking
Los Angeles

Impact and outcomes of research sponsored by the American Society for Gastrointestinal Endoscopy

Madhoun, M. F., Cote, G. A., Ahlawat, S. K., Ahmad, N. A., Buscaglia, J. M., Calderwood, A. H., Crockett, S., Early, D. S., Gleeson, F. C., Gurudu, S. R., Imperiale, T. F., Liu, J. J., Mosler, P., Pannala, R., Pfau, P. R., Romagnuolo, J., Samadder, N. J., Sethi, A., Shergill, A. K., Shin, E. J. & 2 others, Willingham, F. & Dominitz, J. A., 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Gastrointestinal Endoscopy
Organized Financing
Outcome Assessment (Health Care)
Publications
Research
6 Citations (Scopus)

Irritable Bowel Syndrome and Female Patients

Harris, L. A., Umar, S. B., Baffy, N. & Heitkemper, M. M., Jun 1 2016, In : Gastroenterology Clinics of North America. 45, 2, p. 179-204 26 p.

Research output: Contribution to journalReview article

Irritable Bowel Syndrome
Gastrointestinal Diseases
Abdominal Pain
Therapeutics